Glucocorticoids Shape Macrophage Phenotype for Tissue Repair.

abstract：:The classical model of cytokine signaling dominates our view of specific gene activation by cytokines such as the interferons (IFNs). The importance of the model extends beyond cytokines and applies to hormones such as growth hormone (GH) and insulin, and growth factors such as epidermal growth factor (EGF) and fibrob...

journal_title：Frontiers in immunology

authors： Johnson HM,Noon-Song EN,Dabelic R,Ahmed CM

更新日期：2013-07-25 00:00:00

abstract：:The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration, crossing of biologic...

journal_title：Frontiers in immunology

authors： Dupré L,Houmadi R,Tang C,Rey-Barroso J

更新日期：2015-11-18 00:00:00

abstract：:Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressiv...

journal_title：Frontiers in immunology

authors： Stegner D,Klaus V,Nieswandt B

更新日期：2019-11-01 00:00:00

abstract：:Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epi...

journal_title：Frontiers in immunology

authors： Ogishi M,Yotsuyanagi H

更新日期：2019-04-16 00:00:00

abstract：:Acute pancreatitis (AP) is a common and devastating inflammatory disorder of the pancreas. However, there are still no effective treatments available for the disease. Therefore, it is important to discover new therapeutic targets and strategies for better treatment and prognosis of AP patients. Toll-like receptor 3 (T...

journal_title：Frontiers in immunology

authors： Huang C,Chen S,Zhang T,Li D,Huang Z,Huang J,Qin Y,Chen B,Cheng G,Ma F,Zhou M

更新日期：2019-05-03 00:00:00

abstract：:The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory responses. The delineation of innate and adaptive immune milieu among the broad leukocyte infiltrate, and the gene networks, which construct these responses, a...

journal_title：Frontiers in immunology

authors： Natoli R,Mason E,Jiao H,Chuah A,Patel H,Fernando N,Valter K,Wells CA,Provis J,Rutar M

更新日期：2018-07-18 00:00:00

abstract：:Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal immunization include natural concern about safety as well as a d...

journal_title：Frontiers in immunology

authors： Whittaker E,Goldblatt D,McIntyre P,Levy O

更新日期：2018-04-04 00:00:00

abstract：:Ninety percent of those diagnosed with systemic lupus erythematosus are female, with peak incidence between the ages of 15 and 45, when women are most hormonally active. Despite significant research effort, the mechanisms underlying this sex bias remain unclear. We previously showed that a functional knockout of estro...

journal_title：Frontiers in immunology

authors： Cunningham MA,Wirth JR,Scott JL,Eudaly J,Collins EL,Gilkeson GS

更新日期：2016-02-15 00:00:00

abstract：Introduction:High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activ...

journal_title：Frontiers in immunology

authors： Marín-Palma D,Castro GA,Cardona-Arias JA,Urcuqui-Inchima S,Hernandez JC

更新日期：2018-06-14 00:00:00

abstract：:IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide. However, IgAN rarely affects African Blacks and is uncommon in African Americans. Polymeric IgA1 with galactose-deficient hinge-region glycans is recognized as auto-antigen by glycan-specific antibodies, leading to formation of circul...

journal_title：Frontiers in immunology

authors： Zachova K,Kosztyu P,Zadrazil J,Matousovic K,Vondrak K,Hubacek P,Julian BA,Moldoveanu Z,Novak Z,Kostovcikova K,Raska M,Mestecky J

更新日期：2020-02-28 00:00:00

abstract：:Membranous nephropathy (MN) is an autoimmune disease caused by binding of circulating antibodies to podocyte antigens in the kidney. For decades and still today primary MN has been considered to have an unspecified IgG4-driven autoimmune genesis, while secondary MN has been associated with other diseases, most notably...

journal_title：Frontiers in immunology

authors： von Haxthausen F,Reinhard L,Pinnschmidt HO,Rink M,Soave A,Hoxha E,Stahl RAK

更新日期：2018-12-20 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for many types of hematological malignancies. Matching of donor and recipient for the major histocompatibility complex (MHC) improves the HSCT reconstitution, but donor-derived T cells reactive to non-MHC encoded minor histocompat...

journal_title：Frontiers in immunology

authors： Choi EY,Choi K,Nam G,Kim W,Chung M

更新日期：2020-06-10 00:00:00

abstract：:Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to tailor these alterations in gene expression to the requirements of the inflammatory process, tight and coordinate regulation of gene expression by environmental cues, microbial or danger-associated molecules or cytokines, are m...

journal_title：Frontiers in immunology

authors： Platanitis E,Decker T

更新日期：2018-11-13 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the central nervous system. It was previously shown that toll-like receptor (TLR)-2 signaling plays a key role in the murine experimental autoimmune encephalomyelitis (EAE) model of MS, and that TLR2-stimulation of regulatory T cells (...

journal_title：Frontiers in immunology

authors： Hossain MJ,Morandi E,Tanasescu R,Frakich N,Caldano M,Onion D,Faraj TA,Erridge C,Gran B

更新日期：2018-03-14 00:00:00

abstract：:Worldwide, breast cancer (BC) is the leading cause of cancer death among women. For many patients the most effective treatment is a resection surgery that removes the tumor. Within this subset, patients sometimes receive chemotherapy treatment (CT) prior to surgery aiming to reduce tumor size in order to preserve heal...

journal_title：Frontiers in immunology

authors： Valdés-Ferrada J,Muñoz-Durango N,Pérez-Sepulveda A,Muñiz S,Coronado-Arrázola I,Acevedo F,Soto JA,Bueno SM,Sánchez C,Kalergis AM

更新日期：2020-07-09 00:00:00

abstract：:In humans, loss-of-function mutation in the Signal Transducer and Activator of Transcription 3 (STAT3) gene is frequently associated with susceptibility to bacterial as well as fungal infections including aspergillosis, although its pathogenesis remains largely unknown. In the present study, we investigated the immune...

journal_title：Frontiers in immunology

authors： Danion F,Aimanianda V,Bayry J,Duréault A,Wong SSW,Bougnoux ME,Tcherakian C,Alyanakian MA,Guegan H,Puel A,Picard C,Lortholary O,Lanternier F,Latgé JP

更新日期：2020-01-28 00:00:00

abstract：:Dysregulation of macrophage has been demonstrated to contribute to aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. In the present study, we explored the effect of leukadherin-1 (LA1), an ago...

journal_title：Frontiers in immunology

authors： Yao X,Dong G,Zhu Y,Yan F,Zhang H,Ma Q,Fu X,Li X,Zhang Q,Zhang J,Shi H,Ning Z,Dai J,Li Z,Li C,Wang B,Ming J,Yang Y,Hong F,Meng X,Xiong H,Si C

更新日期：2019-02-12 00:00:00

abstract：:It was recently proposed that T lymphocytes, which closely interact with APCs, can extract surface molecules from the presenting cells when they dissociate. These observations question the classical view of discrete interactions between phenotypically defined cell populations. In this review, we summarize some reports...

journal_title：Frontiers in immunology

authors： Dhainaut M,Moser M

更新日期：2014-03-28 00:00:00

abstract：:TILRR (Toll-like interleukin-1 receptor regulator), a transcript variant of FREM1, is a novel regulatory component, which stimulates innate immune responses through binding to IL-1R1 (Interleukin-1 receptor, type 1) and TLR (Toll-like receptor) complex. However, it is not known whether TILRR expression influences othe...

journal_title：Frontiers in immunology

authors： Kashem MA,Li H,Toledo NP,Omange RW,Liang B,Liu LR,Li L,Yang X,Yuan XY,Kindrachuk J,Plummer FA,Luo M

更新日期：2019-02-28 00:00:00

abstract：:Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence in a process known as TCR convergence. Substitution sequencing errors introduced by TCRβ (TCRB) repertoire sequencing may create artifacts resembling TCR conver...

journal_title：Frontiers in immunology

authors： Looney TJ,Topacio-Hall D,Lowman G,Conroy J,Morrison C,Oh D,Fong L,Zhang L

更新日期：2020-01-09 00:00:00

abstract：:Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a decreased secretion ...

journal_title：Frontiers in immunology

authors： Darweesh M,Kamel W,Gavrilin MA,Akusjärvi G,Svensson C

更新日期：2019-11-28 00:00:00

abstract：Purpose:Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective:To evaluate changes in lipoproteins, insulin resistance, mediators of systemi...

journal_title：Frontiers in immunology

authors： Yadav R,Hama S,Liu Y,Siahmansur T,Schofield J,Syed AA,France M,Pemberton P,Adam S,Ho JH,Aghamohammadzadeh R,Dhage S,Donn R,Malik RA,New JP,Jeziorska M,Durrington P,Ammori BA,Soran H

更新日期：2017-11-15 00:00:00

abstract：:Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation. Ageing populations also exhibit a decline in immune competence referred to as immunosenescence, which...

journal_title：Frontiers in immunology

authors： Trim W,Turner JE,Thompson D

更新日期：2018-02-09 00:00:00

abstract：:Abnormal gene expression patterns underlie many diseases that represent major public health concerns and robust therapeutic challenges. Posttranscriptional gene regulation by RNA-binding proteins (RBPs) is well-recognized, and the biological functions of RBPs have been implicated in many diseases, such as autoimmune d...

journal_title：Frontiers in immunology

authors： Nyati KK,Agarwal RG,Sharma P,Kishimoto T

更新日期：2019-12-05 00:00:00

abstract：:Mycobacteria display pro- and anti-inflammatory effects in human and experimental pathology. We show here that both effects are mediated by Toll-like receptor 2 (Tlr2), by exploiting a previously characterized Tlr2 variant (Met82Ile). Tlr2 82ile promoted self-specific proinflammatory polarization as well as expansion ...

journal_title：Frontiers in immunology

authors： Piermattei A,Migliara G,Di Sante G,Foti M,Hayrabedyan SB,Papagna A,Geloso MC,Corbi M,Valentini M,Sgambato A,Delogu G,Constantin G,Ria F

更新日期：2016-05-24 00:00:00

abstract：:Vaccines aiming to promote T-cell-mediated immune responses have so far showed limited efficacy, and there is a need for novel strategies. Studies indicate that autophagy plays an inherent role in antigen processing and presentation for CD4(+) and CD8(+) T cells. Here, we report a novel vaccine strategy based on fusio...

journal_title：Frontiers in immunology

authors： Andersen AN,Landsverk OJ,Simonsen A,Bogen B,Corthay A,Øynebråten I

更新日期：2016-05-10 00:00:00

abstract：:The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self receptors and effector mechanisms differ greatly among animal phyla, some aspects of recognition, regulation, and response are broadly conserved. A gene regulatory ne...

journal_title：Frontiers in immunology

authors： Buckley KM,Rast JP

更新日期：2017-10-23 00:00:00

abstract：:Flow cytometry has emerged as a useful technology that has facilitated our understanding of the human immune system. Primary immune deficiency disorders (PIDDs) are a heterogeneous group of inherited disorders affecting the immune system. More than 350 genes causing various PIDDs have been identified. While the initia...

journal_title：Frontiers in immunology

authors： Rawat A,Arora K,Shandilya J,Vignesh P,Suri D,Kaur G,Rikhi R,Joshi V,Das J,Mathew B,Singh S

更新日期：2019-09-11 00:00:00

abstract：:Anaphylaxis in humans is inherently difficult to study due to the acuteness of symptoms and the lack of biomarkers serving as risk predictors. Most cases are related to IgE sensitizations to foods, insect venoms, and drugs with mastocytosis patients forming a smaller risk group. However, identifying the relatively sma...

journal_title：Frontiers in immunology

authors： Poulsen LK,Jensen BM,Esteban V,Garvey LH

更新日期：2017-08-10 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory condition with no effective treatment. Probiotics have gained wide attention because of their outstanding advantages in intestinal health issues. In previous studies, a novel soluble protein, HM0539, which is derived from Lactobacillus...

journal_title：Frontiers in immunology

authors： Li Y,Yang S,Lun J,Gao J,Gao X,Gong Z,Wan Y,He X,Cao H

更新日期：2020-10-05 00:00:00