Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors.

abstract：:Accumulation of dendritic cells (DCs) is a special characteristic of the decidual microenvironment. Decidua-infiltrated DCs show unique phenotypes and functions that promote the establishment of fetal-maternal tolerance. However, the regulatory mechanisms yet to be fully investigated. Decidual stromal cells (DSCs) are...

journal_title：Frontiers in immunology

authors： Shao Q,Liu X,Huang Y,Chen X,Wang H

更新日期：2020-10-27 00:00:00

abstract：:The complement system is a key component of innate immunity which readily responds to invading microorganisms. Activation of the complement system typically occurs via three main pathways and can induce various antimicrobial effects, including: neutralization of pathogens, regulation of inflammatory responses, promoti...

journal_title：Frontiers in immunology

authors： Mellors J,Tipton T,Longet S,Carroll M

更新日期：2020-07-09 00:00:00

abstract：:High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of li...

journal_title：Frontiers in immunology

authors： Mamedov IZ,Britanova OV,Zvyagin IV,Turchaninova MA,Bolotin DA,Putintseva EV,Lebedev YB,Chudakov DM

更新日期：2013-12-23 00:00:00

abstract：:Herpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is predominantly due to corneal scarring and neovascularization caused by inflammation. In the infected cornea, HSV can activate innate a...

journal_title：Frontiers in immunology

authors： Wang L,Wang R,Xu C,Zhou H

更新日期：2020-05-13 00:00:00

abstract：:Human Campylobacter infections are progressively rising and of high socioeconomic impact. In the present preclinical intervention study we investigated anti-pathogenic, immuno-modulatory, and intestinal epithelial barrier preserving properties of vitamin D applying an acute campylobacteriosis model. Therefore, seconda...

journal_title：Frontiers in immunology

authors： Mousavi S,Lobo de Sá FD,Schulzke JD,Bücker R,Bereswill S,Heimesaat MM

更新日期：2019-09-03 00:00:00

abstract：:Acinetobacter baumannii (A. baumannii) is becoming a common global concern due to the emergence of multi-drug or pan-drug resistant strains. Confronting the issue of antimicrobial resistance by developing vaccines against the resistant pathogen is becoming a common strategy. In this study, different methods for prepar...

journal_title：Frontiers in immunology

authors： Li S,Chen DQ,Ji L,Sun S,Jin Z,Jin ZL,Sun HW,Zeng H,Zhang WJ,Lu DS,Luo P,Zhao AN,Luo J,Zou QM,Li HB

更新日期：2020-06-23 00:00:00

abstract：:Responsiveness of maturing natural killer (NK) cells to chemotactic molecules directly affect their retention and relocation in selected bone marrow (BM) microenvironment during development, as well as their localization at sites of immune response during inflammatory diseases. BM is the main site of NK cell generatio...

journal_title：Frontiers in immunology

authors： Bernardini G,Sciumè G,Santoni A

更新日期：2013-01-30 00:00:00

abstract：:CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR). CoBRR has been attributed in part to pathogen-driven T cell repert...

journal_title：Frontiers in immunology

authors： Espinosa JR,Mou D,Adams BW,DiBernardo LR,MacDonald AL,McRae M,Miller AN,Song M,Stempora LL,Wang J,Iwakoshi NN,Kirk AD

更新日期：2018-06-15 00:00:00

abstract：:The VH replacement process is a RAG-mediated secondary recombination in which the variable region of a rearranged VHDJH is replaced by a different germline VH gene. In almost all human and mouse VH genes, two sequence features appear to be crucial for VH replacement. First, an embedded heptamer, which is located near ...

journal_title：Frontiers in immunology

authors： Sun Y,Liu Z,Li Z,Lian Z,Zhao Y

更新日期：2012-12-20 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen presenting cells that are exquisitely adapted to sense pathogens and induce the development of adaptive immune responses. They form a complex network of phenotypically and functionally distinct subsets. Within this network, individual DC subsets display highly specific rol...

journal_title：Frontiers in immunology

authors： Chopin M,Allan RS,Belz GT

更新日期：2012-02-27 00:00:00

abstract：:Virus-specific CD4(+) T cells play a major role in viral infections, such as hepatitis C virus (HCV). Viral clearance is associated with vigorous and multi-specific CD4(+) T-cell responses, while chronic infection has been shown to be associated with weak or absent T-cell responses. Most of these studies have used fun...

journal_title：Frontiers in immunology

authors： Lokhande MU,Thimme R,Klenerman P,Semmo N

更新日期：2015-02-25 00:00:00

abstract：:Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome. However, it remains largely unknown whether paclitaxel, a microtubule-stabilizing agent being used in cancer thera...

journal_title：Frontiers in immunology

authors： Zeng QZ,Yang F,Li CG,Xu LH,He XH,Mai FY,Zeng CY,Zhang CC,Zha QB,Ouyang DY

更新日期：2019-01-29 00:00:00

abstract：:Neisseria gonorrhoeae is a significant health problem worldwide due to multi-drug resistance issues and absence of an effective vaccine. Patients infected with N. gonorrhoeae have not shown a better immune response in successive infections. This might be explained by the fact that N. gonorrhoeae possesses several mech...

journal_title：Frontiers in immunology

authors： Escobar A,Rodas PI,Acuña-Castillo C

更新日期：2018-12-21 00:00:00

abstract：:New vaccine design approaches would be greatly facilitated by a better understanding of the early systemic changes, and those that occur at the site of injection, responsible for the installation of a durable and oriented protective response. We performed a detailed characterization of very early infection and host re...

journal_title：Frontiers in immunology

authors： Rosenbaum P,Tchitchek N,Joly C,Stimmer L,Hocini H,Dereuddre-Bosquet N,Beignon AS,Chapon C,Levy Y,Le Grand R,Martinon F

更新日期：2018-04-25 00:00:00

abstract：:Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed ...

journal_title：Frontiers in immunology

authors： Muire PJ,Mangum LH,Wenke JC

更新日期：2020-06-04 00:00:00

abstract：:Mycobacteria propelled modulation of host responses is of considerable interest in the face of emerging drug resistance. Although it is known that Abl tyrosine kinases affect entry and persistence of mycobacteria, mechanisms that couple c-Abl to proximal signaling pathways during immunity are poorly understood. Loss-o...

journal_title：Frontiers in immunology

authors： Mahadik K,Prakhar P,Rajmani RS,Singh A,Balaji KN

更新日期：2018-02-01 00:00:00

abstract：:Secretion of extracellular vesicles (EVs) is a ubiquitous mechanism of intercellular communication based on the exchange of effector molecules, such as growth factors, cytokines, and nucleic acids. Recent studies identified tumor-derived EVs as central players in tumor progression and the establishment of the tumor mi...

journal_title：Frontiers in immunology

authors： Dörsam B,Bösl T,Reiners KS,Barnert S,Schubert R,Shatnyeva O,Zigrino P,Engert A,Hansen HP,von Strandmann EP

更新日期：2018-06-18 00:00:00

abstract：:T-cell memory to pathogens can be envisioned as a receptor-based imprint of the pathogenic environment on the naïve repertoire of clonotypes. Recurrent exposures to a pathogen inform and reinforce memory, leading to a mature state. The complexity and temporal stability of this system in man is only beginning to be ade...

journal_title：Frontiers in immunology

authors： Naumova EN,Yassai MB,Demos W,Reed E,Unruh M,Haribhai D,Williams CB,Naumov YN,Gorski J

更新日期：2019-08-06 00:00:00

abstract：:Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of in v...

journal_title：Frontiers in immunology

authors： Mardente S,Mari E,Massimi I,Tafani M,Guerriero R,Morsilli O,Pulcinelli FM,Bianchi ME,Zicari A

更新日期：2018-01-12 00:00:00

abstract：:While developing adaptive immune responses, young infants are especially vulnerable to serious infections, including sepsis, meningitis, and pneumonia. Antimicrobial proteins and peptides (APPs) are key effectors that function as broad-spectrum anti-infectives. This review seeks to summarize the clinically relevant fu...

journal_title：Frontiers in immunology

authors： Battersby AJ,Khara J,Wright VJ,Levy O,Kampmann B

更新日期：2016-08-18 00:00:00

abstract：:A common feature of many acute and chronic oral diseases is microbial-induced inflammation. Innate immune responses are the first line of defense against pathogenic microorganisms and are initiated by pattern recognition receptors (PRRs) that specifically recognize pathogen-associated molecular patterns and danger-ass...

journal_title：Frontiers in immunology

authors： Wang L,Sun L,Byrd KM,Ko CC,Zhao Z,Fang J

更新日期：2020-08-13 00:00:00

abstract：:Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract infections in children worldwide. Development of a vaccine has been hindered by the risk of developing enhanced respiratory disease (ERD) upon natural exposure to the virus. Generation of higher quality neutralizing antibodies w...

journal_title：Frontiers in immunology

authors： Eichinger KM,Kosanovich JL,Gidwani SV,Zomback A,Lipp MA,Perkins TN,Oury TD,Petrovsky N,Marshall CP,Yondola MA,Empey KM

更新日期：2020-07-29 00:00:00

abstract：:Delivery of cell-associated antigen represents an important strategy for vaccination. While many experimental models have been developed in order to define the critical parameters for efficient cross-priming, few have utilized quantitative methods that permit the study of the endogenous repertoire. Comparing different...

journal_title：Frontiers in immunology

authors： Bouvier I,Jusforgues-Saklani H,Lim A,Lemaître F,Lemercier B,Auriau C,Nicola MA,Leroy S,Law HK,Bandeira A,Moon JJ,Bousso P,Albert ML

更新日期：2011-12-08 00:00:00

abstract：:We consider the problem of self-tolerance in the frame of a minimalistic model of the idiotypic network. A node of this network represents a population of B-lymphocytes of the same idiotype, which is encoded by a bit string. The links of the network connect nodes with (nearly) complementary strings. The population of ...

journal_title：Frontiers in immunology

authors： Schulz R,Werner B,Behn U

更新日期：2014-03-10 00:00:00

abstract：:Antibodies have proven their high value in antitumor therapy over the last two decades. They are currently being used as the first-choice to treat some of the most frequent metastatic cancers, like HER2+ breast cancers or colorectal cancers, currently treated with trastuzumab (Herceptin) and bevacizumab (Avastin), res...

journal_title：Frontiers in immunology

authors： Corraliza-Gorjón I,Somovilla-Crespo B,Santamaria S,Garcia-Sanz JA,Kremer L

更新日期：2017-12-21 00:00:00

abstract：:Diet is a major factor determining gut microbiota composition and perturbances in this complex ecosystem are associated with the inflammatory bowel disease (IBD). Here, we used gnotobiotic approach to analyze, how interaction between diet rich in proteins and gut microbiota influences the sensitivity to intestinal inf...

journal_title：Frontiers in immunology

authors： Kostovcikova K,Coufal S,Galanova N,Fajstova A,Hudcovic T,Kostovcik M,Prochazkova P,Jiraskova Zakostelska Z,Cermakova M,Sediva B,Kuzma M,Tlaskalova-Hogenova H,Kverka M

更新日期：2019-04-26 00:00:00

abstract：PURPOSE OF REVIEW:The standard treatment options for systemic lupus erythematosus (SLE) are focused on non-specific immunosuppression. Over the past few years, scientific studies and ongoing clinical trials have shifted the paradigm with rapid advances in developing biologics and small molecules. A number of monoclonal...

journal_title：Frontiers in immunology

authors： Vukelic M,Li Y,Kyttaris VC

更新日期：2018-11-16 00:00:00

abstract：:Efficient tuberculosis (TB) control depends on early TB prediction and prevention. Solution to these tasks requires knowledge of TB protection correlates (TB CoPs), i.e., laboratory markers that are mechanistically involved in the protection and which allow to determine how well an individual is protected against TB o...

journal_title：Frontiers in immunology

authors： Lyadova I,Nikitina I

更新日期：2019-05-08 00:00:00

abstract：:The immune system plays a central role in cancer development, showing both anti-tumor and pro-tumor activities depending on the immune cell subsets and the disease context. While CD8 T cells are associated with a favorable outcome in most cancers, only T helper type 1 (Th1) CD4 T cells play a protective role, in contr...

journal_title：Frontiers in immunology

authors： Bohner P,Chevalier MF,Cesson V,Rodrigues-Dias SC,Dartiguenave F,Burruni R,Tawadros T,Valerio M,Lucca I,Nardelli-Haefliger D,Jichlinski P,Derré L

更新日期：2019-03-29 00:00:00

abstract：:Influenza A virus (IAV) is a significant cause of life-threatening lower respiratory tract infections in children. Antiviral therapy is the mainstay of treatment, but its effectiveness in this age group has been questioned. In addition, damage inflicted on the lungs by the immune response to the virus may be as import...

journal_title：Frontiers in immunology

authors： Coates BM,Staricha KL,Ravindran N,Koch CM,Cheng Y,Davis JM,Shumaker DK,Ridge KM

更新日期：2017-07-10 00:00:00