From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis.

abstract：:IL-1β plays a crucial role in the differentiation of human Th17 cells. We report here that IL-1RI expression is significantly increased in both naive and memory CD4+ T cells derived from relapsing-remitting multiple sclerosis (RR MS) patients in comparison to healthy controls. Interleukin 1 receptor (IL-1R)I expressio...

journal_title：Frontiers in immunology

authors： Sha Y,Markovic-Plese S

更新日期：2016-11-29 00:00:00

abstract：:Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, w...

journal_title：Frontiers in immunology

authors： Dios-Esponera A,Melis N,Subramanian BC,Weigert R,Samelson LE

更新日期：2019-03-05 00:00:00

abstract：:Retinoic acid inducible gene I (RIG-I) is associated to the DExD/H box RNA helicases. It is a pattern recognition receptor (PRR), playing a crucial role in the system and is a germ line encoded host sensor to perceive pathogen-associated molecular patterns (PAMPs). So far, reports are available for the role of RIG-I i...

journal_title：Frontiers in immunology

authors： Banerjee S,Pal A,Pal A,Mandal SC,Chatterjee PN,Chatterjee JK

更新日期：2021-01-08 00:00:00

abstract：:Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1β secretion; however, the underlying mechanisms by which betaine inhibits IL-1β secretion remain to be uncovered. In this review, we summarize the current understanding about the mechanisms of b...

journal_title：Frontiers in immunology

authors： Xia Y,Chen S,Zhu G,Huang R,Yin Y,Ren W

更新日期：2018-11-20 00:00:00

abstract：:Disialoganglioside GD2 is an important target on several pediatric and adult cancer types including neuroblastoma, retinoblastoma, melanoma, small-cell lung cancer, brain tumors, sarcomas, and cancer stem cells. We have utilized structural and computational methods to refine the framework of humanized monoclonal antib...

journal_title：Frontiers in immunology

authors： Ahmed M,Hu J,Cheung NK

更新日期：2014-08-14 00:00:00

abstract：:Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the liposome-based adjuvants CAF01 and CAF09 and the protein-based adjuva...

journal_title：Frontiers in immunology

authors： Bhide Y,Dong W,Gribonika I,Voshart D,Meijerhof T,de Vries-Idema J,Norley S,Guilfoyle K,Skeldon S,Engelhardt OG,Boon L,Christensen D,Lycke N,Huckriede A

更新日期：2019-03-29 00:00:00

abstract：:Neosporosis is considered as one of the main causes of abortion and severe economic losses in dairy industry. The Canis genus serving as one of the confirmed definitive hosts of the apicomplexan parasite Neospora caninum (N. caninum) plays a critical role in its life cycle. However, the effects of N. caninum on its de...

journal_title：Frontiers in immunology

authors： Wei Z,Hermosilla C,Taubert A,He X,Wang X,Gong P,Li J,Yang Z,Zhang X

更新日期：2016-10-31 00:00:00

abstract：:New approaches are needed to develop more effective interventions to prevent long-term rejection of organ allografts. Computational biology provides a powerful tool to assess the large amount of complex data that is generated in longitudinal studies in this area. This manuscript outlines how our two groups are using m...

journal_title：Frontiers in immunology

authors： Stegall MD,Borrows R

更新日期：2015-08-03 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation, and excessive production of proinflammatory mediators, such as tumor nec...

journal_title：Frontiers in immunology

authors： Roberts CA,Dickinson AK,Taams LS

更新日期：2015-11-19 00:00:00

abstract：:To improve the efficacy of immunotherapy for cancer and autoimmune diseases, recent ongoing and completed clinical trials have focused on specific targets to redirect the immune network toward eradicating a variety of tumors and ameliorating the self-destructive process. In a previous review, both systemic immunomodul...

journal_title：Frontiers in immunology

authors： Kong YC,Flynn JC

更新日期：2014-05-16 00:00:00

abstract：:Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expr...

journal_title：Frontiers in immunology

authors： Faber H,Kurtoic D,Krishnamoorthy G,Weber P,Pütz B,Müller-Myhsok B,Weber F,Andlauer TFM

更新日期：2020-09-18 00:00:00

abstract：:Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE-/-) mice exhibit systemic effects including skin inflammation and hypertrophic lymph nodes (LNs). However...

journal_title：Frontiers in immunology

authors： Tay MHD,Lim SYJ,Leong YFI,Thiam CH,Tan KW,Torta FT,Narayanaswamy P,Wenk M,Angeli V

更新日期：2019-03-27 00:00:00

abstract：:Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome (pSS). Chromosome X open reading frame 21 (CXorf21) escapes X-inactivation and is an SLE risk gene of previously unknown function. We undertook the pre...

journal_title：Frontiers in immunology

authors： Harris VM,Koelsch KA,Kurien BT,Harley ITW,Wren JD,Harley JB,Scofield RH

更新日期：2019-10-21 00:00:00

abstract：:The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid cancer 1, in intratumoral activated CD8+ T cells ...

journal_title：Frontiers in immunology

authors： Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA

更新日期：2017-03-22 00:00:00

abstract：:Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation. The molecular machinery of macroautophagy, a catabolic pathway that delivers cytoplasmic constituents to...

journal_title：Frontiers in immunology

authors： Münz C

更新日期：2018-11-27 00:00:00

abstract：:Many a disease associates with inflammation. Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-α and proteases, causing fibroblasts to release endogenous antigens that may be cross reactive with exogenous antigens. We made a predictive dynamic map of ...

journal_title：Frontiers in immunology

authors： Abudukelimu A,Barberis M,Redegeld FA,Sahin N,Westerhoff HV

更新日期：2018-08-07 00:00:00

abstract：:Tuberculosis (TB) is one of the prevalent causes of death worldwide, with 95% of these deaths occurring in developing countries, like India. The causative agent, Mycobacterium tuberculosis (MTb) has the tenacious ability to circumvent the host's immune system for its own advantage. Macrophages are one of the phagocyti...

journal_title：Frontiers in immunology

authors： Ahluwalia PK,Pandey RK,Sehajpal PK,Prajapati VK

更新日期：2017-02-08 00:00:00

abstract：:Cells communicate with other cells in their microenvironment by transferring lipids, peptides, RNA, and sugars in extracellular vesicles (EVs), thereby also influencing recipient cell functions. Several studies indicate that these vesicles are involved in a variety of critical cellular processes including immune, meta...

journal_title：Frontiers in immunology

authors： Karasu E,Eisenhardt SU,Harant J,Huber-Lang M

更新日期：2018-04-11 00:00:00

abstract：:Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact adaptive immune responses in the lymphoid follicles and germinal centers (GC). Since their relatively recent discovery, several studies have revealed that Tfr interact with other cells within this niche and shape ensuing res...

journal_title：Frontiers in immunology

authors： Miles B,Connick E

更新日期：2018-11-20 00:00:00

abstract：:Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence neoplastic cell functional behavior, remodeling TME and generating a tumor cell niche that supports tissue neovascularization, tumor invasion an...

journal_title：Frontiers in immunology

authors： Poggi A,Varesano S,Zocchi MR

更新日期：2018-02-19 00:00:00

abstract：:Cholera toxin (CT) is one of most strong mucosal adjuvants, but it cannot be clinically used owing to its toxicity. The cytosolic A1 subunit of CT (CTA1) is the molecule responsible for its immunostimulatory activity, which increases the concentration of cyclic AMP and causes the induction of pro-inflammatory cytokine...

journal_title：Frontiers in immunology

authors： Kim MS,Yi EJ,Kim YI,Kim SH,Jung YS,Kim SR,Iwawaki T,Ko HJ,Chang SY

更新日期：2019-06-04 00:00:00

abstract：:Lymphatic filariasis (LF) is a tropical parasitic infection of human transmitted by mosquitoes. Chronic infection results in severe physical disability in the infected patients. Although several potential vaccine antigens were identified by several groups, there are no licensed prophylactic vaccine to date against thi...

journal_title：Frontiers in immunology

authors： Chauhan N,Khatri V,Banerjee P,Kalyanasundaram R

更新日期：2018-07-02 00:00:00

abstract：:Visceral leishmaniasis is a severe form of the disease, caused by Leishmania infantum in the New World. Patients present an anergic immune response that favors parasite establishment and spreading through tissues like bone marrow and liver. On the other hand, Leishmania braziliensis causes localized cutaneous lesions,...

journal_title：Frontiers in immunology

authors： Falcão Sde A,Jaramillo TM,Ferreira LG,Bernardes DM,Santana JM,Favali CB

更新日期：2016-08-03 00:00:00

abstract：:Viral defense at mucosal sites depends on interferons (IFN) and IFN stimulated genes (ISGs), either of which may be constitutively expressed to maintain an "antiviral state" (AVS). However, the mechanisms that govern the AVS are poorly defined. Using a BEAS-2B respiratory epithelial cell line deficient in IRF1, we dem...

journal_title：Frontiers in immunology

authors： Panda D,Gjinaj E,Bachu M,Squire E,Novatt H,Ozato K,Rabin RL

更新日期：2019-05-15 00:00:00

abstract：:Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

journal_title：Frontiers in immunology

authors： Corbett AJ,Awad W,Wang H,Chen Z

更新日期：2020-08-27 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin. Although CD4(+) T cell function in MS pathology has been extensively studied, there is also strong evidence that CD8(+) T lymphocytes play a key role. Intriguingly, CD8(+) T cells accumula...

journal_title：Frontiers in immunology

authors： Ignatius Arokia Doss PM,Roy AP,Wang A,Anderson AC,Rangachari M

更新日期：2015-10-22 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGvHD) is a major complication affecting 40-70% of all transplant patients, whereby the earliest and most frequent presentation is in the skin. MicroRNAs play a ...

journal_title：Frontiers in immunology

authors： Atarod S,Norden J,Bibby LA,Janin A,Ratajczak P,Lendrem C,Pearce KF,Wang XN,O'Reilly S,Van Laar JM,Collin M,Dickinson AM,Crossland RE

更新日期：2018-07-10 00:00:00

abstract：:The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies have demonstrated that the human FOXP3+ subset is functionally heterogeneous, whereby ...

journal_title：Frontiers in immunology

authors： Bin Dhuban K,Bartolucci S,d'Hennezel E,Piccirillo CA

更新日期：2019-07-18 00:00:00

abstract：:There have been exhaustive efforts to develop an efficient vaccine against leishmaniasis. Factors like host and parasite genetic characteristics, virulence, epidemiological scenarios, and, mainly, diverse immune responses triggered by Leishmania species make the achievement of this aim a complex task. It is already cl...

journal_title：Frontiers in immunology

authors： De Luca PM,Macedo AB

更新日期：2016-04-21 00:00:00

abstract：:Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for M...

journal_title：Frontiers in immunology

authors： Hart PH,Lucas RM,Booth DR,Carroll WM,Nolan D,Cole JM,Jones AP,Kermode AG

更新日期：2017-01-24 00:00:00