Evaluating the Vaccine Potential of a Tetravalent Fusion Protein (rBmHAXT) Vaccine Antigen Against Lymphatic Filariasis in a Mouse Model.

abstract：:Dendritic cells (DCs), Langerhans cells (LCs), and macrophages are innate immune cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 infection. These innate cells play distinct roles in initiation of HIV-1 infection and induction of anti-viral immunity. DCs are potent migratory cells that ...

journal_title：Frontiers in immunology

authors： Mesman AW,Geijtenbeek TB

更新日期：2012-03-26 00:00:00

abstract：:Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mediates potent suppression of T-cell dependent immune responses. The suppressive effects of TCDD occur early during CD4(+) T-cell differentiation in the absence of effects on proliferation and have ...

journal_title：Frontiers in immunology

authors： Rohlman D,Pham D,Yu Z,Steppan LB,Kerkvliet NI

更新日期：2012-08-06 00:00:00

abstract：:Memory B cells that are generated during an infection or following vaccination act as sentinels to guard against future infections. Upon repeat antigen exposure memory B cells differentiate into new antibody-secreting plasma cells to provide rapid and sustained protection. Some pathogens evade or suppress the humoral ...

journal_title：Frontiers in immunology

authors： Shah HB,Smith K,Wren JD,Webb CF,Ballard JD,Bourn RL,James JA,Lang ML

更新日期：2019-01-15 00:00:00

abstract：:Natural killer (NK) cells are effector lymphocytes of the innate immune system that are able to mount a multifaceted antiviral response within hours following infection. This is achieved through an array of cell surface receptors surveilling host cells for alterations in human leukocyte antigen class I (HLA-I) express...

journal_title：Frontiers in immunology

authors： Hölzemer A,Garcia-Beltran WF,Altfeld M

更新日期：2017-11-14 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which is different from linear RNA. CircRNA is an RNA molecule with a closed loop structure formed by reverse splicing. CircRNAs have been studied in several organisms, however, the circRNAs associated with the response to Salmonella enterica serovar En...

journal_title：Frontiers in immunology

authors： Zheng L,Liu L,Lin L,Tang H,Fan X,Lin H,Li X

更新日期：2019-05-31 00:00:00

abstract：:Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miR...

journal_title：Frontiers in immunology

authors： Croston TL,Lemons AR,Beezhold DH,Green BJ

更新日期：2018-02-07 00:00:00

abstract：:Treatment with the macrolide antibiotic azithromycin (AZM) is an important intervention for controlling infection of children with Bordetella pertussis and as a prophylaxis for preventing transmission to family members. However, antibiotics are known to have immunomodulatory effects independent of their antimicrobial ...

journal_title：Frontiers in immunology

authors： Borkner L,Misiak A,Wilk MM,Mills KHG

更新日期：2018-07-30 00:00:00

abstract：:We have previously shown that the human obese adipose tissue (AT) contributes to increased secretion of adipocyte-specific IgG antibodies in individuals with obesity. This occurs without any exogenous stimulation, because the ongoing process of cell death in the obese AT leads to the release of "self" antigens able to...

journal_title：Frontiers in immunology

authors： Frasca D,Diaz A,Romero M,Garcia D,Jayram D,Thaller S,Del Carmen Piqueras M,Bhattacharya S,Blomberg BB

更新日期：2020-02-28 00:00:00

abstract：:Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex sy...

journal_title：Frontiers in immunology

authors： Mozzi A,Forni D,Clerici M,Cagliani R,Sironi M

更新日期：2018-09-11 00:00:00

abstract：:The complement system represents an effective arsenal of innate immunity as well as an interface between innate and adaptive immunity. Activation of the complement system culminates with the assembly of the C5b-9 terminal complement complex on cell membranes, inducing target cell lysis. Translation of this sequence of...

journal_title：Frontiers in immunology

authors： Vlaicu SI,Tatomir A,Rus V,Rus H

更新日期：2019-05-09 00:00:00

abstract：:Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1β secretion; however, the underlying mechanisms by which betaine inhibits IL-1β secretion remain to be uncovered. In this review, we summarize the current understanding about the mechanisms of b...

journal_title：Frontiers in immunology

authors： Xia Y,Chen S,Zhu G,Huang R,Yin Y,Ren W

更新日期：2018-11-20 00:00:00

abstract：:Salmonella infections remain a big problem worldwide, causing enteric fever by Salmonella Typhi (or Paratyphi) or self-limiting gastroenteritis by non-typhoidal Salmonella (NTS) in healthy individuals. NTS may become invasive and cause septicemia in elderly or immuno-compromised individuals, leading to high mortality ...

journal_title：Frontiers in immunology

authors： Li P,Liu Q,Luo H,Liang K,Yi J,Luo Y,Hu Y,Han Y,Kong Q

更新日期：2017-12-04 00:00:00

abstract：:A major obstacle in kidney transplantation for primary focal segmental glomerulosclerosis (FSGS) is the risk of disease recurrence. Recurrent FSGS affects up to 60% of first kidney grafts and exceeds 80% in patients who have lost their first graft due to recurrent FSGS. Clinical and experimental evidence support the h...

journal_title：Frontiers in immunology

authors： Kienzl-Wagner K,Waldegger S,Schneeberger S

更新日期：2019-07-17 00:00:00

abstract：:Developing thymocytes interact sequentially with two distinct structures within the thymus: the cortex and medulla. Surviving single-positive and double-positive thymocytes from the cortex migrate into the medulla, where they interact with medullary thymic epithelial cells (mTECs). These cells ectopically express a va...

journal_title：Frontiers in immunology

authors： Passos GA,Mendes-da-Cruz DA,Oliveira EH

更新日期：2015-07-14 00:00:00

abstract：:Atherosclerosis is an inflammatory disease caused by endothelial injury, lipid deposition, and oxidative stress. This progressive disease can be converted into an acute clinical event by plaque rupture and thrombosis. In the context of atherosclerosis, the underlying cause of myocardial infarction and stroke, macropha...

journal_title：Frontiers in immunology

authors： de Gaetano M,Crean D,Barry M,Belton O

更新日期：2016-07-19 00:00:00

abstract：:The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that express a distinct T cell receptor (TCR) composed of γδ chains i...

journal_title：Frontiers in immunology

authors： Latha TS,Reddy MC,Durbaka PV,Rachamallu A,Pallu R,Lomada D

更新日期：2014-11-10 00:00:00

abstract：:Glycoproteins perform extra- and intracellular functions in innate and adaptive immunity by lectin-based interactions to exposed glyco-determinants. Herein, we document and mechanistically explain the formation of subcellular-specific N-glycosylation determinants on glycoproteins trafficking through the shared biosynt...

journal_title：Frontiers in immunology

authors： Lee LY,Lin CH,Fanayan S,Packer NH,Thaysen-Andersen M

更新日期：2014-08-25 00:00:00

abstract：:Continued discoveries of negative regulators of inflammatory signaling provide detailed molecular insights into peripheral tolerance and anti-tumor immunity. Accumulating evidence indicates that peripheral tolerance is maintained at multiple levels of immune responses by negative regulators of proinflammatory signalin...

journal_title：Frontiers in immunology

authors： Guram K,Kim SS,Wu V,Sanders PD,Patel S,Schoenberger SP,Cohen EEW,Chen SY,Sharabi AB

更新日期：2019-03-18 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the complex clinical phen...

journal_title：Frontiers in immunology

authors： Seleman M,Hoyos-Bachiloglu R,Geha RS,Chou J

更新日期：2017-07-24 00:00:00

abstract：:Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE-/-) mice exhibit systemic effects including skin inflammation and hypertrophic lymph nodes (LNs). However...

journal_title：Frontiers in immunology

authors： Tay MHD,Lim SYJ,Leong YFI,Thiam CH,Tan KW,Torta FT,Narayanaswamy P,Wenk M,Angeli V

更新日期：2019-03-27 00:00:00

abstract：:We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase II-III trial against medium-dose IFN-α2b. All vaccinated patients immunized intradermally developed...

journal_title：Frontiers in immunology

authors： Aris M,Bravo AI,Barrio MM,Mordoh J

更新日期：2015-03-30 00:00:00

abstract：:Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystemic disorder, belonging to the small vessel anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, defined as an eosinophil-rich and necrotizing granulomatous inflammation often involving the respiratory tract, and necrotizing vasculitis p...

journal_title：Frontiers in immunology

authors： Gioffredi A,Maritati F,Oliva E,Buzio C

更新日期：2014-11-03 00:00:00

abstract：:The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow outputs measurement have been widely implemented in newborn screenin...

journal_title：Frontiers in immunology

authors： Kwok JSY,Cheung SKF,Ho JCY,Tang IWH,Chu PWK,Leung EYS,Lee PPW,Cheuk DKL,Lee V,Ip P,Lau YL

更新日期：2020-07-16 00:00:00

abstract：:Vaccines against a variety of infectious diseases have been developed and tested. Although there have been some notable successes, most are less than optimal or have failed outright. There has been discussion about whether either B cells or dendritic cells (DCs) could be useful for the development of antimicrobial vac...

journal_title：Frontiers in immunology

authors： Fujii SI,Yamasaki S,Sato Y,Shimizu K

更新日期：2018-06-04 00:00:00

abstract：:X-linked agammaglobulinemia (XLA) is a clinically and genetically well-defined immunodeficiency and the most common form of agammaglobulinemia. It is characterized by susceptibility to recurrent bacterial infections, profound hypogammaglobulinemia, and few or no circulating B cells. XLA is caused by mutations in the B...

journal_title：Frontiers in immunology

authors： Rivière JG,Franco-Jarava C,Martínez-Gallo M,Aguiló-Cucurull A,Blasco-Pérez L,Paramonov I,Antolín M,Martín-Nalda A,Soler-Palacín P,Colobran R

更新日期：2020-02-12 00:00:00

abstract：:Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with inflammatory diseases, cancer, after transplantation, and particularly in a...

journal_title：Frontiers in immunology

authors： Ran Z,Yue-Bei L,Qiu-Ming Z,Huan Y

更新日期：2020-08-20 00:00:00

abstract：:Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oli...

journal_title：Frontiers in immunology

authors： Wu X,Dong L,Lin X,Li J

更新日期：2017-12-12 00:00:00

abstract：:Crystallopathies are a heterogeneous group of diseases caused by intrinsic or environmental microparticles or crystals, promoting tissue inflammation and scarring. Certain proteins interfere with crystal formation and growth, e.g., with intrarenal calcium oxalate (CaOx) crystal formation, a common cause of kidney ston...

journal_title：Frontiers in immunology

authors： Steiger S,Grill JF,Ma Q,Bäuerle T,Jordan J,Smolle M,Böhland C,Lech M,Anders HJ

更新日期：2018-03-29 00:00:00

abstract：:Autoimmune myopathies (myositides) are strongly associated with malignancy. The link between myositis and cancer, originally noticed by Bohan and Peter in their classification in 1975 (1), has been evidenced by large population-based cohort studies and a recent meta-analysis. The numerous reports of cases in which the...

journal_title：Frontiers in immunology

authors： Aussy A,Boyer O,Cordel N

更新日期：2017-08-21 00:00:00

abstract：:Blood-borne monocyte derived cells play a pivotal, initially unrecognized, role in most central nervous system disorders, including diseases initially classified as purely neurodegenerative (i.e., Alzheimer's disease, Parkinson's disease, and ALS). Their trafficking to the brain and spinal cord has been extensively st...

journal_title：Frontiers in immunology

authors： Nigro A,Colombo F,Casella G,Finardi A,Verderio C,Furlan R

更新日期：2016-01-29 00:00:00