How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive.

abstract：:Plasma cells (PCs) are essentially characterized by the co-expression of CD138 and CD38, which allows their identification in flow cytometry in bone marrow (BM), peripheral blood, or cell suspensions from tissues. These terminally differentiated B-cells may lose the expression of surface CD19 and that of CD20 while re...

journal_title：Frontiers in immunology

authors： Robillard N,Wuillème S,Moreau P,Béné MC

更新日期：2014-03-31 00:00:00

abstract：:Cancer immunotherapy (CIT) with antibodies targeting the programmed cell death 1 protein (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis have changed the standard of care in multiple cancers. However, durable antitumor responses have been observed in only a minority of patients, indicating the presence of other i...

journal_title：Frontiers in immunology

authors： Hack SP,Zhu AX,Wang Y

更新日期：2020-11-05 00:00:00

abstract：:The lymphoid follicle is critical for the development of humoral immune responses. Cell circulation to this site is highly regulated by the differential expression of chemokine receptors. This feature contributes to the establishment of viral reservoirs in lymphoid follicles and the development of some types of malign...

journal_title：Frontiers in immunology

authors： Perdomo-Celis F,Taborda NA,Rugeles MT

更新日期：2017-09-29 00:00:00

abstract：:T cells recognizing epitopes on the surface of mycobacteria-infected macrophages can impart protection, but with associated risk for reactivation to lung pathology. We aimed to identify antibodies specific to such epitopes, which carry potentials for development toward novel therapeutic constructs. Since epitopes pres...

journal_title：Frontiers in immunology

authors： Ortega PA,Silva-Miranda M,Torres-Larios A,Campos-Chávez E,Franken KCLCM,Ottenhoff THM,Ivanyi J,Espitia C

更新日期：2020-10-02 00:00:00

abstract：:Functional cross-talk between osteoblasts and osteoclasts is a key process for bone homeostasis. Although osteoblast hypoxia-inducible factor-1α (HIF-1α) pathway activation results in impaired osteoclastogenesis via the direct regulation of osteoprotegerin (OPG), it is unclear whether there are other efficient mediato...

journal_title：Frontiers in immunology

authors： Kang H,Yang K,Xiao L,Guo L,Guo C,Yan Y,Qi J,Wang F,Ryffel B,Li C,Deng L

更新日期：2017-10-16 00:00:00

abstract：:Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged-immune related adverse events. The observation that therapeutic blockade of these inhibitory receptors is sufficie...

journal_title：Frontiers in immunology

authors： Paluch C,Santos AM,Anzilotti C,Cornall RJ,Davis SJ

更新日期：2018-10-08 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs capable of rapidly producing copious amounts of type I IFN (IFN-I) in response to viral infections. The mechanism regulating rapid production of IFN-I after pDCs are exposed to viral nucleic acids remains elusive. Here, we show that the transcription ...

journal_title：Frontiers in immunology

authors： Ko YA,Chan YH,Liu CH,Liang JJ,Chuang TH,Hsueh YP,Lin YL,Lin KI

更新日期：2018-08-07 00:00:00

abstract：:Human rotavirus remains a major cause of gastroenteritis worldwide despite the availability of effective vaccines. In this study, we investigated the genetic diversity of rotaviruses circulating in Lebanon. We genetically characterized the VP4 and VP7 genes encoding the outer capsid proteins of 132 rotavirus-associate...

journal_title：Frontiers in immunology

authors： Harastani HH,Reslan L,Sabra A,Ali Z,Hammadi M,Ghanem S,Hajar F,Matar GM,Dbaibo GS,Zaraket H

更新日期：2020-02-26 00:00:00

abstract：:Myasthenia gravis is an autoimmune disease in which immunoglobulin G (IgG) autoantibodies are formed against the nicotinic acetylcholine receptor (AChR) or other components of the neuromuscular junction. Though effective treatments are currently available, many commonly used therapies have important limitations and al...

journal_title：Frontiers in immunology

authors： Gable KL,Guptill JT

更新日期：2020-01-10 00:00:00

abstract：:The variables that influence the selection of a preparative regimen for a pediatric hematopoietic stem cell transplant procedure encompasses many issues. When one considers this procedure for non-malignant diseases, components in a preparative regimen that were historically developed to reduce malignant tumor burden m...

journal_title：Frontiers in immunology

authors： Hayashi RJ

更新日期：2020-10-19 00:00:00

abstract：:Developing lymphocytes express the recombination activating genes (RAGs) 1 and 2 products that form a site specific recombinase complex (RAG), introducing double strand DNA breaks (DSBs) at recombination signal sequences (RSSs) flanking the V, D, and J gene segments in the antigen receptor loci. The subsequent steps i...

journal_title：Frontiers in immunology

authors： Bonnet M,Sarmento LM,Martins AC,Sobral D,Silva J,Demengeot J

更新日期：2017-11-10 00:00:00

abstract：:Nutrition plays a major role in the management of both acute and chronic diseases, in terms of body's response to the pathogenic organism. An array of nutrients like macro- and micro-nutrients, vitamins, etc., are associated with boosting the host's immune responses against intracellular pathogens including mycobacter...

journal_title：Frontiers in immunology

authors： Chandrasekaran P,Saravanan N,Bethunaickan R,Tripathy S

更新日期：2017-10-18 00:00:00

abstract：:Superparamagnetic iron oxide nanoparticles (SPION) are employed as diagnostics and therapeutics following intravenous delivery for the treatment of iron deficiency anemia (IDA) in adult patients with chronic kidney failure. Neutrophils are the first defense against blood borne foreign insult and recruit to vascular si...

journal_title：Frontiers in immunology

authors： Garcia G,Kim MH,Morikis VA,Simon SI

更新日期：2020-12-09 00:00:00

abstract：:Determining whether an asymptomatic individual with Prostate-Specific Antigen (PSA) levels below 20 ng ml-1 has prostate cancer in the absence of definitive, biopsy-based evidence continues to present a significant challenge to clinicians who must decide whether such individuals with low PSA values have prostate cance...

journal_title：Frontiers in immunology

authors： Cosma G,McArdle SE,Reeder S,Foulds GA,Hood S,Khan M,Pockley AG

更新日期：2017-12-18 00:00:00

abstract：:Allergic asthma is a chronic Th2 inflammatory disease of the lower airways affecting a growing number of people worldwide. The impact of infections and microbiota composition on allergic asthma has been investigated frequently. Until now, however, there have been few attempts to investigate the impact of asthma on the...

journal_title：Frontiers in immunology

authors： Machelart A,Potemberg G,Van Maele L,Demars A,Lagneaux M,De Trez C,Sabatel C,Bureau F,De Prins S,Percier P,Denis O,Jurion F,Romano M,Vanderwinden JM,Letesson JJ,Muraille E

更新日期：2018-08-10 00:00:00

abstract：:Induction of immune tolerance is a key process by which the immune system is educated to modulate reactions against benign stimuli such as self-antigens and commensal microbes. Understanding and harnessing the natural mechanisms of immune tolerance may become an increasingly useful strategy for treating many types of ...

journal_title：Frontiers in immunology

authors： Lundy SK,Klinker MW,Fox DA

更新日期：2015-03-20 00:00:00

abstract：:The receptor for advanced glycation endproducts (RAGE) can engage a diverse class of ligands and contribute to the immune and inflammatory response to infection and injury. It is known to be a pathogenic receptor in many inflammatory diseases, including ischemia/reperfusion (IR) injuries in several tissues; however, i...

journal_title：Frontiers in immunology

authors： Wu MC,Gilmour TD,Mantovani S,Woodruff TM

更新日期：2015-12-07 00:00:00

abstract：:pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NETosis). However, how...

journal_title：Frontiers in immunology

authors： Naffah de Souza C,Breda LCD,Khan MA,de Almeida SR,Câmara NOS,Sweezey N,Palaniyar N

更新日期：2018-01-09 00:00:00

abstract：:Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an "alarmin" role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells and T helper 2 cell...

journal_title：Frontiers in immunology

authors： Li L,Zhu H,Zuo X

更新日期：2018-11-15 00:00:00

abstract：:Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations. Respiratory viruses can cause exacerbations in chronic pulmonary diseases including COPD or asthma and have been suggested to contribute to...

journal_title：Frontiers in immunology

authors： Sörensen M,Kantorek J,Byrnes L,Boutin S,Mall MA,Lasitschka F,Zabeck H,Nguyen D,Dalpke AH

更新日期：2020-02-04 00:00:00

abstract：:Dendritic epidermal T cells (DETCs) and dermal Vγ4 T cells engage in wound re-epithelialization and skin inflammation. However, it remains unknown whether a functional link between Vγ4 T cell pro-inflammation and DETC pro-healing exists to affect the outcome of skin wound closure. Here, we revealed that Vγ4 T cell-der...

journal_title：Frontiers in immunology

authors： Li Y,Wang Y,Zhou L,Liu M,Liang G,Yan R,Jiang Y,Hao J,Zhang X,Hu X,Huang Y,Wang R,Yin Z,Wu J,Luo G,He W

更新日期：2018-02-12 00:00:00

abstract：:We have previously shown that the human obese adipose tissue (AT) contributes to increased secretion of adipocyte-specific IgG antibodies in individuals with obesity. This occurs without any exogenous stimulation, because the ongoing process of cell death in the obese AT leads to the release of "self" antigens able to...

journal_title：Frontiers in immunology

authors： Frasca D,Diaz A,Romero M,Garcia D,Jayram D,Thaller S,Del Carmen Piqueras M,Bhattacharya S,Blomberg BB

更新日期：2020-02-28 00:00:00

abstract：:Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polym...

journal_title：Frontiers in immunology

authors： Xu-Yang Z,Pei-Yu B,Chuan-Tao Y,Wei Y,Hong-Wei M,Kang T,Chun-Mei Z,Ying-Feng L,Xin W,Ping-Zhong W,Chang-Xing H,Xue-Fan B,Ying Z,Zhan-Sheng J

更新日期：2017-01-03 00:00:00

abstract：:Many a disease associates with inflammation. Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-α and proteases, causing fibroblasts to release endogenous antigens that may be cross reactive with exogenous antigens. We made a predictive dynamic map of ...

journal_title：Frontiers in immunology

authors： Abudukelimu A,Barberis M,Redegeld FA,Sahin N,Westerhoff HV

更新日期：2018-08-07 00:00:00

abstract：:Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by the production of a monoclonal immunoglobulin (mc Ig) which for subsets...

journal_title：Frontiers in immunology

authors： Bosseboeuf A,Allain-Maillet S,Mennesson N,Tallet A,Rossi C,Garderet L,Caillot D,Moreau P,Piver E,Girodon F,Perreault H,Brouard S,Nicot A,Bigot-Corbel E,Hermouet S,Harb J

更新日期：2017-10-19 00:00:00

abstract：:Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors targeting the indo...

journal_title：Frontiers in immunology

authors： Hornyák L,Dobos N,Koncz G,Karányi Z,Páll D,Szabó Z,Halmos G,Székvölgyi L

更新日期：2018-01-31 00:00:00

abstract：:The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in PRF1, UNC13D, STX11, or STXBP2 leads to a potentially fatal immune dysregulation,...

journal_title：Frontiers in immunology

authors： Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

更新日期：2018-03-15 00:00:00

abstract：:The dramatic female sex bias observed in human lupus is thought to be due, at least in part, to estrogens. Using mouse models, we have shown that estrogens, acting through estrogen receptor alpha (ERα) promote lupus development and contribute significantly to the female sex bias observed in this disease. C57Bl/6 (B6) ...

journal_title：Frontiers in immunology

authors： Graham JH,Yoachim SD,Gould KA

更新日期：2020-11-10 00:00:00

abstract：:Enhanced susceptibility to bacterial infection in the days following an acute virus infection such as flu is a major clinical problem. Mouse models have provided major advances in understanding viral-bacterial superinfections, yet interactions of the anti-viral and anti-bacterial responses remain elusive. Here, we hav...

journal_title：Frontiers in immunology

authors： Boucontet L,Passoni G,Thiry V,Maggi L,Herbomel P,Levraud JP,Colucci-Guyon E

更新日期：2018-05-24 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00