Malnutrition: Modulator of Immune Responses in Tuberculosis.

abstract：:Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation an...

journal_title：Frontiers in immunology

authors： Zhao D,Abou-Daya KI,Dai H,Oberbarnscheidt MH,Li XC,Lakkis FG

更新日期：2020-05-28 00:00:00

abstract：:Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, stimulator of interferon genes (STING) encoded by Tmem173. In this study, we demonstrate that STING triggers adaptive immune responses that control Th17 differentiation. Cyclic dinucleotides recognition enables classical den...

journal_title：Frontiers in immunology

authors： Liu S,Xia Q,Wu X,Sun F,Hu Q,Wu J,Wang M,Rao Q,Guan W

更新日期：2018-05-16 00:00:00

abstract：:Obesity is associated with a chronic low-grade inflammatory state that drives the -development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This metabolic inflammation is thought to originate in the adipose tissue, ...

journal_title：Frontiers in immunology

authors： Morrison MC,Kleemann R

更新日期：2015-06-15 00:00:00

abstract：:THE REGULATORY CYTOKINE TUMOR NECROSIS FACTOR (TNF) EXERTS ITS EFFECTS THROUGH TWO RECEPTORS: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases. One new treatment strategy for autoimmune disease is selective destruction of autoreactive T cells by administration of TNF, TNF ind...

journal_title：Frontiers in immunology

authors： Faustman DL,Davis M

更新日期：2013-12-23 00:00:00

abstract：:Glioblastoma (GBM) is the most malignant form of astrocytoma with short survival and a high recurrence rate and remains a global problem. Currently, surgery, chemotherapy, radiotherapy, and other comprehensive treatments are the main treatment modalities, but patients still have a poor prognosis mainly due to the infi...

journal_title：Frontiers in immunology

authors： Kang X,Zheng Y,Hong W,Chen X,Li H,Huang B,Huang Z,Tang H,Geng W

更新日期：2020-10-21 00:00:00

abstract：:CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, "natural" Treg (nTreg) cells that develop in the thymus, and "induced" Treg (iTreg) cells that arise in the periphery from CD4(+) Foxp3(-) conventional...

journal_title：Frontiers in immunology

authors： Schmitt EG,Williams CB

更新日期：2013-06-19 00:00:00

abstract：:The complement system is a dynamic subset of the innate immune system, playing roles in host defense, clearance of immune complexes and cell debris, and priming the adaptive immune response. Over the last 40 years our understanding of the complement system has evolved from identifying its presence and recognizing its ...

journal_title：Frontiers in immunology

authors： Nauser CL,Howard MC,Fanelli G,Farrar CA,Sacks S

更新日期：2018-09-06 00:00:00

abstract：:Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. In this study, we aimed to further characterize the role of macrophage-derived EVs in immune responses against hepatitis C virus (HCV) and the potential of polyunsaturated fatty acids (PUFAs) to modulate thi...

journal_title：Frontiers in immunology

authors： Cai C,Koch B,Morikawa K,Suda G,Sakamoto N,Rueschenbaum S,Akhras S,Dietz J,Hildt E,Zeuzem S,Welsch C,Lange CM

更新日期：2018-04-12 00:00:00

abstract：:Antibodies against HLA and non-HLA are associated with transplantation outcome. Recently, pretransplant serum IgG antibody levels against apoptotic cells were found to correlate with kidney allograft loss. We investigated the presence of these antibodies in lung transplantation (LTx) patients and evaluated the correla...

journal_title：Frontiers in immunology

authors： Budding K,van de Graaf EA,Kardol-Hoefnagel T,Oudijk ED,Kwakkel-van Erp JM,Hack CE,Otten HG

更新日期：2017-03-21 00:00:00

abstract：:Accumulation of dendritic cells (DCs) is a special characteristic of the decidual microenvironment. Decidua-infiltrated DCs show unique phenotypes and functions that promote the establishment of fetal-maternal tolerance. However, the regulatory mechanisms yet to be fully investigated. Decidual stromal cells (DSCs) are...

journal_title：Frontiers in immunology

authors： Shao Q,Liu X,Huang Y,Chen X,Wang H

更新日期：2020-10-27 00:00:00

abstract：:Macrophages form an important component of the innate immune system and serve as first responders against invading pathogens. While pathways critical for initiation of inflammatory responses between macrophages and other LysM+ myeloid cells are largely similar, it remains unknown whether a specific pathway has differe...

journal_title：Frontiers in immunology

authors： Xiong X,Mathewson ND,Li H,Tan M,Fujiwara H,Li H,Reddy P,Sun Y

更新日期：2018-12-06 00:00:00

abstract：:Sepsis is characterized by the host's dysregulated immune response to an infection followed by a potentially fatal organ dysfunction. Although there have been some advances in the treatment of sepsis, mainly focused on broad-spectrum antibiotics, mortality rates remain high, urging for the search of new therapies. Oxi...

journal_title：Frontiers in immunology

authors： Navegantes-Lima KC,Monteiro VVS,de França Gaspar SL,de Brito Oliveira AL,de Oliveira JP,Reis JF,de Souza Gomes R,Rodrigues CA,Stutz H,Sovrani V,Peres A,Romão PRT,Monteiro MC

更新日期：2020-07-01 00:00:00

abstract：:B cell activation and differentiation yields plasma cells with high affinity antibodies to a given antigen in a time-frame that allows for host protection. Although the end product is most commonly humoral immunity, the rapid proliferation and somatic mutation of the B cell receptor also results in oncogenic mutations...

journal_title：Frontiers in immunology

authors： Barwick BG,Gupta VA,Vertino PM,Boise LH

更新日期：2019-05-21 00:00:00

abstract：:Hyaluronan is made and extruded from cells to form a pericellular or extracellular matrix (ECM) and is present in virtually all tissues in the body. The size and form of hyaluronan present in tissues are indicative of a healthy or inflamed tissue, and the interactions of hyaluronan with immune cells can influence thei...

journal_title：Frontiers in immunology

authors： Lee-Sayer SS,Dong Y,Arif AA,Olsson M,Brown KL,Johnson P

更新日期：2015-04-14 00:00:00

abstract：:Lymphatic filariasis (LF) is a tropical parasitic infection of human transmitted by mosquitoes. Chronic infection results in severe physical disability in the infected patients. Although several potential vaccine antigens were identified by several groups, there are no licensed prophylactic vaccine to date against thi...

journal_title：Frontiers in immunology

authors： Chauhan N,Khatri V,Banerjee P,Kalyanasundaram R

更新日期：2018-07-02 00:00:00

abstract：Background:Selenium (Se) levels decrease in the circulation during acute inflammatory states and sepsis, and are inversely associated with morbidity and mortality. A more specific understanding of where selenoproteins and Se processing are compromised during insult is needed. We investigated the acute signaling respons...

journal_title：Frontiers in immunology

authors： Sherlock LG,Sjostrom K,Sian L,Delaney C,Tipple TE,Krebs NF,Nozik-Grayck E,Wright CJ

更新日期：2020-11-05 00:00:00

abstract：:The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. However, recent work demonstrates that both the ligands bound by MR1 and the T cells restricted by it are more diverse than originally thought...

journal_title：Frontiers in immunology

authors： Kulicke C,Karamooz E,Lewinsohn D,Harriff M

更新日期：2020-09-02 00:00:00

abstract：:Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL). The proper o...

journal_title：Frontiers in immunology

authors： Bannas P,Hambach J,Koch-Nolte F

更新日期：2017-11-22 00:00:00

abstract：:Human papillomavirus (HPV) vaccines are safe and effective in preventing HPV infection and cervical precancers. Neutralizing antibodies are thought to be the primary mechanism of protection for HPV vaccines, although the exact level required for protection has not been identified. Three common serological assays used ...

journal_title：Frontiers in immunology

authors： Toh ZQ,He L,Chen C,Huang A,Russell FM,Garland SM,Reyburn R,Ratu T,Tuivaga E,Frazer IH,Mulholland EK,Licciardi PV

更新日期：2020-10-28 00:00:00

abstract：:The role of macrophages during regeneration in zebrafish has been well-documented. Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous population of cells, and that they can play different roles during immune responses and in tissue restoration after damage and infection. In this work, ...

journal_title：Frontiers in immunology

authors： Morales RA,Allende ML

更新日期：2019-02-15 00:00:00

abstract：:This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, ser...

journal_title：Frontiers in immunology

authors： Wang D,Jiang X,Teng S,Zhang Y,Liu Y,Li X,Li Y

更新日期：2019-05-08 00:00:00

abstract：:Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lup...

journal_title：Frontiers in immunology

authors： Zipfel PF,Wiech T,Rudnick R,Afonso S,Person F,Skerka C

更新日期：2019-09-27 00:00:00

abstract：Introduction:The broccoli isothiocyanate sulforaphane was shown to inhibit inflammation and tumor progression, also in pancreatic cancer, while its effect on tumor immunity is poorly understood. We investigated the immunoregulatory effect of sulforaphane on human dendritic cells alone and in presence of pancreatic tumo...

journal_title：Frontiers in immunology

authors： Wang Y,Petrikova E,Gross W,Sticht C,Gretz N,Herr I,Karakhanova S

更新日期：2020-10-30 00:00:00

abstract：:Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular events are involved in controlling malignant cell process. In this sense, the importance of studying multiple cell alterations in this pathology is overriding. A well-identified fact on immune response is that it can vary depend ...

journal_title：Frontiers in immunology

authors： Segovia-Mendoza M,Morales-Montor J

更新日期：2019-03-01 00:00:00

abstract：:The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epito...

journal_title：Frontiers in immunology

authors： Gupta S,Agarwal A,Kumar A,Biswas D

更新日期：2018-04-10 00:00:00

abstract：:Background: Haploinsufficiency A20 (HA20) is a newly described monogenic disease characterized by a wide spectrum of manifestations and caused by heterozygous mutations in TNFAIP3 which encodes A20 protein. TNFAIP3 mutation leads to disruption of the A20 ovarian tumor (OTU) domain and/or the zinc finger (ZnF) domain. ...

journal_title：Frontiers in immunology

authors： Chen Y,Ye Z,Chen L,Qin T,Seidler U,Tian D,Xiao F

更新日期：2020-09-23 00:00:00

abstract：:Intracellular adenosine monophosphate (AMP) is indispensable for cellular metabolic processes, and it is interconverted to ADP and/or ATP or activates AMP-activated protein kinase (AMPK). However, the specific biological function of extracellular AMP has not been identified. We evaluated the effect of extracellular AM...

journal_title：Frontiers in immunology

authors： Hua Y,Liu D,Zhang D,Wang X,Wei Q,Qin W

更新日期：2020-07-07 00:00:00

abstract：:The Kallikrein-Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report, we show that KKS regulate...

journal_title：Frontiers in immunology

authors： Seliga A,Lee MH,Fernandes NC,Zuluaga-Ramirez V,Didukh M,Persidsky Y,Potula R,Gallucci S,Sriram U

更新日期：2018-02-02 00:00:00

abstract：:DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune thrombocytopenia. B cells in DiGeorge syndrome show impaired maturation, wit...

journal_title：Frontiers in immunology

authors： Klocperk A,Paračková Z,Bloomfield M,Rataj M,Pokorný J,Unger S,Warnatz K,Šedivá A

更新日期：2018-07-23 00:00:00

abstract：:The killer-cell Ig-like receptors (KIR) form a multigene entity involved in modulating immune responses through interactions with MHC class I molecules. The complexity of the KIR cluster is reflected by, for instance, abundant levels of allelic polymorphism, gene copy number variation, and stochastic expression profil...

journal_title：Frontiers in immunology

authors： Bruijnesteijn J,van der Wiel MKH,de Groot N,Otting N,de Vos-Rouweler AJM,Lardy NM,de Groot NG,Bontrop RE

更新日期：2018-12-04 00:00:00