Complement Inhibitors in Clinical Trials for Glomerular Diseases.

Abstract:

:Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lupus nephritis, membranous nephropathy, and chronic transplant mediated glomerulopathy. Here we summarize ongoing clinical trials of complement inhibitors in nine glomerular diseases and show which inhibitors are used in trials for these renal disorders (http://clinicaltrials.gov).

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Zipfel PF,Wiech T,Rudnick R,Afonso S,Person F,Skerka C

doi

10.3389/fimmu.2019.02166

subject

Has Abstract

pub_date

2019-09-27 00:00:00

pages

2166

issn

1664-3224

journal_volume

10

pub_type

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