Macrophage-Derived Extracellular Vesicles Induce Long-Lasting Immunity Against Hepatitis C Virus Which Is Blunted by Polyunsaturated Fatty Acids.

abstract：:The newborn's immune system must transition from a sterile haploidentical uterus to the world full of antigens. Regulatory B-cells (Breg; broadly defined as CD19+CD24hiCD38hi) are tolerance promoters in the adult immune system. They can inhibit IFN-γ and IL-17 production by T-cells and are essential in different condi...

journal_title：Frontiers in immunology

authors： Esteve-Solé A,Teixidó I,Deyà-Martínez A,Yagüe J,Plaza-Martín AM,Juan M,Alsina L

更新日期：2017-03-07 00:00:00

abstract：:The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a hormone peptide able to bind to ferroportin, leading to its degradat...

journal_title：Frontiers in immunology

authors： Lepanto MS,Rosa L,Cutone A,Conte MP,Paesano R,Valenti P

更新日期：2018-09-21 00:00:00

abstract：:Antigen capturing at the periphery is one of the earliest, crucial functions of antigen-presenting cells (APCs) to initiate immune responses. Langerhans cells (LCs), the epidermal APCs migrate to draining lymph nodes (DLNs) upon acquiring antigens. An arsenal of endocytic molecules is available to this end, including ...

journal_title：Frontiers in immunology

authors： Becerril-García MA,Yam-Puc JC,Maqueda-Alfaro R,Beristain-Covarrubias N,Heras-Chavarría M,Gallegos-Hernández IA,Calderón-Amador J,Munguía-Fuentes R,Donis-Maturano L,Flores-Langarica A,Flores-Romo L

更新日期：2020-04-27 00:00:00

abstract：:Increasing studies have highlighted the effects of the tumor immune micro-environment (TIM) on colon cancer (CC) tumorigenesis, prognosis, and metastasis. However, there is no reliable molecular marker that can effectively estimate the immune infiltration and predict the CC relapse risk. Here, we leveraged the gene ex...

journal_title：Frontiers in immunology

authors： Li X,Wen D,Li X,Yao C,Chong W,Chen H

更新日期：2020-09-03 00:00:00

abstract：:Neutrophil extracellular traps (NETs), DNA webs released into the extracellular environment by activated neutrophils, are thought to play a key role in the entrapment and eradication of microbes. However, NETs are highly cytotoxic and a likely source of autoantigens, suggesting that NET release is tightly regulated. N...

journal_title：Frontiers in immunology

authors： Majewski P,Majchrzak-Gorecka M,Grygier B,Skrzeczynska-Moncznik J,Osiecka O,Cichy J

更新日期：2016-06-30 00:00:00

abstract：:The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases, Lck. Upon T-cell antigen receptor (TCR) triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formation of complex signaling network and cytoskeletal re...

journal_title：Frontiers in immunology

authors： Ballek O,Valečka J,Dobešová M,Broučková A,Manning J,Řehulka P,Stulík J,Filipp D

更新日期：2016-10-27 00:00:00

abstract：:In addition to their detrimental role in allergic diseases, mast cells (MCs) are well known to be important cells of the innate immune system. In the last decade, they have been shown to contribute significantly to optimal host defense against numerous pathogens including parasites, bacteria, and viruses. The contribu...

journal_title：Frontiers in immunology

authors： Saluja R,Metz M,Maurer M

更新日期：2012-06-13 00:00:00

abstract：:Many pathogens, including the malaria parasite Plasmodium falciparum, display high levels of polymorphism within T-cell epitope regions of proteins associated with protective immunity. The T-cell epitope variants are often non-cross-reactive. Herein, we show in a murine model, which modifies a protective CD8 T-cell ep...

journal_title：Frontiers in immunology

authors： Minigo G,Flanagan KL,Slattery RM,Plebanski M

更新日期：2017-02-14 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and renal failure. It is caused by genetic or acquired defects of the complement alternative pathway. Factor H autoantibodies (anti-FHs) have been reported in 10% of aHUS patients and are as...

journal_title：Frontiers in immunology

authors： Valoti E,Alberti M,Iatropoulos P,Piras R,Mele C,Breno M,Cremaschi A,Bresin E,Donadelli R,Alizzi S,Amoroso A,Benigni A,Remuzzi G,Noris M

更新日期：2019-05-01 00:00:00

abstract：:The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback. By imposing antibody feedback, germinal centers can interact and regulate the output of other germinal centers. Using ...

journal_title：Frontiers in immunology

authors： Arulraj T,Binder SC,Robert PA,Meyer-Hermann M

更新日期：2019-09-06 00:00:00

abstract：:SARS-CoV-2 is a novel coronavirus, not encountered before by humans. The wide spectrum of clinical expression of SARS-CoV-2 illness suggests that individual immune responses to SARS-CoV-2 play a crucial role in determining the clinical course after first infection. Immunological studies have focused on patients with m...

journal_title：Frontiers in immunology

authors： Carsetti R,Zaffina S,Piano Mortari E,Terreri S,Corrente F,Capponi C,Palomba P,Mirabella M,Cascioli S,Palange P,Cuccaro I,Milito C,Zumla A,Maeurer M,Camisa V,Vinci MR,Santoro A,Cimini E,Marchioni L,Nicastri E,Palmi

更新日期：2020-12-16 00:00:00

abstract：:Endothelial cells are thought to play a central role in the pathogenesis of antiphospholipid syndrome (APS). Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation has been shown to improve endothelial function in a number of diseases; thus, it could be of high clinical relevance in APS. The aim of this study w...

journal_title：Frontiers in immunology

authors： Felau SM,Sales LP,Solis MY,Hayashi AP,Roschel H,Sá-Pinto AL,Andrade DCO,Katayama KY,Irigoyen MC,Consolim-Colombo F,Bonfa E,Gualano B,Benatti FB

更新日期：2018-03-02 00:00:00

abstract：:Hyaluronan (HA), the major extracellular matrix component, is often anchored to CD44, a family of structurally/functionally important cell surface receptors. Recent results indicate that UV irradiation (UVR)-induced cutaneous squamous cell carcinomas (SCC) overexpress a variety of CD44 variant isoforms (CD44v), with d...

journal_title：Frontiers in immunology

authors： Bourguignon LY,Bikle D

更新日期：2015-05-13 00:00:00

abstract：:Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence in a process known as TCR convergence. Substitution sequencing errors introduced by TCRβ (TCRB) repertoire sequencing may create artifacts resembling TCR conver...

journal_title：Frontiers in immunology

authors： Looney TJ,Topacio-Hall D,Lowman G,Conroy J,Morrison C,Oh D,Fong L,Zhang L

更新日期：2020-01-09 00:00:00

abstract：:Vaccination is the most reliable measure to prevent infectious diseases in domestic animals. Development of novel vaccines demands extensive studies with new technologies, such as using novel adjuvants and immunomodulatory molecules. The co-stimulatory molecule 4-1BB provides a key signal that directs the fate of T ce...

journal_title：Frontiers in immunology

authors： Huang G,Liu X,Duszynski DW,Tang X,El-Ashram S,Liu Z,Suo X,Li Q

更新日期：2017-12-18 00:00:00

abstract：:Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated vasculitis and rheuma...

journal_title：Frontiers in immunology

authors： Tacnet-Delorme P,Gabillet J,Chatfield S,Thieblemont N,Frachet P,Witko-Sarsat V

更新日期：2018-04-25 00:00:00

abstract：:The onset of hepatic disorders in patients with systemic lupus erythematosus (SLE) is frequent; however, the etiology and liver pathogenesis of SLE remain unknown. In the present study, the role of hepatic deposited immunoglobulin G (IgG) in SLE-derived liver damage was investigated. From a retrospective analysis of t...

journal_title：Frontiers in immunology

authors： Fang X,Zaman MH,Guo X,Ding H,Xie C,Zhang X,Deng GM

更新日期：2018-06-25 00:00:00

abstract：:Maternal immune activation (MIA) caused by exposure to pathogens or inflammation during critical periods of neurodevelopment is a major risk factor for behavioral deficits and psychiatric illness in offspring. A spectrum of behavioral abnormalities can be recapitulated in rodents by inducing MIA using the viral mimeti...

journal_title：Frontiers in immunology

authors： Baines KJ,Hillier DM,Haddad FL,Rajakumar N,Schmid S,Renaud SJ

更新日期：2020-06-09 00:00:00

abstract：:Background: Butyric acid (BA) is a short-chain fatty acid (SCFA) with anti-inflammatory properties, which promotes intestinal barrier function. Medium-chain fatty acids (MCFA), including caproic acid (CA), promote TH1 and TH17 differentiation, thus supporting inflammation. Aim: Since most SCFAs are absorbed in the cec...

journal_title：Frontiers in immunology

authors： Saresella M,Marventano I,Barone M,La Rosa F,Piancone F,Mendozzi L,d'Arma A,Rossi V,Pugnetti L,Roda G,Casagni E,Cas MD,Paroni R,Brigidi P,Turroni S,Clerici M

更新日期：2020-07-07 00:00:00

abstract：:In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma. This tumor stroma, comprised of various cells, and extracellular mat...

journal_title：Frontiers in immunology

authors： Menon H,Ramapriyan R,Cushman TR,Verma V,Kim HH,Schoenhals JE,Atalar C,Selek U,Chun SG,Chang JY,Barsoumian HB,Nguyen QN,Altan M,Cortez MA,Hahn SM,Welsh JW

更新日期：2019-02-15 00:00:00

abstract：:Two decades of clinical cancer research with dendritic cell (DC)-based vaccination have proved that this type of personalized medicine is safe and has the capacity to improve survival, but monotherapy is unlikely to cure the cancer. Designed to empower the patient's antitumor immunity, huge research efforts are set to...

journal_title：Frontiers in immunology

authors： Versteven M,Van den Bergh JMJ,Marcq E,Smits ELJ,Van Tendeloo VFI,Hobo W,Lion E

更新日期：2018-03-01 00:00:00

abstract：:Tuberculosis (TB) is one of the prevalent causes of death worldwide, with 95% of these deaths occurring in developing countries, like India. The causative agent, Mycobacterium tuberculosis (MTb) has the tenacious ability to circumvent the host's immune system for its own advantage. Macrophages are one of the phagocyti...

journal_title：Frontiers in immunology

authors： Ahluwalia PK,Pandey RK,Sehajpal PK,Prajapati VK

更新日期：2017-02-08 00:00:00

abstract：:FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunoglobulins (IVIg) the...

journal_title：Frontiers in immunology

authors： Anania JC,Trist HM,Palmer CS,Tan PS,Kouskousis BP,Chenoweth AM,Kent SJ,Mackay GA,Hoi A,Koelmeyer R,Slade C,Bryant VL,Hodgkin PD,Aui PM,van Zelm MC,Wines BD,Hogarth PM

更新日期：2018-08-20 00:00:00

abstract：:New approaches are needed to develop more effective interventions to prevent long-term rejection of organ allografts. Computational biology provides a powerful tool to assess the large amount of complex data that is generated in longitudinal studies in this area. This manuscript outlines how our two groups are using m...

journal_title：Frontiers in immunology

authors： Stegall MD,Borrows R

更新日期：2015-08-03 00:00:00

abstract：:Objectives: Considering the critical role of microRNAs (miRNAs) in regulation of cell activation, we investigated their role in circulating type-2 conventional dendritic cells (cDC2s) of patients with primary Sjögren's syndrome (pSS) compared to healthy controls (HC). Methods: CD1c-expressing cDC2s were isolated from ...

journal_title：Frontiers in immunology

authors： Lopes AP,van Roon JAG,Blokland SLM,Wang M,Chouri E,Hartgring SAY,van der Wurff-Jacobs KMG,Kruize AA,Burgering BMT,Rossato M,Radstake TRDJ,Hillen MR

更新日期：2019-06-20 00:00:00

abstract：:HLA-E is a member of the non-classical HLA molecules and by interaction with activating or inhibitory receptors of NK and T cells, HLA-E can lead to immune activation or suppression context-dependently. Recently, the non-classical HLA molecules gain more attention in the setting of allogeneic hematopoietic stem cell t...

journal_title：Frontiers in immunology

authors： Kordelas L,Schwich E,Lindemann M,Heinemann FM,Buttkereit U,Horn PA,Beelen DW,Rebmann V

更新日期：2020-01-10 00:00:00

abstract：:Recent years have seen an unprecedented rise in the incidence of multidrug-resistant (MDR) Gram-negative bacteria (GNBs) such as Acinetobacter and Klebsiella species. In view of the shortage of novel drugs in the pipeline, alternative strategies to prevent, and treat infections by GNBs are urgently needed. Previously,...

journal_title：Frontiers in immunology

authors： Youssef EG,Zhang L,Alkhazraji S,Gebremariam T,Singh S,Yount NY,Yeaman MR,Uppuluri P,Ibrahim AS

更新日期：2020-02-18 00:00:00

abstract：:Cyclic dinucleotides are bacterial signal transducers that bind to host intracellular protein, stimulator of interferon genes (STING) encoded by Tmem173. In this study, we demonstrate that STING triggers adaptive immune responses that control Th17 differentiation. Cyclic dinucleotides recognition enables classical den...

journal_title：Frontiers in immunology

authors： Liu S,Xia Q,Wu X,Sun F,Hu Q,Wu J,Wang M,Rao Q,Guan W

更新日期：2018-05-16 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor in children and, in the high-risk group, has a 5-year mortality rate of ~50%. The high mortality rate and significant treatment-related morbidities associated with current standard of care therapies belie the critical need for more tolerable and effective ...

journal_title：Frontiers in immunology

authors： McNerney KO,Karageorgos SA,Hogarty MD,Bassiri H

更新日期：2020-05-08 00:00:00

abstract：:Follicular development is a highly coordinated process that in humans takes more than 6 months. Pituitary gonadotropins and a variety of locally produced growth factors and cytokines are involved in determining a precise sequence of changes in cell metabolism, proliferation, vascularization, and matrix remodeling in o...

journal_title：Frontiers in immunology

authors： Camaioni A,Klinger FG,Campagnolo L,Salustri A

更新日期：2018-11-29 00:00:00