Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment.


:In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma. This tumor stroma, comprised of various cells, and extracellular matrix (ECM), has been shown to aid in suppressing host immune responses against tumor cells. Through immunosuppressive cytokine secretion, metabolic alterations, and other mechanisms, the tumor stroma provides a complex network of safeguards for tumor proliferation. With recent advances in more effective, localized treatment, radiation therapy (XRT) has allowed for strategies that can effectively alter and ablate tumor stromal tissue. This includes promoting immunogenic cell death through tumor antigen release to increasing immune cell trafficking, XRT has a unique advantage against the tumoral immune evasion mechanisms that are orchestrated by stromal cells. Current studies are underway to elucidate pathways within the tumor stroma as potential targets for immunotherapy and chemoradiation. This review summarizes the effects of tumor stroma in tumor immune evasion, explains how XRT may help overcome these effects, with potential combinatorial approaches for future treatment modalities.


Front Immunol


Frontiers in immunology


Menon H,Ramapriyan R,Cushman TR,Verma V,Kim HH,Schoenhals JE,Atalar C,Selek U,Chun SG,Chang JY,Barsoumian HB,Nguyen QN,Altan M,Cortez MA,Hahn SM,Welsh JW




Has Abstract


2019-02-15 00:00:00








  • The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice.

    abstract::This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, ser...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wang D,Jiang X,Teng S,Zhang Y,Liu Y,Li X,Li Y

    更新日期:2019-05-08 00:00:00

  • Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis.

    abstract::The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of experimental autoimmune enc...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Prado C,Gaiazzi M,González H,Ugalde V,Figueroa A,Osorio-Barrios FJ,López E,Lladser A,Rasini E,Marino F,Zaffaroni M,Cosentino M,Pacheco R

    更新日期:2018-03-21 00:00:00

  • Non-canonical Functions of Macroautophagy Proteins During Endocytosis by Myeloid Antigen Presenting Cells.

    abstract::Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation. The molecular machinery of macroautophagy, a catabolic pathway that delivers cytoplasmic constituents to...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Münz C

    更新日期:2018-11-27 00:00:00

  • Peripheral Blood Classical Monocytes and Plasma Interleukin 10 Are Associated to Neoadjuvant Chemotherapy Response in Breast Cancer Patients.

    abstract::Worldwide, breast cancer (BC) is the leading cause of cancer death among women. For many patients the most effective treatment is a resection surgery that removes the tumor. Within this subset, patients sometimes receive chemotherapy treatment (CT) prior to surgery aiming to reduce tumor size in order to preserve heal...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Valdés-Ferrada J,Muñoz-Durango N,Pérez-Sepulveda A,Muñiz S,Coronado-Arrázola I,Acevedo F,Soto JA,Bueno SM,Sánchez C,Kalergis AM

    更新日期:2020-07-09 00:00:00

  • A New Tool for Complement Research: In vitro Reconstituted Human Classical Complement Pathway.

    abstract::The complement, as part of the innate immune system, represents the first line of defense against Gram-negative bacteria invading the bloodstream. The complement system is a zymogen cascade that ultimately assemble into the so-called membrane attack complex (MAC), which lyses Gram-negative bacteria upon insertion into...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mutti M,Ramoni K,Nagy G,Nagy E,Szijártó V

    更新日期:2018-12-04 00:00:00

  • Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases.

    abstract::Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matr...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Mozos I,Malainer C,Horbańczuk J,Gug C,Stoian D,Luca CT,Atanasov AG

    更新日期:2017-08-31 00:00:00

  • Genome-Wide Analysis of the Malaria Parasite Plasmodium falciparum Isolates From Togo Reveals Selective Signals in Immune Selection-Related Antigen Genes.

    abstract::Malaria is a public health concern worldwide, and Togo has proven to be no exception. Effective approaches to provide information on biological insights for disease elimination are therefore a research priority. Local selection on malaria pathogens is due to multiple factors including host immunity. We undertook genom...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kassegne K,Komi Koukoura K,Shen HM,Chen SB,Fu HT,Chen YQ,Zhou XN,Chen JH,Cheng Y

    更新日期:2020-10-23 00:00:00

  • Distinct progenitor origin distinguishes a lineage of dendritic-like cells in spleen.

    abstract::The dendritic cell (DC) compartment comprises subsets of cells with distinct phenotypes. Previously this lab reported methodology for hematopoiesis of dendritic-like cells in vitro dependent on a murine splenic stromal cell line (5G3). Co-cultures of lineage-depleted bone marrow (Lin(-) BM) over 5G3 continuously produ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Petvises S,O'Neill HC

    更新日期:2014-01-02 00:00:00

  • Immunomodulation by IVIg and the Role of Fc-Gamma Receptors: Classic Mechanisms of Action after all?

    abstract::Intravenous IgG (IVIg) contains polyclonal immunoglobulin G (IgG) from thousands of donors. It is administered at a low dose at regular intervals as antibody replacement therapy and at a higher dose as immunomodulatory treatment in various auto-immune or auto-inflammatory diseases. The working mechanism of immunomodul...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Nagelkerke SQ,Kuijpers TW

    更新日期:2015-01-21 00:00:00

  • Interleukin-2 production by dendritic cells and its immuno-regulatory functions.

    abstract::Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire microbial products and prime adaptive immune responses against pathogens. Furthermore, DCs also play a key role in induction and maintenance of tolerance. Although numerous studies have assessed the diverse functions of DCs, many unanswere...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zelante T,Fric J,Wong AY,Ricciardi-Castagnoli P

    更新日期:2012-06-18 00:00:00

  • MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps.

    abstract::Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones. The aim of this study was to examine the role of miR-155 in controlling PAD4-dependent generation of NETs. Bone marr...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hawez A,Al-Haidari A,Madhi R,Rahman M,Thorlacius H

    更新日期:2019-11-01 00:00:00

  • Potential Cross-Reactive Immunity to SARS-CoV-2 From Common Human Pathogens and Vaccines.

    abstract::The recently emerged SARS-CoV-2 causing the ongoing COVID-19 pandemic is particularly virulent in the elderly while children are largely spared. Here, we explored the potential role of cross-reactive immunity acquired from pediatric vaccinations and exposure to common human pathogens in the protection and pathology of...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Reche PA

    更新日期:2020-10-16 00:00:00

  • Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection.

    abstract::Respiratory syncytial virus (RSV) remains the most common cause of lower respiratory tract infections in children worldwide. Development of a vaccine has been hindered by the risk of developing enhanced respiratory disease (ERD) upon natural exposure to the virus. Generation of higher quality neutralizing antibodies w...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Eichinger KM,Kosanovich JL,Gidwani SV,Zomback A,Lipp MA,Perkins TN,Oury TD,Petrovsky N,Marshall CP,Yondola MA,Empey KM

    更新日期:2020-07-29 00:00:00

  • H60: A Unique Murine Hematopoietic Cell-Restricted Minor Histocompatibility Antigen for Graft-versus-Leukemia Effect.

    abstract::Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for many types of hematological malignancies. Matching of donor and recipient for the major histocompatibility complex (MHC) improves the HSCT reconstitution, but donor-derived T cells reactive to non-MHC encoded minor histocompat...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Choi EY,Choi K,Nam G,Kim W,Chung M

    更新日期:2020-06-10 00:00:00

  • Corrigendum: Liver-Stage Specific Response among Endemic Populations: Diet and Immunity.

    abstract::[This corrects the article on p. 125 in vol. 6, PMID: 25852693.]. ...

    journal_title:Frontiers in immunology

    pub_type: 已发布勘误


    authors: Dalai SK,Yadav N,Patidar M,Patel H,Singh AP

    更新日期:2015-06-22 00:00:00

  • Pre-transplant HLA Antibodies and Delayed Graft Function in the Current Era of Kidney Transplantation.

    abstract::Delayed graft function (DGF) occurs in a significant proportion of deceased donor kidney transplant recipients and was associated with graft injury and inferior clinical outcome. The aim of the present multi-center study was to identify the immunological and non-immunological predictors of DGF and to determine its inf...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Morath C,Döhler B,Kälble F,Pego da Silva L,Echterdiek F,Schwenger V,Živčić-Ćosić S,Katalinić N,Kuypers D,Benöhr P,Haubitz M,Ziemann M,Nitschke M,Emmerich F,Pisarski P,Karakizlis H,Weimer R,Ruhenstroth A,Scherer S,Tr

    更新日期:2020-08-26 00:00:00

  • CD4+ T Cells Play a Critical Role in Microbiota-Maintained Anti-HBV Immunity in a Mouse Model.

    abstract::The ability of the host to clear hepatitis B virus (HBV) is closely correlated to the establishment of commensal microbiota. However, how microbiota affects anti-HBV immunity is still unclear. Using a well-known hydrodynamical HBV transfection mouse model and treatment with antibiotics (Atb), we explored the change in...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wu T,Li F,Chen Y,Wei H,Tian Z,Sun C,Sun R

    更新日期:2019-04-30 00:00:00

  • Age Distribution of Multiple Functionally Relevant Subsets of CD4+ T Cells in Human Blood Using a Standardized and Validated 14-Color EuroFlow Immune Monitoring Tube.

    abstract::CD4+ T cells comprise multiple functionally distinct cell populations that play a key role in immunity. Despite blood monitoring of CD4+ T-cell subsets is of potential clinical utility, no standardized and validated approaches have been proposed so far. The aim of this study was to design and validate a single 14-colo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Botafogo V,Pérez-Andres M,Jara-Acevedo M,Bárcena P,Grigore G,Hernández-Delgado A,Damasceno D,Comans S,Blanco E,Romero A,Arriba-Méndez S,Gastaca-Abasolo I,Pedreira CE,van Gaans-van den Brink JAM,Corbiere V,Mascart F,van El

    更新日期:2020-02-27 00:00:00

  • Intestinal Dysbiosis in Autoimmune Diabetes Is Correlated With Poor Glycemic Control and Increased Interleukin-6: A Pilot Study.

    abstract::Intestinal dysbiosis associated with immunological deregulation, leaky gut, bacterial translocation, and systemic inflammation has been associated with autoimmune diseases, such as type 1 diabetes (T1D). The aim of this study was to investigate the intestinal dysbiosis in T1D patients and correlate these results with ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Higuchi BS,Rodrigues N,Gonzaga MI,Paiolo JCC,Stefanutto N,Omori WP,Pinheiro DG,Brisotti JL,Matheucci E Jr,Mariano VS,de Oliveira GLV

    更新日期:2018-07-25 00:00:00

  • The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game.

    abstract::Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (MØs) and dendritic cells (DCs), but also in controlling the function ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Zhan Y,Lew AM,Chopin M

    更新日期:2019-11-15 00:00:00

  • (-)-Epigallocatechin Gallate Targets Notch to Attenuate the Inflammatory Response in the Immediate Early Stage in Human Macrophages.

    abstract::Inflammation plays important roles at different stages of diabetes mellitus, tumorigenesis, and cardiovascular diseases. (-)-Epigallocatechin gallate (EGCG) can attenuate inflammatory responses effectively. However, the immediate early mechanism of EGCG in inflammation remains unclear. Here, we showed that EGCG attenu...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wang T,Xiang Z,Wang Y,Li X,Fang C,Song S,Li C,Yu H,Wang H,Yan L,Hao S,Wang X,Sheng J

    更新日期:2017-04-10 00:00:00

  • Vaccination with Altered Peptide Ligands of a Plasmodium berghei Circumsporozoite Protein CD8 T-Cell Epitope: A Model to Generate T Cells Resistant to Immune Interference by Polymorphic Epitopes.

    abstract::Many pathogens, including the malaria parasite Plasmodium falciparum, display high levels of polymorphism within T-cell epitope regions of proteins associated with protective immunity. The T-cell epitope variants are often non-cross-reactive. Herein, we show in a murine model, which modifies a protective CD8 T-cell ep...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Minigo G,Flanagan KL,Slattery RM,Plebanski M

    更新日期:2017-02-14 00:00:00

  • T-cell immunity to infection with dengue virus in humans.

    abstract::Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Weiskopf D,Sette A

    更新日期:2014-03-07 00:00:00

  • Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells.

    abstract::Protein 4.1R, a member of the 4.1 family, functions as a bridge between cytoskeletal and plasma membrane proteins. It is expressed in T cells, where it binds to a linker for activation of T cell (LAT) family member 1 and inhibits its phosphorylation and downstream signaling events after T cell receptor triggering. The...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Draberova L,Draberova H,Potuckova L,Halova I,Bambouskova M,Mohandas N,Draber P

    更新日期:2020-01-14 00:00:00

  • CXCR5+PD1+ICOS+ Circulating T Follicular Helpers Are Associated With de novo Donor-Specific Antibodies After Renal Transplantation.

    abstract::Donor-specific anti-HLA antibodies (DSAs) are a major risk factor associated with renal allograft outcomes. As a trigger of B cell antibody production, T follicular helper cells (Tfhs) promote DSA appearance. Herein, we evaluated whether circulating Tfhs (cTfhs) are associated with the genesis of antibody-mediated rej...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Danger R,Chesneau M,Delbos F,Le Bot S,Kerleau C,Chenouard A,Ville S,Degauque N,Conchon S,Cesbron A,Giral M,Brouard S

    更新日期:2019-09-10 00:00:00

  • Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis.

    abstract::Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many cell adhesion molecules within the tumor microenvironment are changed and significant alterations of glycosylation are observed. These changes ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Läubli H,Borsig L

    更新日期:2019-09-06 00:00:00

  • ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death.

    abstract::Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles. The etiologies vary among different subtypes of ALS, and no effective management or medication could be provided to the patients, with the un...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Liu Z,Li H,Hong C,Chen M,Yue T,Chen C,Wang Z,You Q,Li C,Weng Q,Xie H,Hu R

    更新日期:2018-11-14 00:00:00

  • A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury.

    abstract:Introduction:C-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation. We recently described pro-inflammatory properties of CRP, which are mediated by conformational changes from pCRP to bioactive isofo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Thiele JR,Zeller J,Kiefer J,Braig D,Kreuzaler S,Lenz Y,Potempa LA,Grahammer F,Huber TB,Huber-Lang M,Bannasch H,Stark GB,Peter K,Eisenhardt SU

    更新日期:2018-04-16 00:00:00

  • Coordination of Immune-Stroma Crosstalk by IL-6 Family Cytokines.

    abstract::Stromal cells are a subject of rapidly growing immunological interest based on their ability to influence virtually all aspects of innate and adaptive immunity. Present in every bodily tissue, stromal cells complement the functions of classical immune cells by sensing pathogens and tissue damage, coordinating leukocyt...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: West NR

    更新日期:2019-05-15 00:00:00

  • Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells.

    abstract::The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

    更新日期:2020-12-23 00:00:00