Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment.

Abstract:

:In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma. This tumor stroma, comprised of various cells, and extracellular matrix (ECM), has been shown to aid in suppressing host immune responses against tumor cells. Through immunosuppressive cytokine secretion, metabolic alterations, and other mechanisms, the tumor stroma provides a complex network of safeguards for tumor proliferation. With recent advances in more effective, localized treatment, radiation therapy (XRT) has allowed for strategies that can effectively alter and ablate tumor stromal tissue. This includes promoting immunogenic cell death through tumor antigen release to increasing immune cell trafficking, XRT has a unique advantage against the tumoral immune evasion mechanisms that are orchestrated by stromal cells. Current studies are underway to elucidate pathways within the tumor stroma as potential targets for immunotherapy and chemoradiation. This review summarizes the effects of tumor stroma in tumor immune evasion, explains how XRT may help overcome these effects, with potential combinatorial approaches for future treatment modalities.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Menon H,Ramapriyan R,Cushman TR,Verma V,Kim HH,Schoenhals JE,Atalar C,Selek U,Chun SG,Chang JY,Barsoumian HB,Nguyen QN,Altan M,Cortez MA,Hahn SM,Welsh JW

doi

10.3389/fimmu.2019.00193

subject

Has Abstract

pub_date

2019-02-15 00:00:00

pages

193

issn

1664-3224

journal_volume

10

pub_type

杂志文章,评审
  • Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments.

    abstract::Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understanding of Treg cell biology provided us with molecular mechanisms-both transcriptional and epi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.02634

    authors: Korn T,Muschaweckh A

    更新日期:2019-11-14 00:00:00

  • The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?

    abstract::Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small lung cancer or renal cell carcinoma. These humanized monoclonal antibodies target inhibitory receptors (e.g. CTLA-4, PD-1, LAG-3, TIM-3) and lig...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.574271

    authors: Franzin R,Netti GS,Spadaccino F,Porta C,Gesualdo L,Stallone G,Castellano G,Ranieri E

    更新日期:2020-10-08 00:00:00

  • A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors.

    abstract::Therapeutic monoclonal antibodies (mAbs), targeting tumor antigens, or immune checkpoints, have demonstrated a remarkable anti-tumor effect against various malignancies. However, high costs for mono- or combination therapies, associated with adverse effects or possible development of resistance in some patients, warra...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.00895

    authors: Tobias J,Battin C,De Sousa Linhares A,Lebens M,Baier K,Ambroz K,Drinić M,Högler S,Inic-Kanada A,Garner-Spitzer E,Preusser M,Kenner L,Kundi M,Zielinski CC,Steinberger P,Wiedermann U

    更新日期:2020-05-27 00:00:00

  • Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis.

    abstract::Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome (pSS). Chromosome X open reading frame 21 (CXorf21) escapes X-inactivation and is an SLE risk gene of previously unknown function. We undertook the pre...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.02160

    authors: Harris VM,Koelsch KA,Kurien BT,Harley ITW,Wren JD,Harley JB,Scofield RH

    更新日期:2019-10-21 00:00:00

  • Presence of Infected Gr-1intCD11bhiCD11cint Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice.

    abstract::Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with immunomodulatory function. To study the mechanism by which MDSC affect antimicrobial immunity, we infected mice with two M. avium strains of differential virulence, highly virulent Mycobacterium avium subsp. avium strain 25291 (MAA) and low virule...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.02317

    authors: Abdissa K,Nerlich A,Beineke A,Ruangkiattikul N,Pawar V,Heise U,Janze N,Falk C,Bruder D,Schleicher U,Bogdan C,Weiss S,Goethe R

    更新日期:2018-10-16 00:00:00

  • Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease.

    abstract::Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders. Despite rapid progress in understanding GVHD pathogenesis, broad immunosuppressive agents are most often used to prevent and remain the fir...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.00309

    authors: Thangavelu G,Blazar BR

    更新日期:2019-03-06 00:00:00

  • The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game.

    abstract::Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (MØs) and dendritic cells (DCs), but also in controlling the function ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.02679

    authors: Zhan Y,Lew AM,Chopin M

    更新日期:2019-11-15 00:00:00

  • Previous Radiotherapy Increases the Efficacy of IL-2 in Malignant Pleural Effusion: Potential Evidence of a Radio-Memory Effect?

    abstract::Preclinical and clinical studies have shown that prior receipt of radiotherapy enhances antitumor immune responses, a phenomenon we call the "radio-memory effect." However, all of the evidence regarding this effect to date comes from work with PD1/PDL1 inhibitors. Here we explored whether this effect also occurs with ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,多中心研究

    doi:10.3389/fimmu.2018.02916

    authors: Chen D,Song X,Wang H,Gao Z,Meng W,Chen S,Ma Y,Wang Y,Li K,Yu J,Yue J

    更新日期:2018-12-11 00:00:00

  • The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection.

    abstract::The RTS,S/AS01 vaccine provides partial protection against Plasmodium falciparum infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associated with RTS,S/AS01 efficacy against controlled human malaria infect...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2020.00669

    authors: Du Y,Thompson EG,Muller J,Valvo J,Braun J,Shankar S,van den Berg RA,Jongert E,Dover D,Sadoff J,Hendriks J,Gardner MJ,Ballou WR,Regules JA,van der Most R,Aderem A,Ockenhouse CF,Hill AV,Wille-Reece U,Zak DE

    更新日期:2020-04-28 00:00:00

  • The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells.

    abstract::Degeneration of central cholinergic neurons impairs memory, and enhancement of cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti-inflammatory, and neuroinflammation is increasingly linked to adverse memory, especially in Alzheimer's disease. Much of the evidence surrounding choliner...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.01489

    authors: Maurer SV,Williams CL

    更新日期:2017-11-08 00:00:00

  • Decreased Soluble Human Leukocyte Antigen E Levels in Patients After Allogeneic Hematopoietic Stem Cell Transplantation Are Associated With Severe Acute and Extended Chronic Graft-versus-Host Disease and Inferior Overall Survival.

    abstract::HLA-E is a member of the non-classical HLA molecules and by interaction with activating or inhibitory receptors of NK and T cells, HLA-E can lead to immune activation or suppression context-dependently. Recently, the non-classical HLA molecules gain more attention in the setting of allogeneic hematopoietic stem cell t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.03027

    authors: Kordelas L,Schwich E,Lindemann M,Heinemann FM,Buttkereit U,Horn PA,Beelen DW,Rebmann V

    更新日期:2020-01-10 00:00:00

  • Retinoic Acid Mediated Clearance of Citrobacter rodentium in Vitamin A Deficient Mice Requires CD11b+ and T Cells.

    abstract::Vitamin A deficiency affects over 250 million preschool-age children worldwide and is associated with increased childhood mortality and risk of developing enteric infections. Vitamin A deficient (A-) mice developed chronic Citrobacter rodentium infection. A single oral dose of retinoic acid (RA) at d7 post-infection w...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.03090

    authors: Snyder LM,McDaniel KL,Tian Y,Wei CH,Kennett MJ,Patterson AD,Ross AC,Cantorna MT

    更新日期:2019-01-08 00:00:00

  • Performance of an Ultra-Sensitive Assay Targeting the Circulating Anodic Antigen (CAA) for Detection of Schistosoma mansoni Infection in a Low Endemic Area in Brazil.

    abstract::Techniques with high sensitivity and specificity are required for an accurate diagnosis in low-transmission settings, where the conventional parasitological methods are insensitive. We determined the accuracy of an up-converting phosphor-lateral flow circulating anodic antigen (UCP-LF CAA) assay in urine and serum for...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.00682

    authors: Sousa MS,van Dam GJ,Pinheiro MCC,de Dood CJ,Peralta JM,Peralta RHS,Daher EF,Corstjens PLAM,Bezerra FSM

    更新日期:2019-04-04 00:00:00

  • The Role of Maternal HIV Envelope-Specific Antibodies and Mother-to-Child Transmission Risk.

    abstract::Despite the wide availability of antiretroviral therapy (ART) prophylaxis during pregnancy, >150,000 infants become infected through mother-to-child transmission (MTCT) of HIV worldwide. It is likely that additional intervention strategies, such as a maternal HIV vaccine, will be required to eliminate pediatric HIV in...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.01091

    authors: Douglas AO,Martinez DR,Permar SR

    更新日期:2017-09-04 00:00:00

  • Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Campylobacter jejuni Induced Enterocolitis Model.

    abstract::Human Campylobacter infections are progressively rising and of high socioeconomic impact. In the present preclinical intervention study we investigated anti-pathogenic, immuno-modulatory, and intestinal epithelial barrier preserving properties of vitamin D applying an acute campylobacteriosis model. Therefore, seconda...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.02094

    authors: Mousavi S,Lobo de Sá FD,Schulzke JD,Bücker R,Bereswill S,Heimesaat MM

    更新日期:2019-09-03 00:00:00

  • The Use of TB-Specific Antigen/Phytohemagglutinin Ratio for Diagnosis and Treatment Monitoring of Extrapulmonary Tuberculosis.

    abstract::Extrapulmonary tuberculosis (EPTB) has become more common in recent years; however, the diagnosis of EPTB remains a challenge. In this study, we analyzed the performance of the ratio of TB-specific antigen (TBAg) to phytohemagglutinin (PHA) (TBAg/PHA ratio) in T-SPOT.TB (T-SPOT) assay for diagnosis and treatment monit...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.01047

    authors: Wang F,Yu J,Zhou Y,Luo Y,Wu S,Huang M,Yin B,Huang J,Mao L,Sun Z

    更新日期:2018-05-14 00:00:00

  • Methylation of FOXP3 TSDR Underlies the Impaired Suppressive Function of Tregs from Long-term Belatacept-Treated Kidney Transplant Patients.

    abstract::Regulatory T cells (Tregs) are considered key players in the prevention of allograft rejection in transplanted patients. Belatacept (BLT) is an effective alternative to calcineurin inhibitors that appears to preserve graft survival and function; however, the impact of this drug in the homeostasis of Tregs in transplan...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.00219

    authors: Alvarez Salazar EK,Cortés-Hernández A,Alemán-Muench GR,Alberú J,Rodríguez-Aguilera JR,Recillas-Targa F,Chagoya de Sánchez V,Cuevas E,Mancilla-Urrea E,Pérez García M,Mondragón-Ramírez G,Vilatobá M,Bostock I,Hernández-Méndez E,

    更新日期:2017-03-03 00:00:00

  • Antigen Production After Latency Reversal and Expression of Inhibitory Receptors in CD8+ T Cells Limit the Killing of HIV-1 Reactivated Cells.

    abstract::The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. Consequently, fundamental questi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.03162

    authors: Ruiz A,Blanch-Lombarte O,Jimenez-Moyano E,Ouchi D,Mothe B,Peña R,Galvez C,Genescà M,Martinez-Picado J,Goulder P,Barnard R,Howell B,Clotet B,Prado JG

    更新日期:2019-01-22 00:00:00

  • Combined Expression of IFN-γ, IL-17, and IL-4 mRNA by Recall PBMCs Moderately Discriminates Active Tuberculosis from Latent Mycobacterium tuberculosis Infection in Patients with Miscellaneous Inflammatory Underlying Conditions.

    abstract::New biomarkers are needed for discriminating active tuberculosis (TB) from latent TB infection (LTBI), especially in vulnerable groups representing the major diagnostic challenge. This pilot study was carried out to explore the diagnostic potential of selected genes, IFN-γ, IL-17, IL-4, and FoxP3, associated with TB i...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2016.00239

    authors: Savolainen LE,Kantele A,Knuuttila A,Pusa L,Karttunen R,Valleala H,Tuuminen T

    更新日期:2016-06-14 00:00:00

  • Granulocytes: New Members of the Antigen-Presenting Cell Family.

    abstract::Granulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in orchestrating adaptive immune responses. A substantial body of rece...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2017.01781

    authors: Lin A,Loré K

    更新日期:2017-12-11 00:00:00

  • Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination.

    abstract::Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELISPOT response, PBMC transcriptomics, and PBMC cell compositions at 0, 3, and 28 days post-immu...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2019.00180

    authors: Voigt EA,Ovsyannikova IG,Kennedy RB,Grill DE,Goergen KM,Schaid DJ,Poland GA

    更新日期:2019-02-27 00:00:00

  • Corrigendum: Zoledronate Triggers Vδ2 T Cells to Destroy and Kill Spheroids of Colon Carcinoma: Quantitative Image Analysis of Three-Dimensional Cultures.

    abstract::[This corrects the article on p. 998 in vol. 9, PMID: 29867975.]. ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fimmu.2018.01343

    authors: Varesano S,Zocchi MR,Poggi A

    更新日期:2018-06-13 00:00:00

  • CD38: A Target for Immunotherapeutic Approaches in Multiple Myeloma.

    abstract::Multiple Myeloma (MM) is a hematological cancer characterized by proliferation of malignant plasma cells in the bone marrow (BM). MM represents the second most frequent hematological malignancy, accounting 1% of all cancer and 13% of hematological tumors, with ~9,000 new cases per year. Patients with monoclonal gammop...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2018.02722

    authors: Morandi F,Horenstein AL,Costa F,Giuliani N,Pistoia V,Malavasi F

    更新日期:2018-11-28 00:00:00

  • Natural Killer Cells and Type 1 Innate Lymphoid Cells Are New Actors in Non-alcoholic Fatty Liver Disease.

    abstract::Obesity and associated liver diseases (Non Alcoholic Fatty Liver Disease, NAFLD) are a major public health problem with increasing incidence in Western countries (25% of the affected population). These complications develop from a fatty liver (steatosis) to an inflammatory state (steatohepatitis) evolving toward fibro...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2019.01192

    authors: Luci C,Vieira E,Perchet T,Gual P,Golub R

    更新日期:2019-05-28 00:00:00

  • Cell Versus Cytokine - Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous hyperinflammatory syndrome with different pathways of pathogenesis resulting in similar clinical presentations. It is best defined and understood if presenting in the context of genetic immunodeficiencies associated with defects of lymphocyte cytotoxicity. In...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2020.00808

    authors: Wegehaupt O,Wustrau K,Lehmberg K,Ehl S

    更新日期:2020-05-08 00:00:00

  • The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells.

    abstract::Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of dendritic cell (DC) known to be involved in antigen cross-presentation. This review aims to summarize the known biology of the XCR1 receptor and its chemokine ligand XCL1, both in the mouse and the human. Further, any invol...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2012.00014

    authors: Kroczek RA,Henn V

    更新日期:2012-02-10 00:00:00

  • Silent Witness: Dual-Species Transcriptomics Reveals Epithelial Immunological Quiescence to Helminth Larval Encounter and Fostered Larval Development.

    abstract::Gastrointestinal nematodes are among the most prevalent parasites infecting humans and livestock worldwide. Infective larvae of the soil-transmitted nematode Ascaris spp. enter the host and start tissue migration by crossing the intestinal epithelial barrier. The initial interaction of the intestinal epithelium with t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.01868

    authors: Ebner F,Kuhring M,Radonić A,Midha A,Renard BY,Hartmann S

    更新日期:2018-08-15 00:00:00

  • Oxidized Hemoglobin Is Antigenic and Immunogenic in Lupus.

    abstract::Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in deleterious immunolo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2017.00732

    authors: Jain S,Bose A,Bastia B,Sharma H,Sachdeva R,Jain AK,Pal R

    更新日期:2017-06-26 00:00:00

  • Recent Progress toward Engineering HIV-1-Specific Neutralizing Monoclonal Antibodies.

    abstract::The recent discoveries of broadly potent neutralizing human monoclonal antibodies represent a new generation of antiretrovirals for the treatment and prophylaxis. Antibodies are generally considered more effective and safer and have been proved to provide passive protection against mucosal challenge in humanized mice ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审

    doi:10.3389/fimmu.2016.00391

    authors: Sun M,Li Y,Zheng H,Shao Y

    更新日期:2016-09-30 00:00:00

  • Leukocyte-Derived Interleukin-10 Aggravates Postoperative Ileus.

    abstract::Objective: Postoperative ileus (POI) is an inflammation-mediated complication of abdominal surgery, characterized by intestinal dysmotility and leukocyte infiltration into the muscularis externa (ME). Previous studies indicated that interleukin (IL)-10 is crucial for the resolution of a variety of inflammation-driven ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章

    doi:10.3389/fimmu.2018.02599

    authors: Stein K,Lysson M,Schumak B,Vilz T,Specht S,Heesemann J,Roers A,Kalff JC,Wehner S

    更新日期:2018-11-13 00:00:00