Computational Biology: Modeling Chronic Renal Allograft Injury.

abstract：:Many current vaccines are less immunogenic and less effective in elderly compared to younger adults due to age-related changes of the immune system. Most vaccines utilized in the elderly contain antigens, which the target population has had previous contact with due to previous vaccination or infection. Therefore, mos...

journal_title：Frontiers in immunology

authors： Weinberger B,Haks MC,de Paus RA,Ottenhoff THM,Bauer T,Grubeck-Loebenstein B

更新日期：2018-05-15 00:00:00

abstract：:Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk functionality changes (e.g., tracing serum polyclonal antibody proteins). Studying a single B cell disregards the majority of the humora...

journal_title：Frontiers in immunology

authors： Yermanos AD,Dounas AK,Stadler T,Oxenius A,Reddy ST

更新日期：2018-10-02 00:00:00

abstract：:COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public health measures remain the most effective protection strategy at this stage, when the peak passes, it will leave in its wake important health problems. Historically, very few viruses have ever been eradicated. Instead, the virus...

journal_title：Frontiers in immunology

authors： Sviridov D,Miller YI,Ballout RA,Remaley AT,Bukrinsky M

更新日期：2020-09-29 00:00:00

abstract：:Human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have become a useful clinical biomarker for the diagnosis of a spectrum of inflammatory demyelinating disorders. Live cell-based assays that detect MOG Ab against conformational MOG are currently the gold standard. Flow cytometry, in which ser...

journal_title：Frontiers in immunology

authors： Tea F,Pilli D,Ramanathan S,Lopez JA,Merheb V,Lee FXZ,Zou A,Liyanage G,Bassett CB,Thomsen S,Reddel SW,Barnett MH,Brown DA,Dale RC,Brilot F,Australasian New Zealand MOG Study Group.

更新日期：2020-02-06 00:00:00

abstract：:Lower respiratory infection caused by human pathogens such as influenza and respiratory syncytial virus (RSV) is a significant healthcare burden that must be addressed. The preferred options to achieve this goal are usually to develop vaccines for prophylaxis and to develop antiviral small molecules to treat infected ...

journal_title：Frontiers in immunology

authors： Nyanguile O

更新日期：2019-06-21 00:00:00

abstract：:Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant source of morbidity worldwide. Here, we show that blood plasmablasts and CD27- memory B cells are elevated in untreated Lyme disease, with higher plasmablast levels associated with more rapid resolution of clinical symptoms. Stro...

journal_title：Frontiers in immunology

authors： Blum LK,Adamska JZ,Martin DS,Rebman AW,Elliott SE,Cao RRL,Embers ME,Aucott JN,Soloski MJ,Robinson WH

更新日期：2018-07-18 00:00:00

abstract：:Attenuated vaccinia virus (VACV) vectors are considered prime vaccine candidates for use in immunotherapy of infectious disease. In spite of this, recent data show that the level of attenuation may hamper the efficient generation of protective CD8 T cells. This suggests that additional adjuvant-like activities may nee...

journal_title：Frontiers in immunology

authors： Zhao Y,Tahiliani V,Salek-Ardakani S,Croft M

更新日期：2012-11-08 00:00:00

abstract：:Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expr...

journal_title：Frontiers in immunology

authors： Faber H,Kurtoic D,Krishnamoorthy G,Weber P,Pütz B,Müller-Myhsok B,Weber F,Andlauer TFM

更新日期：2020-09-18 00:00:00

abstract：:Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Upon binding to CD38-expressing MM cells, isatuximab is thought to induce tumor cell killing via fragment crystallizable (...

journal_title：Frontiers in immunology

authors： Zhu C,Song Z,Wang A,Srinivasan S,Yang G,Greco R,Theilhaber J,Shehu E,Wu L,Yang ZY,Passe-Coutrin W,Fournier A,Tai YT,Anderson KC,Wiederschain D,Bahjat K,Adrián FJ,Chiron M

更新日期：2020-08-14 00:00:00

abstract：:Autoimmune diseases, such as systemic lupus erythematosus, are characterized by excessive inflammation in response to self-antigens. Loss of appropriate immunoregulatory mechanisms contribute to disease exacerbation. We previously showed the suppressive effect of vancomycin treatment during the "active-disease" stage ...

journal_title：Frontiers in immunology

authors： Mu Q,Edwards MR,Swartwout BK,Cabana Puig X,Mao J,Zhu J,Grieco J,Cecere TE,Prakash M,Reilly CM,Puglisi C,Bachali P,Grammer AC,Lipsky PE,Luo XM

更新日期：2020-11-10 00:00:00

abstract：:Acquired generalized lipodystrophy (AGL) is a rare condition characterized by an altered distribution of adipose tissue and predisposition to develop hepatic steatosis and fibrosis, diabetes, and hypertriglyceridemia. Diagnosis of AGL is based on the observation of generalized fat loss, autoimmunity and lack of family...

journal_title：Frontiers in immunology

authors： Corvillo F,Aparicio V,López-Lera A,Garrido S,Araújo-Vilar D,de Miguel MP,López-Trascasa M

更新日期：2018-09-19 00:00:00

abstract：:DT-13(25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on TNF-α-induced endothelial permeability and the potential molecular mechanisms remain unclear. Hence, th...

journal_title：Frontiers in immunology

authors： Zhang Y,Han Y,Zhao Y,Lv Y,Hu Y,Tan Y,Bi X,Yu B,Kou J

更新日期：2017-08-14 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs) are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells. Recent studies have described several mutant mice exhibiting both AD-like skin inflammation and MPN. Common path...

journal_title：Frontiers in immunology

authors： Kawakami T,Ando T,Kawakami Y

更新日期：2015-08-24 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：:Blood-borne monocyte derived cells play a pivotal, initially unrecognized, role in most central nervous system disorders, including diseases initially classified as purely neurodegenerative (i.e., Alzheimer's disease, Parkinson's disease, and ALS). Their trafficking to the brain and spinal cord has been extensively st...

journal_title：Frontiers in immunology

authors： Nigro A,Colombo F,Casella G,Finardi A,Verderio C,Furlan R

更新日期：2016-01-29 00:00:00

abstract：:GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. GPR84 activation is involved in the inflammatory response, but the mechanisms by which it modulates inflammation have been incompletely described. In this study, we investigated GP...

journal_title：Frontiers in immunology

authors： Recio C,Lucy D,Purvis GSD,Iveson P,Zeboudj L,Iqbal AJ,Lin D,O'Callaghan C,Davison L,Griesbach E,Russell AJ,Wynne GM,Dib L,Monaco C,Greaves DR

更新日期：2018-06-20 00:00:00

abstract：:In the last few years, there has been a twist in cancer treatment toward immunotherapy thanks to the impressive results seen in advanced patients from several tumor pathologies. Cutaneous melanoma is a highly mutated and immunogenic tumor that has been a test field for the development of immunotherapy. However, there ...

journal_title：Frontiers in immunology

authors： Aris M,Mordoh J,Barrio MM

更新日期：2017-08-25 00:00:00

abstract：:Despite the wide availability of antiretroviral therapy (ART) prophylaxis during pregnancy, >150,000 infants become infected through mother-to-child transmission (MTCT) of HIV worldwide. It is likely that additional intervention strategies, such as a maternal HIV vaccine, will be required to eliminate pediatric HIV in...

journal_title：Frontiers in immunology

authors： Douglas AO,Martinez DR,Permar SR

更新日期：2017-09-04 00:00:00

abstract：:Phloretin (PT), isolated from the apple tree, was previously demonstrated to have antioxidative and anti-inflammatory effects in macrophages and anti-adiposity effects in adipocytes. Inflammatory immune cells generate high levels of reactive oxygen species (ROS) for stimulated severe airway hyperresponsiveness (AHR) a...

journal_title：Frontiers in immunology

authors： Huang WC,Fang LW,Liou CJ

更新日期：2017-02-13 00:00:00

abstract：:Lung cancer is the leading cause of cancer-associated deaths worldwide, with non-small cell-lung cancer (NSCLC) accounting for approximately 80% of cases. Immune escape has been demonstrated to play a key role in the initiation and progression of NSCLC, although the underlying mechanisms are diverse and their puzzling...

journal_title：Frontiers in immunology

authors： Xie M,Wei J,Xu J

更新日期：2020-04-28 00:00:00

abstract：:Background: Disease progression monitoring through CD4 counts alone can be inadequate in HIV infection as ongoing immune activation may result in Serious non-AIDS events (SNAEs). SNAEs involve monocyte activation driven chronic inflammation with significant sequelae observed even during HAART. Here, we attempted to de...

journal_title：Frontiers in immunology

authors： Prabhu VM,Singh AK,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-12-06 00:00:00

abstract：:TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphyloco...

journal_title：Frontiers in immunology

authors： Ehrnström B,Beckwith KS,Yurchenko M,Moen SH,Kojen JF,Lentini G,Teti G,Damås JK,Espevik T,Stenvik J

更新日期：2017-10-03 00:00:00

abstract：:Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae, a debilitating disease that affects the skin and peripheral nerves. It is possible that tissue changes during infection with leprosy are related to alterations in the activity of the Notch signaling pathway, an innate signaling pathway in t...

journal_title：Frontiers in immunology

authors： Serrano-Coll H,Ospina JP,Salazar-Peláez L,Cardona-Castro N

更新日期：2020-03-19 00:00:00

abstract：:The host immune response to gastrointestinal (GI) infections, hypersensitivity reactions, or GI cancers comprises numerous pathways that elicit responses on different host cells. Some of these include (1) the stimulation of mast cells via their IgE receptor, (2) the production of antibodies leading to antibody-mediate...

journal_title：Frontiers in immunology

authors： El-Zaatari M,Kao JY

更新日期：2017-01-27 00:00:00

abstract：:There is far less information available about the tumor infiltrating B (TIL-B) cells, than about the tumor infiltrating T cells. We focused on discovering the features and potential role of B lymphocytes in solid tumors. Our project aimed to develop innovative strategies to define cancer membrane structures. We chose ...

journal_title：Frontiers in immunology

authors： Kotlan B,Horvath S,Eles K,Plotar VK,Naszados G,Czirbesz K,Blank M,Farkas E,Toth L,Tovari J,Szekacs A,Shoenfeld Y,Godeny M,Kasler M,Liszkay G

更新日期：2019-04-05 00:00:00

abstract：:Combination therapy with inhibitors of cytotoxic T lymphocyte-associated protein (CTLA)4 and programmed death (PD)-1 has demonstrated efficacy in cancer patients. However, there is little information on CTLA4 and PD-1 expression levels and their clinical significance across diverse cancers. In this study, we addressed...

journal_title：Frontiers in immunology

authors： Liu JN,Kong XS,Huang T,Wang R,Li W,Chen QF

更新日期：2020-09-10 00:00:00

abstract：:Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to orchestrate their expansion, functional polarization and effector activity in non-lymphoid tissues or in their draining lymph nodes. The concept of harnessing DC immunogenicity to induce protective responses in cancer patients was ...

journal_title：Frontiers in immunology

authors： Cancel JC,Crozat K,Dalod M,Mattiuz R

更新日期：2019-02-12 00:00:00

abstract：:Despite the ever present need for an effective Mycobacterium tuberculosis (Mtb) vaccine, efforts for development have been largely unsuccessful. Correlates of immune protection against Mtb are not wholly defined, but Th1 and likely Th17 adaptive immune responses have been demonstrated to be necessary for vaccine-media...

journal_title：Frontiers in immunology

authors： Smith AJ,Miller SM,Buhl C,Child R,Whitacre M,Schoener R,Ettenger G,Burkhart D,Ryter K,Evans JT

更新日期：2019-02-28 00:00:00

abstract：:Significant advances have been made to identify effective therapies that either restore or generate de novo a patient's immune response to cancer, so-called immunotherapy or immuno-oncology (IO) therapies. Some tumors overcome immune surveillance by promoting mechanisms to evade or suppress the immune system. This con...

journal_title：Frontiers in immunology

authors： Wilkinson RW,Leishman AJ

更新日期：2018-06-01 00:00:00

abstract：:Acute pancreatitis (AP) is a common and devastating inflammatory disorder of the pancreas. However, there are still no effective treatments available for the disease. Therefore, it is important to discover new therapeutic targets and strategies for better treatment and prognosis of AP patients. Toll-like receptor 3 (T...

journal_title：Frontiers in immunology

authors： Huang C,Chen S,Zhang T,Li D,Huang Z,Huang J,Qin Y,Chen B,Cheng G,Ma F,Zhou M

更新日期：2019-05-03 00:00:00