Computational Biology: Modeling Chronic Renal Allograft Injury.


:New approaches are needed to develop more effective interventions to prevent long-term rejection of organ allografts. Computational biology provides a powerful tool to assess the large amount of complex data that is generated in longitudinal studies in this area. This manuscript outlines how our two groups are using mathematical modeling to analyze predictors of graft loss using both clinical and experimental data and how we plan to expand this approach to investigate specific mechanisms of chronic renal allograft injury.


Front Immunol


Frontiers in immunology


Stegall MD,Borrows R




Has Abstract


2015-08-03 00:00:00








  • Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3.

    abstract::Innate lymphoid cells (ILCs) are the most recently identified family of the innate immune system and are hypothesized to modulate immune functions prior to the generation of adaptive immune responses. Subsets of ILCs reside in the mucosa and regulate immune responses to external pathogens; however, their role and the ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Yin S,Yu J,Hu B,Lu C,Liu X,Gao X,Li W,Zhou L,Wang J,Wang D,Lu L,Wang L

    更新日期:2018-09-12 00:00:00

  • Dendritic Cell Regulation of Graft-Vs.-Host Disease: Immunostimulation and Tolerance.

    abstract::Graft-vs.-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Significant progresses have been made in defining the dichotomous role of dendritic cells (DCs) in the development of GVHD. Host-derived DCs are important to elicit...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Yu H,Tian Y,Wang Y,Mineishi S,Zhang Y

    更新日期:2019-02-01 00:00:00

  • Murine Intraepithelial Dendritic Cells Interact With Phagocytic Cells During Aspergillus fumigatus-Induced Inflammation.

    abstract::People are constantly exposed to airborne fungal spores, including Aspergillus fumigatus conidia that can cause life-threatening conditions in immunocompromised patients or acute exacerbations in allergics. However, immunocompetent hosts do not exhibit mycoses or systemic inflammation, due to the sufficient but not ex...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bogorodskiy AO,Bolkhovitina EL,Gensch T,Troyanova NI,Mishin AV,Okhrimenko IS,Braun A,Spies E,Gordeliy VI,Sapozhnikov AM,Borshchevskiy VI,Shevchenko MA

    更新日期:2020-02-25 00:00:00

  • Toll-Like Receptor 4 Inhibition Improves Oxidative Stress and Mitochondrial Health in Isoproterenol-Induced Cardiac Hypertrophy in Rats.

    abstract:BACKGROUND:Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll-like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Katare PB,Bagul PK,Dinda AK,Banerjee SK

    更新日期:2017-06-22 00:00:00

  • Nitric oxide synthase: non-canonical expression patterns.

    abstract::Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS) is abundant in neural tissue, NOS2 is upregulated in a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Mattila JT,Thomas AC

    更新日期:2014-10-09 00:00:00

  • Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis.

    abstract::Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little is known about its action in the suppressi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Li Y,Zheng JY,Liu JQ,Yang J,Liu Y,Wang C,Ma XN,Liu BL,Xin GZ,Liu LF

    更新日期:2016-12-07 00:00:00

  • l-Arginine-Dependent Epigenetic Regulation of Interleukin-10, but Not Transforming Growth Factor-β, Production by Neonatal Regulatory T Lymphocytes.

    abstract::A growing number of diseases in humans, including trauma, certain cancers, and infection, are known to be associated with l-arginine deficiency. In addition, l-arginine must be supplemented by diet during pregnancy to aid fetal development. In conditions of l-arginine depletion, T cell proliferation is impaired. We ha...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Yu HR,Tsai CC,Chang LS,Huang HC,Cheng HH,Wang JY,Sheen JM,Kuo HC,Hsieh KS,Huang YH,Yang KD,Hsu TY

    更新日期:2017-04-25 00:00:00

  • Deletion of the Mineralocorticoid Receptor in Myeloid Cells Attenuates Central Nervous System Autoimmunity.

    abstract::Myeloid cells play an important role in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Monocytes, macrophages, and microglia can adopt two distinct phenotypes, with M1-polarized cells being more related to inflammation and autoimmunity while M2-polariz...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Montes-Cobos E,Schweingruber N,Li X,Fischer HJ,Reichardt HM,Lühder F

    更新日期:2017-10-13 00:00:00

  • IgA and FcαRI: Pathological Roles and Therapeutic Opportunities.

    abstract::Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces. The production of IgA exceeds the production of all other antibodies combined, supporting its prominent role in host-pathogen defense. IgA closely interacts with the intestinal microbiota to enhance its diversity, and IgA has a pas...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Breedveld A,van Egmond M

    更新日期:2019-03-22 00:00:00

  • Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract.

    abstract::Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Dougan M

    更新日期:2017-11-15 00:00:00

  • The Intersection of IgE Autoantibodies and Eosinophilia in the Pathogenesis of Bullous Pemphigoid.

    abstract::Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are occasionally reported in other autoimmune blistering diseases, BP is unique in that most BP patients develop an IgE autoantibody response. It is not known why ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Messingham KN,Crowe TP,Fairley JA

    更新日期:2019-10-04 00:00:00

  • Age Distribution of Multiple Functionally Relevant Subsets of CD4+ T Cells in Human Blood Using a Standardized and Validated 14-Color EuroFlow Immune Monitoring Tube.

    abstract::CD4+ T cells comprise multiple functionally distinct cell populations that play a key role in immunity. Despite blood monitoring of CD4+ T-cell subsets is of potential clinical utility, no standardized and validated approaches have been proposed so far. The aim of this study was to design and validate a single 14-colo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Botafogo V,Pérez-Andres M,Jara-Acevedo M,Bárcena P,Grigore G,Hernández-Delgado A,Damasceno D,Comans S,Blanco E,Romero A,Arriba-Méndez S,Gastaca-Abasolo I,Pedreira CE,van Gaans-van den Brink JAM,Corbiere V,Mascart F,van El

    更新日期:2020-02-27 00:00:00

  • Systems Immunology Characterization of Novel Vaccine Formulations for Mycoplasma hyopneumoniae Bacterins.

    abstract::We characterized five different vaccine candidates and a commercial vaccine in terms of safety, immunogenicity and using a systems vaccinology approach, with the aim to select novel vaccine candidates against Mycoplasma hyopneumoniae. Seven groups of six M. hyopneumoniae-free piglets were primo- and booster vaccinated...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Matthijs AMF,Auray G,Jakob V,García-Nicolás O,Braun RO,Keller I,Bruggman R,Devriendt B,Boyen F,Guzman CA,Michiels A,Haesebrouck F,Collin N,Barnier-Quer C,Maes D,Summerfield A

    更新日期:2019-05-24 00:00:00

  • Flow Cytometry for Diagnosis of Primary Immune Deficiencies-A Tertiary Center Experience From North India.

    abstract::Flow cytometry has emerged as a useful technology that has facilitated our understanding of the human immune system. Primary immune deficiency disorders (PIDDs) are a heterogeneous group of inherited disorders affecting the immune system. More than 350 genes causing various PIDDs have been identified. While the initia...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Rawat A,Arora K,Shandilya J,Vignesh P,Suri D,Kaur G,Rikhi R,Joshi V,Das J,Mathew B,Singh S

    更新日期:2019-09-11 00:00:00

  • How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets.

    abstract::In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules. There are three major functionally distinct effector states for iNKT cells. Owning to these innate-like effector...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Wang H,Hogquist KA

    更新日期:2018-06-26 00:00:00

  • Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity.

    abstract::The protein kinase C-θ (PKCθ), which is essential for T cell function and survival, is also required for efficient anti-tumor immune surveillance. Natural killer (NK) cells, which express PKCθ, play a prominent role in this process, mainly by elimination of tumor cells with reduced or absent major histocompatibility c...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Anel A,Aguiló JI,Catalán E,Garaude J,Rathore MG,Pardo J,Villalba M

    更新日期:2012-07-05 00:00:00

  • Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries.

    abstract::Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Corbett AJ,Awad W,Wang H,Chen Z

    更新日期:2020-08-27 00:00:00

  • Plasma Eicosanoid Profile in Plasmodium vivax Malaria: Clinical Analysis and Impacts of Self-Medication.

    abstract::The participation of cytokines and chemokines in Plasmodium vivax malaria (Pv-malaria) activates the immune response and thus causes the production of several inflammatory mediators. This process is already well-established, but little is known about eicosanoids in malaria physiopathology, especially in regards to inf...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Abreu-Filho PG,Tarragô AM,Costa AG,Monteiro WM,Meielles AFG,Costa TCC,Silva JS,Zambuzi FA,Gardinassi LG,Moraes LAB,Lacerda MVG,Sorgi CA,Faccioli LH,Malheiro A

    更新日期:2019-09-18 00:00:00

  • Therapeutic implications of immunogenic cell death in human cancer.

    abstract::Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, deve...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Palombo F,Focaccetti C,Barnaba V

    更新日期:2014-01-06 00:00:00

  • Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.

    abstract::To improve the efficacy of immunotherapy for cancer and autoimmune diseases, recent ongoing and completed clinical trials have focused on specific targets to redirect the immune network toward eradicating a variety of tumors and ameliorating the self-destructive process. In a previous review, both systemic immunomodul...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Kong YC,Flynn JC

    更新日期:2014-05-16 00:00:00

  • Persistence of Activated and Adaptive-Like NK Cells in HIV+ Individuals despite 2 Years of Suppressive Combination Antiretroviral Therapy.

    abstract::Innate immune dysfunction persists in HIV+ individuals despite effective combination antiretroviral therapy (cART). We recently demonstrated that an adaptive-like CD56dim NK cell population lacking the signal transducing protein FcRγ is expanded in HIV+ individuals. Here, we analyzed a cohort of HIV+ men who have sex ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hearps AC,Agius PA,Zhou J,Brunt S,Chachage M,Angelovich TA,Cameron PU,Giles M,Price P,Elliott J,Jaworowski A

    更新日期:2017-06-30 00:00:00

  • Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections.

    abstract::CD8+ T cells represent one of the most versatile immune cells critical for clearing away viral infections. Due to their important role, CD8+ T cell activation and memory formation during viral infection have been the focus of several studies recently. Although CD8+ T cell activation and memory formation have been asso...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Gupta SS,Wang J,Chen M

    更新日期:2020-05-22 00:00:00

  • A Novel Role for Triglyceride Metabolism in Foxp3 Expression.

    abstract::Lipid metabolism plays a key role in many cellular processes. We show here that regulatory T cells have enhanced lipid storage within subcellular lipid droplets (LD). They also express elevated amounts of both isoforms of diacylglycerol acyl transferase (DGAT1 & 2), enzymes required for the terminal step of triacylgly...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Howie D,Ten Bokum A,Cobbold SP,Yu Z,Kessler BM,Waldmann H

    更新日期:2019-08-13 00:00:00

  • Mode of Proximal Tubule Damage: Differential Cause for the Release of TFF3?

    abstract::Proximal tubular epithelial cells are particularly sensitive to damage. In search of a biomarker, this study evaluated the potential of different cell activation models (hypoxia/replenishment and protein overload) to lead to a release of trefoil factor 3 (TFF3). Surprisingly, we found disparity in the ability of the d...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Zwaini Z,Alammari D,Byrne S,Stover C

    更新日期:2016-03-30 00:00:00

  • Targeting Head and Neck Cancer by Vaccination.

    abstract::Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomav...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Wang C,Dickie J,Sutavani RV,Pointer C,Thomas GJ,Savelyeva N

    更新日期:2018-04-23 00:00:00

  • Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus?

    abstract::The expression of human endogenous retroviruses (HERVs) has been associated with Multiple Sclerosis (MS). The MS-related retrovirus (MSRV/HERV-W) has the potential to activate inflammatory immunity, which could promote both susceptibility and progression toward MS. A connection between HERVs and MS is also supported b...

    journal_title:Frontiers in immunology

    pub_type: 临床试验,杂志文章


    authors: Morandi E,Tanasescu R,Tarlinton RE,Constantin-Teodosiu D,Gran B

    更新日期:2019-01-22 00:00:00

  • Human b1 cell frequency: isolation and analysis of human b1 cells.

    abstract::Controversy over the frequency of human B1 cells in normal individuals has arisen as different labs have begun to employ non-uniform techniques to study this population. The phenotypic profile and relative paucity of circulating human B1 cells place constraints on methodology to identify and isolate this population. M...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Griffin DO,Rothstein TL

    更新日期:2012-05-25 00:00:00

  • Emerging Concepts about NAIP/NLRC4 Inflammasomes.

    abstract::Neuronal apoptosis inhibitory protein (NAIP)/NOD-like receptor (NLR) containing a caspase activating and recruitment domain (CARD) 4 (NLRC4) inflammasome complexes are activated in response to proteins from virulent bacteria that reach the cell cytosol. Specific NAIP proteins bind to the agonists and then physically a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Lage SL,Longo C,Branco LM,da Costa TB,Buzzo Cde L,Bortoluci KR

    更新日期:2014-07-02 00:00:00

  • Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages.

    abstract::TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphyloco...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ehrnström B,Beckwith KS,Yurchenko M,Moen SH,Kojen JF,Lentini G,Teti G,Damås JK,Espevik T,Stenvik J

    更新日期:2017-10-03 00:00:00

  • A mechanistic model for naive CD4 T cell homeostasis in healthy adults and children.

    abstract::The size and composition of the T lymphocyte compartment is subject to strict homeostatic regulation and is remarkably stable throughout life in spite of variable dynamics in cell production and death during T cell development and immune responses. Homeostasis is achieved by careful orchestration of lymphocyte surviva...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hapuarachchi T,Lewis J,Callard RE

    更新日期:2013-11-11 00:00:00