Characterization of the Highly Prevalent Regulatory CD24hiCD38hi B-Cell Population in Human Cord Blood.

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

journal_title：Frontiers in immunology

authors： Martin-Gayo E,Yu XG

更新日期：2019-06-06 00:00:00

abstract：:Cholera toxin (CT) is one of most strong mucosal adjuvants, but it cannot be clinically used owing to its toxicity. The cytosolic A1 subunit of CT (CTA1) is the molecule responsible for its immunostimulatory activity, which increases the concentration of cyclic AMP and causes the induction of pro-inflammatory cytokine...

journal_title：Frontiers in immunology

authors： Kim MS,Yi EJ,Kim YI,Kim SH,Jung YS,Kim SR,Iwawaki T,Ko HJ,Chang SY

更新日期：2019-06-04 00:00:00

abstract：:PD-1, TIM-3, and LAG-3 are molecules shown to have immune modulatory properties, and although initially classified as indicators of T cell hyporesponsiveness, it has become clear that they are also associated with the normal course of T cell activation. Functional studies have focused mainly on CD8(+) T cells during c...

journal_title：Frontiers in immunology

authors： Sabins NC,Harman BC,Barone LR,Shen S,Santulli-Marotto S

更新日期：2016-06-16 00:00:00

abstract：:Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA. Recently, there has been a growing interest in investigating physiological regulators of PAD acti...

journal_title：Frontiers in immunology

authors： Nagar M,Tilvawala R,Thompson PR

更新日期：2019-02-19 00:00:00

abstract：:SARS-CoV-2 is a novel coronavirus, not encountered before by humans. The wide spectrum of clinical expression of SARS-CoV-2 illness suggests that individual immune responses to SARS-CoV-2 play a crucial role in determining the clinical course after first infection. Immunological studies have focused on patients with m...

journal_title：Frontiers in immunology

authors： Carsetti R,Zaffina S,Piano Mortari E,Terreri S,Corrente F,Capponi C,Palomba P,Mirabella M,Cascioli S,Palange P,Cuccaro I,Milito C,Zumla A,Maeurer M,Camisa V,Vinci MR,Santoro A,Cimini E,Marchioni L,Nicastri E,Palmi

更新日期：2020-12-16 00:00:00

abstract：:Food allergy is an atopic disease that is caused by the immune system targeting harmless food antigens that can result in life-threatening anaphylaxis. As humans and microbes have co-evolved, inevitably commensal microbes have a tremendous impact on our health. As such, the gut with its enormous microbial richness ref...

journal_title：Frontiers in immunology

authors： Kreft L,Hoffmann C,Ohnmacht C

更新日期：2020-08-14 00:00:00

abstract：:Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of caspase-1. Therefore, the amount and nature of ASC monomers and polymer...

journal_title：Frontiers in immunology

authors： Gavrilin MA,McAndrew CC,Prather ER,Tsai M,Spitzer CR,Song MA,Mitra S,Sarkar A,Shields PG,Diaz PT,Wewers MD

更新日期：2020-03-19 00:00:00

abstract：:Ninety percent of those diagnosed with systemic lupus erythematosus are female, with peak incidence between the ages of 15 and 45, when women are most hormonally active. Despite significant research effort, the mechanisms underlying this sex bias remain unclear. We previously showed that a functional knockout of estro...

journal_title：Frontiers in immunology

authors： Cunningham MA,Wirth JR,Scott JL,Eudaly J,Collins EL,Gilkeson GS

更新日期：2016-02-15 00:00:00

abstract：:The host's ability to discriminate friend and foe and to establish a precise homeostasis with its associated microbiota is crucial for its survival and fitness. Among the mediators of intestinal host-microbe interactions, NOD-like receptor (NLR) proteins take center stage. They are present in the epithelial lining and...

journal_title：Frontiers in immunology

authors： Lipinski S,Rosenstiel P

更新日期：2013-12-27 00:00:00

abstract：:HLA-E is a member of the non-classical HLA molecules and by interaction with activating or inhibitory receptors of NK and T cells, HLA-E can lead to immune activation or suppression context-dependently. Recently, the non-classical HLA molecules gain more attention in the setting of allogeneic hematopoietic stem cell t...

journal_title：Frontiers in immunology

authors： Kordelas L,Schwich E,Lindemann M,Heinemann FM,Buttkereit U,Horn PA,Beelen DW,Rebmann V

更新日期：2020-01-10 00:00:00

abstract：:This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with coronary artery disease. We assessed 84 patients with coronary ar...

journal_title：Frontiers in immunology

authors： Gruzdeva O,Uchasova E,Dyleva Y,Borodkina D,Akbasheva O,Antonova L,Matveeva V,Belik E,Ivanov S,Sotnikov A,Kozyrin K,Brel N,Sinitsky M,Karetnikova V,Kokov A,Bychkova E,Pecherina T,Barbarash O

更新日期：2019-09-19 00:00:00

abstract：:Paclitaxel is a chemotherapeutic drug commonly used to treat different types of cancer. In addition to its antitumor effect, paclitaxel is also known to promote Toll-like receptor (TLR) 4-dependent inflammatory responses, which may lower its chemotherapeutic efficacy. However, it remains unclear whether paclitaxel is ...

journal_title：Frontiers in immunology

authors： Son S,Shim DW,Hwang I,Park JH,Yu JW

更新日期：2019-05-16 00:00:00

abstract：:The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demo...

journal_title：Frontiers in immunology

authors： de Salort J,Cuenca M,Terhorst C,Engel P,Romero X

更新日期：2013-07-31 00:00:00

abstract：:The pathogenicity of group A Streptococcus (GAS) is mediated by direct bacterial invasivity and toxin-associated damage. Among the extracellular products, the exotoxin streptolysin O (SLO) is produced by almost all GAS strains. SLO is a pore forming toxin (PFT) hemolitically active and extremely toxic in vivo. Recent ...

journal_title：Frontiers in immunology

authors： Vita GM,De Simone G,Leboffe L,Montagnani F,Mariotti D,Di Bella S,Luzzati R,Gori A,Ascenzi P,di Masi A

更新日期：2020-12-08 00:00:00

abstract：:Mild modification of intravenous immunoglobulin (IVIG) has been reported to result in enhanced polyspecificity and leveraged therapeutic effects in animal models of inflammation. Here, we observed that IVIG modification by ferrous ions, heme or low pH exposure, shifted the repertoires of specificities in different dir...

journal_title：Frontiers in immunology

authors： Graeter S,Schneider C,Verschoor D,von Däniken S,Seibold F,Yawalkar N,Villiger P,Dimitrov JD,Smith DF,Cummings RD,Simon HU,Vassilev T,von Gunten S

更新日期：2020-05-19 00:00:00

abstract：Background:Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. Objectives:To determine whether normal pregnancy and delivery are associated with local activation of...

journal_title：Frontiers in immunology

authors： Livson S,Jarva H,Kalliala I,Lokki AI,Heikkinen-Eloranta J,Nieminen P,Meri S

更新日期：2021-01-11 00:00:00

abstract：:The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, only clinically diagnosed since the lack of reliable biomarkers. Autism etiology is probably attributable to the combination of genetic vulnerability and environmental factors, and recently, maternal immune activation has been...

journal_title：Frontiers in immunology

authors： Balestrieri E,Cipriani C,Matteucci C,Benvenuto A,Coniglio A,Argaw-Denboba A,Toschi N,Bucci I,Miele MT,Grelli S,Curatolo P,Sinibaldi-Vallebona P

更新日期：2019-09-26 00:00:00

abstract：:Protein 4.1R, a member of the 4.1 family, functions as a bridge between cytoskeletal and plasma membrane proteins. It is expressed in T cells, where it binds to a linker for activation of T cell (LAT) family member 1 and inhibits its phosphorylation and downstream signaling events after T cell receptor triggering. The...

journal_title：Frontiers in immunology

authors： Draberova L,Draberova H,Potuckova L,Halova I,Bambouskova M,Mohandas N,Draber P

更新日期：2020-01-14 00:00:00

abstract：:Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations. Respiratory viruses can cause exacerbations in chronic pulmonary diseases including COPD or asthma and have been suggested to contribute to...

journal_title：Frontiers in immunology

authors： Sörensen M,Kantorek J,Byrnes L,Boutin S,Mall MA,Lasitschka F,Zabeck H,Nguyen D,Dalpke AH

更新日期：2020-02-04 00:00:00

abstract：:Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC), represent a major global health burden. A large population of microorganisms residing in the GI tract regulate physiological processes, such as the immune response, metabolic balance, and homeostasis. Accumulating evidence has reveal...

journal_title：Frontiers in immunology

authors： Peng C,Ouyang Y,Lu N,Li N

更新日期：2020-06-30 00:00:00

abstract：:Chronic spontaneous urtcaria (CSU) can represent the leading sign of a wide spectrum of systemic diseases, including primary immunodeficiencies. We describe the case of a young adult female with coexisting CSU and common variable immunodeficiency (CVID) successfully treated with omalizumab. The patient, with a history...

journal_title：Frontiers in immunology

authors： Comberiati P,Costagliola G,Carli N,Legitimo A,D'Elios S,Consolini R,Peroni DG

更新日期：2019-07-17 00:00:00

abstract：:The mechanisms underlying pathophysiological regulation of tissue macrophage (Mφ) subsets remain poorly understood. From the expression of 207 Mφ genes comprising 31 markers for 10 subsets, 45 transcription factors (TFs), 56 immunometabolism enzymes, 23 trained immunity (innate immune memory) enzymes, and 52 other gen...

journal_title：Frontiers in immunology

authors： Lai B,Wang J,Fagenson A,Sun Y,Saredy J,Lu Y,Nanayakkara G,Yang WY,Yu D,Shao Y,Drummer C 4th,Johnson C,Saaoud F,Zhang R,Yang Q,Xu K,Mastascusa K,Cueto R,Fu H,Wu S,Sun L,Zhu P,Qin X,Yu J,Fan D,Shen YH,Su

更新日期：2019-11-14 00:00:00

abstract：:Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount of lactic acid through aerobic glycolysis during the early pregnan...

journal_title：Frontiers in immunology

authors： Ma LN,Huang XB,Muyayalo KP,Mor G,Liao AH

更新日期：2020-02-27 00:00:00

abstract：:Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated vasculitis and rheuma...

journal_title：Frontiers in immunology

authors： Tacnet-Delorme P,Gabillet J,Chatfield S,Thieblemont N,Frachet P,Witko-Sarsat V

更新日期：2018-04-25 00:00:00

abstract：:The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and adaptive immunity. The secret of this functional diversity, in turn, r...

journal_title：Frontiers in immunology

authors： Ghebrehiwet B,Kandov E,Kishore U,Peerschke EIB

更新日期：2018-02-05 00:00:00

abstract：:A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and infections. Therefore, it is necessary to seek novel immunosuppressive ...

journal_title：Frontiers in immunology

authors： Zeng Q,Qiu F,Chen Y,Liu C,Liu H,Liang CL,Zhang Q,Dai Z

更新日期：2019-04-01 00:00:00

abstract：:The main role of the human immune system is to eliminate cells presenting foreign antigens and abnormal patterns, while maintaining self-tolerance. However, when facing highly variable pathogens or antigens very similar to self-antigens, this system can fail in completely eliminating the anomalies, leading to the esta...

journal_title：Frontiers in immunology

authors： Vigano S,Bobisse S,Coukos G,Perreau M,Harari A

更新日期：2020-06-30 00:00:00

abstract：:Volcanic ash is a heterogeneous mineral dust that is typically composed of a mixture of amorphous (glass) and crystalline (mineral) fragments. It commonly contains an abundance of the crystalline silica (SiO2) polymorph cristobalite. Inhalation of crystalline silica can induce inflammation by stimulating the NLRP3 inf...

journal_title：Frontiers in immunology

authors： Damby DE,Horwell CJ,Baxter PJ,Kueppers U,Schnurr M,Dingwell DB,Duewell P

更新日期：2018-01-22 00:00:00

abstract：:TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously showed that in human primary monocytes and monocyte derived macrophages, TLR8 senses entire Staphylococcus aureus and Streptococcus agalactiae (group B strepto...

journal_title：Frontiers in immunology

authors： Moen SH,Ehrnström B,Kojen JF,Yurchenko M,Beckwith KS,Afset JE,Damås JK,Hu Z,Yin H,Espevik T,Stenvik J

更新日期：2019-05-31 00:00:00

abstract：:A successful outcome to pregnancy is dependent on the ability of the maternal uterine microenvironment to regulate inflammation processes and establish maternal tolerance. Recently, B cells have been shown to influence pregnancy outcomes as aberrations in their numbers and functions are associated with obstetric compl...

journal_title：Frontiers in immunology

authors： Guzman-Genuino RM,Eldi P,Garcia-Valtanen P,Hayball JD,Diener KR

更新日期：2019-12-11 00:00:00