Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells.

abstract：:Overexpression of interleukin 6 (IL-6) has been proposed to contribute to pulmonary fibrosis and other fibrotic diseases. However, the regulatory mechanisms and the role of IL-6 in fibrosis remain poorly understood. Epigenetics refers to alterations of gene expression without changes in the DNA sequence. Alternation o...

journal_title：Frontiers in immunology

authors： Hu L,Yu Y,Huang H,Fan H,Hu L,Yin C,Li K,Fulton DJ,Chen F

更新日期：2017-01-30 00:00:00

abstract：:We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs. This CXCR4 mimetic peptide, termed CX4-M1, presents the three extracellular loops (ECLs) of the receptor. In binding assays i...

journal_title：Frontiers in immunology

authors： Groß A,Möbius K,Haußner C,Donhauser N,Schmidt B,Eichler J

更新日期：2013-09-03 00:00:00

abstract：:The intestinal microbiome maintains a close relationship with the host immunity. This connection fosters a health state by direct and indirect mechanisms. Direct influences occur mainly through the production of short-chain fatty acids (SCFAs), gastrointestinal hormones and precursors of bioactive molecules. Indirect ...

journal_title：Frontiers in immunology

authors： Elias-Oliveira J,Leite JA,Pereira ÍS,Guimarães JB,Manso GMDC,Silva JS,Tostes RC,Carlos D

更新日期：2020-08-11 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the complex clinical phen...

journal_title：Frontiers in immunology

authors： Seleman M,Hoyos-Bachiloglu R,Geha RS,Chou J

更新日期：2017-07-24 00:00:00

abstract：:Plasma cells (PCs), the B lineage cells responsible for producing and secreting antibodies (Abs), are critical cellular components of the humoral immune system. While most of the antibody-secreting cells in the body have a rather short lifetime of a few days, some of them can become long-lived and persist in the body ...

journal_title：Frontiers in immunology

authors： Lindquist RL,Niesner RA,Hauser AE

更新日期：2019-04-24 00:00:00

abstract：:The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrate neutrophil recruitment to inflammatory sites through chemotactic gu...

journal_title：Frontiers in immunology

authors： Isles HM,Herman KD,Robertson AL,Loynes CA,Prince LR,Elks PM,Renshaw SA

更新日期：2019-07-31 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although majority of TILs consist of CD8+/CD4+ T cells, the presence of NK cells and their role in the pathogenesis of PDAC remains elusive. We perform...

journal_title：Frontiers in immunology

authors： Lim SA,Kim J,Jeon S,Shin MH,Kwon J,Kim TJ,Im K,Han Y,Kwon W,Kim SW,Yee C,Kim SJ,Jang JY,Lee KM

更新日期：2019-04-09 00:00:00

abstract：OBJECTIVE:Multiple solid cancers contain tertiary lymphoid organs (TLO). However, it is unclear whether they promote tumor rejection, facilitate tumor evasion, or simply whether they are a byproduct of chronic inflammation. We hypothesize that although chronic inflammation induces TLO formation, the tumor milieu can mo...

journal_title：Frontiers in immunology

authors： García-Hernández ML,Uribe-Uribe NO,Espinosa-González R,Kast WM,Khader SA,Rangel-Moreno J

更新日期：2017-05-17 00:00:00

abstract：:Effector CD8+ T cells generally produce type-1 cytokines and mediators of the perforin/granzyme cytolytic pathway, yet type-2-polarized CD8+ cells (Tc2) are detected in type-2 (T2) cytokine-driven diseases such as asthma. It is unclear whether T2 cytokine exposure during activation is sufficient to polarize human CD8+...

journal_title：Frontiers in immunology

authors： Fox A,Harland KL,Kedzierska K,Kelso A

更新日期：2018-05-28 00:00:00

abstract：:Cancer immunotherapy (CIT) with antibodies targeting the programmed cell death 1 protein (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis have changed the standard of care in multiple cancers. However, durable antitumor responses have been observed in only a minority of patients, indicating the presence of other i...

journal_title：Frontiers in immunology

authors： Hack SP,Zhu AX,Wang Y

更新日期：2020-11-05 00:00:00

abstract：:The intestinal mucosa is constantly facing a high load of antigens including bacterial antigens derived from the microbiota and food. Despite this, the immune cells present in the gastrointestinal tract do not initiate a pro-inflammatory immune response. Toll-like receptors (TLRs) are pattern recognition receptors exp...

journal_title：Frontiers in immunology

authors： de Kivit S,Tobin MC,Forsyth CB,Keshavarzian A,Landay AL

更新日期：2014-02-18 00:00:00

abstract：:Therapeutic monoclonal antibodies (mAbs), targeting tumor antigens, or immune checkpoints, have demonstrated a remarkable anti-tumor effect against various malignancies. However, high costs for mono- or combination therapies, associated with adverse effects or possible development of resistance in some patients, warra...

journal_title：Frontiers in immunology

authors： Tobias J,Battin C,De Sousa Linhares A,Lebens M,Baier K,Ambroz K,Drinić M,Högler S,Inic-Kanada A,Garner-Spitzer E,Preusser M,Kenner L,Kundi M,Zielinski CC,Steinberger P,Wiedermann U

更新日期：2020-05-27 00:00:00

abstract：:Mild modification of intravenous immunoglobulin (IVIG) has been reported to result in enhanced polyspecificity and leveraged therapeutic effects in animal models of inflammation. Here, we observed that IVIG modification by ferrous ions, heme or low pH exposure, shifted the repertoires of specificities in different dir...

journal_title：Frontiers in immunology

authors： Graeter S,Schneider C,Verschoor D,von Däniken S,Seibold F,Yawalkar N,Villiger P,Dimitrov JD,Smith DF,Cummings RD,Simon HU,Vassilev T,von Gunten S

更新日期：2020-05-19 00:00:00

abstract：:iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and protects against cancer in vivo. Monoclonal antibodies (mAbs) that detec...

journal_title：Frontiers in immunology

authors： Clark K,Yau J,Bloom A,Wang J,Venzon DJ,Suzuki M,Pasquet L,Compton BJ,Cardell SL,Porcelli SA,Painter GF,Zajonc DM,Berzofsky JA,Terabe M

更新日期：2019-10-09 00:00:00

abstract：:The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal studies have indicated that allergic diseases occur in a time-based order: from atopic dermatitis and food allergy in infancy to gradual development into allergic asthma and allergic rhinitis in childhood. This phenomenon is defined...

journal_title：Frontiers in immunology

authors： Yang L,Fu J,Zhou Y

更新日期：2020-08-27 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory condition with no effective treatment. Probiotics have gained wide attention because of their outstanding advantages in intestinal health issues. In previous studies, a novel soluble protein, HM0539, which is derived from Lactobacillus...

journal_title：Frontiers in immunology

authors： Li Y,Yang S,Lun J,Gao J,Gao X,Gong Z,Wan Y,He X,Cao H

更新日期：2020-10-05 00:00:00

abstract：:Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of...

journal_title：Frontiers in immunology

authors： Loewendorf AI,Matynia A,Saribekyan H,Gross N,Csete M,Harrington M

更新日期：2016-04-19 00:00:00

abstract：:Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA. Recently, there has been a growing interest in investigating physiological regulators of PAD acti...

journal_title：Frontiers in immunology

authors： Nagar M,Tilvawala R,Thompson PR

更新日期：2019-02-19 00:00:00

abstract：:Transition from resting to cell cycle in response to antigenic stimulation is an essential step for naïve CD8+ T cells to differentiate to effector and memory cells. Leaving the resting state requires dramatic changes of chromatin status in the key cell cycle inhibitors but the details of these concerted events are no...

journal_title：Frontiers in immunology

authors： Chen G,Subedi K,Chakraborty S,Sharov A,Lu J,Kim J,Mi X,Wersto R,Sung MH,Weng NP

更新日期：2018-03-26 00:00:00

abstract：:Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. However, limited data are available on their conclusive phenotypes and their correlation with clinical settings. The aim of this study was ...

journal_title：Frontiers in immunology

authors： Toor SM,Syed Khaja AS,El Salhat H,Bekdache O,Kanbar J,Jaloudi M,Elkord E

更新日期：2016-12-08 00:00:00

abstract：:Innate immune dysfunction persists in HIV+ individuals despite effective combination antiretroviral therapy (cART). We recently demonstrated that an adaptive-like CD56dim NK cell population lacking the signal transducing protein FcRγ is expanded in HIV+ individuals. Here, we analyzed a cohort of HIV+ men who have sex ...

journal_title：Frontiers in immunology

authors： Hearps AC,Agius PA,Zhou J,Brunt S,Chachage M,Angelovich TA,Cameron PU,Giles M,Price P,Elliott J,Jaworowski A

更新日期：2017-06-30 00:00:00

abstract：:Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal inflammation triggered by food intake. Taking advantage of the translucency of the larvae and the availability of transgenic zebrafish lin...

journal_title：Frontiers in immunology

authors： Coronado M,Solis CJ,Hernandez PP,Feijóo CG

更新日期：2019-04-02 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for many types of hematological malignancies. Matching of donor and recipient for the major histocompatibility complex (MHC) improves the HSCT reconstitution, but donor-derived T cells reactive to non-MHC encoded minor histocompat...

journal_title：Frontiers in immunology

authors： Choi EY,Choi K,Nam G,Kim W,Chung M

更新日期：2020-06-10 00:00:00

abstract：:Natural killer (NK) cells contribute to immunosurveillance and first-line defense in the control of tumor growth and metastasis diffusion. NK-cell-derived extracellular vesicles (NKEVs) are constitutively secreted and biologically active. They reflect the protein and genetic repertoire of originating cells, and exert ...

journal_title：Frontiers in immunology

authors： Federici C,Shahaj E,Cecchetti S,Camerini S,Casella M,Iessi E,Camisaschi C,Paolino G,Calvieri S,Ferro S,Cova A,Squarcina P,Bertuccini L,Iosi F,Huber V,Lugini L

更新日期：2020-03-13 00:00:00

abstract：:This is the first case of NBAS disease detected by NBS for primary immunodeficiency. NBS with KRECs is revealing unknown potentialities detecting conditions that benefit from early recognition like NBAS deficiency. Immune phenotyping should be mandatory in patients with NBAS deficiency since they can exhibit severe im...

journal_title：Frontiers in immunology

authors： Ricci S,Lodi L,Serranti D,Moroni M,Belli G,Mancano G,La Barbera A,Forzano G,Mangone G,Indolfi G,Azzari C

更新日期：2019-08-27 00:00:00

abstract：:Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to establish antitumoral immunity. The antitumoral activity of Vγ9Vδ2-T cells is governed by a complicated set of activating and inhibitor...

journal_title：Frontiers in immunology

authors： Xiang Z,Tu W

更新日期：2017-08-28 00:00:00

abstract：:Over the past two decades, heat shock proteins (HSPs) have been implicated in inflammatory responses and autoimmunity. HSPs were originally believed to maintain protein quality control in the cytosol. However, they also exist extracellularly and appear to act as inflammatory factors. Recently, a growing body of eviden...

journal_title：Frontiers in immunology

authors： Morito D,Nagata K

更新日期：2012-03-15 00:00:00

abstract：:The progressive infiltration of immune cells is associated with the progression of melanoma. Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor effects. It is now necessary to understand the contradictory data associated with how Th17 cells play a role in melanoma. This review will ...

journal_title：Frontiers in immunology

authors： Chen C,Gao FH

更新日期：2019-02-08 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease in young children and a substantial contributor to respiratory tract disease throughout life and as such a high priority for vaccine development. However, after nearly 60 years of research no vaccine is yet available. The ch...

journal_title：Frontiers in immunology

authors： Boyoglu-Barnum S,Chirkova T,Anderson LJ

更新日期：2019-07-25 00:00:00

abstract：:Preclinical and early human clinical studies of broadly neutralizing antibodies (bNAbs) to prevent and treat HIV infection support the clinical utility and potential of bNAbs for prevention, postexposure prophylaxis, and treatment of acute and chronic infection. Observed and potential limitations of bNAbs from these r...

journal_title：Frontiers in immunology

authors： Hua CK,Ackerman ME

更新日期：2017-11-28 00:00:00