Th17 Cells Paradoxical Roles in Melanoma and Potential Application in Immunotherapy.


:The progressive infiltration of immune cells is associated with the progression of melanoma. Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor effects. It is now necessary to understand the contradictory data associated with how Th17 cells play a role in melanoma. This review will summarize the current knowledge regarding the potential mechanisms that may be involved in the effects of Th17 cells in melanoma progression. Currently, since adoptive transferring Th17 cells has been successful in eradicating melanoma in mice, it offers promise for next-generation adoptive cell transfer, as ex vivo expanded stemness-like memory Th17 cells which are induced by distinct cytokines or pharmacologic reagents may be infused into melanoma patients to potentiate treatment outcome.


Front Immunol


Frontiers in immunology


Chen C,Gao FH




Has Abstract


2019-02-08 00:00:00








  • Endometriosis, a disease of the macrophage.

    abstract::Endometriosis, a common cause of pelvic pain and female infertility, depends on the growth of vascularized endometrial tissue at ectopic sites. Endometrial fragments reach the peritoneal cavity during the fertile years: local cues decide whether they yield endometriotic lesions. Macrophages are recruited at sites of h...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Capobianco A,Rovere-Querini P

    更新日期:2013-01-28 00:00:00

  • Individual MHCI-Restricted T-Cell Receptors are Characterized by a Unique Peptide Recognition Signature.

    abstract::Effective immunity requires that a limited TCR repertoire is able to recognize a vast number of foreign peptide-MHCI (peptide-major histocompatibility complex class I) molecules. This challenge is overcome by the ability of individual TCRs to recognize large numbers of peptides. Recently, it was demonstrated that MHCI...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wooldridge L

    更新日期:2013-07-23 00:00:00

  • Enrichment of HLA Types and Single-Nucleotide Polymorphism Associated With Non-progression in a Strictly Defined Cohort of HIV-1 Controllers.

    abstract::HIV-1 controllers (HIC) are extremely rare patients with the ability to control viral replication, maintain unchanging CD4 T-cell count, and evade disease progression for extensive periods of time, in the absence of antiretroviral therapy. In order to establish the representation of key genetic correlates of atypical ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Westrop SJ,Cocker ATH,Boasso A,Sullivan AK,Nelson MR,Imami N

    更新日期:2017-06-27 00:00:00

  • Mycobacterium leprae-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT.

    abstract::Leprosy serology reflects the bacillary load of patients and multidrug therapy (MDT) reduces Mycobacterium leprae-specific antibody titers of multibacillary (MB) patients. The Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil (U-MDT/CT-BR) compared outcomes of regular 12 doses MDT/R-M...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hungria EM,Bührer-Sékula S,Oliveira RM,Aderaldo LC,Pontes MAA,Cruz R,de Gonçalves HS,Penna MLF,Penna GO,Stefani MMA

    更新日期:2018-05-14 00:00:00

  • Generation and function of induced regulatory T cells.

    abstract::CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, "natural" Treg (nTreg) cells that develop in the thymus, and "induced" Treg (iTreg) cells that arise in the periphery from CD4(+) Foxp3(-) conventional...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schmitt EG,Williams CB

    更新日期:2013-06-19 00:00:00

  • Cell Cycle-Associated CXCR4 Expression in Germinal Center B Cells and Its Implications on Affinity Maturation.

    abstract::Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high-affinity antibodies that aid both to clear and protect against reinfection of invading pathogens. Within GCs, light and ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Weber TS

    更新日期:2018-06-12 00:00:00

  • Corrigendum: PTX3 Intercepts Vascular Inflammation in Systemic Immune-Mediated Diseases.

    abstract::[This corrects the article DOI: 10.3389/fimmu.2019.01135.]. ...

    journal_title:Frontiers in immunology

    pub_type: 已发布勘误


    authors: Ramirez GA,Rovere-Querini P,Blasi M,Sartorelli S,Di Chio MC,Baldini M,De Lorenzo R,Bozzolo EP,Leone R,Mantovani A,Manfredi AA,Tombetti E

    更新日期:2019-07-24 00:00:00

  • Novel Association of High C-Reactive Protein Levels and A69S at Risk Alleles in Wet Age-Related Macular Degeneration Women.

    abstract:Purpose:To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods:Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) ca...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Fernandez-Robredo P,Recalde S,Hernandez M,Zarranz-Ventura J,Molins B,Casaroli-Marano RP,Adan A,Saenz-de-Viteri M,García-Layana A

    更新日期:2018-08-14 00:00:00

  • Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections.

    abstract::CD8+ T cells represent one of the most versatile immune cells critical for clearing away viral infections. Due to their important role, CD8+ T cell activation and memory formation during viral infection have been the focus of several studies recently. Although CD8+ T cell activation and memory formation have been asso...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Gupta SS,Wang J,Chen M

    更新日期:2020-05-22 00:00:00

  • MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice.

    abstract::Infections with respiratory syncytial virus (RSV) occurs repeatedly throughout life because sustained, protective memory responses fail to develop. Why this occurs is not known. During RSV infection the recognition of the virus via the cytosolic RIG-I like receptors and signaling via the adaptor protein MAVS is crucia...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Paulsen M,Varese A,Pinpathomrat N,Kirsebom FCM,Paulsen M,Johansson C

    更新日期:2020-10-06 00:00:00

  • TLR3 Activation of Intratumoral CD103+ Dendritic Cells Modifies the Tumor Infiltrate Conferring Anti-tumor Immunity.

    abstract::An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact that has been related to the pre-existence of an efficient anti-tumor immune response. Different strategies are being proposed to promote tumor immunity and to be used in combi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Roselli E,Araya P,Núñez NG,Gatti G,Graziano F,Sedlik C,Benaroch P,Piaggio E,Maccioni M

    更新日期:2019-03-20 00:00:00

  • Breast Milk and Solid Food Shaping Intestinal Immunity.

    abstract::After birth, the intestinal immune system enters a critical developmental stage, in which tolerogenic and pro-inflammatory cells emerge to contribute to the overall health of the host. The neonatal health is continuously challenged by microbial colonization and food intake, first in the form of breast milk or formula ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Parigi SM,Eldh M,Larssen P,Gabrielsson S,Villablanca EJ

    更新日期:2015-08-19 00:00:00

  • HCMV-Encoded NK Modulators: Lessons From in vitro and in vivo Genetic Variation.

    abstract::Human cytomegalovirus (HCMV) is under constant selective pressure from the immune system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically altered by, such selection can focus research toward findings of in vivo significance. We have been particularly interested in the most pronounced ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Patel M,Vlahava VM,Forbes SK,Fielding CA,Stanton RJ,Wang ECY

    更新日期:2018-10-01 00:00:00

  • Anti-CD20-Mediated B Cell Depletion Is Associated With Bone Preservation in Lymphoma Patients and Bone Mass Increase in Mice.

    abstract::Immunotherapy with anti-CD20-specific antibodies (rituximab), has become the standard of care for B cell lymphoproliferative disorders and many autoimmune diseases. In rheumatological patients the effect of rituximab on bone mass yielded conflicting results, while in lymphoma patients it has not yet been described. He...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kolomansky A,Kaye I,Ben-Califa N,Gorodov A,Awida Z,Sadovnic O,Ibrahim M,Liron T,Hiram-Bab S,Oster HS,Sarid N,Perry C,Gabet Y,Mittelman M,Neumann D

    更新日期:2020-10-19 00:00:00

  • Ontogeny of Tissue-Resident Macrophages.

    abstract::The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Hoeffel G,Ginhoux F

    更新日期:2015-09-22 00:00:00

  • Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells.

    abstract::Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed after antigen clearance and a long-term resting phase accompanied ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Onodera A,Kokubo K,Nakayama T

    更新日期:2018-12-12 00:00:00

  • Characterization of γδ T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity.

    abstract::γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. However, the presence of this T cell subset in ancient vertebrates remains unclear. In this study, γδ T cells from a zebrafish (Danio rerio) model were subjected to...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wan F,Hu CB,Ma JX,Gao K,Xiang LX,Shao JZ

    更新日期:2017-01-09 00:00:00

  • Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages.

    abstract::TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphyloco...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ehrnström B,Beckwith KS,Yurchenko M,Moen SH,Kojen JF,Lentini G,Teti G,Damås JK,Espevik T,Stenvik J

    更新日期:2017-10-03 00:00:00

  • Role of innate immune response in non-alcoholic Fatty liver disease: metabolic complications and therapeutic tools.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, both in adults and children. It is characterized by an aberrant lipid storage in hepatocytes, named hepatic steatosis. Simple steatosis remains a benign process in most affected patients, while some of them develop superimp...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Meli R,Mattace Raso G,Calignano A

    更新日期:2014-04-23 00:00:00

  • Human Decidual Stromal Cells in Early Pregnancy Induce Functional Re-Programming of Monocyte-Derived Dendritic Cells via Crosstalk Between G-CSF and IL-1β.

    abstract::Accumulation of dendritic cells (DCs) is a special characteristic of the decidual microenvironment. Decidua-infiltrated DCs show unique phenotypes and functions that promote the establishment of fetal-maternal tolerance. However, the regulatory mechanisms yet to be fully investigated. Decidual stromal cells (DSCs) are...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Shao Q,Liu X,Huang Y,Chen X,Wang H

    更新日期:2020-10-27 00:00:00

  • Recombinant ATPase of Virulent Aeromonas hydrophila Protects Channel Catfish Against Motile Aeromonas Septicemia.

    abstract::Channel catfish farming dominates the aquaculture industry in the United States. However, epidemic outbreaks of motile Aeromonas septicemia (MAS), caused by virulent Aeromonas hydrophila (vAh), have become a prominent problem in the catfish industry. Although vaccination is an effective preventive method, there is no ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Abdelhamed H,Banes M,Karsi A,Lawrence ML

    更新日期:2019-07-16 00:00:00

  • Oral Administration of Acrylamide Worsens the Inflammatory Responses in the Airways of Asthmatic Mice Through Agitation of Oxidative Stress in the Lungs.

    abstract::Acrylamide is a toxic chemical substance produced when starch-rich foods are fried at high temperatures. Asthma is a chronic and complicated respiratory disease, of which genetic and environmental factors are the main triggers. Orally-received components may have an effect on asthma pathophysiology. The aim of this st...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hajimohammadi B,Athari SM,Abdollahi M,Vahedi G,Athari SS

    更新日期:2020-10-09 00:00:00

  • Paired Rheumatoid Arthritis Synovial Biopsies From Small and Large Joints Show Similar Global Transcriptomic Patterns With Enrichment of Private Specificity TCRB and TCR Signaling Pathways.

    abstract:Objectives:We explored histological and transcriptomic profiles of paired synovial biopsies from rheumatoid arthritis (RA) patients, in order to assess homogeneity in synovial tissue at the individual level. Methods:Synovial biopsies were performed simultaneously in one small and one large joint per patient using need...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Triaille C,Vansteenkiste L,Constant M,Ambroise J,Méric de Bellefon L,Nzeusseu Toukap A,Sokolova T,Galant C,Coulie P,Carrasco J,Durez P,Lauwerys BR

    更新日期:2020-11-23 00:00:00

  • Molecular Determinants of Target Cell Recognition by Human γδ T Cells.

    abstract::The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Simões AE,Di Lorenzo B,Silva-Santos B

    更新日期:2018-04-27 00:00:00

  • Clinical, Immunological, and Molecular Heterogeneity of 173 Patients With the Phenotype of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome.

    abstract::Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition, there has been an increasing number of patients with wild-type FOXP3 gene and, in some cases, mutations in other immune regulatory genes. Objectiv...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gambineri E,Ciullini Mannurita S,Hagin D,Vignoli M,Anover-Sombke S,DeBoer S,Segundo GRS,Allenspach EJ,Favre C,Ochs HD,Torgerson TR

    更新日期:2018-11-01 00:00:00

  • Streptococcal Enzymes as Precision Tools Against Pathogenic IgG Autoantibodies in Small Vessel Vasculitis.

    abstract::In primary systemic small vessel vasculitis autoantibodies are common and seem to play an important role in the pathogenesis. Autoantibodies in vasculitis are preferentially directed against components of the immune system or directly against components of the vessel wall. Plasmapheresis is often applied in emergency ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Segelmark M,Björck L

    更新日期:2019-09-20 00:00:00

  • Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.

    abstract::Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity. However, insights into the role of CFH in B cell biology are limited. Here, we demonstrate that defic...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ

    更新日期:2019-07-11 00:00:00

  • Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation.

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cerqueira OLD,Clavijo-Salomon MA,Cardoso EC,Citrangulo Tortelli Junior T,Mendonça SA,Barbuto JAM,Strauss BE

    更新日期:2020-10-22 00:00:00

  • Nanoparticle Interactions with the Immune System: Clinical Implications for Liposome-Based Cancer Chemotherapy.

    abstract::The development of stable and long-circulating liposomes provides protection of the drug cargo from degradation and increases tumor drug delivery, leading to the design of liposome formulations with great potential in cancer therapy. However, despite the sound pharmacologic basis, many liposomal as well as other nanop...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: La-Beck NM,Gabizon AA

    更新日期:2017-04-06 00:00:00

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    abstract:BACKGROUND:Serotype-specific antibody responses to unconjugated pneumococcal polysaccharide vaccine (PPV) evaluated by a World Health Organization (WHO)-standardized enzyme-linked immunosorbent assay (ELISA) are the gold standard for diagnosis of specific polysaccharide antibody deficiency (SAD). The American Academy o...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schaballie H,Bosch B,Schrijvers R,Proesmans M,De Boeck K,Boon MN,Vermeulen F,Lorent N,Dillaerts D,Frans G,Moens L,Derdelinckx I,Peetermans W,Kantsø B,Jørgensen CS,Emonds MP,Bossuyt X,Meyts I

    更新日期:2017-05-12 00:00:00