Abstract:
:Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation and how to target it is highly desirable. Here, we review the latest advances in innate immunity in transplantation focusing on the roles and mechanisms of innate allorecognition and memory in myeloid cells. These novel concepts could explain why alloimmune response do not abate over time and shed light on new molecular pathways that can be interrupted to prevent or treat chronic rejection.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Zhao D,Abou-Daya KI,Dai H,Oberbarnscheidt MH,Li XC,Lakkis FGdoi
10.3389/fimmu.2020.00918subject
Has Abstractpub_date
2020-05-28 00:00:00pages
918issn
1664-3224journal_volume
11pub_type
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journal_title:Frontiers in immunology
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journal_title:Frontiers in immunology
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
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pub_type: 杂志文章,评审
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