Measurement of Human Papillomavirus-Specific Antibodies Using a Pseudovirion-Based ELISA Method.

abstract：:A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological malignancies is the prevention of graft-vs-host disease (GVHD) while main...

journal_title：Frontiers in immunology

authors： Hillhouse EE,Delisle JS,Lesage S

更新日期：2013-01-24 00:00:00

abstract：:Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA. Recently, there has been a growing interest in investigating physiological regulators of PAD acti...

journal_title：Frontiers in immunology

authors： Nagar M,Tilvawala R,Thompson PR

更新日期：2019-02-19 00:00:00

abstract：:As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated immunization of stages IIB-III CM patients with the irradiated, allogeneic cellular CSF-470 vaccine plu...

journal_title：Frontiers in immunology

authors： Pampena MB,Cartar HC,Cueto GR,Levy EM,Blanco PA,Barrio MM,Mordoh J

更新日期：2018-11-02 00:00:00

abstract：:Malaria infections remain a serious global health problem in the world, particularly among children and pregnant women in Sub-Saharan Africa. Moreover, malaria control and elimination is hampered by rapid development of resistance by the parasite and the vector to commonly used antimalarial drugs and insecticides, res...

journal_title：Frontiers in immunology

authors： Kengne-Ouafo JA,Sutherland CJ,Binka FN,Awandare GA,Urban BC,Dinko B

更新日期：2019-02-11 00:00:00

abstract：:Anaphylaxis in humans is inherently difficult to study due to the acuteness of symptoms and the lack of biomarkers serving as risk predictors. Most cases are related to IgE sensitizations to foods, insect venoms, and drugs with mastocytosis patients forming a smaller risk group. However, identifying the relatively sma...

journal_title：Frontiers in immunology

authors： Poulsen LK,Jensen BM,Esteban V,Garvey LH

更新日期：2017-08-10 00:00:00

abstract：:The Pediatric Acute Liver Failure (PALF) study is a multicenter, observational cohort study of infants and children diagnosed with this complex clinical syndrome. Outcomes in PALF reflect interactions among the child's clinical condition, response to supportive care, disease severity, potential for recovery, and, if n...

journal_title：Frontiers in immunology

authors： Vodovotz Y,Barclay D,Yin J,Squires RH,Zamora R

更新日期：2021-01-15 00:00:00

abstract：:The potential of tolerogenic dendritic cells (tolDCs) to shape immune responses and restore tolerance has turn them into a promising therapeutic tool for cellular therapies directed toward immune regulation in autoimmunity. Although the cellular mechanisms by which these cells can exert their regulatory function are w...

journal_title：Frontiers in immunology

authors： García-González PA,Maggi J,Schinnerling K,Sepúlveda-Gutiérrez A,Soto L,Neira O,Mehdi AM,Nel HJ,Pesce B,Aravena O,Molina MC,Catalán D,Thomas R,Verdugo RA,Aguillón JC

更新日期：2019-05-28 00:00:00

abstract：:Diseases due to mycobacteria, including tuberculosis, leprosy, and Buruli ulcer, rank among the top causes of death and disability worldwide. Animal studies have revealed the importance of T cells in controlling these infections. However, the specific antigens recognized by T cells that confer protective immunity and ...

journal_title：Frontiers in immunology

authors： James CA,Seshadri C

更新日期：2020-02-11 00:00:00

abstract：:The potential of natural killer (NK) cells to target numerous malignancies in vitro has been well documented; however, only limited success has been seen in the clinic. Although NK cells prove non-toxic and safe regardless of the cell numbers injected, there is often little persistence and expansion observed in a pati...

journal_title：Frontiers in immunology

authors： Domogala A,Madrigal JA,Saudemont A

更新日期：2015-06-03 00:00:00

abstract：:Multiple sclerosis (MS) is assumed to be an autoimmune disease initiated by autoreactive T cells that recognize central nervous system antigens. Although adaptive immunity is clearly involved in MS pathogenesis, innate immunity increasingly appears to be implicated in the disease. We and others have presented evidence...

journal_title：Frontiers in immunology

authors： Chanvillard C,Jacolik RF,Infante-Duarte C,Nayak RC

更新日期：2013-03-13 00:00:00

abstract：:Induction of immune tolerance is a key process by which the immune system is educated to modulate reactions against benign stimuli such as self-antigens and commensal microbes. Understanding and harnessing the natural mechanisms of immune tolerance may become an increasingly useful strategy for treating many types of ...

journal_title：Frontiers in immunology

authors： Lundy SK,Klinker MW,Fox DA

更新日期：2015-03-20 00:00:00

abstract：:Background: Vascular microthrombotic lesions in lupus nephritis with or without antiphospholipid antibodies may relate to worse renal outcomes. Whether microthrombotic lesions are a consequence of renal inflammation or independently contribute to renal damage is unclear. Our aim was to investigate the relationship bet...

journal_title：Frontiers in immunology

authors： Gonzalo-Gil E,García-Herrero C,Toldos O,Usategui A,Criado G,Pérez-Yagüe S,Barber DF,Pablos JL,Galindo M

更新日期：2018-08-28 00:00:00

abstract：:Implantation of the fertilized egg into the maternal uterus is a crucial step in pregnancy establishment. Increasing evidence suggests that its success depends on various cell types of the innate immune system and on the fine balance between inflammatory and anti-inflammatory processes. In addition, it has recently be...

journal_title：Frontiers in immunology

authors： Zenclussen AC,Hämmerling GJ

更新日期：2015-06-17 00:00:00

abstract：:Anti-tumor immunity is limited by a number of factors including the lack of fully activated T-cells, insufficient antigenic stimulation and the immune-suppressive tumor microenvironment. We addressed these hurdles by developing a novel class of immunoconjugates, Antibody-Targeted Pathogen-derived Peptides (ATPPs), whi...

journal_title：Frontiers in immunology

authors： Sefrin JP,Hillringhaus L,Mundigl O,Mann K,Ziegler-Landesberger D,Seul H,Tabares G,Knoblauch D,Leinenbach A,Friligou I,Dziadek S,Offringa R,Lifke V,Lifke A

更新日期：2019-08-21 00:00:00

abstract：:Background: Disease progression monitoring through CD4 counts alone can be inadequate in HIV infection as ongoing immune activation may result in Serious non-AIDS events (SNAEs). SNAEs involve monocyte activation driven chronic inflammation with significant sequelae observed even during HAART. Here, we attempted to de...

journal_title：Frontiers in immunology

authors： Prabhu VM,Singh AK,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-12-06 00:00:00

abstract：:Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains largely unknown. The titers of serum anti-nuclear-IgG antibodies (ANA-...

journal_title：Frontiers in immunology

authors： Pan Q,Xiao H,Shi L,He Y,Cai J,Wu J,Li A,Ye L,Yang C,Liu HF

更新日期：2020-06-17 00:00:00

abstract：:The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not normally available from patients in sufficient numbers for therapeutic purposes. In particular, the development of protocols for the differentiation of populations of leu...

journal_title：Frontiers in immunology

authors： Sachamitr P,Leishman AJ,Davies TJ,Fairchild PJ

更新日期：2018-01-08 00:00:00

abstract：:Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are targeted by the damaging immune response. Many studies have focuse...

journal_title：Frontiers in immunology

authors： Jin F,Hu H,Xu M,Zhan S,Wang Y,Zhang H,Chen X

更新日期：2018-10-16 00:00:00

abstract：:Obesity induces local/systemic inflammation accompanied by increases in macrophage infiltration into adipose tissue and production of inflammatory cytokines, chemokines, and hormones. Previous studies have shown that probiotics could improve the intestinal dysbiosis induced by metabolic diseases such as obesity, diabe...

journal_title：Frontiers in immunology

authors： Fabersani E,Abeijon-Mukdsi MC,Ross R,Medina R,González S,Gauffin-Cano P

更新日期：2017-03-13 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequently occurring primary brain tumor and has a very poor prognosis, with only around 5% of patients surviving for a period of 5 years or more after diagnosis. Despite aggressive multimodal therapy, consisting mostly of a combination of surgery, radiotherapy, and temozolomi...

journal_title：Frontiers in immunology

authors： Pearson JRD,Cuzzubbo S,McArthur S,Durrant LG,Adhikaree J,Tinsley CJ,Pockley AG,McArdle SEB

更新日期：2020-10-15 00:00:00

abstract：:Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to orchestrate their expansion, functional polarization and effector activity in non-lymphoid tissues or in their draining lymph nodes. The concept of harnessing DC immunogenicity to induce protective responses in cancer patients was ...

journal_title：Frontiers in immunology

authors： Cancel JC,Crozat K,Dalod M,Mattiuz R

更新日期：2019-02-12 00:00:00

abstract：:Mutants of a catalytically inactive variant of Proteinase 3 (PR3)-iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103-offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether such interactions can...

journal_title：Frontiers in immunology

authors： Pang YP,Casal Moura M,Thompson GE,Nelson DR,Hummel AM,Jenne DE,Emerling D,Volkmuth W,Robinson WH,Specks U

更新日期：2019-10-25 00:00:00

abstract：:High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of li...

journal_title：Frontiers in immunology

authors： Mamedov IZ,Britanova OV,Zvyagin IV,Turchaninova MA,Bolotin DA,Putintseva EV,Lebedev YB,Chudakov DM

更新日期：2013-12-23 00:00:00

abstract：:In humans, loss-of-function mutation in the Signal Transducer and Activator of Transcription 3 (STAT3) gene is frequently associated with susceptibility to bacterial as well as fungal infections including aspergillosis, although its pathogenesis remains largely unknown. In the present study, we investigated the immune...

journal_title：Frontiers in immunology

authors： Danion F,Aimanianda V,Bayry J,Duréault A,Wong SSW,Bougnoux ME,Tcherakian C,Alyanakian MA,Guegan H,Puel A,Picard C,Lortholary O,Lanternier F,Latgé JP

更新日期：2020-01-28 00:00:00

abstract：:Since the discovery of the first virus-like particle (VLP) derived from hepatitis B virus in 1980 (1), the field has expanded substantially. Besides successful use of VLPs as safe autologous virus-targeting vaccines, the powerful immunogenicity of VLPs has been also harnessed to generate immune response against hetero...

journal_title：Frontiers in immunology

authors： Gomes AC,Flace A,Saudan P,Zabel F,Cabral-Miranda G,Turabi AE,Manolova V,Bachmann MF

更新日期：2017-03-06 00:00:00

abstract：:During the entire processes of thymus organogenesis, maturation, and involution, gene regulation occurs post-transcriptionally via recently discovered microRNA (miRNA) transcripts. Numerous reports indicate that miRNAs may be involved in the construction of a normal thymic microenvironment, which constitutes a critica...

journal_title：Frontiers in immunology

authors： Xu M,Gan T,Ning H,Wang L

更新日期：2018-09-11 00:00:00

abstract：:Recent genome-wide studies have revealed the presence of thousands of long non-protein-coding RNAs (lncRNAs), some of which may play critical roles in the cell. We have previously shown that a large number of lncRNAs show differential expression in response to interferon (IFN)α stimulation in primary human cells. Here...

journal_title：Frontiers in immunology

authors： Kambara H,Gunawardane L,Zebrowski E,Kostadinova L,Jobava R,Krokowski D,Hatzoglou M,Anthony DD,Valadkhan S

更新日期：2015-01-30 00:00:00

abstract：:Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease...

journal_title：Frontiers in immunology

authors： Ndlovu H,Marakalala MJ

更新日期：2016-10-24 00:00:00

abstract：:The effects of calcium (Ca) or strontium (Sr) on host osteogenesis and immune responses have been investigated separately. In clinical practice, these two elements may both be present around an orthopedic device, but their potential synergistic effects on osteogenesis and the immune response have not been explored to ...

journal_title：Frontiers in immunology

authors： Yuan X,Cao H,Wang J,Tang K,Li B,Zhao Y,Cheng M,Qin H,Liu X,Zhang X

更新日期：2017-09-29 00:00:00

abstract：:Malaria is a public health concern worldwide, and Togo has proven to be no exception. Effective approaches to provide information on biological insights for disease elimination are therefore a research priority. Local selection on malaria pathogens is due to multiple factors including host immunity. We undertook genom...

journal_title：Frontiers in immunology

authors： Kassegne K,Komi Koukoura K,Shen HM,Chen SB,Fu HT,Chen YQ,Zhou XN,Chen JH,Cheng Y

更新日期：2020-10-23 00:00:00