Estrogen Receptor Alpha Signaling Is Responsible for the Female Sex Bias in the Loss of Tolerance and Immune Cell Activation Induced by the Lupus Susceptibility Locus Sle1b.

abstract：:Ticks, blood-feeding arthropods, and secrete immunosuppressive molecules that inhibit host immune responses and provide survival advantages to pathogens. In this study, we characterized the immunosuppressive function of a novel tick salivary protein, DsCystatin, from Dermacentor silvarum of China. DsCystatin directly ...

journal_title：Frontiers in immunology

authors： Sun T,Wang F,Pan W,Wu Q,Wang J,Dai J

更新日期：2018-06-01 00:00:00

abstract：:The Kallikrein-Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report, we show that KKS regulate...

journal_title：Frontiers in immunology

authors： Seliga A,Lee MH,Fernandes NC,Zuluaga-Ramirez V,Didukh M,Persidsky Y,Potula R,Gallucci S,Sriram U

更新日期：2018-02-02 00:00:00

abstract：:Background: Vascular microthrombotic lesions in lupus nephritis with or without antiphospholipid antibodies may relate to worse renal outcomes. Whether microthrombotic lesions are a consequence of renal inflammation or independently contribute to renal damage is unclear. Our aim was to investigate the relationship bet...

journal_title：Frontiers in immunology

authors： Gonzalo-Gil E,García-Herrero C,Toldos O,Usategui A,Criado G,Pérez-Yagüe S,Barber DF,Pablos JL,Galindo M

更新日期：2018-08-28 00:00:00

abstract：:Heat-shock protein 70 (Hsp70) is frequently found on the plasma membrane of a large number of malignant tumors including non-small cell lung cancer (NSCLC) and gets released into the blood circulation in lipid vesicles. On the one hand, a membrane (m)Hsp70-positive phenotype correlates with a high aggressiveness of th...

journal_title：Frontiers in immunology

authors： Gunther S,Ostheimer C,Stangl S,Specht HM,Mozes P,Jesinghaus M,Vordermark D,Combs SE,Peltz F,Jung MP,Multhoff G

更新日期：2015-11-02 00:00:00

abstract：:Skeletal health is maintained by bone remodeling, a process in which microscopic sites of effete or damaged bone are degraded on bone surfaces by osteoclasts and subsequently replaced by new bone, which is laid down by osteoblasts. This normal process can be disturbed in a variety of pathologic processes, including lo...

journal_title：Frontiers in immunology

authors： Boyce BF,Li J,Xing L,Yao Z

更新日期：2018-09-28 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle equipped with mechanisms for proper protein folding, trafficking, and degradation to maintain protein homeostasis in the secretory pathway. As a defense mechanism, perturbation of ER proteostasis by ER stress agents activates a cascade of signaling pathways from the ER to...

journal_title：Frontiers in immunology

authors： Li A,Song NJ,Riesenberg BP,Li Z

更新日期：2020-02-11 00:00:00

abstract：:The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

journal_title：Frontiers in immunology

authors： Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

更新日期：2020-12-23 00:00:00

abstract：:Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential induction of autoimmune responses that escape central and peripheral tole...

journal_title：Frontiers in immunology

authors： Javidi E,Magnus T

更新日期：2019-04-02 00:00:00

abstract：:The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of ...

journal_title：Frontiers in immunology

authors： Rubin DC,Shaker A,Levin MS

更新日期：2012-05-08 00:00:00

abstract：:Inflammation is a common characteristic of chronic liver disease (CLD). Inflammasomes are multiprotein complexes that can sense and recognize various exogenous and endogenous danger signals, eventually activating interleukin (IL)-1β and IL-18. The sensor component of the inflammasome system is a nucleotide-binding oli...

journal_title：Frontiers in immunology

authors： Wu X,Dong L,Lin X,Li J

更新日期：2017-12-12 00:00:00

abstract：:Schnitzler syndrome (SchS) is a rare autoinflammatory disease, characterized by urticarial rash, recurrent fever, osteo-articular pain/arthritis with bone condensation, and monoclonal gammopathy. Diagnosis may be difficult due to overlapping signs with other diseases. Here, we describe the case of a 62-year-old man wi...

journal_title：Frontiers in immunology

authors： Hodl I,Bosch P,Dreo B,Stradner MH

更新日期：2020-09-30 00:00:00

abstract：:Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS) is abundant in neural tissue, NOS2 is upregulated in a...

journal_title：Frontiers in immunology

authors： Mattila JT,Thomas AC

更新日期：2014-10-09 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the complex clinical phen...

journal_title：Frontiers in immunology

authors： Seleman M,Hoyos-Bachiloglu R,Geha RS,Chou J

更新日期：2017-07-24 00:00:00

abstract：:Mutants of a catalytically inactive variant of Proteinase 3 (PR3)-iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103-offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether such interactions can...

journal_title：Frontiers in immunology

authors： Pang YP,Casal Moura M,Thompson GE,Nelson DR,Hummel AM,Jenne DE,Emerling D,Volkmuth W,Robinson WH,Specks U

更新日期：2019-10-25 00:00:00

abstract：:Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing i...

journal_title：Frontiers in immunology

authors： Sancho D,Enamorado M,Garaude J

更新日期：2017-05-08 00:00:00

abstract：:Immunotherapies are rapidly being integrated into standard of care (SOC) therapy in conjunction with surgery, chemotherapy, and radiotherapy for many cancers and a large number of clinical studies continue to explore immunotherapy alone and as part of combination therapies in patients with cancer. It is evident that c...

journal_title：Frontiers in immunology

authors： Holl EK,Frazier VN,Landa K,Beasley GM,Hwang ES,Nair SK

更新日期：2019-07-31 00:00:00

abstract：:The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together with a...

journal_title：Frontiers in immunology

authors： Ubah OC,Steven J,Kovaleva M,Ferguson L,Barelle C,Porter AJR,Barelle CJ

更新日期：2017-12-22 00:00:00

abstract：:This review discusses the mechanisms and consequences of degradation of tryptophan (Trp) in the placenta, focusing mainly on the role of indoleamine 2,3-dioxygenase-1 (IDO1), one of three enzymes catalyzing the first step of the kynurenine pathway of Trp degradation. IDO1 has been implicated in regulation of feto-mate...

journal_title：Frontiers in immunology

authors： Sedlmayr P,Blaschitz A,Stocker R

更新日期：2014-05-19 00:00:00

abstract：:The global health burden associated with melanoma continues to increase while treatment options for metastatic melanoma are limited. Nevertheless, in the past decade, the field of cancer immunotherapy has witnessed remarkable advances for the treatment of a number of malignancies including metastatic melanoma. Althoug...

journal_title：Frontiers in immunology

authors： Sadozai H,Gruber T,Hunger RE,Schenk M

更新日期：2017-12-08 00:00:00

abstract：:M2 macrophage (Mφ) promotes pathologic angiogenesis through a release of pro-angiogenic mediators or the direct cell-cell interaction with endothelium in the micromilieu of several chronic inflammatory diseases, including rheumatoid arthritis and cancer, where interleukin (IL)-18 also contributes to excessive angiogen...

journal_title：Frontiers in immunology

authors： Kobori T,Hamasaki S,Kitaura A,Yamazaki Y,Nishinaka T,Niwa A,Nakao S,Wake H,Mori S,Yoshino T,Nishibori M,Takahashi H

更新日期：2018-03-06 00:00:00

abstract：:Autoimmune bullous dermatoses (AIBD) include a series of typical organ-specific autoimmune diseases characterized by extensive mucocutaneous blisters. It is generally accepted to be caused by pathological autoantibodies that directly target specific adhesion components of the skin or the adjacent mucous membranes. Bot...

journal_title：Frontiers in immunology

authors： Cao T,Shao S,Fang H,Li B,Wang G

更新日期：2019-08-02 00:00:00

abstract：:A body of evidence suggests that food allergy (FA) has increased in prevalence over the past few decades. Novel findings support the hypothesis that some commensal bacteria and particularly microbial metabolites might contribute to development of oral tolerance and prevention from FA. Recently, beneficial effects of s...

journal_title：Frontiers in immunology

authors： Luu M,Monning H,Visekruna A

更新日期：2020-06-16 00:00:00

abstract：:While developing adaptive immune responses, young infants are especially vulnerable to serious infections, including sepsis, meningitis, and pneumonia. Antimicrobial proteins and peptides (APPs) are key effectors that function as broad-spectrum anti-infectives. This review seeks to summarize the clinically relevant fu...

journal_title：Frontiers in immunology

authors： Battersby AJ,Khara J,Wright VJ,Levy O,Kampmann B

更新日期：2016-08-18 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, exten...

journal_title：Frontiers in immunology

authors： Herrada AA,Escobedo N,Iruretagoyena M,Valenzuela RA,Burgos PI,Cuitino L,Llanos C

更新日期：2019-04-15 00:00:00

abstract：:Plasminogen activation is essential for fibrinolysis-the breakdown of fibrin polymers in blood clots. Besides this important function, plasminogen activation participates in a wide variety of inflammatory conditions. One of these conditions is hereditary angioedema (HAE), a rare disease with characteristic attacks of ...

journal_title：Frontiers in immunology

authors： Maas C

更新日期：2019-08-27 00:00:00

abstract：:HERV-H endogenous retroviruses are thought to be essential to stem cell identity in humans. We embrace several decades of HERV-H research in order to relate the transcription of HERV-H loci to their genomic structure. We find that highly transcribed HERV-H loci are younger, more fragmented, and less likely to be prese...

journal_title：Frontiers in immunology

authors： Gemmell P,Hein J,Katzourakis A

更新日期：2019-07-09 00:00:00

abstract：:Cytokines are major players regulating immune responses toward inflammatory and tolerogenic results. In organ and bone marrow transplantation, new reagents are needed to inhibit tissue destructive mechanisms and eventually induce immune tolerance without overall immunosuppression. IL-34 is a cytokine with no significa...

journal_title：Frontiers in immunology

authors： Bézie S,Freuchet A,Sérazin C,Salama A,Vimond N,Anegon I,Guillonneau C

更新日期：2020-08-11 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, both in adults and children. It is characterized by an aberrant lipid storage in hepatocytes, named hepatic steatosis. Simple steatosis remains a benign process in most affected patients, while some of them develop superimp...

journal_title：Frontiers in immunology

authors： Meli R,Mattace Raso G,Calignano A

更新日期：2014-04-23 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection disrupts immune functions, including that of cytotoxic CD8+ T-cells which are important mediators of immune response. While HCV cure aims to eliminate long term sequelae of infection, whether direct-acting antiviral (DAA) treatment results in immune reconstitution remains uncl...

journal_title：Frontiers in immunology

authors： Vranjkovic A,Deonarine F,Kaka S,Angel JB,Cooper CL,Crawley AM

更新日期：2019-08-13 00:00:00

abstract：:Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed ...

journal_title：Frontiers in immunology

authors： Muire PJ,Mangum LH,Wenke JC

更新日期：2020-06-04 00:00:00