Follicular CD8+ T Cells: Origin, Function and Importance during HIV Infection.

abstract：:Despite the wide availability of antiretroviral therapy (ART) prophylaxis during pregnancy, >150,000 infants become infected through mother-to-child transmission (MTCT) of HIV worldwide. It is likely that additional intervention strategies, such as a maternal HIV vaccine, will be required to eliminate pediatric HIV in...

journal_title：Frontiers in immunology

authors： Douglas AO,Martinez DR,Permar SR

更新日期：2017-09-04 00:00:00

abstract：:There is an exponentially growing interest in targeting immune checkpoint molecules in breast cancer (BC), particularly in the triple-negative subtype where unmet treatment needs remain. This study was designed to analyze the expression, localization, and prognostic role of PD-1, PD-L1, PD-L2, CTLA-4, LAG3, and TIM3 i...

journal_title：Frontiers in immunology

authors： Solinas C,Garaud S,De Silva P,Boisson A,Van den Eynden G,de Wind A,Risso P,Rodrigues Vitória J,Richard F,Migliori E,Noël G,Duvillier H,Craciun L,Veys I,Awada A,Detours V,Larsimont D,Piccart-Gebhart M,Willard-Gallo K

更新日期：2017-10-30 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2020.01529.]. ...

journal_title：Frontiers in immunology

authors： Zhou JO,Zaidi HA,Ton T,Fera D

更新日期：2020-11-18 00:00:00

abstract：:Malaria remains a significant health problem in many tropical and sub-tropical regions. The development of vaccines against the clinically active blood-stage of infection needs to consider variability and polymorphism in target antigens, and an adjuvant system able to induce broad spectrum immunity comprising both ant...

journal_title：Frontiers in immunology

authors： Wilson KL,Pouniotis D,Hanley J,Xiang SD,Ma C,Coppel RL,Plebanski M

更新日期：2019-03-15 00:00:00

abstract：:HIV-2 infection is characterized by low viremia and slow disease progression as compared to HIV-1 infection. Circulating CD14++CD16+ monocytes were found to accumulate and CD11c+ conventional dendritic cells (cDC) to be depleted in a Portuguese cohort of people living with HIV-2 (PLWHIV-2), compared to blood bank heal...

journal_title：Frontiers in immunology

authors： Iannetta M,Isnard S,Manuzak J,Guillerme JB,Notin M,Bailly K,Andrieu M,Amraoui S,Vimeux L,Figueiredo S,Charmeteau-de Muylder B,Vaton L,Hatton EX,Samri A,Autran B,Thiébaut R,Chaghil N,Glohi D,Charpentier C,Descamps D

更新日期：2020-08-13 00:00:00

abstract：:Circumventricular organs (CVOs), neural structures located around the third and fourth ventricles, harbor, similarly to the choroid plexus, vessels devoid of a blood-brain barrier (BBB). This enables them to sense immune-stimulatory molecules in the blood circulation, but may also increase chances of exposure to micro...

journal_title：Frontiers in immunology

authors： Bentivoglio M,Kristensson K,Rottenberg ME

更新日期：2018-12-11 00:00:00

abstract：:The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is know...

journal_title：Frontiers in immunology

authors： Maeda DLNF,Batista MT,Pereira LR,de Jesus Cintra M,Amorim JH,Mathias-Santos C,Pereira SA,Boscardin SB,Silva SDR,Faquim-Mauro EL,Silveira VB,Oliveira DBL,Johnston SA,Ferreira LCS,Rodrigues JF

更新日期：2017-09-25 00:00:00

abstract：:In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the IL-22-pSTAT3 pathway have been identified as risk factors for inflammatory bowel disease (IBD) and some of them are considered as promising therapeutic targets. However, new pers...

journal_title：Frontiers in immunology

authors： Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW

更新日期：2018-11-05 00:00:00

abstract：:Cross-presentation of endocytosed antigen as peptide/class I major histocompatibility complex complexes plays a central role in the elicitation of CD8(+) T cell clones that mediate anti-viral and anti-tumor immune responses. While it has been clear that there are specific subsets of professional antigen presenting cel...

journal_title：Frontiers in immunology

authors： Compeer EB,Flinsenberg TW,van der Grein SG,Boes M

更新日期：2012-03-07 00:00:00

abstract：:Intestinal dysbiosis associated with immunological deregulation, leaky gut, bacterial translocation, and systemic inflammation has been associated with autoimmune diseases, such as type 1 diabetes (T1D). The aim of this study was to investigate the intestinal dysbiosis in T1D patients and correlate these results with ...

journal_title：Frontiers in immunology

authors： Higuchi BS,Rodrigues N,Gonzaga MI,Paiolo JCC,Stefanutto N,Omori WP,Pinheiro DG,Brisotti JL,Matheucci E Jr,Mariano VS,de Oliveira GLV

更新日期：2018-07-25 00:00:00

abstract：:The autoimmune regulator AIRE controls the negative selection of self-reactive T-cells as well as the induction of regulatory T-cells in the thymus by mastering the transcription and presentation of tissue restricted antigens (TRAs) in thymic cells. However, extrathymic AIRE expression of hitherto unknown clinical sig...

journal_title：Frontiers in immunology

authors： Bergström B,Lundqvist C,Vasileiadis GK,Carlsten H,Ekwall O,Ekwall AH

更新日期：2019-06-18 00:00:00

abstract：:Plasma cells (PCs), the B lineage cells responsible for producing and secreting antibodies (Abs), are critical cellular components of the humoral immune system. While most of the antibody-secreting cells in the body have a rather short lifetime of a few days, some of them can become long-lived and persist in the body ...

journal_title：Frontiers in immunology

authors： Lindquist RL,Niesner RA,Hauser AE

更新日期：2019-04-24 00:00:00

abstract：:Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between immune, glial, and neural cells is integral to the development of pathological pain. Modulation of these communications may hold the key to improved pain manag...

journal_title：Frontiers in immunology

authors： Vanderwall AG,Milligan ED

更新日期：2019-12-23 00:00:00

abstract：:Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of schizophrenia cases can be defined as having a "high inflammatory/immune biotype." Recent studies implicate both complement and macrophages i...

journal_title：Frontiers in immunology

authors： Purves-Tyson TD,Robinson K,Brown AM,Boerrigter D,Cai HQ,Weissleder C,Owens SJ,Rothmond DA,Shannon Weickert C

更新日期：2020-09-29 00:00:00

abstract：:Toll-like receptor 9 (TLR9) belongs to the group of endosomal receptors of the innate immune system with the ability to recognize hypomethylated CpG sequences from DNA. There is scarce information about TLR9 expression and its association with the circadian cycle (CC). Different patterns of TLR9 expression are regulat...

journal_title：Frontiers in immunology

authors： Martínez-García EA,Zavala-Cerna MG,Lujano-Benítez AV,Sánchez-Hernández PE,Martín-Márquez BT,Sandoval-García F,Vázquez-Del Mercado M

更新日期：2018-07-06 00:00:00

abstract：:DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune thrombocytopenia. B cells in DiGeorge syndrome show impaired maturation, wit...

journal_title：Frontiers in immunology

authors： Klocperk A,Paračková Z,Bloomfield M,Rataj M,Pokorný J,Unger S,Warnatz K,Šedivá A

更新日期：2018-07-23 00:00:00

abstract：:Overcoming the first line of the innate immune system is a general hallmark of pathogenic microbes to avoid recognition and to enter the human host. In particular, spirochetes belonging to the Borrelia burgdorferi sensu lato complex have developed various means to counter the immune response and to successfully surviv...

journal_title：Frontiers in immunology

authors： Kraiczy P

更新日期：2016-09-26 00:00:00

abstract：:Ataxia telangiectasia (AT) is a genetic condition caused by mutations involving ATM (Ataxia Telangiectasia Mutated). This gene is responsible for the expression of a DNA double stranded break repair kinase, the ATM protein kinase. The syndrome encompasses combined immunodeficiency and various degrees of neurological a...

journal_title：Frontiers in immunology

authors： Mandola AB,Reid B,Sirror R,Brager R,Dent P,Chakroborty P,Bulman DE,Roifman CM

更新日期：2019-12-20 00:00:00

abstract：:This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, ser...

journal_title：Frontiers in immunology

authors： Wang D,Jiang X,Teng S,Zhang Y,Liu Y,Li X,Li Y

更新日期：2019-05-08 00:00:00

abstract：:Crystallopathies are a heterogeneous group of diseases caused by intrinsic or environmental microparticles or crystals, promoting tissue inflammation and scarring. Certain proteins interfere with crystal formation and growth, e.g., with intrarenal calcium oxalate (CaOx) crystal formation, a common cause of kidney ston...

journal_title：Frontiers in immunology

authors： Steiger S,Grill JF,Ma Q,Bäuerle T,Jordan J,Smolle M,Böhland C,Lech M,Anders HJ

更新日期：2018-03-29 00:00:00

abstract：:The latest advancements in oncology research are focused on autologous immune cell therapy. However, the effectiveness of this type of immunotherapy for cancer remediation is not equivalent for all patients or cancer types. This suggests the need for better preclinical screening models that more closely recapitulate i...

journal_title：Frontiers in immunology

authors： Sherman H,Gitschier HJ,Rossi AE

更新日期：2018-04-23 00:00:00

abstract：:A novel coronavirus, which has been designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan China and causes the highly infectious disease referred to as COVID-19. COVID-19 has now spread worldwide to become a global pandemic affecting over 24 million pe...

journal_title：Frontiers in immunology

authors： Sharma O,Sultan AA,Ding H,Triggle CR

更新日期：2020-10-14 00:00:00

abstract：:Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polym...

journal_title：Frontiers in immunology

authors： Xu-Yang Z,Pei-Yu B,Chuan-Tao Y,Wei Y,Hong-Wei M,Kang T,Chun-Mei Z,Ying-Feng L,Xin W,Ping-Zhong W,Chang-Xing H,Xue-Fan B,Ying Z,Zhan-Sheng J

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll-like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important ...

journal_title：Frontiers in immunology

authors： Katare PB,Bagul PK,Dinda AK,Banerjee SK

更新日期：2017-06-22 00:00:00

abstract：:The immune response of a host to a pathogen is typically described as either innate or adaptive. The innate form of the immune response is conserved across all organisms, including insects. Previous and recent research has focused on the nature of the insect immune system and the results imply that the innate immune r...

journal_title：Frontiers in immunology

authors： Cooper D,Eleftherianos I

更新日期：2017-05-09 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.00702.]. ...

journal_title：Frontiers in immunology

authors： Ryffel B,Huang F,Robinet P,Panek C,Couillin I,Erard F,Piotet J,Le Bert M,Mackowiak C,Torres Arias M,Dimier-Poisson I,Zheng SG

更新日期：2020-10-28 00:00:00

abstract：:Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of human plasmablasts...

journal_title：Frontiers in immunology

authors： Pak HK,Nam B,Lee YK,Kim YW,Roh J,Son J,Chung YS,Choe J,Park CS

更新日期：2018-07-27 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a heterogeneous subset of lymphocytes deeply implicated in the innate immune responses to different pathogens, in lymphoid organogenesis and in the maintenance of tissue homeostasis. Group 3 innate lymphoid cells (ILC3) have been detected in human decidua, where they play a role in the...

journal_title：Frontiers in immunology

authors： Pelosi A,Alicata C,Tumino N,Ingegnere T,Loiacono F,Mingari MC,Moretta L,Vacca P

更新日期：2020-02-06 00:00:00

abstract：:Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential induction of autoimmune responses that escape central and peripheral tole...

journal_title：Frontiers in immunology

authors： Javidi E,Magnus T

更新日期：2019-04-02 00:00:00

abstract：:Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones. The aim of this study was to examine the role of miR-155 in controlling PAD4-dependent generation of NETs. Bone marr...

journal_title：Frontiers in immunology

authors： Hawez A,Al-Haidari A,Madhi R,Rahman M,Thorlacius H

更新日期：2019-11-01 00:00:00