1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.

abstract：:Autoimmune blistering diseases (AIBDs) of the skin are characterized by autoantibodies against different intra-/extracellular structures within the epidermis and at the basement membrane zone (BMZ). Binding of the antibodies to their target antigen leads to inflammation at the respective binding site and degradation o...

journal_title：Frontiers in immunology

authors： Olbrich M,Künstner A,Witte M,Busch H,Fähnrich A

更新日期：2019-10-15 00:00:00

abstract：:Piscirickettsia salmonis, an aggressive intracellular pathogen, is the etiological agent of salmonid rickettsial septicemia (SRS). This is a chronic multisystemic disease that generates high mortalities and large losses in Chilean salmon farming, threatening the sustainability of the salmon industry. Previous reports ...

journal_title：Frontiers in immunology

authors： Pérez-Stuardo D,Espinoza A,Tapia S,Morales-Reyes J,Barrientos C,Vallejos-Vidal E,Sandino AM,Spencer E,Toro-Ascuy D,Rivas-Pardo JA,Reyes-López FE,Reyes-Cerpa S

更新日期：2020-11-12 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2020.01529.]. ...

journal_title：Frontiers in immunology

authors： Zhou JO,Zaidi HA,Ton T,Fera D

更新日期：2020-11-18 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strateg...

journal_title：Frontiers in immunology

authors： Ochando J,Conde P,Utrero-Rico A,Paz-Artal E

更新日期：2019-03-06 00:00:00

abstract：:Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However, the clinical course following SCT appears to demonstrate many characteristics of dynamical systems, especially when outcomes are considered in the context of immune reconstitution. Dynamical systems tend to evolve over time acco...

journal_title：Frontiers in immunology

authors： Toor AA,Kobulnicky JD,Salman S,Roberts CH,Jameson-Lee M,Meier J,Scalora A,Sheth N,Koparde V,Serrano M,Buck GA,Clark WB,McCarty JM,Chung HM,Manjili MH,Sabo RT,Neale MC

更新日期：2014-12-03 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune neurological disorder typified by skeletal muscle fatigue and most often production of autoantibodies against the nicotinic acetylcholine receptor (AChR). The present study was undertaken to assess the extent of AChR-peptide recognition in MG patients using co-culturing (DC:TC) ...

journal_title：Frontiers in immunology

authors： Sharma S,Malmeström C,Lindberg C,Meisel S,Schön K,Verolin M,Lycke NY

更新日期：2017-10-24 00:00:00

abstract：:Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumstances (i.e., strong...

journal_title：Frontiers in immunology

authors： Agazio A,Cimons J,Shotts KM,Guo K,Santiago ML,Pelanda R,Torres RM

更新日期：2020-07-22 00:00:00

abstract：:We aimed to explore the prognostic value of blood leukocyte and to generate a predictive model to refine risk stratification for colorectal cancers. 6,558 patients with colorectal cancers were identified eligible respectively in Fudan University Shanghai Cancer Center (FUSCC) between May, 2008 and October, 2016. Then ...

journal_title：Frontiers in immunology

authors： Hu X,Li YQ,Li QG,Ma YL,Peng JJ,Cai SJ

更新日期：2018-10-12 00:00:00

abstract：:Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8+CD45RClow/- Tregs expressing Foxp3 and p...

journal_title：Frontiers in immunology

authors： Bézie S,Meistermann D,Boucault L,Kilens S,Zoppi J,Autrusseau E,Donnart A,Nerrière-Daguin V,Bellier-Waast F,Charpentier E,Duteille F,David L,Anegon I,Guillonneau C

更新日期：2018-01-31 00:00:00

abstract：:An essential role of the intestine is to build and maintain a barrier preventing the luminal gut microbiota from invading the host. This involves two coordinated physical and immunological barriers formed by single layers of intestinal epithelial and endothelial cells, which avoid the activation of local immune respon...

journal_title：Frontiers in immunology

authors： López-Posadas R,Stürzl M,Atreya I,Neurath MF,Britzen-Laurent N

更新日期：2017-10-05 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen presenting cells that are exquisitely adapted to sense pathogens and induce the development of adaptive immune responses. They form a complex network of phenotypically and functionally distinct subsets. Within this network, individual DC subsets display highly specific rol...

journal_title：Frontiers in immunology

authors： Chopin M,Allan RS,Belz GT

更新日期：2012-02-27 00:00:00

abstract：:Acute infection of bovine viral diarrhea virus (BVDV) is associated with immune dysfunction and can cause peripheral blood lymphopenia and lymphocyte apoptosis. Our previous study has confirmed that programmed death-1 (PD-1) blockade inhibits peripheral blood lymphocyte (PBL) apoptosis and restores proliferation and a...

journal_title：Frontiers in immunology

authors： Liu Y,Liu S,Wu C,Huang W,Xu B,Lian S,Wang L,Yue S,Chen N,Zhu Z

更新日期：2020-03-17 00:00:00

abstract：:In dairy herds, mastitis caused by Staphylococcus aureus is difficult to completely cure on the account that S. aureus can invade bovine mammary epithelial cells (BMECs) and result in persistent infection in the mammary gland. Recent studies have demonstrated that autophagy can participate in cell homeostasis by elimi...

journal_title：Frontiers in immunology

authors： Geng N,Wang X,Yu X,Wang R,Zhu Y,Zhang M,Liu J,Liu Y

更新日期：2020-05-05 00:00:00

abstract：:Anti-drug antibodies to coagulation factor VIII (fVIII), often termed inhibitors, present the greatest economical and treatment related obstacle in the management of hemophilia A. Although several genetic and environmental risk factors associated with inhibitor development have been identified, the precise mechanisms ...

journal_title：Frontiers in immunology

authors： Zakas PM,Healey JF,Smith IW,Lillicrap D,Lollar P

更新日期：2020-02-07 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) elite controllers (ELCs) represent a unique population that control viral replication in the absence of antiretroviral therapy (cART). It is well established that expression of multiple inhibitory receptors on CD8+ T cells is associated with HIV-1 disease progression. Howeve...

journal_title：Frontiers in immunology

authors： Noyan K,Nguyen S,Betts MR,Sönnerborg A,Buggert M

更新日期：2018-01-22 00:00:00

abstract：:Immunomodulation and chronic inflammation are important mechanisms utilized by cancer cells to evade the immune defense and promote tumor progression. Therefore, various efforts were focused on the development of approaches to reprogram the immune response to increase the immune detection of cancer cells and enhance p...

journal_title：Frontiers in immunology

authors： Hammoudeh SM,Venkatachalam T,Ansari AW,Bendardaf R,Hamid Q,Rahmani M,Hamoudi R

更新日期：2020-12-14 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which is different from linear RNA. CircRNA is an RNA molecule with a closed loop structure formed by reverse splicing. CircRNAs have been studied in several organisms, however, the circRNAs associated with the response to Salmonella enterica serovar En...

journal_title：Frontiers in immunology

authors： Zheng L,Liu L,Lin L,Tang H,Fan X,Lin H,Li X

更新日期：2019-05-31 00:00:00

abstract：:Tumor-mediated regulation of the host immune system involves an intricate signaling network that results in the tumor's inherent survival benefit. Myeloid cells are central in orchestrating the mechanisms by which tumors escape immune detection and continue their proliferative programming. Myeloid cell activation has ...

journal_title：Frontiers in immunology

authors： Davidov V,Jensen G,Mai S,Chen SH,Pan PY

更新日期：2020-09-02 00:00:00

abstract：:Dendritic epidermal T cells (DETCs) and dermal Vγ4 T cells engage in wound re-epithelialization and skin inflammation. However, it remains unknown whether a functional link between Vγ4 T cell pro-inflammation and DETC pro-healing exists to affect the outcome of skin wound closure. Here, we revealed that Vγ4 T cell-der...

journal_title：Frontiers in immunology

authors： Li Y,Wang Y,Zhou L,Liu M,Liang G,Yan R,Jiang Y,Hao J,Zhang X,Hu X,Huang Y,Wang R,Yin Z,Wu J,Luo G,He W

更新日期：2018-02-12 00:00:00

abstract：:The development of autoimmunity involves complex interactions between genetics and environmental triggers. The gut microbiota is an important environmental constituent that can heavily influence both local and systemic immune reactivity through distinct mechanisms. It is therefore a relevant environmental trigger or a...

journal_title：Frontiers in immunology

authors： Brown J,Robusto B,Morel L

更新日期：2020-08-04 00:00:00

abstract：:Despite the ever present need for an effective Mycobacterium tuberculosis (Mtb) vaccine, efforts for development have been largely unsuccessful. Correlates of immune protection against Mtb are not wholly defined, but Th1 and likely Th17 adaptive immune responses have been demonstrated to be necessary for vaccine-media...

journal_title：Frontiers in immunology

authors： Smith AJ,Miller SM,Buhl C,Child R,Whitacre M,Schoener R,Ettenger G,Burkhart D,Ryter K,Evans JT

更新日期：2019-02-28 00:00:00

abstract：:Altered macrophage infiltration upon tissue damage results in inadequate healing due to inappropriate remodeling and stem cell recruitment and differentiation. We investigated in vivo whether cells of endothelial origin phenotypically change upon heterotopic ossification induction and whether infiltration of innate im...

journal_title：Frontiers in immunology

authors： Tirone M,Giovenzana A,Vallone A,Zordan P,Sormani M,Nicolosi PA,Meneveri R,Gigliotti CR,Spinelli AE,Bocciardi R,Ravazzolo R,Cifola I,Brunelli S

更新日期：2019-07-19 00:00:00

abstract：:The rabbit monoclonal antibodies (mAbs) have advantages in pharmaceuticals and diagnostics with high affinity and specificity. During the past decade, many techniques have been developed for isolating rabbit mAbs, including single B cell antibody technologies. This review describes the basic characterization of rabbit...

journal_title：Frontiers in immunology

authors： Zhang Z,Liu H,Guan Q,Wang L,Yuan H

更新日期：2017-05-05 00:00:00

abstract：:Mycolic acid (MA), a major lipid component of Mycobacterium tuberculosis (Mtb) cell wall, can be presented by the non-polymorphic antigen presenting molecule CD1b to T cells isolated from Mtb-infected individuals. These MA-specific CD1b-restricted T cells are cytotoxic, produce Th1 cytokines, and form memory populatio...

journal_title：Frontiers in immunology

authors： Shang S,Kats D,Cao L,Morgun E,Velluto D,He Y,Xu Q,Wang CR,Scott EA

更新日期：2018-11-27 00:00:00

abstract：:People are constantly exposed to airborne fungal spores, including Aspergillus fumigatus conidia that can cause life-threatening conditions in immunocompromised patients or acute exacerbations in allergics. However, immunocompetent hosts do not exhibit mycoses or systemic inflammation, due to the sufficient but not ex...

journal_title：Frontiers in immunology

authors： Bogorodskiy AO,Bolkhovitina EL,Gensch T,Troyanova NI,Mishin AV,Okhrimenko IS,Braun A,Spies E,Gordeliy VI,Sapozhnikov AM,Borshchevskiy VI,Shevchenko MA

更新日期：2020-02-25 00:00:00

abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies target the hemidesmosomal components BP180 and/or BP230 in basal keratinocytes. In BP, 80 to 90% of autoantibodies target the juxtamembranous extracellular non-collagenous 16th A (NC16A) domain of BP180. Recently, the administrat...

journal_title：Frontiers in immunology

authors： Mai Y,Nishie W,Izumi K,Shimizu H

更新日期：2019-05-29 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for many types of hematological malignancies. Matching of donor and recipient for the major histocompatibility complex (MHC) improves the HSCT reconstitution, but donor-derived T cells reactive to non-MHC encoded minor histocompat...

journal_title：Frontiers in immunology

authors： Choi EY,Choi K,Nam G,Kim W,Chung M

更新日期：2020-06-10 00:00:00

abstract：:T cells recognizing epitopes on the surface of mycobacteria-infected macrophages can impart protection, but with associated risk for reactivation to lung pathology. We aimed to identify antibodies specific to such epitopes, which carry potentials for development toward novel therapeutic constructs. Since epitopes pres...

journal_title：Frontiers in immunology

authors： Ortega PA,Silva-Miranda M,Torres-Larios A,Campos-Chávez E,Franken KCLCM,Ottenhoff THM,Ivanyi J,Espitia C

更新日期：2020-10-02 00:00:00

abstract：:Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4+Foxp3+ regulatory T cells (Tregs) constitutively express the high affinity IL-2 receptor (CD25/IL-2Rα) and rapidly respond to IL-2 to elaborate numerous suppressive mechanisms that limit immune-me...

journal_title：Frontiers in immunology

authors： Abo H,Flannigan KL,Geem D,Ngo VL,Harusato A,Denning TL

更新日期：2019-03-14 00:00:00

abstract：:[This corrects the article on p. 998 in vol. 9, PMID: 29867975.]. ...

journal_title：Frontiers in immunology

authors： Varesano S,Zocchi MR,Poggi A

更新日期：2018-06-13 00:00:00