Canine Neutrophil Extracellular Traps Release Induced by the Apicomplexan Parasite Neospora caninum In Vitro.

abstract：:Modern animal and crop production practices are associated with the regular use of antimicrobials, potentially increasing selection pressure on bacteria to become resistant. Alternative approaches are needed in order to satisfy the demands of the growing human population without the indiscriminate use of antimicrobial...

journal_title：Frontiers in immunology

authors： Villena J,Kitazawa H,Van Wees SCM,Pieterse CMJ,Takahashi H

更新日期：2018-09-27 00:00:00

abstract：:Clinically isolated syndrome (CIS) is a first episode of neurological symptoms that may precede a diagnosis of multiple sclerosis (MS). Therefore, studying individuals with CIS may lead to breakthroughs in understanding the development and pathogenesis of MS. In this study, serum levels of immunoglobulin (Ig)G, IgA, I...

journal_title：Frontiers in immunology

authors： Trend S,Jones AP,Cha L,Byrne SN,Geldenhuys S,Fabis-Pedrini MJ,Carroll WM,Cole JM,Booth DR,Lucas RM,Kermode AG,French MA,Hart PH

更新日期：2018-07-13 00:00:00

abstract：:Previous studies have shown targeting different tissues via the transcutaneous (TC) and intramuscular injection (IM) with or without electroporation (EP) has the potential to trigger immune responses to DNA vaccination. The CUTHIVTHER 001 Phase I/II randomized controlled clinical trial was designed to determine whethe...

journal_title：Frontiers in immunology

authors： Haidari G,Day S,Wood M,Ridgers H,Cope AV,Fleck S,Yan C,Reijonen K,Hannaman D,Spentzou A,Hayes P,Vogt A,Combadiere B,Cook A,McCormack S,Shattock RJ

更新日期：2019-12-13 00:00:00

abstract：:Plasma cells (PCs) are essentially characterized by the co-expression of CD138 and CD38, which allows their identification in flow cytometry in bone marrow (BM), peripheral blood, or cell suspensions from tissues. These terminally differentiated B-cells may lose the expression of surface CD19 and that of CD20 while re...

journal_title：Frontiers in immunology

authors： Robillard N,Wuillème S,Moreau P,Béné MC

更新日期：2014-03-31 00:00:00

abstract：:Multiple Myeloma (MM) is a hematological cancer characterized by proliferation of malignant plasma cells in the bone marrow (BM). MM represents the second most frequent hematological malignancy, accounting 1% of all cancer and 13% of hematological tumors, with ~9,000 new cases per year. Patients with monoclonal gammop...

journal_title：Frontiers in immunology

authors： Morandi F,Horenstein AL,Costa F,Giuliani N,Pistoia V,Malavasi F

更新日期：2018-11-28 00:00:00

abstract：:Autoimmune myopathies (myositides) are strongly associated with malignancy. The link between myositis and cancer, originally noticed by Bohan and Peter in their classification in 1975 (1), has been evidenced by large population-based cohort studies and a recent meta-analysis. The numerous reports of cases in which the...

journal_title：Frontiers in immunology

authors： Aussy A,Boyer O,Cordel N

更新日期：2017-08-21 00:00:00

abstract：:Objective: Postoperative ileus (POI) is an inflammation-mediated complication of abdominal surgery, characterized by intestinal dysmotility and leukocyte infiltration into the muscularis externa (ME). Previous studies indicated that interleukin (IL)-10 is crucial for the resolution of a variety of inflammation-driven ...

journal_title：Frontiers in immunology

authors： Stein K,Lysson M,Schumak B,Vilz T,Specht S,Heesemann J,Roers A,Kalff JC,Wehner S

更新日期：2018-11-13 00:00:00

abstract：:Autoimmune bullous dermatoses (AIBD) include a series of typical organ-specific autoimmune diseases characterized by extensive mucocutaneous blisters. It is generally accepted to be caused by pathological autoantibodies that directly target specific adhesion components of the skin or the adjacent mucous membranes. Bot...

journal_title：Frontiers in immunology

authors： Cao T,Shao S,Fang H,Li B,Wang G

更新日期：2019-08-02 00:00:00

abstract：:B cells in fish were recently proven to have potent innate immune activities like macrophages. This inspired us to further explore the innate nature of B cells in fish. Moreover, antimicrobial peptides (AMPs) are representative molecules of innate immunity, and they can modulate the functions of macrophages. These mak...

journal_title：Frontiers in immunology

authors： Zhang XJ,Wang P,Zhang N,Chen DD,Nie P,Li JL,Zhang YA

更新日期：2017-04-04 00:00:00

abstract：:Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent ...

journal_title：Frontiers in immunology

authors： Blomberg J,Gottfries CG,Elfaitouri A,Rizwan M,Rosén A

更新日期：2018-02-15 00:00:00

abstract：:Epstein Barr virus (EBV) is a gamma herpes virus associated with certain malignancies and autoimmune diseases. EBV maintains latency in B cells with occasional reactivation, in part by overcoming the host immune response with viral homologs of several human proteins. EBV interleukin 10 (vIL-10), a lytic phase protein,...

journal_title：Frontiers in immunology

authors： Jog NR,Chakravarty EF,Guthridge JM,James JA

更新日期：2018-10-09 00:00:00

abstract：:One of the main functions of the human placenta is to provide a barrier between the fetal and maternal blood circulations, where gas exchange and transfer of nutrients to the developing fetus take place. Despite being a barrier, there is a multitude of crosstalk between maternal immune cells and fetally derived semi-a...

journal_title：Frontiers in immunology

authors： Kaipe H,Raffetseder J,Ernerudh J,Solders M,Tiblad E

更新日期：2020-08-19 00:00:00

abstract：:Scavenger receptors are cell surface membrane-bound receptors that typically bind multiple ligands and promote the removal of endogenous proteins and pathogens. In this study, we characterized a novel scavenger receptor-like protein, namely, SpBark. SpBark was upregulated in hemocytes after challenges with bacteria, s...

journal_title：Frontiers in immunology

authors： Li XC,Zhou J,Zhou JF,Wang Y,Ma H,Wang Y,Zhao S,Fang WH

更新日期：2019-08-23 00:00:00

abstract：:Schistosomiasis, caused by Schistosoma mansoni trematode worm, affects more than 1.5 million people in Brazil. The current treatment consists in the administration of Praziquantel, the only medicine used for treatment for more than 40 years. Some of the limitations of this drug consist in its inactivity against schist...

journal_title：Frontiers in immunology

authors： Cagnazzo TDO,Nogueira CT,de Castro CA,Neris DM,Fattori ACM,Correia RO,Albuquerque YR,Fragelli BDL,Mendes TMF,Allegretti SM,Soares EG,Romanello L,Torini JR,Pereira HD,Anibal FF

更新日期：2020-09-23 00:00:00

abstract：:Despite continuous exposure and development of specific immunity, Staphylococcus aureus (Sa) remains one of the leading causes of severe infections worldwide. Although innate immune defense mechanisms are well understood, the role of the T cell response has not been fully elucidated. Here, we demonstrate that Sa and o...

journal_title：Frontiers in immunology

authors： Uebele J,Habenicht K,Ticha O,Bekeredjian-Ding I

更新日期：2020-09-30 00:00:00

abstract：:As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated immunization of stages IIB-III CM patients with the irradiated, allogeneic cellular CSF-470 vaccine plu...

journal_title：Frontiers in immunology

authors： Pampena MB,Cartar HC,Cueto GR,Levy EM,Blanco PA,Barrio MM,Mordoh J

更新日期：2018-11-02 00:00:00

abstract：:The RTS,S/AS01 vaccine provides partial protection against Plasmodium falciparum infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associated with RTS,S/AS01 efficacy against controlled human malaria infect...

journal_title：Frontiers in immunology

authors： Du Y,Thompson EG,Muller J,Valvo J,Braun J,Shankar S,van den Berg RA,Jongert E,Dover D,Sadoff J,Hendriks J,Gardner MJ,Ballou WR,Regules JA,van der Most R,Aderem A,Ockenhouse CF,Hill AV,Wille-Reece U,Zak DE

更新日期：2020-04-28 00:00:00

abstract：:The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae, the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alteratio...

journal_title：Frontiers in immunology

authors： Silva CAM,Belisle JT

更新日期：2018-02-02 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous hyperinflammatory syndrome with different pathways of pathogenesis resulting in similar clinical presentations. It is best defined and understood if presenting in the context of genetic immunodeficiencies associated with defects of lymphocyte cytotoxicity. In...

journal_title：Frontiers in immunology

authors： Wegehaupt O,Wustrau K,Lehmberg K,Ehl S

更新日期：2020-05-08 00:00:00

abstract：:Monocytes are critical defense components that play an important role in the primary innate immune response. The heterogeneous nature of monocytes and their ability to differentiate into either monocyte-derived macrophages or monocyte-derived dendritic cells allows them to serve as a bridge between the innate and adap...

journal_title：Frontiers in immunology

authors： Sampath P,Moideen K,Ranganathan UD,Bethunaickan R

更新日期：2018-07-30 00:00:00

abstract：:Pertussis or whooping cough, mainly caused by Bordetella pertussis, is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. Vaccines against this disease are widely available since the 1950s. Despite high global vaccination coverage, the disease ...

journal_title：Frontiers in immunology

authors： Solans L,Locht C

更新日期：2019-01-14 00:00:00

abstract：:Food allergy is an atopic disease that is caused by the immune system targeting harmless food antigens that can result in life-threatening anaphylaxis. As humans and microbes have co-evolved, inevitably commensal microbes have a tremendous impact on our health. As such, the gut with its enormous microbial richness ref...

journal_title：Frontiers in immunology

authors： Kreft L,Hoffmann C,Ohnmacht C

更新日期：2020-08-14 00:00:00

abstract：:Leprosy serology reflects the bacillary load of patients and multidrug therapy (MDT) reduces Mycobacterium leprae-specific antibody titers of multibacillary (MB) patients. The Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil (U-MDT/CT-BR) compared outcomes of regular 12 doses MDT/R-M...

journal_title：Frontiers in immunology

authors： Hungria EM,Bührer-Sékula S,Oliveira RM,Aderaldo LC,Pontes MAA,Cruz R,de Gonçalves HS,Penna MLF,Penna GO,Stefani MMA

更新日期：2018-05-14 00:00:00

abstract：:B-1 cells constitute a unique subpopulation of lymphocytes residing mainly in body cavities like the peritoneal cavity (PerC) but are also found in spleen and bone marrow (BM). As innate-like B cells, they mediate first line immune defense through low-affinity natural IgM (nIgM) antibodies. PerC B-1 cells can egress t...

journal_title：Frontiers in immunology

authors： Bröker K,Figge J,Magnusen AF,Manz RA,Köhl J,Karsten CM

更新日期：2018-02-19 00:00:00

abstract：:Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has...

journal_title：Frontiers in immunology

authors： Dougan M

更新日期：2017-11-15 00:00:00

abstract：:The global health burden associated with melanoma continues to increase while treatment options for metastatic melanoma are limited. Nevertheless, in the past decade, the field of cancer immunotherapy has witnessed remarkable advances for the treatment of a number of malignancies including metastatic melanoma. Althoug...

journal_title：Frontiers in immunology

authors： Sadozai H,Gruber T,Hunger RE,Schenk M

更新日期：2017-12-08 00:00:00

abstract：:Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, w...

journal_title：Frontiers in immunology

authors： Dios-Esponera A,Melis N,Subramanian BC,Weigert R,Samelson LE

更新日期：2019-03-05 00:00:00

abstract：:Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on α7 nicotinic acetylcho...

journal_title：Frontiers in immunology

authors： Cao M,MacDonald JW,Liu HL,Weaver M,Cortes M,Durosier LD,Burns P,Fecteau G,Desrochers A,Schulkin J,Antonelli MC,Bernier RA,Dorschner M,Bammler TK,Frasch MG

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from i...

journal_title：Frontiers in immunology

authors： Castro Eiro MD,Alvarez MG,Cooley G,Viotti RJ,Bertocchi GL,Lococo B,Albareda MC,De Rissio AM,Natale MA,Parodi C,Tarleton RL,Laucella SA

更新日期：2017-09-15 00:00:00

abstract：:The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion ...

journal_title：Frontiers in immunology

authors： Jia W,He MX,McLeod IX,He YW

更新日期：2013-07-04 00:00:00