Abstract:
:Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin. Although CD4(+) T cell function in MS pathology has been extensively studied, there is also strong evidence that CD8(+) T lymphocytes play a key role. Intriguingly, CD8(+) T cells accumulate in great numbers in the CNS in progressive MS, a form of the disease that is refractory to current disease-modifying therapies that target the CD4(+) T cell response. Here, we discuss the function of CD8(+) T cells in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. In particular, we describe EAE in non-obese diabetic (NOD) background mice, which develop a pattern of disease characterized by multiple attacks and remissions followed by a progressively worsening phase. This is highly reminiscent of the pattern of disease observed in nearly half of MS patients. Particular attention is paid to a newly described transgenic mouse strain (1C6) on the NOD background whose CD4(+) and CD8(+) T cells are directed against the encephalitogenic peptide MOG[35-55]. Use of this model will give us a more complete picture of the role(s) played by distinct T cell subsets in CNS autoimmunity.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Ignatius Arokia Doss PM,Roy AP,Wang A,Anderson AC,Rangachari Mdoi
10.3389/fimmu.2015.00541subject
Has Abstractpub_date
2015-10-22 00:00:00pages
541issn
1664-3224journal_volume
6pub_type
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abstract::Among kidney transplant recipients, the treatment of choice for acute T cell-mediated rejection (TCMR) with pulse steroids or antibody protocols has variable outcomes. Some rejection episodes are resistant to an initial steroid pulse, but respond to subsequent antibody protocols. The biological mechanisms causing the ...
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pub_type: 杂志文章
doi:10.3389/fimmu.2020.00083
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fimmu.2017.01924
更新日期:2018-01-04 00:00:00
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2020.586669
更新日期:2020-10-07 00:00:00
abstract::Viral defense at mucosal sites depends on interferons (IFN) and IFN stimulated genes (ISGs), either of which may be constitutively expressed to maintain an "antiviral state" (AVS). However, the mechanisms that govern the AVS are poorly defined. Using a BEAS-2B respiratory epithelial cell line deficient in IRF1, we dem...
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pub_type: 杂志文章
doi:10.3389/fimmu.2019.01019
更新日期:2019-05-15 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.00857
更新日期:2018-04-23 00:00:00
abstract::The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration, crossing of biologic...
journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
doi:10.3389/fimmu.2015.00586
更新日期:2015-11-18 00:00:00
abstract::Macrophages form an important component of the innate immune system and serve as first responders against invading pathogens. While pathways critical for initiation of inflammatory responses between macrophages and other LysM+ myeloid cells are largely similar, it remains unknown whether a specific pathway has differe...
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pub_type: 杂志文章
doi:10.3389/fimmu.2018.02882
更新日期:2018-12-06 00:00:00
abstract::[This corrects the article on p. 998 in vol. 9, PMID: 29867975.]. ...
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pub_type: 杂志文章,已发布勘误
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更新日期:2018-06-13 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2015-06-29 00:00:00
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pub_type: 杂志文章
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更新日期:2014-06-30 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-06-25 00:00:00