Time Course of Immune Response and Immunomodulation During Normal and Delayed Healing of Musculoskeletal Wounds.

abstract：:The development of stable and long-circulating liposomes provides protection of the drug cargo from degradation and increases tumor drug delivery, leading to the design of liposome formulations with great potential in cancer therapy. However, despite the sound pharmacologic basis, many liposomal as well as other nanop...

journal_title：Frontiers in immunology

authors： La-Beck NM,Gabizon AA

更新日期：2017-04-06 00:00:00

abstract：:Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro generated OT-II T helper (Th) 1 cells into C57BL/6 mice (Thy1.2+) and then either ...

journal_title：Frontiers in immunology

authors： Langenhorst D,Haack S,Göb S,Uri A,Lühder F,Vanhove B,Hünig T,Beyersdorf N

更新日期：2018-05-16 00:00:00

abstract：:Scavenger receptors are cell surface membrane-bound receptors that typically bind multiple ligands and promote the removal of endogenous proteins and pathogens. In this study, we characterized a novel scavenger receptor-like protein, namely, SpBark. SpBark was upregulated in hemocytes after challenges with bacteria, s...

journal_title：Frontiers in immunology

authors： Li XC,Zhou J,Zhou JF,Wang Y,Ma H,Wang Y,Zhao S,Fang WH

更新日期：2019-08-23 00:00:00

abstract：:Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expressio...

journal_title：Frontiers in immunology

authors： Liu Y,Munker S,Müllenbach R,Weng HL

更新日期：2012-05-11 00:00:00

abstract：:Thrombocytes, nucleated hemostatic blood cells of non-mammalian vertebrates, are regarded as the functional equivalent of anucleated mammalian platelets. Additional immune functions, including phagocytosis, have also been suggested for thrombocytes, but no conclusive molecular or cellular experimental evidence for the...

journal_title：Frontiers in immunology

authors： Nagasawa T,Nakayasu C,Rieger AM,Barreda DR,Somamoto T,Nakao M

更新日期：2014-09-16 00:00:00

abstract：:Kidney damage is a well-recognized complication of the antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-associated APS. Kidney involvement in APS involves a variety of manifestations, such as renal artery thrombosis or stenosis, renal vein thrombosis, allograft loss due to thrombos...

journal_title：Frontiers in immunology

authors： Tektonidou MG

更新日期：2018-05-31 00:00:00

abstract：:CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecules, we administered OM-conjugated murine myelin oligodendrocyte glycoprotein pept...

journal_title：Frontiers in immunology

authors： Dagkonaki A,Avloniti M,Evangelidou M,Papazian I,Kanistras I,Tseveleki V,Lampros F,Tselios T,Jensen LT,Möbius W,Ruhwedel T,Androutsou ME,Matsoukas J,Anagnostouli M,Lassmann H,Probert L

更新日期：2020-11-19 00:00:00

abstract：:In primary systemic small vessel vasculitis autoantibodies are common and seem to play an important role in the pathogenesis. Autoantibodies in vasculitis are preferentially directed against components of the immune system or directly against components of the vessel wall. Plasmapheresis is often applied in emergency ...

journal_title：Frontiers in immunology

authors： Segelmark M,Björck L

更新日期：2019-09-20 00:00:00

abstract：:Autoimmune diseases, such as systemic lupus erythematosus, are characterized by excessive inflammation in response to self-antigens. Loss of appropriate immunoregulatory mechanisms contribute to disease exacerbation. We previously showed the suppressive effect of vancomycin treatment during the "active-disease" stage ...

journal_title：Frontiers in immunology

authors： Mu Q,Edwards MR,Swartwout BK,Cabana Puig X,Mao J,Zhu J,Grieco J,Cecere TE,Prakash M,Reilly CM,Puglisi C,Bachali P,Grammer AC,Lipsky PE,Luo XM

更新日期：2020-11-10 00:00:00

abstract：:For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment ...

journal_title：Frontiers in immunology

authors： Caratelli S,Sconocchia T,Arriga R,Coppola A,Lanzilli G,Lauro D,Venditti A,Del Principe MI,Buccisano F,Maurillo L,Ferrone S,Sconocchia G

更新日期：2017-04-27 00:00:00

abstract：:Immunoediting is an important concept in oncology, delineating the mechanisms through which tumors are selected for resistance to immune-mediated elimination. The recent emergence of immunotherapies, such as checkpoint inhibitors, as pillars of cancer therapy has intensified interest in immunoediting as a constraint l...

journal_title：Frontiers in immunology

authors： Huang SH,McCann CD,Mota TM,Wang C,Lipkin SM,Jones RB

更新日期：2019-08-06 00:00:00

abstract：:Extracellular vesicle or EV is a term that encompasses all classes of secreted lipid membrane vesicles. Despite being scientific novelties, EVs are gaining importance as a mediator of important physiological and pathological intercellular activities possibly through the transfer of their cargo of protein and RNA betwe...

journal_title：Frontiers in immunology

authors： Zhang B,Yin Y,Lai RC,Lim SK

更新日期：2014-10-22 00:00:00

abstract：:The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together with a...

journal_title：Frontiers in immunology

authors： Ubah OC,Steven J,Kovaleva M,Ferguson L,Barelle C,Porter AJR,Barelle CJ

更新日期：2017-12-22 00:00:00

abstract：:Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and arises from developing sympathetic nervous system. Most primary tumors localize in the abdomen, the adrenal gland, or lumbar sympathetic ganglia. Amplification in tumor cells of MYCN, the major oncogenic driver, patients' age over 18 mont...

journal_title：Frontiers in immunology

authors： Bottino C,Dondero A,Bellora F,Moretta L,Locatelli F,Pistoia V,Moretta A,Castriconi R

更新日期：2014-02-12 00:00:00

abstract：:Recent genome-wide studies have revealed the presence of thousands of long non-protein-coding RNAs (lncRNAs), some of which may play critical roles in the cell. We have previously shown that a large number of lncRNAs show differential expression in response to interferon (IFN)α stimulation in primary human cells. Here...

journal_title：Frontiers in immunology

authors： Kambara H,Gunawardane L,Zebrowski E,Kostadinova L,Jobava R,Krokowski D,Hatzoglou M,Anthony DD,Valadkhan S

更新日期：2015-01-30 00:00:00

abstract：Objective:To examine the utility of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as biomarkers of prognosis in seropositive autoimmune encephalitis (AE). Methods:In this multicenter study, we retrospectively analyzed 57 cases of seropositive AE with hospital admissio...

journal_title：Frontiers in immunology

authors： Broadley J,Wesselingh R,Seneviratne U,Kyndt C,Beech P,Buzzard K,Nesbitt C,D'Souza W,Brodtmann A,Kalincik T,Butzkueven H,O'Brien TJ,Monif M,Australian Autoimmune Encephalitis Consortium.

更新日期：2021-01-14 00:00:00

abstract：:Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes hallmark debilitating polyarthralgia, fever, and rash in patients. T cell-mediated immunity, especially CD4+ T cells, are known to participate in the pathogenic role of CHIKV immunopathology. The other T cell subsets, notably CD8+, NKT, and gamma-d...

journal_title：Frontiers in immunology

authors： Poh CM,Chan YH,Ng LFP

更新日期：2020-02-21 00:00:00

abstract：:Dendritic cell (DCs) activation by Toll-like receptor (TLR) agonist induces robust metabolic rewiring toward glycolysis. Recent findings in the field identified mechanistic details governing these metabolic adaptations. However, it is unknown whether a switch to glycolysis from oxidative phosphorylation (OXPHOS) is a ...

journal_title：Frontiers in immunology

authors： Basit F,de Vries IJM

更新日期：2019-10-15 00:00:00

abstract：:Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent ...

journal_title：Frontiers in immunology

authors： Blomberg J,Gottfries CG,Elfaitouri A,Rizwan M,Rosén A

更新日期：2018-02-15 00:00:00

abstract：:Effector T cells exit the inflamed vasculature into an environment shaped by tissue-specific structural configurations and inflammation-imposed extrinsic modifications. Once within interstitial spaces of non-lymphoid tissues, T cells migrate in an apparent random, non-directional, fashion. Efficient T cell scanning of...

journal_title：Frontiers in immunology

authors： Gaylo A,Schrock DC,Fernandes NR,Fowell DJ

更新日期：2016-10-14 00:00:00

abstract：:Recent clinical observations indicate that bacterial vaccines induce cross-protection against infections produced by different microorganisms. MV130, a polyvalent bacterial sublingual preparation designed to prevent recurrent respiratory infectious diseases, reduces the infection rate in patients with recurrent respir...

journal_title：Frontiers in immunology

authors： Vázquez A,Fernández-Sevilla LM,Jiménez E,Pérez-Cabrera D,Yañez R,Subiza JL,Varas A,Valencia J,Vicente A

更新日期：2020-11-19 00:00:00

abstract：:Retinoic acid inducible gene I (RIG-I) is associated to the DExD/H box RNA helicases. It is a pattern recognition receptor (PRR), playing a crucial role in the system and is a germ line encoded host sensor to perceive pathogen-associated molecular patterns (PAMPs). So far, reports are available for the role of RIG-I i...

journal_title：Frontiers in immunology

authors： Banerjee S,Pal A,Pal A,Mandal SC,Chatterjee PN,Chatterjee JK

更新日期：2021-01-08 00:00:00

abstract：:The complement system represents an effective arsenal of innate immunity as well as an interface between innate and adaptive immunity. Activation of the complement system culminates with the assembly of the C5b-9 terminal complement complex on cell membranes, inducing target cell lysis. Translation of this sequence of...

journal_title：Frontiers in immunology

authors： Vlaicu SI,Tatomir A,Rus V,Rus H

更新日期：2019-05-09 00:00:00

abstract：:Interleukin 10 is a central regulator of the antigen-presenting function of myeloid cells. It exerts immunomodulatory effects in vivo and induces a regulatory phenotype in monocyte-derived cells in vitro. We analyzed phenotype and function of monocytic cells in vitro in relation to the cytokine milieu and the timing o...

journal_title：Frontiers in immunology

authors： Krakow S,Crescimone ML,Bartels C,Wiegering V,Eyrich M,Schlegel PG,Wölfl M

更新日期：2019-06-28 00:00:00

abstract：:The apoptosis of hemocytes plays an essential function in shrimp immune defense against pathogen invasions. In order to further elucidate the differential apoptotic responses of the granulocytes and the hyalinocytes in Fenneropenaeus chinensis post WSSV infection, the characteristics of apoptotic dynamics and viral pr...

journal_title：Frontiers in immunology

authors： Cui C,Liang Q,Tang X,Xing J,Sheng X,Zhan W

更新日期：2020-12-07 00:00:00

abstract：:Viral defense at mucosal sites depends on interferons (IFN) and IFN stimulated genes (ISGs), either of which may be constitutively expressed to maintain an "antiviral state" (AVS). However, the mechanisms that govern the AVS are poorly defined. Using a BEAS-2B respiratory epithelial cell line deficient in IRF1, we dem...

journal_title：Frontiers in immunology

authors： Panda D,Gjinaj E,Bachu M,Squire E,Novatt H,Ozato K,Rabin RL

更新日期：2019-05-15 00:00:00

abstract：:Hyaluronan is made and extruded from cells to form a pericellular or extracellular matrix (ECM) and is present in virtually all tissues in the body. The size and form of hyaluronan present in tissues are indicative of a healthy or inflamed tissue, and the interactions of hyaluronan with immune cells can influence thei...

journal_title：Frontiers in immunology

authors： Lee-Sayer SS,Dong Y,Arif AA,Olsson M,Brown KL,Johnson P

更新日期：2015-04-14 00:00:00

abstract：:Developing lymphocytes express the recombination activating genes (RAGs) 1 and 2 products that form a site specific recombinase complex (RAG), introducing double strand DNA breaks (DSBs) at recombination signal sequences (RSSs) flanking the V, D, and J gene segments in the antigen receptor loci. The subsequent steps i...

journal_title：Frontiers in immunology

authors： Bonnet M,Sarmento LM,Martins AC,Sobral D,Silva J,Demengeot J

更新日期：2017-11-10 00:00:00

abstract：:In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the IL-22-pSTAT3 pathway have been identified as risk factors for inflammatory bowel disease (IBD) and some of them are considered as promising therapeutic targets. However, new pers...

journal_title：Frontiers in immunology

authors： Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW

更新日期：2018-11-05 00:00:00

abstract：:Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on α7 nicotinic acetylcho...

journal_title：Frontiers in immunology

authors： Cao M,MacDonald JW,Liu HL,Weaver M,Cortes M,Durosier LD,Burns P,Fecteau G,Desrochers A,Schulkin J,Antonelli MC,Bernier RA,Dorschner M,Bammler TK,Frasch MG

更新日期：2019-05-09 00:00:00