Cell Differentiation Degree as a Factor Determining the Role for Different T-Helper Populations in Tuberculosis Protection.

abstract：:It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapabl...

journal_title：Frontiers in immunology

authors： Nikolaev EV,Zloza A,Sontag ED

更新日期：2019-01-28 00:00:00

abstract：:The caspase recruitment domain family member 11 (CARD11 or CARMA1)-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) [CBM] signalosome complex serves as a molecular bridge between cell surface antigen receptor signaling and the activation of the NF-κB, JNK, and mTORC1 signaling axes. This positions the CBM comp...

journal_title：Frontiers in immunology

authors： Lu HY,Bauman BM,Arjunaraja S,Dorjbal B,Milner JD,Snow AL,Turvey SE

更新日期：2018-09-19 00:00:00

abstract：:Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

journal_title：Frontiers in immunology

authors： Harvie M,Camberis M,Le Gros G

更新日期：2013-03-20 00:00:00

abstract：:In primary systemic small vessel vasculitis autoantibodies are common and seem to play an important role in the pathogenesis. Autoantibodies in vasculitis are preferentially directed against components of the immune system or directly against components of the vessel wall. Plasmapheresis is often applied in emergency ...

journal_title：Frontiers in immunology

authors： Segelmark M,Björck L

更新日期：2019-09-20 00:00:00

abstract：:The last decade has seen much progress in adjunctive cell therapy for immune disorders. Both corporate and institutional Phase III studies have been run using mesenchymal stromal cells (MSC) for treatment of Graft versus Host Disease (GvHD), and product approval has been achieved for treatment of pediatric GvHD in Can...

journal_title：Frontiers in immunology

authors： Vaes B,Van't Hof W,Deans R,Pinxteren J

更新日期：2012-11-27 00:00:00

abstract：:The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a hormone peptide able to bind to ferroportin, leading to its degradat...

journal_title：Frontiers in immunology

authors： Lepanto MS,Rosa L,Cutone A,Conte MP,Paesano R,Valenti P

更新日期：2018-09-21 00:00:00

abstract：:The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functio...

journal_title：Frontiers in immunology

authors： Wosen JE,Ilstad-Minnihan A,Co JY,Jiang W,Mukhopadhyay D,Fernandez-Becker NQ,Kuo CJ,Amieva MR,Mellins ED

更新日期：2019-08-20 00:00:00

abstract：:PU.1 is an ETS-family transcription factor that plays a broad range of roles in hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs, and a well-known antagonist of terminal erythroid cell differentiation, it is also expressed in the earliest stages of T-cell development of each...

journal_title：Frontiers in immunology

authors： Rothenberg EV,Hosokawa H,Ungerbäck J

更新日期：2019-02-20 00:00:00

abstract：:Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex sy...

journal_title：Frontiers in immunology

authors： Mozzi A,Forni D,Clerici M,Cagliani R,Sironi M

更新日期：2018-09-11 00:00:00

abstract：:A new paradigm of mucosal vaccination against human immunodeficiency virus (HIV) infection has been investigated in the macaque model. A vaccine consisting of inactivated simian immunodeficiency virus (SIV)mac239 particles together with a living bacterial adjuvant (either the Calmette and Guerin bacillus, Lactobacillu...

journal_title：Frontiers in immunology

authors： Andrieu JM,Chen S,Lai C,Guo W,Lu W

更新日期：2014-06-30 00:00:00

abstract：:Chemokines and their cognate receptors have been identified as major factors initiating and governing cell movement and interaction. These ligands and their receptors are expressed on a wide variety of cells and act during steady-state migration as well as inflammatory recruitment. CCR6 is a non-promiscuous chemokine ...

journal_title：Frontiers in immunology

authors： Lee AY,Eri R,Lyons AB,Grimm MC,Korner H

更新日期：2013-07-15 00:00:00

abstract：:The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion ...

journal_title：Frontiers in immunology

authors： Jia W,He MX,McLeod IX,He YW

更新日期：2013-07-04 00:00:00

abstract：:CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecules, we administered OM-conjugated murine myelin oligodendrocyte glycoprotein pept...

journal_title：Frontiers in immunology

authors： Dagkonaki A,Avloniti M,Evangelidou M,Papazian I,Kanistras I,Tseveleki V,Lampros F,Tselios T,Jensen LT,Möbius W,Ruhwedel T,Androutsou ME,Matsoukas J,Anagnostouli M,Lassmann H,Probert L

更新日期：2020-11-19 00:00:00

abstract：Introduction:The broccoli isothiocyanate sulforaphane was shown to inhibit inflammation and tumor progression, also in pancreatic cancer, while its effect on tumor immunity is poorly understood. We investigated the immunoregulatory effect of sulforaphane on human dendritic cells alone and in presence of pancreatic tumo...

journal_title：Frontiers in immunology

authors： Wang Y,Petrikova E,Gross W,Sticht C,Gretz N,Herr I,Karakhanova S

更新日期：2020-10-30 00:00:00

abstract：:Influenza A viruses (IAVs) take advantage of the host acetylation system for their own benefit. Whether the nucleoprotein (NP) of IAVs undergoes acetylation and the interaction between the NP and the class I histone deacetylases (HDACs) were largely unknown. Here, we showed that the NP protein of IAV interacted with H...

journal_title：Frontiers in immunology

authors： Chen L,Wang C,Luo J,Su W,Li M,Zhao N,Lyu W,Attaran H,He Y,Ding H,He H

更新日期：2017-12-12 00:00:00

abstract：:Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations. Respiratory viruses can cause exacerbations in chronic pulmonary diseases including COPD or asthma and have been suggested to contribute to...

journal_title：Frontiers in immunology

authors： Sörensen M,Kantorek J,Byrnes L,Boutin S,Mall MA,Lasitschka F,Zabeck H,Nguyen D,Dalpke AH

更新日期：2020-02-04 00:00:00

abstract：:Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

journal_title：Frontiers in immunology

authors： Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

更新日期：2019-06-04 00:00:00

abstract：:According to the "two-step model," the intrathymic generation of CD4⁺ regulatory T (T(reg)) cells segregates into a first, T cell receptor (TCR)-driven phase and a second, cytokine-dependent phase. The initial TCR stimulus gives rise to a CD25⁺Foxp3⁻ developmental intermediate. These precursors subsequently require cy...

journal_title：Frontiers in immunology

authors： Hinterberger M,Wirnsberger G,Klein L

更新日期：2011-07-25 00:00:00

abstract：:TNFAIP3 encodes the NF-κB regulatory protein A20. High-penetrance heterozygous mutations in TNFAIP3 cause a haploinsufficiency of A20 (HA20), inadequate inhibition of NF-κB pathway, and an early onset autoinflammatory disorder. However, the clinical phenotype of patients with HA20 varies greatly and clinical diagnoses...

journal_title：Frontiers in immunology

authors： Lawless D,Pathak S,Scambler TE,Ouboussad L,Anwar R,Savic S

更新日期：2018-07-04 00:00:00

abstract：Objective:To examine the utility of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as biomarkers of prognosis in seropositive autoimmune encephalitis (AE). Methods:In this multicenter study, we retrospectively analyzed 57 cases of seropositive AE with hospital admissio...

journal_title：Frontiers in immunology

authors： Broadley J,Wesselingh R,Seneviratne U,Kyndt C,Beech P,Buzzard K,Nesbitt C,D'Souza W,Brodtmann A,Kalincik T,Butzkueven H,O'Brien TJ,Monif M,Australian Autoimmune Encephalitis Consortium.

更新日期：2021-01-14 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are quiescent cells with self-renewal capacity and the ability to generate all mature blood cells. HSCs normally reside in specialized niches in the bone marrow that help maintain their quiescence and long-term repopulating activity. There is emerging evidence that certain cytokines ind...

journal_title：Frontiers in immunology

authors： Schuettpelz LG,Link DC

更新日期：2013-07-19 00:00:00

abstract：Purpose:In the elderly population, the influenza infection and its clinical complications are important causes of hospitalization and death, particularly, in longer-lived age. The objective of this study is to analyze the impact of influenza virus circulation on mortality in the elderly and adults, in years with differ...

journal_title：Frontiers in immunology

authors： Freitas ARR,Donalisio MR

更新日期：2018-01-08 00:00:00

abstract：:The suppressor of cytokine signaling (SOCS) family of intracellular checkpoint inhibitors has received little recognition compared to other checkpoint inhibitors. Two members of this family, SOCS1 and SOCS3, are indispensable, since SOCS1 knockout in mice results in neonatal death due to interferon gamma (IFNγ) induce...

journal_title：Frontiers in immunology

authors： Johnson HM,Lewin AS,Ahmed CM

更新日期：2020-10-23 00:00:00

abstract：:Recombinant proteins are gaining enormous importance these days due to their wide application as biopharmaceutical products and proven safety record. Various recombinant proteins of therapeutic and prophylactic importance have been successfully produced in microbial and higher expression host systems. Since there is n...

journal_title：Frontiers in immunology

authors： Tripathi NK,Shrivastava A

更新日期：2018-08-23 00:00:00

abstract：:Objectives: Regulatory T cells (Tregs) are frequently functionally impaired in patients with granulomatosis with polyangiitis (GPA). However, the mechanism underlying their impaired function is unknown. Here, we hypothesized that Treg dysfunction in GPA is due to altered microRNA (miRNA) expression. Methods: RNA isola...

journal_title：Frontiers in immunology

authors： Dekkema GJ,Bijma T,Jellema PG,Van Den Berg A,Kroesen BJ,Stegeman CA,Heeringa P,Abdulahad WH,Sanders JS

更新日期：2019-09-12 00:00:00

abstract：:The vast initial diversity of the antibody repertoire is generated centrally by means of a complex series of V(D)J gene rearrangement events, variation in the site of gene segment joining, and TdT catalyzed N-region addition. Although the diversity is great, close inspection has revealed distinct and unique characteri...

journal_title：Frontiers in immunology

authors： Mroczek ES,Ippolito GC,Rogosch T,Hoi KH,Hwangpo TA,Brand MG,Zhuang Y,Liu CR,Schneider DA,Zemlin M,Brown EE,Georgiou G,Schroeder HW Jr

更新日期：2014-03-19 00:00:00

abstract：:Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation an...

journal_title：Frontiers in immunology

authors： Voos P,Fuck S,Weipert F,Babel L,Tandl D,Meckel T,Hehlgans S,Fournier C,Moroni A,Rödel F,Thiel G

更新日期：2018-04-30 00:00:00

abstract：:Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and arises from developing sympathetic nervous system. Most primary tumors localize in the abdomen, the adrenal gland, or lumbar sympathetic ganglia. Amplification in tumor cells of MYCN, the major oncogenic driver, patients' age over 18 mont...

journal_title：Frontiers in immunology

authors： Bottino C,Dondero A,Bellora F,Moretta L,Locatelli F,Pistoia V,Moretta A,Castriconi R

更新日期：2014-02-12 00:00:00

abstract：:Polarization has been a useful concept for describing activated macrophage phenotypes and gene expression profiles. However, macrophage activation status within tumors and other settings are often inferred based on only a few markers. Complicating matters for relevance to human biology, many macrophage activation mark...

journal_title：Frontiers in immunology

authors： Sudan B,Wacker MA,Wilson ME,Graff JW

更新日期：2015-05-27 00:00:00

abstract：:Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophylactic strategy to ...

journal_title：Frontiers in immunology

authors： Jamal F,Singh MK,Hansa J,Pushpanjali,Ahmad G,Dikhit MR,Umar MS,Bimal S,Das P,Mujeeb AA,Singh SK,Zubair S,Owais M

更新日期：2020-06-02 00:00:00