Diet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Mice.

abstract：:Distinctive molecular characteristics of functionally diverse lymphocyte populations may represent novel pharmacological targets for immunotherapy. The intrinsic apoptosis pathway is differently regulated among conventional and regulatory T cells (Tregs). Targeted pharmacological modulation of this pathway with a smal...

journal_title：Frontiers in immunology

authors： Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE

更新日期：2016-03-01 00:00:00

abstract：:microRNAs (miRNAs) are conserved non-coding small nucleotide molecules found in nearly all species and breastmilk. miRNAs present in breastmilk are very stable to freeze-thaw, RNase treatment, and low pH as they are protected inside exosomes. They are involved in regulating several physiologic and pathologic processes...

journal_title：Frontiers in immunology

authors： Carr LE,Bowlin AK,Elolimy AA,Byrum SD,Washam CL,Randolph CE,MacLeod SL,Yeruva L

更新日期：2020-06-23 00:00:00

abstract：:T lymphocytes first carried foreign genes safely into humans over two decades ago. Since these pioneering studies, scientific techniques to better understand the genomic landscape of cells has directly led to a more sophisticated appreciation of the diversity, functional complexity, and therapeutic potential of T cell...

journal_title：Frontiers in immunology

authors： Kerkar SP

更新日期：2013-09-27 00:00:00

abstract：:Macrophages have been found to both promote liver fibrosis and contribute to its resolution by acquiring different phenotypes based on signals from the micro-environment. The best-characterized phenotypes in the macrophage spectrum are labeled M1 (classically activated) and M2 (alternatively activated). Until now the ...

journal_title：Frontiers in immunology

authors： Beljaars L,Schippers M,Reker-Smit C,Martinez FO,Helming L,Poelstra K,Melgert BN

更新日期：2014-09-08 00:00:00

abstract：:Sex-related differences in asthma prevalence are well established and change through the reproductive phases of life. As children, boys have increased prevalence of asthma compared to girls. However, as adults, women have increased prevalence of asthma compared to men. Many factors, including genetics, environment, im...

journal_title：Frontiers in immunology

authors： Shah R,Newcomb DC

更新日期：2018-12-18 00:00:00

abstract：:During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival, and to induce pro-angiogenic factors. Hypoxia-induced factors (HIFs) regulate these transcriptional alterations. Failure to restore oxygen levels results in cell death by necrosis. IL-1α is one of the most im...

journal_title：Frontiers in immunology

authors： Rider P,Kaplanov I,Romzova M,Bernardis L,Braiman A,Voronov E,Apte RN

更新日期：2012-09-14 00:00:00

abstract：:NK cells play an important role in the innate defenses against tumor growth and metastases. Human NK cell activation and function are regulated by an array of HLA class I-specific inhibitory receptors and activating receptors recognizing ligands expressed de novo on tumor or virus-infected cells. NK cells have been ex...

journal_title：Frontiers in immunology

authors： Vacca P,Pietra G,Tumino N,Munari E,Mingari MC,Moretta L

更新日期：2020-01-17 00:00:00

abstract：:Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-β1), are involved in tumor immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represent opportunities for the...

journal_title：Frontiers in immunology

authors： Klöss S,Chambron N,Gardlowski T,Weil S,Koch J,Esser R,Pogge von Strandmann E,Morgan MA,Arseniev L,Seitz O,Köhl U

更新日期：2015-11-02 00:00:00

abstract：:Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4+Foxp3+ regulatory T cells (Tregs) constitutively express the high affinity IL-2 receptor (CD25/IL-2Rα) and rapidly respond to IL-2 to elaborate numerous suppressive mechanisms that limit immune-me...

journal_title：Frontiers in immunology

authors： Abo H,Flannigan KL,Geem D,Ngo VL,Harusato A,Denning TL

更新日期：2019-03-14 00:00:00

abstract：:In head and neck squamous cell carcinoma (HNSCC) tumors that over-expresses huEGFR, the anti-EGFR antibody, cetuximab, antagonizes tumor cell viability and sensitizes to radiation therapy. However, the immunologic interactions between cetuximab and radiation therapy are not well understood. We transduced two syngeneic...

journal_title：Frontiers in immunology

authors： Jin WJ,Erbe AK,Schwarz CN,Jaquish AA,Anderson BR,Sriramaneni RN,Jagodinsky JC,Bates AM,Clark PA,Le T,Lan KH,Chen Y,Kim K,Morris ZS

更新日期：2020-11-12 00:00:00

abstract：:Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and ...

journal_title：Frontiers in immunology

authors： Oliveira-Nascimento L,Massari P,Wetzler LM

更新日期：2012-04-18 00:00:00

abstract：:Influenza A virus (IAV) remains a significant global health issue causing annual epidemics, pandemics, and sporadic human infections with highly pathogenic avian or swine influenza viruses. Current inactivated and live vaccines are the mainstay of the public health response to influenza, although vaccine efficacy is l...

journal_title：Frontiers in immunology

authors： Sridhar S

更新日期：2016-05-19 00:00:00

abstract：:Stromal cells provide the structural foundation of secondary lymphoid organs (SLOs), and regulate leukocyte access and cell migration within the different compartments of spleen and lymph nodes (LNs). Furthermore, several stromal cell subsets have been implied in shaping of T cell responses through direct presentation...

journal_title：Frontiers in immunology

authors： Onder L,Scandella E,Chai Q,Firner S,Mayer CT,Sparwasser T,Thiel V,Rülicke T,Ludewig B

更新日期：2011-10-12 00:00:00

abstract：:T-cell-based immunotherapy strategies have profoundly improved the clinical management of several solid tumors and hematological malignancies. A recently developed and promising immunotherapy approach is to redirect polyclonal MHC-unrestricted T lymphocytes toward cancer cells by bispecific antibodies (bsAbs) that eng...

journal_title：Frontiers in immunology

authors： Satta A,Grazia G,Caroli F,Frigerio B,Di Nicola M,Raspagliesi F,Mezzanzanica D,Zaffaroni N,Gianni AM,Anichini A,Figini M

更新日期：2019-10-25 00:00:00

abstract：:Influenza A viruses (IAVs) take advantage of the host acetylation system for their own benefit. Whether the nucleoprotein (NP) of IAVs undergoes acetylation and the interaction between the NP and the class I histone deacetylases (HDACs) were largely unknown. Here, we showed that the NP protein of IAV interacted with H...

journal_title：Frontiers in immunology

authors： Chen L,Wang C,Luo J,Su W,Li M,Zhao N,Lyu W,Attaran H,He Y,Ding H,He H

更新日期：2017-12-12 00:00:00

abstract：:The dynamics of skin-draining cells following infection or vaccination provide important insight into the initiation of immune responses. In this study, the local recruitment and activation of immune cells in draining lymph nodes (LNs) was studied in calves in an adjuvant-induced inflammation. A transient but remarkab...

journal_title：Frontiers in immunology

authors： Lund H,Boysen P,Åkesson CP,Lewandowska-Sabat AM,Storset AK

更新日期：2016-08-29 00:00:00

abstract：:Malaria vaccine development has largely focused on Plasmodium falciparum; however, a reawakening to the importance of Plasmodium vivax has spurred efforts to develop vaccines against this difficult to treat and at times severe form of relapsing malaria, which constitutes a significant proportion of human malaria cases...

journal_title：Frontiers in immunology

authors： de Cassan SC,Shakri AR,Llewellyn D,Elias SC,Cho JS,Goodman AL,Jin J,Douglas AD,Suwanarusk R,Nosten FH,Rénia L,Russell B,Chitnis CE,Draper SJ

更新日期：2015-07-08 00:00:00

abstract：BACKGROUND:Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll-like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important ...

journal_title：Frontiers in immunology

authors： Katare PB,Bagul PK,Dinda AK,Banerjee SK

更新日期：2017-06-22 00:00:00

abstract：:Natural killer (NK) cells are a promising tool for the use in adoptive immunotherapy, since they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an attractive option to increase NK cells in numbers and to improve their antitumor potential prior to clinical applications. Consequently...

journal_title：Frontiers in immunology

authors： Granzin M,Wagner J,Köhl U,Cerwenka A,Huppert V,Ullrich E

更新日期：2017-04-26 00:00:00

abstract：:There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial vaccines containing aluminum hydroxide or an equivalent dose of this compound only with the ai...

journal_title：Frontiers in immunology

authors： Varela-Martínez E,Abendaño N,Asín J,Sistiaga-Poveda M,Pérez MM,Reina R,de Andrés D,Luján L,Jugo BM

更新日期：2018-10-23 00:00:00

abstract：:The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progressi...

journal_title：Frontiers in immunology

authors： Terry S,Buart S,Chouaib S

更新日期：2017-11-24 00:00:00

abstract：BACKGROUND:Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from i...

journal_title：Frontiers in immunology

authors： Castro Eiro MD,Alvarez MG,Cooley G,Viotti RJ,Bertocchi GL,Lococo B,Albareda MC,De Rissio AM,Natale MA,Parodi C,Tarleton RL,Laucella SA

更新日期：2017-09-15 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a breakdown of self-tolerance, production of auto-antibodies and immune-mediated injury, resulting in damage accrual in multiple organs. Kidney involvement, termed lupus nephritis, is a major cause of morbidity and mortality that affects over...

journal_title：Frontiers in immunology

authors： Yung S,Chan TM

更新日期：2015-09-15 00:00:00

abstract：Background:Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. Objectives:To determine whether normal pregnancy and delivery are associated with local activation of...

journal_title：Frontiers in immunology

authors： Livson S,Jarva H,Kalliala I,Lokki AI,Heikkinen-Eloranta J,Nieminen P,Meri S

更新日期：2021-01-11 00:00:00

abstract：:Newborns are at significantly increased risk of severe disease following infection with influenza virus. This is the collective result of their naïve status, altered immune responsiveness, and the lack of a vaccine that is effective in these individuals. Numerous studies have revealed impairments in both the innate an...

journal_title：Frontiers in immunology

authors： Alexander-Miller MA

更新日期：2020-09-16 00:00:00

abstract：PURPOSE OF REVIEW:The standard treatment options for systemic lupus erythematosus (SLE) are focused on non-specific immunosuppression. Over the past few years, scientific studies and ongoing clinical trials have shifted the paradigm with rapid advances in developing biologics and small molecules. A number of monoclonal...

journal_title：Frontiers in immunology

authors： Vukelic M,Li Y,Kyttaris VC

更新日期：2018-11-16 00:00:00

abstract：:Fracture repair is initiated by a multitude of immune cells and induction of an inflammatory cascade. Alterations in the early healing response due to an aged adaptive immune system leads to impaired bone repair, delayed healing or even formation of non-union. However, immuno-senescence is not limited to the adaptive ...

journal_title：Frontiers in immunology

authors： Löffler J,Sass FA,Filter S,Rose A,Ellinghaus A,Duda GN,Dienelt A

更新日期：2019-10-18 00:00:00

abstract：:Under normal conditions our intestines are inhabited by trillions of diverse microorganisms composing the intestinal microbiota, which are mostly non-pathogenic anaerobic commensal bacteria vital for the maintenance of immune homeostasis. The composition and diversity of the intestinal microbiota can be disturbed by v...

journal_title：Frontiers in immunology

authors： Köhler N,Zeiser R

更新日期：2019-01-17 00:00:00

abstract：:Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal protection against pathogens and long-term protection against allergies and autoimmune diseases. Although several proteins have been identified to have anti-viral or anti-bacterial effects like secretory IgA or lactoferrin, the...

journal_title：Frontiers in immunology

authors： Koning N,Kessen SF,Van Der Voorn JP,Appelmelk BJ,Jeurink PV,Knippels LM,Garssen J,Van Kooyk Y

更新日期：2015-03-13 00:00:00

abstract：:Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases, such as rheumatoid arthritis (RA). Here, we characterize monocyte-derived TolDCs from RA patients modulated with dexamethasone and activated with monophosphoryl lipid A (MPLA), referred to as MPLA-tDCs, in terms of gene expres...

journal_title：Frontiers in immunology

authors： García-González PA,Schinnerling K,Sepúlveda-Gutiérrez A,Maggi J,Hoyos L,Morales RA,Mehdi AM,Nel HJ,Soto L,Pesce B,Molina MC,Cuchacovich M,Larrondo ML,Neira Ó,Catalán DF,Hilkens CM,Thomas R,Verdugo RA,Aguillón JC

更新日期：2016-10-25 00:00:00