Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.

abstract：:Lower respiratory infection caused by human pathogens such as influenza and respiratory syncytial virus (RSV) is a significant healthcare burden that must be addressed. The preferred options to achieve this goal are usually to develop vaccines for prophylaxis and to develop antiviral small molecules to treat infected ...

journal_title：Frontiers in immunology

authors： Nyanguile O

更新日期：2019-06-21 00:00:00

abstract：:[This corrects the article on p. 998 in vol. 9, PMID: 29867975.]. ...

journal_title：Frontiers in immunology

authors： Varesano S,Zocchi MR,Poggi A

更新日期：2018-06-13 00:00:00

abstract：:Lymphatic filariasis (LF) is a tropical parasitic infection of human transmitted by mosquitoes. Chronic infection results in severe physical disability in the infected patients. Although several potential vaccine antigens were identified by several groups, there are no licensed prophylactic vaccine to date against thi...

journal_title：Frontiers in immunology

authors： Chauhan N,Khatri V,Banerjee P,Kalyanasundaram R

更新日期：2018-07-02 00:00:00

abstract：:A successful outcome to pregnancy is dependent on the ability of the maternal uterine microenvironment to regulate inflammation processes and establish maternal tolerance. Recently, B cells have been shown to influence pregnancy outcomes as aberrations in their numbers and functions are associated with obstetric compl...

journal_title：Frontiers in immunology

authors： Guzman-Genuino RM,Eldi P,Garcia-Valtanen P,Hayball JD,Diener KR

更新日期：2019-12-11 00:00:00

abstract：:Erythropoiesis is a highly regulated process where sequential events ensure the proper differentiation of hematopoietic stem cells into, ultimately, red blood cells (RBCs). Macrophages in the bone marrow play an important role in hematopoiesis by providing signals that induce differentiation and proliferation of the e...

journal_title：Frontiers in immunology

authors： Klei TR,Meinderts SM,van den Berg TK,van Bruggen R

更新日期：2017-02-02 00:00:00

abstract：:Amino acids (AAs) are necessary nutrients which act not only as building blocks in protein synthesis but also in crucial anabolic cellular signaling pathways. It has been demonstrated that SLC7A5 is a critical transporter that mediates uptake of several essential amino acids in highly proliferative tumors and activate...

journal_title：Frontiers in immunology

authors： Yoon BR,Oh YJ,Kang SW,Lee EB,Lee WW

更新日期：2018-01-25 00:00:00

abstract：:Monoclonal antibodies against the cell surface antigen CD38, e.g., isatuximab, daratumumab, or Mor202, have entered the therapeutic armamentarium in multiple myeloma due to single agent overall response rates of 29 vs. 36 vs. 31%, effectivity in combination regimen, e.g., with lenalidomide or bortezomib plus dexametha...

journal_title：Frontiers in immunology

authors： Seckinger A,Hillengass J,Emde M,Beck S,Kimmich C,Dittrich T,Hundemer M,Jauch A,Hegenbart U,Raab MS,Ho AD,Schönland S,Hose D

更新日期：2018-07-20 00:00:00

abstract：:Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1), Th17, and regulatory T-cell (Treg) responses, throughout life. Although known to be the major cause of peptic ulcer disease and gastric cancer, disease occurs in a minority of thos...

journal_title：Frontiers in immunology

authors： Hussain K,Letley DP,Greenaway AB,Kenefeck R,Winter JA,Tomlinson W,Rhead J,Staples E,Kaneko K,Atherton JC,Robinson K

更新日期：2016-03-07 00:00:00

abstract：:The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases, Lck. Upon T-cell antigen receptor (TCR) triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formation of complex signaling network and cytoskeletal re...

journal_title：Frontiers in immunology

authors： Ballek O,Valečka J,Dobešová M,Broučková A,Manning J,Řehulka P,Stulík J,Filipp D

更新日期：2016-10-27 00:00:00

abstract：:Type 2 diabetes is a metabolic disorder characterized by persistently elevated glucose levels. There is no effective treatment strategy for this condition, and it poses a massive economic burden globally. Schistosoma soluble egg antigen (SEA)-induced immunomodulatory mechanisms have been reported in the treatment of a...

journal_title：Frontiers in immunology

authors： Tang CL,Yu XH,Li Y,Zhang RH,Xie J,Liu ZM

更新日期：2019-06-26 00:00:00

abstract：:Mechanisms driving acute graft-versus-host disease (aGVHD) onset in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are still poorly understood. To provide a detailed characterization of tissue-infiltrating T lymphocytes (TL) and search for eventual site-specific specificities, we de...

journal_title：Frontiers in immunology

authors： Alhaj Hussen K,Michonneau D,Biajoux V,Keita S,Dubouchet L,Nelson E,Setterblad N,Le Buanec H,Bouaziz JD,Guimiot F,Socié G,Canque B

更新日期：2020-11-24 00:00:00

abstract：Objectives:We explored histological and transcriptomic profiles of paired synovial biopsies from rheumatoid arthritis (RA) patients, in order to assess homogeneity in synovial tissue at the individual level. Methods:Synovial biopsies were performed simultaneously in one small and one large joint per patient using need...

journal_title：Frontiers in immunology

authors： Triaille C,Vansteenkiste L,Constant M,Ambroise J,Méric de Bellefon L,Nzeusseu Toukap A,Sokolova T,Galant C,Coulie P,Carrasco J,Durez P,Lauwerys BR

更新日期：2020-11-23 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of transcription (STAT)-3 as dominant signaling mode. IL-10, formerly known as c...

journal_title：Frontiers in immunology

authors： Mühl H

更新日期：2013-02-04 00:00:00

abstract：:For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve pa...

journal_title：Frontiers in immunology

authors： Ghimire S,Weber D,Mavin E,Wang XN,Dickinson AM,Holler E

更新日期：2017-03-20 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment option for hematologic malignancies but relapse remains the most common cause of death. Infusion of donor lymphocytes (DLIs) can induce remission and prolong survival by exerting graft-vs.-leukemia (GVL) effects. However, sufficient tumor...

journal_title：Frontiers in immunology

authors： Jahnke S,Schmid H,Secker KA,Einhaus J,Duerr-Stoerzer S,Keppeler H,Schober-Melms I,Baur R,Schumm M,Handgretinger R,Bethge W,Kanz L,Schneidawind C,Schneidawind D

更新日期：2019-07-09 00:00:00

abstract：:Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential induction of autoimmune responses that escape central and peripheral tole...

journal_title：Frontiers in immunology

authors： Javidi E,Magnus T

更新日期：2019-04-02 00:00:00

abstract：:Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomav...

journal_title：Frontiers in immunology

authors： Wang C,Dickie J,Sutavani RV,Pointer C,Thomas GJ,Savelyeva N

更新日期：2018-04-23 00:00:00

abstract：:The critical role of interferons (IFNs) in mediating the innate immune response to cytomegalovirus (CMV) infection is well established. However, in recent years the functional importance of the IFN-independent antiviral response has become clearer. IFN-independent, IFN regulatory factor 3 (IRF3)-dependent interferon-s...

journal_title：Frontiers in immunology

authors： Ashley CL,Abendroth A,McSharry BP,Slobedman B

更新日期：2019-12-11 00:00:00

abstract：:The mechanisms underlying pathophysiological regulation of tissue macrophage (Mφ) subsets remain poorly understood. From the expression of 207 Mφ genes comprising 31 markers for 10 subsets, 45 transcription factors (TFs), 56 immunometabolism enzymes, 23 trained immunity (innate immune memory) enzymes, and 52 other gen...

journal_title：Frontiers in immunology

authors： Lai B,Wang J,Fagenson A,Sun Y,Saredy J,Lu Y,Nanayakkara G,Yang WY,Yu D,Shao Y,Drummer C 4th,Johnson C,Saaoud F,Zhang R,Yang Q,Xu K,Mastascusa K,Cueto R,Fu H,Wu S,Sun L,Zhu P,Qin X,Yu J,Fan D,Shen YH,Su

更新日期：2019-11-14 00:00:00

abstract：:The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport, and antigen presentation of IgG-opsonized antigens. Previously, we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T-dependent humoral immune response with increased IgG pr...

journal_title：Frontiers in immunology

authors： Schneider Z,Jani PK,Szikora B,Végh A,Kövesdi D,Iliás A,Cervenak J,Balogh P,Kurucz I,Kacskovics I

更新日期：2015-07-20 00:00:00

abstract：:The receptor for advanced glycation endproducts (RAGE) can engage a diverse class of ligands and contribute to the immune and inflammatory response to infection and injury. It is known to be a pathogenic receptor in many inflammatory diseases, including ischemia/reperfusion (IR) injuries in several tissues; however, i...

journal_title：Frontiers in immunology

authors： Wu MC,Gilmour TD,Mantovani S,Woodruff TM

更新日期：2015-12-07 00:00:00

abstract：:GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. GPR84 activation is involved in the inflammatory response, but the mechanisms by which it modulates inflammation have been incompletely described. In this study, we investigated GP...

journal_title：Frontiers in immunology

authors： Recio C,Lucy D,Purvis GSD,Iveson P,Zeboudj L,Iqbal AJ,Lin D,O'Callaghan C,Davison L,Griesbach E,Russell AJ,Wynne GM,Dib L,Monaco C,Greaves DR

更新日期：2018-06-20 00:00:00

abstract：:All animals develop in association with complex microbial communities. It is now well established that commensal microbiota is essential for the correct functionality of each organ in the host. Particularly, the commensal gastro-intestinal microbiota (CGIM) is a key factor for development, immunity and nutrient conver...

journal_title：Frontiers in immunology

authors： Montalban-Arques A,De Schryver P,Bossier P,Gorkiewicz G,Mulero V,Gatlin DM 3rd,Galindo-Villegas J

更新日期：2015-10-09 00:00:00

abstract：:Despite continuous exposure and development of specific immunity, Staphylococcus aureus (Sa) remains one of the leading causes of severe infections worldwide. Although innate immune defense mechanisms are well understood, the role of the T cell response has not been fully elucidated. Here, we demonstrate that Sa and o...

journal_title：Frontiers in immunology

authors： Uebele J,Habenicht K,Ticha O,Bekeredjian-Ding I

更新日期：2020-09-30 00:00:00

abstract：:The natural cysteine to serine variation at position 31 of Tat in HIV-1C disrupts the dicysteine motif attenuating the chemokine function of Tat. We ask if there exists a trade-off in terms of a gain of function for HIV-1C Tat due to this natural variation. We constructed two Tat-expression vectors encoding Tat protei...

journal_title：Frontiers in immunology

authors： Menon M,Budhwar R,Shukla RN,Bankar K,Vasudevan M,Ranga U

更新日期：2020-09-25 00:00:00

abstract：:Immunotherapy approaches currently make their way into the clinics to improve the outcome of standard radiochemotherapy (RCT). The programed cell death receptor ligand 1 (PD-L1) is one possible target that, upon blockade, allows T cell-dependent antitumor immune responses to be executed. To date, it is unclear which R...

journal_title：Frontiers in immunology

authors： Derer A,Spiljar M,Bäumler M,Hecht M,Fietkau R,Frey B,Gaipl US

更新日期：2016-12-22 00:00:00

abstract：:Gastrointestinal nematodes are among the most prevalent parasites infecting humans and livestock worldwide. Infective larvae of the soil-transmitted nematode Ascaris spp. enter the host and start tissue migration by crossing the intestinal epithelial barrier. The initial interaction of the intestinal epithelium with t...

journal_title：Frontiers in immunology

authors： Ebner F,Kuhring M,Radonić A,Midha A,Renard BY,Hartmann S

更新日期：2018-08-15 00:00:00

abstract：:An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact that has been related to the pre-existence of an efficient anti-tumor immune response. Different strategies are being proposed to promote tumor immunity and to be used in combi...

journal_title：Frontiers in immunology

authors： Roselli E,Araya P,Núñez NG,Gatti G,Graziano F,Sedlik C,Benaroch P,Piaggio E,Maccioni M

更新日期：2019-03-20 00:00:00

abstract：:We recently identified a new human subset of NK-like [KIR/NKG2A(+)] CD8(+) T cells with a marked/memory phenotype, high Eomesodermin expression, potent antigen-independent cytotoxic activity, and the capacity to generate IFN-γ rapidly after exposure to pro-inflammatory cytokines. These features support the hypothesis ...

journal_title：Frontiers in immunology

authors： Jacomet F,Cayssials E,Barbarin A,Desmier D,Basbous S,Lefèvre L,Levescot A,Robin A,Piccirilli N,Giraud C,Guilhot F,Roy L,Herbelin A,Gombert JM

更新日期：2017-01-16 00:00:00