Abstract:
:Stromal cells provide the structural foundation of secondary lymphoid organs (SLOs), and regulate leukocyte access and cell migration within the different compartments of spleen and lymph nodes (LNs). Furthermore, several stromal cell subsets have been implied in shaping of T cell responses through direct presentation of antigen. Despite significant gain of knowledge on the biology of different SLO-resident stromal cell subsets, their molecular and functional characterization has remained incomplete. To address this need, we have generated a bacterial artificial chromosome-transgenic mouse model that utilizes the podoplanin (pdpn) promoter to express the Cre-recombinase exclusively in stromal cells of SLOs. The characterization of the Pdpn-Cre mouse revealed transgene expression in subsets of fibroblastic reticular cells and lymphatic endothelial cells in LNs. Furthermore, the transgene facilitated the identification of a novel splenic perivascular stromal cell subpopulation that forms web-like structures around central arterioles. Assessment of the in vivo antigen expression in the genetically tagged stromal cells in Pdpn-Cre mice revealed activation of both MHC I and II-restricted TCR transgenic T cells. Taken together, stromal pdpn-Cre expression is well-suited to characterize the phenotype and to dissect the function of lymphoid organ stromal cells.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Onder L,Scandella E,Chai Q,Firner S,Mayer CT,Sparwasser T,Thiel V,Rülicke T,Ludewig Bdoi
10.3389/fimmu.2011.00050subject
Has Abstractpub_date
2011-10-12 00:00:00pages
50issn
1664-3224journal_volume
2pub_type
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.3389/fimmu.2019.01121
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pub_type: 杂志文章
doi:10.3389/fimmu.2019.02889
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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abstract::[This corrects the article DOI: 10.3389/fimmu.2019.00917.]. ...
journal_title:Frontiers in immunology
pub_type: 已发布勘误
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type: 杂志文章,评审
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journal_title:Frontiers in immunology
pub_type: 杂志文章
doi:10.3389/fimmu.2018.00204
更新日期:2018-02-07 00:00:00
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pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-24 00:00:00
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pub_type: 杂志文章
doi:10.3389/fimmu.2019.01346
更新日期:2019-06-14 00:00:00