Sex Bias in Asthma Prevalence and Pathogenesis.


:Sex-related differences in asthma prevalence are well established and change through the reproductive phases of life. As children, boys have increased prevalence of asthma compared to girls. However, as adults, women have increased prevalence of asthma compared to men. Many factors, including genetics, environment, immunological responses, and sex hormones, affect the sex disparity associated with the development and control of asthma and other allergic diseases. Fluctuations of hormones during puberty, menstruation, pregnancy, and menopause, alter asthma symptoms and severity. In this article, we review clinical and epidemiological studies that examined the sex disparity in asthma and other allergic diseases as well as the role of sex hormones on asthma pathogenesis.


Front Immunol


Frontiers in immunology


Shah R,Newcomb DC




Has Abstract


2018-12-18 00:00:00








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    abstract::Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8+CD45RClow/- Tregs expressing Foxp3 and p...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bézie S,Meistermann D,Boucault L,Kilens S,Zoppi J,Autrusseau E,Donnart A,Nerrière-Daguin V,Bellier-Waast F,Charpentier E,Duteille F,David L,Anegon I,Guillonneau C

    更新日期:2018-01-31 00:00:00

  • Preparing unbiased T-cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling.

    abstract::High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of li...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Mamedov IZ,Britanova OV,Zvyagin IV,Turchaninova MA,Bolotin DA,Putintseva EV,Lebedev YB,Chudakov DM

    更新日期:2013-12-23 00:00:00

  • Transcription Factor KLF10 Constrains IL-17-Committed Vγ4+ γδ T Cells.

    abstract::γδ T cells, known to be an important source of innate IL-17 in mice, provide critical contributions to host immune responses. Development and function of γδ T cells are directed by networks of diverse transcription factors (TFs). Here, we examine the role of the zinc finger TFs, Kruppel-like factor 10 (KLF10), in the ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kim G,Gu MJ,Kim SJ,Ko KH,Kye YC,Kim CG,Cho JH,Lee WK,Song KD,Chu H,Park YM,Han SH,Yun CH

    更新日期:2018-02-28 00:00:00

  • B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure.

    abstract::Cigarette smoke (CS) is the major cause of chronic lung injuries, such as chronic obstructive pulmonary disease (COPD). In patients with severe COPD, tertiary lymphoid follicles containing B lymphocytes and B cell-activating factor (BAFF) overexpression are associated with disease severity. In addition, BAFF promotes ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Nascimento M,Huot-Marchand S,Gombault A,Panek C,Bourinet M,Fanny M,Savigny F,Schneider P,Le Bert M,Ryffel B,Riteau N,Quesniaux VFJ,Couillin I

    更新日期:2020-07-29 00:00:00

  • Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis.

    abstract::Immunoproteasome (IP) inhibition holds potential as a novel treatment option for various immune-mediated pathologies. The IP inhibitor ONX 0914 reduced T cell cytokine secretion and Th17 polarization and showed pre-clinical efficacy in a range of autoimmune disorders, transplant-allograft rejection, virus-mediated tis...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schmidt C,Berger T,Groettrup M,Basler M

    更新日期:2018-10-26 00:00:00

  • Interleukin-1 Receptor Antagonist Protects Newborn Mice Against Pulmonary Hypertension.

    abstract::Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is strongly correlated with the severity and long-term outcome of BPD infa...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bui CB,Kolodziej M,Lamanna E,Elgass K,Sehgal A,Rudloff I,Schwenke DO,Tsuchimochi H,Kroon MAGM,Cho SX,Maksimenko A,Cholewa M,Berger PJ,Young MJ,Bourke JE,Pearson JT,Nold MF,Nold-Petry CA

    更新日期:2019-07-11 00:00:00

  • The Repertoires of Peptides Presented by MHC-II in the Thymus and in Peripheral Tissue: A Clue for Autoimmunity?

    abstract::T-cell tolerance to self-antigens is established in the thymus through the recognition by developing thymocytes of self-peptide-MHC complexes and induced and maintained in the periphery. Efficient negative selection of auto-reactive T cells in the thymus is dependent on the in situ expression of both ubiquitous and ti...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Collado JA,Guitart C,Ciudad MT,Alvarez I,Jaraquemada D

    更新日期:2013-12-17 00:00:00

  • Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation.

    abstract::An essential role of the intestine is to build and maintain a barrier preventing the luminal gut microbiota from invading the host. This involves two coordinated physical and immunological barriers formed by single layers of intestinal epithelial and endothelial cells, which avoid the activation of local immune respon...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: López-Posadas R,Stürzl M,Atreya I,Neurath MF,Britzen-Laurent N

    更新日期:2017-10-05 00:00:00

  • CD38 as Immunotherapeutic Target in Light Chain Amyloidosis and Multiple Myeloma-Association With Molecular Entities, Risk, Survival, and Mechanisms of Upfront Resistance.

    abstract::Monoclonal antibodies against the cell surface antigen CD38, e.g., isatuximab, daratumumab, or Mor202, have entered the therapeutic armamentarium in multiple myeloma due to single agent overall response rates of 29 vs. 36 vs. 31%, effectivity in combination regimen, e.g., with lenalidomide or bortezomib plus dexametha...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Seckinger A,Hillengass J,Emde M,Beck S,Kimmich C,Dittrich T,Hundemer M,Jauch A,Hegenbart U,Raab MS,Ho AD,Schönland S,Hose D

    更新日期:2018-07-20 00:00:00

  • Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells.

    abstract::Mast cells are implicated as detrimental players in inflammatory lung diseases, particularly asthma. Mast cells respond to activating stimuli by releasing a wide panel of pro-inflammatory compounds that can contribute profoundly to the pathology, and there is currently an unmet need for strategies that efficiently ame...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Paivandy A,Sandelin M,Igelström H,Landelius P,Janson C,Melo FR,Pejler G

    更新日期:2017-11-27 00:00:00

  • Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells.

    abstract::The secondary analyses for correlates of risk of infection in the RV144 HIV-1 vaccine trial implicated vaccine-induced antibody-dependent cellular cytotoxicity (ADCC) responses in the observed protection, highlighting the importance of assessing such responses in ongoing and future HIV-1 vaccine trials. However, in vi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,随机对照试验


    authors: Fisher L,Zinter M,Stanfield-Oakley S,Carpp LN,Edwards RW,Denny T,Moodie Z,Laher F,Bekker LG,McElrath MJ,Gilbert PB,Corey L,Tomaras G,Pollara J,Ferrari G

    更新日期:2019-11-27 00:00:00

  • Comparative functional genomics and the bovine macrophage response to strains of the mycobacterium genus.

    abstract::Mycobacterial infections are major causes of morbidity and mortality in cattle and are also potential zoonotic agents with implications for human health. Despite the implementation of comprehensive animal surveillance programs, many mycobacterial diseases have remained recalcitrant to eradication in several industrial...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Rue-Albrecht K,Magee DA,Killick KE,Nalpas NC,Gordon SV,MacHugh DE

    更新日期:2014-11-05 00:00:00

  • A critical analysis of rejection in vascularized composite allotransplantation: clinical, cellular and molecular aspects, current challenges, and novel concepts.

    abstract::Advances in microsurgical techniques and immunomodulatory protocols have contributed to the expansion of vascularized composite allotransplantation (VCA) with very encouraging immunological, functional, and cosmetic results. Rejection remains however a major hurdle that portends serious threats to recipients. Rejectio...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Sarhane KA,Tuffaha SH,Broyles JM,Ibrahim AE,Khalifian S,Baltodano P,Santiago GF,Alrakan M,Ibrahim Z

    更新日期:2013-11-25 00:00:00

  • Role of Dietary Metabolites in Regulating the Host Immune Response in Gastrointestinal Disease.

    abstract::The host immune response to gastrointestinal (GI) infections, hypersensitivity reactions, or GI cancers comprises numerous pathways that elicit responses on different host cells. Some of these include (1) the stimulation of mast cells via their IgE receptor, (2) the production of antibodies leading to antibody-mediate...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: El-Zaatari M,Kao JY

    更新日期:2017-01-27 00:00:00

  • Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease.

    abstract::Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders. Despite rapid progress in understanding GVHD pathogenesis, broad immunosuppressive agents are most often used to prevent and remain the fir...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Thangavelu G,Blazar BR

    更新日期:2019-03-06 00:00:00

  • Tripartite Motif-Containing Protein 22 Interacts with Class II Transactivator and Orchestrates Its Recruitment in Nuclear Bodies Containing TRIM19/PML and Cyclin T1.

    abstract::Among interferon (IFN) inducible antiviral factors both tripartite motif-containing protein 22 (TRIM22) and class II transactivator (CIITA) share the capacity of repressing human immunodeficiency virus type 1 (HIV-1) proviral transcription. TRIM22 is constitutively expressed in a subset of U937 cell clones poorly perm...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Forlani G,Tosi G,Turrini F,Poli G,Vicenzi E,Accolla RS

    更新日期:2017-05-15 00:00:00

  • Role of innate immune response in non-alcoholic Fatty liver disease: metabolic complications and therapeutic tools.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, both in adults and children. It is characterized by an aberrant lipid storage in hepatocytes, named hepatic steatosis. Simple steatosis remains a benign process in most affected patients, while some of them develop superimp...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Meli R,Mattace Raso G,Calignano A

    更新日期:2014-04-23 00:00:00

  • Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp.

    abstract::Early clearance of tuberculosis is the successful eradication of inhaled bacteria before the development of an adaptive immune response. We previously showed, by utilizing a non-virulent mycobacteria infection model, that C57BL/6 mice are more efficient than BALB/c in their control of bacterial growth in the lungs dur...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Adam L,López-González M,Björk A,Pålsson S,Poux C,Wahren-Herlenius M,Fernández C,Spetz AL

    更新日期:2018-09-03 00:00:00

  • Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy.

    abstract::Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards. Initial phase I trials demonstrated that the administration of a number of...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Phillips BE,Garciafigueroa Y,Engman C,Trucco M,Giannoukakis N

    更新日期:2019-02-06 00:00:00

  • AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis.

    abstract::Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycosylation end-product...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Chen R,Zhu S,Zeng L,Wang Q,Sheng Y,Zhou B,Tang D,Kang R

    更新日期:2019-08-08 00:00:00

  • Recombinant ATPase of Virulent Aeromonas hydrophila Protects Channel Catfish Against Motile Aeromonas Septicemia.

    abstract::Channel catfish farming dominates the aquaculture industry in the United States. However, epidemic outbreaks of motile Aeromonas septicemia (MAS), caused by virulent Aeromonas hydrophila (vAh), have become a prominent problem in the catfish industry. Although vaccination is an effective preventive method, there is no ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Abdelhamed H,Banes M,Karsi A,Lawrence ML

    更新日期:2019-07-16 00:00:00

  • Nuclear Deformation During Neutrophil Migration at Sites of Inflammation.

    abstract::Cell migration is indispensable for various biological processes including angiogenesis, wound healing, and immunity. In general, there are two different migration modes described, the mesenchymal migration mode and the amoeboid migration mode. Neutrophils rapidly migrate toward the sites of injury, infection, and inf...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Salvermoser M,Begandt D,Alon R,Walzog B

    更新日期:2018-11-16 00:00:00

  • Culture-Expanded Human Invariant Natural Killer T Cells Suppress T-Cell Alloreactivity and Eradicate Leukemia.

    abstract::Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

    更新日期:2018-08-06 00:00:00

  • The Small GTPase Rab5c Exerts Bi-Function in Singapore Grouper Iridovirus Infections and Cellular Responses in the Grouper, Epinephelus coioides.

    abstract::The small GTPase Rab5 is one of the master regulators of vesicular trafficking that participates in early stages of the endocytic pathway, such as endocytosis and endosome maturation. Three Rab5 isoforms (a, b, and c) share high sequence identity, and exhibit complex functions. However, the role of Rab5c in virus infe...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wang L,Li C,Zhang X,Yang M,Wei S,Huang Y,Qin Q,Wang S

    更新日期:2020-09-02 00:00:00

  • The Influence of Pentraxin 3 on the Ovarian Function and Its Impact on Fertility.

    abstract::Follicular development is a highly coordinated process that in humans takes more than 6 months. Pituitary gonadotropins and a variety of locally produced growth factors and cytokines are involved in determining a precise sequence of changes in cell metabolism, proliferation, vascularization, and matrix remodeling in o...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Camaioni A,Klinger FG,Campagnolo L,Salustri A

    更新日期:2018-11-29 00:00:00

  • Structural Basis of IL-1 Family Cytokine Signaling.

    abstract::Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli. The basic mechanism of signal initiation is a stepwise process in which an agonist cytokine binds its cognate receptor. Together, this cytokin...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Fields JK,Günther S,Sundberg EJ

    更新日期:2019-06-20 00:00:00

  • Canine Neutrophil Extracellular Traps Release Induced by the Apicomplexan Parasite Neospora caninum In Vitro.

    abstract::Neosporosis is considered as one of the main causes of abortion and severe economic losses in dairy industry. The Canis genus serving as one of the confirmed definitive hosts of the apicomplexan parasite Neospora caninum (N. caninum) plays a critical role in its life cycle. However, the effects of N. caninum on its de...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wei Z,Hermosilla C,Taubert A,He X,Wang X,Gong P,Li J,Yang Z,Zhang X

    更新日期:2016-10-31 00:00:00

  • The Role of microRNAs in Bovine Infection and Immunity.

    abstract::MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Lawless N,Vegh P,O'Farrelly C,Lynn DJ

    更新日期:2014-11-27 00:00:00

  • Novel Mutations of the Tetratricopeptide Repeat Domain 7A Gene and Phenotype/Genotype Comparison.

    abstract::The gastrointestinal tract contains the largest lymphoid organ to react with pathogenic microorganisms and suppress excess inflammation. Patients with primary immunodeficiency diseases (PIDs) can suffer from refractory diarrhea. In this study, we present two siblings who began to suffer from refractory diarrhea with a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Lien R,Lin YF,Lai MW,Weng HY,Wu RC,Jaing TH,Huang JL,Tsai SF,Lee WI

    更新日期:2017-09-07 00:00:00

  • Killed Whole-Cell Oral Cholera Vaccine Induces CCL20 Secretion by Human Intestinal Epithelial Cells in the Presence of the Short-Chain Fatty Acid, Butyrate.

    abstract::Short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, modulate immune responses in the gut. However, the effect of SCFAs on mucosal vaccine-induced immune cell migration is poorly understood. Here, we investigated whether SCFAs modulate chemokine expression induced by the killed whole-cell oral c...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Sim JR,Kang SS,Lee D,Yun CH,Han SH

    更新日期:2018-01-29 00:00:00