Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis.

abstract：:The scavenger receptor SR-F1 binds to and mediates the internalization of a wide range of ligands, and is involved in several immunological processes. We produced recombinant SR-F1 ectodomain and fragments deleted from the last 2 or 5 C-terminal epidermal growth factor-like modules and investigated their role in the b...

journal_title：Frontiers in immunology

authors： Wicker-Planquart C,Dufour S,Tacnet-Delorme P,Bally I,Delneste Y,Frachet P,Housset D,Thielens NM

更新日期：2020-03-31 00:00:00

abstract：:Human cytomegalovirus (HCMV) is under constant selective pressure from the immune system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically altered by, such selection can focus research toward findings of in vivo significance. We have been particularly interested in the most pronounced ...

journal_title：Frontiers in immunology

authors： Patel M,Vlahava VM,Forbes SK,Fielding CA,Stanton RJ,Wang ECY

更新日期：2018-10-01 00:00:00

abstract：:Plasmodium vivax is the most common species that cause malaria outside of the African continent. The development of an efficacious vaccine would contribute greatly to control malaria. Recently, using bacterial and adenoviral recombinant proteins based on the P. vivax circumsporozoite protein (CSP), we demonstrated the...

journal_title：Frontiers in immunology

authors： Gimenez AM,Lima LC,Françoso KS,Denapoli PMA,Panatieri R,Bargieri DY,Thiberge JM,Andolina C,Nosten F,Renia L,Nussenzweig RS,Nussenzweig V,Amino R,Rodrigues MM,Soares IS

更新日期：2017-10-11 00:00:00

abstract：:Clostridium difficile infection (CDI) is the leading cause of world-wide nosocomial acquired diarrhea in adults. Active vaccination is generally accepted as a logical and cost-effective approach to prevent CDI. In this paper, we have generated two novel chimeric proteins; one designated Tcd169, comprised of the glucos...

journal_title：Frontiers in immunology

authors： Wang S,Wang Y,Cai Y,Kelly CP,Sun X

更新日期：2018-10-22 00:00:00

abstract：:In recent years, chimeric antigen receptor (CAR) T-cell therapy has become popular in immunotherapy, particularly after its tremendous success in the treatment of lineage-restricted hematologic cancers. However, the application of CAR T-cell therapy for solid tumors has not reached its full potential because of the la...

journal_title：Frontiers in immunology

authors： Wang Y,Luo F,Yang J,Zhao C,Chu Y

更新日期：2017-12-22 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs) are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells. Recent studies have described several mutant mice exhibiting both AD-like skin inflammation and MPN. Common path...

journal_title：Frontiers in immunology

authors： Kawakami T,Ando T,Kawakami Y

更新日期：2015-08-24 00:00:00

abstract：:Virus-specific CD4(+) T cells play a major role in viral infections, such as hepatitis C virus (HCV). Viral clearance is associated with vigorous and multi-specific CD4(+) T-cell responses, while chronic infection has been shown to be associated with weak or absent T-cell responses. Most of these studies have used fun...

journal_title：Frontiers in immunology

authors： Lokhande MU,Thimme R,Klenerman P,Semmo N

更新日期：2015-02-25 00:00:00

abstract：:Adipose depots are heterogeneous tissues that store and sense fuel levels. Through the secretion of lipids, cytokines, and protein hormones (adipokines), they communicate with other organ systems, informing them of the organism's nutritional status. The adipose tissues include diverse types of adipocytes (white, beige...

journal_title：Frontiers in immunology

authors： Chaurasia B,Talbot CL,Summers SA

更新日期：2020-09-23 00:00:00

abstract：:Cancer is a complex disease and a leading cause of death worldwide. Immunity is critical for cancer control. Cancer cells exhibit high mutational rates and therefore altered self or neo-antigens, eliciting an immune response to promote tumor eradication. Failure to mount a proper immune response leads to cancer progre...

journal_title：Frontiers in immunology

authors： Guri Y,Nordmann TM,Roszik J

更新日期：2018-03-27 00:00:00

abstract：:Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation. The molecular machinery of macroautophagy, a catabolic pathway that delivers cytoplasmic constituents to...

journal_title：Frontiers in immunology

authors： Münz C

更新日期：2018-11-27 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and very few available treatment options. The involvement of the purinergic receptor subtypes P2Y2 and P2X7 in fibrotic lung disease has been demonstrated recently. In this study, we investigated the role of P2Y6 receptors in the pathogenesis of IP...

journal_title：Frontiers in immunology

authors： Müller T,Fay S,Vieira RP,Karmouty-Quintana H,Cicko S,Ayata CK,Zissel G,Goldmann T,Lungarella G,Ferrari D,Di Virgilio F,Robaye B,Boeynaems JM,Lazarowski ER,Blackburn MR,Idzko M

更新日期：2017-08-22 00:00:00

abstract：:The adaptive immune response begins when CD4+ T cells recognize antigenic peptides bound to class II molecules of the Major Histocompatibility Complex (MHCII). The interaction between peptides and MHCII has been historically interpreted as a rigid docking event. However, this model has been challenged by the evidence ...

journal_title：Frontiers in immunology

authors： Ferrante A

更新日期：2013-10-01 00:00:00

abstract：:Sepsis is one of the well-established diseases with specific patterns of neutrophil dysfunctions. Previous studies demonstrated sepsis-related neutrophil dysfunctions in comparison with subjects without infection. Since sepsis and infection are recently recognized as distinctive processes, whether these neutrophil dys...

journal_title：Frontiers in immunology

authors： Seree-Aphinan C,Vichitkunakorn P,Navakanitworakul R,Khwannimit B

更新日期：2020-12-23 00:00:00

abstract：:Background: Each year, over 5 million red blood cell (RBC) transfusions are administered to patients in the USA. Despite the therapeutic benefits of RBC transfusions, there are associated risks. RBC-specific alloantibodies may form in response to antigenic differences between RBC donors and recipients; these alloantib...

journal_title：Frontiers in immunology

authors： Richards AL,Sheldon K,Wu X,Gruber DR,Hudson KE

更新日期：2018-10-05 00:00:00

abstract：:γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-receptors. In order to overcome natural obstacles of γ9δ2T cells, we have deve...

journal_title：Frontiers in immunology

authors： Straetemans T,Kierkels GJJ,Doorn R,Jansen K,Heijhuurs S,Dos Santos JM,van Muyden ADD,Vie H,Clemenceau B,Raymakers R,de Witte M,Sebestyén Z,Kuball J

更新日期：2018-05-30 00:00:00

abstract：:During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival, and to induce pro-angiogenic factors. Hypoxia-induced factors (HIFs) regulate these transcriptional alterations. Failure to restore oxygen levels results in cell death by necrosis. IL-1α is one of the most im...

journal_title：Frontiers in immunology

authors： Rider P,Kaplanov I,Romzova M,Bernardis L,Braiman A,Voronov E,Apte RN

更新日期：2012-09-14 00:00:00

abstract：:It is now apparent that immune cells express a functional cholinergic system and that α7 nicotinic acetylcholine receptors (α7 nAChRs) are involved in regulating T cell differentiation and the synthesis of antigen-specific antibodies and proinflammatory cytokines. Here, we investigated the specific function α7 nAChRs ...

journal_title：Frontiers in immunology

authors： Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K

更新日期：2019-05-31 00:00:00

abstract：:Heat-shock protein 70 (Hsp70) is frequently found on the plasma membrane of a large number of malignant tumors including non-small cell lung cancer (NSCLC) and gets released into the blood circulation in lipid vesicles. On the one hand, a membrane (m)Hsp70-positive phenotype correlates with a high aggressiveness of th...

journal_title：Frontiers in immunology

authors： Gunther S,Ostheimer C,Stangl S,Specht HM,Mozes P,Jesinghaus M,Vordermark D,Combs SE,Peltz F,Jung MP,Multhoff G

更新日期：2015-11-02 00:00:00

abstract：:Highly sensitive reporter-gene assays have been developed that allow both the direct vascular endothelial growth factor (VEGF) neutralizing activity of bevacizumab and the ability of bevacizumab to activate antibody dependent cellular cytotoxicity (ADCC) to be quantified rapidly and in a highly specific manner. The us...

journal_title：Frontiers in immunology

authors： Lallemand C,Ferrando-Miguel R,Auer M,Iglseder S,Czech T,Gaber-Wagener A,Di Pauli F,Deisenhammer F,Tovey MG

更新日期：2020-10-15 00:00:00

abstract：:T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested...

journal_title：Frontiers in immunology

authors： Tasnim H,Fricke GM,Byrum JR,Sotiris JO,Cannon JL,Moses ME

更新日期：2018-07-26 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) is used as replacement therapy in patients with antibody deficiencies and at higher dosages in immune-mediated disorders. Although different mechanisms have been described in vitro, the in vivo immunomodulatory effects of IVIG are poorly understood. Different studies have suggested th...

journal_title：Frontiers in immunology

authors： Mitrevski M,Marrapodi R,Camponeschi A,Cavaliere FM,Lazzeri C,Todi L,Visentini M

更新日期：2015-01-22 00:00:00

abstract：:Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of human plasmablasts...

journal_title：Frontiers in immunology

authors： Pak HK,Nam B,Lee YK,Kim YW,Roh J,Son J,Chung YS,Choe J,Park CS

更新日期：2018-07-27 00:00:00

abstract：:Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

journal_title：Frontiers in immunology

authors： Harvie M,Camberis M,Le Gros G

更新日期：2013-03-20 00:00:00

abstract：:CLEC12A has been proposed as a suitable target for delivering antigen to dendritic cells (DCs) to enhance vaccine efficacy both in human and mouse. In this study, we have characterized the porcine homolog of CLEC12A (poCLEC12A). Using new monoclonal antibodies (mAb), raised against its ectodomain, poCLEC12A was found ...

journal_title：Frontiers in immunology

authors： Álvarez B,Nieto-Pelegrín E,Martínez de la Riva P,Toki D,Poderoso T,Revilla C,Uenishi H,Ezquerra A,Domínguez J

更新日期：2020-05-13 00:00:00

abstract：:Psoriasis is a common inflammatory skin disease characterized by the appearance of red scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration, disability, and associated comorbidity make it a challenge for clinicians of multiple specialties. Likewise, its complex pathogenesis, c...

journal_title：Frontiers in immunology

authors： Boehncke WH

更新日期：2018-04-05 00:00:00

abstract：Background:Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. Objectives:To determine whether normal pregnancy and delivery are associated with local activation of...

journal_title：Frontiers in immunology

authors： Livson S,Jarva H,Kalliala I,Lokki AI,Heikkinen-Eloranta J,Nieminen P,Meri S

更新日期：2021-01-11 00:00:00

abstract：:Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the collectin family of proteins naturally present in the vaginal tract, is a potential HIV-1 ...

journal_title：Frontiers in immunology

authors： Pandit H,Kale K,Yamamoto H,Thakur G,Rokade S,Chakraborty P,Vasudevan M,Kishore U,Madan T,Fichorova RN

更新日期：2019-03-28 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3 in quiescent and activated peripheral blood mononuclear cells (PBMCs)...

journal_title：Frontiers in immunology

authors： Sibbons CM,Irvine NA,Pérez-Mojica JE,Calder PC,Lillycrop KA,Fielding BA,Burdge GC

更新日期：2018-03-05 00:00:00

abstract：:Early clearance of tuberculosis is the successful eradication of inhaled bacteria before the development of an adaptive immune response. We previously showed, by utilizing a non-virulent mycobacteria infection model, that C57BL/6 mice are more efficient than BALB/c in their control of bacterial growth in the lungs dur...

journal_title：Frontiers in immunology

authors： Adam L,López-González M,Björk A,Pålsson S,Poux C,Wahren-Herlenius M,Fernández C,Spetz AL

更新日期：2018-09-03 00:00:00

abstract：:FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunoglobulins (IVIg) the...

journal_title：Frontiers in immunology

authors： Anania JC,Trist HM,Palmer CS,Tan PS,Kouskousis BP,Chenoweth AM,Kent SJ,Mackay GA,Hoi A,Koelmeyer R,Slade C,Bryant VL,Hodgkin PD,Aui PM,van Zelm MC,Wines BD,Hogarth PM

更新日期：2018-08-20 00:00:00