Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD.

abstract：:Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by Plasmodium falciparum blood-stage parasites will help to understand how immunity is acquired and...

journal_title：Frontiers in immunology

authors： Yap XZ,Lundie RJ,Feng G,Pooley J,Beeson JG,O'Keeffe M

更新日期：2019-01-31 00:00:00

abstract：:The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for...

journal_title：Frontiers in immunology

authors： Domnich M,Riedesel J,Pylaeva E,Kürten CHL,Buer J,Lang S,Jablonska J

更新日期：2020-10-09 00:00:00

abstract：:Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies to define the molecular mechanisms of NET generation and the biol...

journal_title：Frontiers in immunology

authors： Rahman S,Gadjeva M

更新日期：2014-08-11 00:00:00

abstract：:The potential of tolerogenic dendritic cells (tolDCs) to shape immune responses and restore tolerance has turn them into a promising therapeutic tool for cellular therapies directed toward immune regulation in autoimmunity. Although the cellular mechanisms by which these cells can exert their regulatory function are w...

journal_title：Frontiers in immunology

authors： García-González PA,Maggi J,Schinnerling K,Sepúlveda-Gutiérrez A,Soto L,Neira O,Mehdi AM,Nel HJ,Pesce B,Aravena O,Molina MC,Catalán D,Thomas R,Verdugo RA,Aguillón JC

更新日期：2019-05-28 00:00:00

abstract：:Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages. Additionally, HIV-specific cytolytic CD4+ T cell responses in acute HIV infection are predictive of disease progression. CD57 expr...

journal_title：Frontiers in immunology

authors： Phetsouphanh C,Aldridge D,Marchi E,Munier CML,Meyerowitz J,Murray L,Van Vuuren C,Goedhals D,Fidler S,Kelleher A,Klenerman P,Frater J

更新日期：2019-08-08 00:00:00

abstract：:Intercellular communication is crucial to the immune system response. In the recent years, the discovery of exosomes has changed the way immune response orchestration was understood. Exosomes are able to operate as independent units that act as mediators in both physiological and pathological conditions. These structu...

journal_title：Frontiers in immunology

authors： Sastre B,Cañas JA,Rodrigo-Muñoz JM,Del Pozo V

更新日期：2017-07-21 00:00:00

abstract：:Epidemiological investigations have shown that smoking ameliorates ulcerative colitis (UC) but exacerbates Crohn's disease (CD), diseases that feature a Th2-mediated and Th1-mediated response, respectively. Cigarette extracts, especially nicotine, affect the Th1/Th2 balance. We previously reported that nicotine protec...

journal_title：Frontiers in immunology

authors： Qin Z,Wang PY,Wan JJ,Zhang Y,Wei J,Sun Y,Liu X

更新日期：2020-02-21 00:00:00

abstract：:The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows t...

journal_title：Frontiers in immunology

authors： Hoeffel G,Ginhoux F

更新日期：2015-09-22 00:00:00

abstract：:Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to tailor these alterations in gene expression to the requirements of the inflammatory process, tight and coordinate regulation of gene expression by environmental cues, microbial or danger-associated molecules or cytokines, are m...

journal_title：Frontiers in immunology

authors： Platanitis E,Decker T

更新日期：2018-11-13 00:00:00

abstract：:Stromal cells provide the structural foundation of secondary lymphoid organs (SLOs), and regulate leukocyte access and cell migration within the different compartments of spleen and lymph nodes (LNs). Furthermore, several stromal cell subsets have been implied in shaping of T cell responses through direct presentation...

journal_title：Frontiers in immunology

authors： Onder L,Scandella E,Chai Q,Firner S,Mayer CT,Sparwasser T,Thiel V,Rülicke T,Ludewig B

更新日期：2011-10-12 00:00:00

abstract：:During the entire processes of thymus organogenesis, maturation, and involution, gene regulation occurs post-transcriptionally via recently discovered microRNA (miRNA) transcripts. Numerous reports indicate that miRNAs may be involved in the construction of a normal thymic microenvironment, which constitutes a critica...

journal_title：Frontiers in immunology

authors： Xu M,Gan T,Ning H,Wang L

更新日期：2018-09-11 00:00:00

abstract：:NK cells play an important role in the innate defenses against tumor growth and metastases. Human NK cell activation and function are regulated by an array of HLA class I-specific inhibitory receptors and activating receptors recognizing ligands expressed de novo on tumor or virus-infected cells. NK cells have been ex...

journal_title：Frontiers in immunology

authors： Vacca P,Pietra G,Tumino N,Munari E,Mingari MC,Moretta L

更新日期：2020-01-17 00:00:00

abstract：:Transcriptional activation and repression of genes that are developmentally regulated or exhibit cell-type specific expression patterns is largely achieved by modifying the chromatin template at a gene locus. Complex formation of stable epigenetic histone marks, loss or gain of DNA methylation, alterations in chromoso...

journal_title：Frontiers in immunology

authors： Aune TM,Collins PL,Collier SP,Henderson MA,Chang S

更新日期：2013-05-16 00:00:00

abstract：:The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance. Recent data suggest that the survival of mTECs extends beyond the Aire+ cell population to ...

journal_title：Frontiers in immunology

authors： Wang X,Laan M,Bichele R,Kisand K,Scott HS,Peterson P

更新日期：2012-03-01 00:00:00

abstract：:A common feature of many acute and chronic oral diseases is microbial-induced inflammation. Innate immune responses are the first line of defense against pathogenic microorganisms and are initiated by pattern recognition receptors (PRRs) that specifically recognize pathogen-associated molecular patterns and danger-ass...

journal_title：Frontiers in immunology

authors： Wang L,Sun L,Byrd KM,Ko CC,Zhao Z,Fang J

更新日期：2020-08-13 00:00:00

abstract：:A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is critical to suppress tumor development and progression, primarily via maintaining effective immunosurveillance. Aberrant expression of immune checkpoints (ICs), including programmed cell death protein 1 (PD-1), cytotoxic ...

journal_title：Frontiers in immunology

authors： Saleh R,Toor SM,Sasidharan Nair V,Elkord E

更新日期：2020-07-14 00:00:00

abstract：:The rabbit monoclonal antibodies (mAbs) have advantages in pharmaceuticals and diagnostics with high affinity and specificity. During the past decade, many techniques have been developed for isolating rabbit mAbs, including single B cell antibody technologies. This review describes the basic characterization of rabbit...

journal_title：Frontiers in immunology

authors： Zhang Z,Liu H,Guan Q,Wang L,Yuan H

更新日期：2017-05-05 00:00:00

abstract：:Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment inhibits allergic sensitization through expansion of regulatory T cells. Here, we tested the impact of an IL-2 agonist in a...

journal_title：Frontiers in immunology

authors： Link CWM,Rau CN,Udoye CC,Ragab M,Korkmaz RÜ,Comdühr S,Clauder AK,Lindemann T,Frehse B,Hofmann K,Almeida LN,Laumonnier Y,Beidaq AE,Finkelman FD,Manz RA

更新日期：2020-12-11 00:00:00

abstract：:The T cell population in an individual needs to avoid harmful activation by self peptides while maintaining the ability to respond to an unknown set of foreign peptides. This property is acquired by a combination of thymic and extra-thymic mechanisms. We extend current models for the development of self/non-self discr...

journal_title：Frontiers in immunology

authors： Best K,Chain B,Watkins C

更新日期：2015-08-07 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment option for hematologic malignancies but relapse remains the most common cause of death. Infusion of donor lymphocytes (DLIs) can induce remission and prolong survival by exerting graft-vs.-leukemia (GVL) effects. However, sufficient tumor...

journal_title：Frontiers in immunology

authors： Jahnke S,Schmid H,Secker KA,Einhaus J,Duerr-Stoerzer S,Keppeler H,Schober-Melms I,Baur R,Schumm M,Handgretinger R,Bethge W,Kanz L,Schneidawind C,Schneidawind D

更新日期：2019-07-09 00:00:00

abstract：:Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as ...

journal_title：Frontiers in immunology

authors： Krupkova O,Sadowska A,Kameda T,Hitzl W,Hausmann ON,Klasen J,Wuertz-Kozak K

更新日期：2018-08-17 00:00:00

abstract：:The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together with a...

journal_title：Frontiers in immunology

authors： Ubah OC,Steven J,Kovaleva M,Ferguson L,Barelle C,Porter AJR,Barelle CJ

更新日期：2017-12-22 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although majority of TILs consist of CD8+/CD4+ T cells, the presence of NK cells and their role in the pathogenesis of PDAC remains elusive. We perform...

journal_title：Frontiers in immunology

authors： Lim SA,Kim J,Jeon S,Shin MH,Kwon J,Kim TJ,Im K,Han Y,Kwon W,Kim SW,Yee C,Kim SJ,Jang JY,Lee KM

更新日期：2019-04-09 00:00:00

abstract：:Migration of human plasmablast to the bone marrow is essential for the final differentiation of plasma cells and maintenance of effective humoral immunity. This migration is controlled by CXCL12/CXCR4-mediated activation of the protein kinase AKT. Herein, we show that the CXCL12-induced migration of human plasmablasts...

journal_title：Frontiers in immunology

authors： Pak HK,Nam B,Lee YK,Kim YW,Roh J,Son J,Chung YS,Choe J,Park CS

更新日期：2018-07-27 00:00:00

abstract：:Neutrophils releasing neutrophil extracellular traps (NETs) infiltrate the pancreas prior to type 1 diabetes (T1D) onset; however, the precise nature of their contribution to disease remains poorly defined. To examine how NETs affect immune functions in T1D, we investigated NET composition and their effect on dendriti...

journal_title：Frontiers in immunology

authors： Parackova Z,Zentsova I,Vrabcova P,Klocperk A,Sumnik Z,Pruhova S,Petruzelkova L,Hasler R,Sediva A

更新日期：2020-04-14 00:00:00

abstract：:In order to combat invading pathogens neutrophils can release neutrophil extracellular traps (NETs). However, since NETs can also damage endogenous cells, several control mechanisms for the formation of NETs must work effectively. For instance, neutrophil activation is silenced within blood circulation by the binding ...

journal_title：Frontiers in immunology

authors： Bornhöfft KF,Rebl A,Gallagher ME,Viergutz T,Zlatina K,Reid C,Galuska SP

更新日期：2019-11-06 00:00:00

abstract：:Natural antibodies (NAbs) are pre-existing antibodies with germline origin that arise in the absence of previous exposure to foreign antigens. NAbs are produced by B-1 lymphocytes and are primarily of the IgM isotype. There is accumulating evidence that - in addition to their role in antimicrobial host defense - NAbs ...

journal_title：Frontiers in immunology

authors： Tsiantoulas D,Gruber S,Binder CJ

更新日期：2013-01-09 00:00:00

abstract：:Myeloid cells play an important role in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Monocytes, macrophages, and microglia can adopt two distinct phenotypes, with M1-polarized cells being more related to inflammation and autoimmunity while M2-polariz...

journal_title：Frontiers in immunology

authors： Montes-Cobos E,Schweingruber N,Li X,Fischer HJ,Reichardt HM,Lühder F

更新日期：2017-10-13 00:00:00

abstract：:Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they r...

journal_title：Frontiers in immunology

authors： Corbett AJ,Awad W,Wang H,Chen Z

更新日期：2020-08-27 00:00:00

abstract：:Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

journal_title：Frontiers in immunology

authors： Bodmer W

更新日期：2019-06-05 00:00:00