Abstract:
:During the entire processes of thymus organogenesis, maturation, and involution, gene regulation occurs post-transcriptionally via recently discovered microRNA (miRNA) transcripts. Numerous reports indicate that miRNAs may be involved in the construction of a normal thymic microenvironment, which constitutes a critical component to support T lymphocyte development. MiRNAs are also expressed in thymic stromal cells including thymic epithelial cells (TECs) during maturation and senescence. This review focuses on the function of miRNAs in thymic development and involution. A better understanding of these processes will provide new insights into the regulatory network of TECs and further comprehension of how genes control TECs to maintain the thymic microenvironment during thymus development and aging, thus supporting a normal cellular immune system.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Xu M,Gan T,Ning H,Wang Ldoi
10.3389/fimmu.2018.02063subject
Has Abstractpub_date
2018-09-11 00:00:00pages
2063issn
1664-3224journal_volume
9pub_type
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