AIM2 Inflammasome's First Decade of Discovery: Focus on Oral Diseases.

abstract：:There is far less information available about the tumor infiltrating B (TIL-B) cells, than about the tumor infiltrating T cells. We focused on discovering the features and potential role of B lymphocytes in solid tumors. Our project aimed to develop innovative strategies to define cancer membrane structures. We chose ...

journal_title：Frontiers in immunology

authors： Kotlan B,Horvath S,Eles K,Plotar VK,Naszados G,Czirbesz K,Blank M,Farkas E,Toth L,Tovari J,Szekacs A,Shoenfeld Y,Godeny M,Kasler M,Liszkay G

更新日期：2019-04-05 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:Monocytes in humans consist of 3 subsets; CD14+CD16- (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), which exhibit distinct and heterogeneous responses to activation. During acute inflammation CD14+CD16- monocytes are significantly elevated and migrate to the sites of injury via the adhesion c...

journal_title：Frontiers in immunology

authors： Lee MKS,Al-Sharea A,Shihata WA,Bertuzzo Veiga C,Cooney OD,Fleetwood AJ,Flynn MC,Claeson E,Palmer CS,Lancaster GI,Henstridge DC,Hamilton JA,Murphy AJ

更新日期：2019-09-06 00:00:00

abstract：:It was recently proposed that T lymphocytes, which closely interact with APCs, can extract surface molecules from the presenting cells when they dissociate. These observations question the classical view of discrete interactions between phenotypically defined cell populations. In this review, we summarize some reports...

journal_title：Frontiers in immunology

authors： Dhainaut M,Moser M

更新日期：2014-03-28 00:00:00

abstract：:DExD/H-box helicase 36 (DHX36) is known to be an ATP-dependent RNA helicase that unwinds the guanine-quadruplexes DNA or RNA, but emerging data suggest that it also functions as pattern recognition receptor in innate immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been ...

journal_title：Frontiers in immunology

authors： Jing H,Zhou Y,Fang L,Ding Z,Wang D,Ke W,Chen H,Xiao S

更新日期：2017-10-23 00:00:00

abstract：:Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role in carcinogenesis, much remains to learn regarding their role in tumor growth and progression. We have identified granulocyte colony-stimulating factor (G-CSF) as one such cytokine, showing that G-CS...

journal_title：Frontiers in immunology

authors： Karagiannidis I,Jerman SJ,Jacenik D,Phinney BB,Yao R,Prossnitz ER,Beswick EJ

更新日期：2020-09-15 00:00:00

abstract：:The immunization of allogeneic hematopoietic cell transplantation (HCT) recipients against vaccine-preventable diseases is a part of posttransplantation guidelines. We conducted a prospective study to assess clinical and immunological parameters that would determine the response and long-term maintenance of protective...

journal_title：Frontiers in immunology

authors： Piekarska A,Wisniewski P,Lewandowski K,Gil L,Trzonkowski P,Bieniaszewska M,Zaucha JM

更新日期：2020-11-24 00:00:00

abstract：:Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

journal_title：Frontiers in immunology

authors： Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

更新日期：2019-06-04 00:00:00

abstract：:Liver fibrosis can result from various causes and could progress to cirrhosis and cancer; however, there are no effective treatments due to that its molecular mechanism is unclear. liver fibrosis model made by Schistosoma japonicum (S. japonicum) infection or Carbon tetrachloride (CCl4) intraperitoneal injection is a ...

journal_title：Frontiers in immunology

authors： Song LJ,Yin XR,Mu SS,Li JH,Gao H,Zhang Y,Dong PP,Mei CJ,Hua ZC

更新日期：2020-10-07 00:00:00

abstract：:Studying the evolutionary diversification of mammalian antiviral defenses is of main importance to better understand our innate immune repertoire. The small HERC proteins are part of a multigene family, including HERC5 and HERC6, which have probably diversified through complex evolutionary history in mammals. Here, we...

journal_title：Frontiers in immunology

authors： Jacquet S,Pontier D,Etienne L

更新日期：2020-12-18 00:00:00

abstract：:For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment ...

journal_title：Frontiers in immunology

authors： Caratelli S,Sconocchia T,Arriga R,Coppola A,Lanzilli G,Lauro D,Venditti A,Del Principe MI,Buccisano F,Maurillo L,Ferrone S,Sconocchia G

更新日期：2017-04-27 00:00:00

abstract：:Emerging and re-emerging viruses pose a significant public health challenge around the world, among which RNA viruses are the cause of many major outbreaks of infectious diseases. As one of the early lines of defense in the human immune system, RIG-I-like receptors (RLRs) play an important role as sentinels to thwart ...

journal_title：Frontiers in immunology

authors： Yong HY,Luo D

更新日期：2018-06-20 00:00:00

abstract：:Bovine neonatal pancytopenia (BNP) was a vaccine-induced alloimmune disease observed in young calves and characterized by hemorrhages, pancytopenia, and severe destruction of the hematopoietic tissues. BNP was induced by alloreactive maternal antibodies present in the colostrum of certain cows vaccinated with a highly...

journal_title：Frontiers in immunology

authors： Kasonta R,Mauritz J,Spohr C,Sauter-Louis C,Duchow K,Cussler K,Holsteg M,Bastian M

更新日期：2018-08-14 00:00:00

abstract：:The Ebola virus (EBOV) epidemic indicated a great need for prophylactic and therapeutic strategies. The use of plants for the production of biopharmaceuticals is a concept being adopted by the pharmaceutical industry, with an enzyme for human use currently commercialized since 2012 and some plant-based vaccines close ...

journal_title：Frontiers in immunology

authors： Rosales-Mendoza S,Nieto-Gómez R,Angulo C

更新日期：2017-03-10 00:00:00

abstract：:Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported that neonatal mice have a rapidly evolving T-cell receptor (TCR) repertoire that impairs CD8+ T cell immunity. To understand the impact of prematurity on the hu...

journal_title：Frontiers in immunology

authors： Carey AJ,Hope JL,Mueller YM,Fike AJ,Kumova OK,van Zessen DBH,Steegers EAP,van der Burg M,Katsikis PD

更新日期：2017-12-19 00:00:00

abstract：:The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly increased numbers of B cells. However, it has remained unclear whether th...

journal_title：Frontiers in immunology

authors： Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J

更新日期：2018-03-22 00:00:00

abstract：:Considerable evidence has been gathered over the last 10 years showing that the tumor microenvironment (TME) is not simply a passive recipient of immune cells, but an active participant in the establishment of immunosuppressive conditions. It is now well documented that hypoxia, within the TME, affects the functions o...

journal_title：Frontiers in immunology

authors： Baginska J,Viry E,Paggetti J,Medves S,Berchem G,Moussay E,Janji B

更新日期：2013-12-25 00:00:00

abstract：:Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matr...

journal_title：Frontiers in immunology

authors： Mozos I,Malainer C,Horbańczuk J,Gug C,Stoian D,Luca CT,Atanasov AG

更新日期：2017-08-31 00:00:00

abstract：:The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases, Lck. Upon T-cell antigen receptor (TCR) triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formation of complex signaling network and cytoskeletal re...

journal_title：Frontiers in immunology

authors： Ballek O,Valečka J,Dobešová M,Broučková A,Manning J,Řehulka P,Stulík J,Filipp D

更新日期：2016-10-27 00:00:00

abstract：:Food allergy is an atopic disease that is caused by the immune system targeting harmless food antigens that can result in life-threatening anaphylaxis. As humans and microbes have co-evolved, inevitably commensal microbes have a tremendous impact on our health. As such, the gut with its enormous microbial richness ref...

journal_title：Frontiers in immunology

authors： Kreft L,Hoffmann C,Ohnmacht C

更新日期：2020-08-14 00:00:00

abstract：:IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retinoic acid receptor-related orphan receptor gamma t (RORγt) but only a ...

journal_title：Frontiers in immunology

authors： Cole S,Murray J,Simpson C,Okoye R,Tyson K,Griffiths M,Baeten D,Shaw S,Maroof A

更新日期：2020-11-20 00:00:00

abstract：:Inducible Bronchus Associated Lymphoid Tissue (iBALT) is an ectopic lymphoid tissue associated with severe forms of chronic lung diseases, including chronic obstructive pulmonary disease, rheumatoid lung disease, hypersensitivity pneumonitis and asthma, suggesting that iBALT may exacerbate these clinical conditions. H...

journal_title：Frontiers in immunology

authors： Hwang JY,Silva-Sanchez A,Carragher DM,Garcia-Hernandez ML,Rangel-Moreno J,Randall TD

更新日期：2020-09-25 00:00:00

abstract：:This study develops an original co-infection model in mice using Brucella melitensis, the most frequent cause of human brucellosis, and Trypanosoma brucei, the agent of African trypanosomiasis. Although the immunosuppressive effects of T. brucei in natural hosts and mice models are well established, we observed that t...

journal_title：Frontiers in immunology

authors： Machelart A,Van Vyve M,Potemberg G,Demars A,De Trez C,Tima HG,Vanwalleghem G,Romano M,Truyens C,Letesson JJ,Muraille E

更新日期：2017-07-31 00:00:00

abstract：:Antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infections has been designed to optimize CD4 T-cell survival and limit HIV replication. Cell types other than CD4 T cells such as monocytes/macrophage, dendritic cells, and granulocytes (collectively known as myeloid cells), are generally not consider...

journal_title：Frontiers in immunology

authors： Murray SM,Zhang Y,Douek DC,Sekaly RP

更新日期：2020-03-04 00:00:00

abstract：:HIV-1 controllers (HIC) are extremely rare patients with the ability to control viral replication, maintain unchanging CD4 T-cell count, and evade disease progression for extensive periods of time, in the absence of antiretroviral therapy. In order to establish the representation of key genetic correlates of atypical ...

journal_title：Frontiers in immunology

authors： Westrop SJ,Cocker ATH,Boasso A,Sullivan AK,Nelson MR,Imami N

更新日期：2017-06-27 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.01135.]. ...

journal_title：Frontiers in immunology

authors： Ramirez GA,Rovere-Querini P,Blasi M,Sartorelli S,Di Chio MC,Baldini M,De Lorenzo R,Bozzolo EP,Leone R,Mantovani A,Manfredi AA,Tombetti E

更新日期：2019-07-24 00:00:00

abstract：:c-Maf belongs to the large Maf family of transcription factors and plays a key role in the regulation of cytokine production and differentiation of TH2, TH17, TFH, and Tr1 cells. Invariant natural killer T (iNKT) cells can rapidly produce large quantity of TH-related cytokines such as IFN-γ, IL-4, and IL-17A upon stim...

journal_title：Frontiers in immunology

authors： Yu JS,Hamada M,Ohtsuka S,Yoh K,Takahashi S,Miaw SC

更新日期：2017-10-27 00:00:00

abstract：:Natural killer (NK) cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a broad array of tissue distribution and phenotypic variability. NK cells express several activating and inhibitory receptors that rec...

journal_title：Frontiers in immunology

authors： Paul S,Lal G

更新日期：2017-09-13 00:00:00

abstract：:Induction of immune tolerance is a key process by which the immune system is educated to modulate reactions against benign stimuli such as self-antigens and commensal microbes. Understanding and harnessing the natural mechanisms of immune tolerance may become an increasingly useful strategy for treating many types of ...

journal_title：Frontiers in immunology

authors： Lundy SK,Klinker MW,Fox DA

更新日期：2015-03-20 00:00:00

abstract：:KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. Unlike KIR2DL1-3, recognizing HLA-C allotypes through Ig-like domains of the D1-D2 type, KIR2DL5 shares a D0-D2 configuration with KIR2DL4, and its ligands have not...

journal_title：Frontiers in immunology

authors： Cisneros E,Estefanía E,Vilches C

更新日期：2017-01-17 00:00:00