Transcriptional regulation of dendritic cell diversity.

abstract：:Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported that neonatal mice have a rapidly evolving T-cell receptor (TCR) repertoire that impairs CD8+ T cell immunity. To understand the impact of prematurity on the hu...

journal_title：Frontiers in immunology

authors： Carey AJ,Hope JL,Mueller YM,Fike AJ,Kumova OK,van Zessen DBH,Steegers EAP,van der Burg M,Katsikis PD

更新日期：2017-12-19 00:00:00

abstract：:Due to their overall immunocompromised state, lung transplant recipients (LTRs) are at increased risk for the development of viral respiratory infections compared to the general population. Such respiratory infections often lead to poor transplant outcomes. We performed a systematic review of the last 30 years of medi...

journal_title：Frontiers in immunology

authors： Bailey ES,Zemke JN,Choi JY,Gray GC

更新日期：2019-12-19 00:00:00

abstract：:Celiac Disease (CD) is a multifactorial, autoimmune enteropathy activated by cereal proteins in genetically predisposed individuals carrying HLA DQ2/8 genes. A heterogenous gene combination of the cereal prolamins is documented in different wheat genotypes, which is suggestive of their variable immunogenic potential. ...

journal_title：Frontiers in immunology

authors： Grover J,Chhuneja P,Midha V,Ghia JE,Deka D,Mukhopadhyay CS,Sood N,Mahajan R,Singh A,Verma R,Bansal E,Sood A

更新日期：2019-02-04 00:00:00

abstract：:The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its u...

journal_title：Frontiers in immunology

authors： Suen JL,Wu TT,Li YH,Lee CL,Kuo FC,Yan PS,Wu CF,Tran M,Wang CJ,Hung CH,Wu MT,Chan MWY,Huang SK

更新日期：2020-12-23 00:00:00

abstract：:Techniques with high sensitivity and specificity are required for an accurate diagnosis in low-transmission settings, where the conventional parasitological methods are insensitive. We determined the accuracy of an up-converting phosphor-lateral flow circulating anodic antigen (UCP-LF CAA) assay in urine and serum for...

journal_title：Frontiers in immunology

authors： Sousa MS,van Dam GJ,Pinheiro MCC,de Dood CJ,Peralta JM,Peralta RHS,Daher EF,Corstjens PLAM,Bezerra FSM

更新日期：2019-04-04 00:00:00

abstract：:The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system. Notably, increasing lines of evidence concerning autoimmune disorders such as Multiple Sclerosis (MS) report an imbalance i...

journal_title：Frontiers in immunology

authors： Antonini M,Lo Conte M,Sorini C,Falcone M

更新日期：2019-08-16 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and multifactorial disease of the gastrointestinal tract. The exact etiology of IBD remains complex and unclear involving an inadequately defined relationship between microbial insult, genetic predisposition, altered intestinal barrier permeability, oxidative stress compon...

journal_title：Frontiers in immunology

authors： Senhaji N,Kojok K,Darif Y,Fadainia C,Zaid Y

更新日期：2015-10-16 00:00:00

abstract：:DNA vaccines have great potential to control infectious disease, particularly those caused by intracellular organisms. They are inexpensive to produce and can be quickly modified to combat emerging infectious threats, but often fail to generate a strong immunologic response limiting enthusiasm for their use in humans ...

journal_title：Frontiers in immunology

authors： Solodushko V,Bitko V,Barrington R,Fouty B

更新日期：2019-10-11 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

journal_title：Frontiers in immunology

authors： Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

更新日期：2018-08-06 00:00:00

abstract：:The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations. Several studies revealed...

journal_title：Frontiers in immunology

authors： Grosche L,Knippertz I,König C,Royzman D,Wild AB,Zinser E,Sticht H,Muller YA,Steinkasserer A,Lechmann M

更新日期：2020-04-17 00:00:00

abstract：:Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T...

journal_title：Frontiers in immunology

authors： Costa MC,Paixão CS,Viana DL,Rocha BO,Saldanha M,da Mota LMH,Machado PRL,Pagliari C,de Oliveira MF,Arruda S,Carvalho EM,Carvalho LP

更新日期：2020-03-25 00:00:00

abstract：:Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory dis...

journal_title：Frontiers in immunology

authors： Mylonas A,Conrad C

更新日期：2018-11-28 00:00:00

abstract：:Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with repetitive antigenic stimulation from chronic infections or tumors. Using intracerebral (i.c.) inoculation with mouse polyomavirus (MuPyV), we have shown that CD8 T cells establish a PD-1hi, tissue-resident memory populat...

journal_title：Frontiers in immunology

authors： Shwetank,Frost EL,Mockus TE,Ren HM,Toprak M,Lauver MD,Netherby-Winslow CS,Jin G,Cosby JM,Evavold BD,Lukacher AE

更新日期：2019-04-17 00:00:00

abstract：:The caspase recruitment domain family member 11 (CARD11 or CARMA1)-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) [CBM] signalosome complex serves as a molecular bridge between cell surface antigen receptor signaling and the activation of the NF-κB, JNK, and mTORC1 signaling axes. This positions the CBM comp...

journal_title：Frontiers in immunology

authors： Lu HY,Bauman BM,Arjunaraja S,Dorjbal B,Milner JD,Snow AL,Turvey SE

更新日期：2018-09-19 00:00:00

abstract：:A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The genetic defect of the CF Transmembrane conductance Regulator (CFTR) ion channel promotes dehydration of the airway surface liquid, a...

journal_title：Frontiers in immunology

authors： Cabrini G,Rimessi A,Borgatti M,Lampronti I,Finotti A,Pinton P,Gambari R

更新日期：2020-08-04 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a heterogeneous subset of lymphocytes deeply implicated in the innate immune responses to different pathogens, in lymphoid organogenesis and in the maintenance of tissue homeostasis. Group 3 innate lymphoid cells (ILC3) have been detected in human decidua, where they play a role in the...

journal_title：Frontiers in immunology

authors： Pelosi A,Alicata C,Tumino N,Ingegnere T,Loiacono F,Mingari MC,Moretta L,Vacca P

更新日期：2020-02-06 00:00:00

abstract：:A successful outcome to pregnancy is dependent on the ability of the maternal uterine microenvironment to regulate inflammation processes and establish maternal tolerance. Recently, B cells have been shown to influence pregnancy outcomes as aberrations in their numbers and functions are associated with obstetric compl...

journal_title：Frontiers in immunology

authors： Guzman-Genuino RM,Eldi P,Garcia-Valtanen P,Hayball JD,Diener KR

更新日期：2019-12-11 00:00:00

abstract：:Extrapulmonary tuberculosis (EPTB) has become more common in recent years; however, the diagnosis of EPTB remains a challenge. In this study, we analyzed the performance of the ratio of TB-specific antigen (TBAg) to phytohemagglutinin (PHA) (TBAg/PHA ratio) in T-SPOT.TB (T-SPOT) assay for diagnosis and treatment monit...

journal_title：Frontiers in immunology

authors： Wang F,Yu J,Zhou Y,Luo Y,Wu S,Huang M,Yin B,Huang J,Mao L,Sun Z

更新日期：2018-05-14 00:00:00

abstract：:The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progressi...

journal_title：Frontiers in immunology

authors： Terry S,Buart S,Chouaib S

更新日期：2017-11-24 00:00:00

abstract：:Background and Objectives: The live non-pathogenic Leishmania tarantolae has recently provided a promising approach as an effective vaccine candidate against experimental leishmaniasis (ILL). Here, we evaluated the immunoprotective potential of the live Iranian Lizard Leishmania mixed with CpG adjuvant against L. majo...

journal_title：Frontiers in immunology

authors： Keshavarzian N,Noroozbeygi M,Haji Molla Hoseini M,Yeganeh F

更新日期：2020-10-23 00:00:00

abstract：:Vaccines against a variety of infectious diseases have been developed and tested. Although there have been some notable successes, most are less than optimal or have failed outright. There has been discussion about whether either B cells or dendritic cells (DCs) could be useful for the development of antimicrobial vac...

journal_title：Frontiers in immunology

authors： Fujii SI,Yamasaki S,Sato Y,Shimizu K

更新日期：2018-06-04 00:00:00

abstract：:An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a ...

journal_title：Frontiers in immunology

authors： Fazilleau N,Aloulou M

更新日期：2018-08-13 00:00:00

abstract：:The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and cellular immunity, removal of apoptotic and dead cells, and engagement ...

journal_title：Frontiers in immunology

authors： Holers VM,Banda NK

更新日期：2018-05-28 00:00:00

abstract：:The immune system contributes to neurodegenerative pathologies. However, the roles of γδ T cells in Alzheimer's disease (AD) are poorly understood. Here, we evaluated somatic variability of T-cell receptor γ genes (TRGs) in patients with AD. We performed deep sequencing of the CDR3 region of TRGs in patients with AD a...

journal_title：Frontiers in immunology

authors： Aliseychik M,Patrikeev A,Gusev F,Grigorenko A,Andreeva T,Biragyn A,Rogaev E

更新日期：2020-01-29 00:00:00

abstract：:Blood-borne monocyte derived cells play a pivotal, initially unrecognized, role in most central nervous system disorders, including diseases initially classified as purely neurodegenerative (i.e., Alzheimer's disease, Parkinson's disease, and ALS). Their trafficking to the brain and spinal cord has been extensively st...

journal_title：Frontiers in immunology

authors： Nigro A,Colombo F,Casella G,Finardi A,Verderio C,Furlan R

更新日期：2016-01-29 00:00:00

abstract：:The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is regulated by members of the interleukin IL-20 subfamily. This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in reg...

journal_title：Frontiers in immunology

authors： Lai X,Li X,Chang L,Chen X,Huang Z,Bao H,Huang J,Yang L,Wu X,Wang Z,Bellanti JA,Zheng SG,Zhang G

更新日期：2019-07-17 00:00:00

abstract：:Many a disease associates with inflammation. Upon binding of antigen-antibody complexes to immunoglobulin-like receptors, mast cells release tumor necrosis factor-α and proteases, causing fibroblasts to release endogenous antigens that may be cross reactive with exogenous antigens. We made a predictive dynamic map of ...

journal_title：Frontiers in immunology

authors： Abudukelimu A,Barberis M,Redegeld FA,Sahin N,Westerhoff HV

更新日期：2018-08-07 00:00:00

abstract：:Interleukin-33 (IL-33) plays multiple roles in tissue homeostasis, prevention of parasitic infection, and induction of allergic inflammation. Especially, IL-33-ST2 (IL-1RL1) axis has been regarded as the villain in allergic diseases such as asthma and atopic dermatitis and in autoimmune diseases such as rheumatoid art...

journal_title：Frontiers in immunology

authors： Takatori H,Makita S,Ito T,Matsuki A,Nakajima H

更新日期：2018-09-04 00:00:00

abstract：:Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between immune, glial, and neural cells is integral to the development of pathological pain. Modulation of these communications may hold the key to improved pain manag...

journal_title：Frontiers in immunology

authors： Vanderwall AG,Milligan ED

更新日期：2019-12-23 00:00:00

abstract：:The intestinal microbiota, composed of a large population of microorganisms, is often considered a "forgotten organ" in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal cancer (CRC). The roles for intestinal microorganisms that initia...

journal_title：Frontiers in immunology

authors： Cheng Y,Ling Z,Li L

更新日期：2020-11-30 00:00:00