Abstract：
:Due to their overall immunocompromised state, lung transplant recipients (LTRs) are at increased risk for the development of viral respiratory infections compared to the general population. Such respiratory infections often lead to poor transplant outcomes. We performed a systematic review of the last 30 years of medical literature to summarize the impact of specific respiratory viruses on LTRs. After screening 2,150 articles for potential inclusion, 39 manuscripts were chosen for final review. We found evidence for an association of respiratory viruses including respiratory syncytial virus (RSV), parainfluenza virus, and influenza viruses with increased morbidity following transplant. Through the literature search, we also documented associations of RSV and adenovirus infections with increased mortality among LTRs. We posit that the medical literature supports aggressive surveillance for respiratory viruses among this population.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Bailey ES,Zemke JN,Choi JY,Gray GCdoi
10.3389/fimmu.2019.02861subject
Has Abstractpub_date
2019-12-19 00:00:00pages
2861issn
1664-3224journal_volume
10pub_type
杂志文章abstract：:Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8+ T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. However, the metabolic determinants of a...
journal_title：Frontiers in immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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abstract：:Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied. Here we report an essential role of protein arginine methyltransferase 5 (PRMT5) in T cell homeostasis and activation-induced expansion. Usi...
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pub_type： 杂志文章
doi：10.3389/fimmu.2018.00235
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2018.02765
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abstract：:The ability of the host to clear hepatitis B virus (HBV) is closely correlated to the establishment of commensal microbiota. However, how microbiota affects anti-HBV immunity is still unclear. Using a well-known hydrodynamical HBV transfection mouse model and treatment with antibiotics (Atb), we explored the change in...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.00927
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abstract：:Vaccination is one of the most cost-effective health interventions and, with the exception of water sanitization, no other action has had such a major effect in mortality reduction. Combined with other approaches, such as clean water, better hygiene, and health education, vaccination contributed to prevent millions of...
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pub_type： 杂志文章
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2011.00040
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2015.00415
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.01149
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2016.00239
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abstract：:The Pediatric Acute Liver Failure (PALF) study is a multicenter, observational cohort study of infants and children diagnosed with this complex clinical syndrome. Outcomes in PALF reflect interactions among the child's clinical condition, response to supportive care, disease severity, potential for recovery, and, if n...
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pub_type： 杂志文章
doi：10.3389/fimmu.2020.610861
更新日期：2021-01-15 00:00:00
abstract：:Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcriptome changes in the blood. Although less relevant to the study of psoriasis pa...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.587946
更新日期：2020-11-24 00:00:00
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.01764
更新日期：2018-07-30 00:00:00
abstract：:CD4+ regulatory T cells have been intensively studied during aging, but little is still known about age-related changes of other regulatory T cell subsets. It was, therefore, the goal of the present study to analyze CD8+human leukocyte antigen-antigen D related (HLADR)+ T cells in old age, a cell population reported t...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.01201
更新日期：2018-06-04 00:00:00
abstract：:Natural killer cells (NK) represent a population of lymphocytes involved in innate immune response. In addition to their role in anti-viral and anti-tumor defense, they also regulate several aspects of the allo-immune response in kidney transplant recipients. Growing evidence suggests a key role of NK cells in the pat...
journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
doi：10.3389/fimmu.2020.01454
更新日期：2020-07-23 00:00:00
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2020.583550
更新日期：2020-10-06 00:00:00
abstract：:The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is know...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2017.01175
更新日期：2017-09-25 00:00:00
abstract：:Because Peyer's patches (PP) are the main inductive sites for gut IgA responses we have focused this review on what we know about the function of PP germinal centers (GC). The vast majority of IgA gene sequences in the gut lamina propria (LP) are heavily mutated arguing for an origin in GC. Because PP GC formation is ...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2012.00329
更新日期：2012-11-07 00:00:00
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.02141
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
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journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.01325
更新日期：2019-06-11 00:00:00
abstract：:Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high-affinity antibodies that aid both to clear and protect against reinfection of invading pathogens. Within GCs, light and ...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.01313
更新日期：2018-06-12 00:00:00
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
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更新日期：2017-03-14 00:00:00
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journal_title：Frontiers in immunology
pub_type： 杂志文章,评审
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更新日期：2019-11-28 00:00:00
abstract：:Cow's milk protein allergy (CMPA) is the most common allergy in the first year of life. Non-IgE mediated CMPA is characterized by digestive symptoms and tolerance development before the age of three. Gut microbiota composition in early life has been associated with food allergy. The ingestion of different foods/nutrie...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2019.01819
更新日期：2019-08-02 00:00:00
abstract：:Chimeric Antigen Receptor (CAR) T cells expressing the fusion of the NKG2D protein with CD3ζ (NKG2D-CAR T Cells) acquire a specificity for stress-induced ligands expressed on hematological and solid cancers. However, these stress ligands are also transiently expressed by activated T cells implying that NKG2D-based T c...
journal_title：Frontiers in immunology
pub_type： 杂志文章
doi：10.3389/fimmu.2018.02940
更新日期：2018-12-12 00:00:00
