Bacterial Lipopolysaccharides Suppress Erythroblastic Islands and Erythropoiesis in the Bone Marrow in an Extrinsic and G- CSF-, IL-1-, and TNF-Independent Manner.

abstract：:Though promoting remyelination in multiple sclerosis (MS) has emerged as a promising therapeutic strategy, it does not address inflammatory signals that continue to induce neuronal damage and inhibit effectiveness of repair mechanisms. Our lab has previously characterized the immunomodulatory tetrapeptide, tuftsin, wh...

journal_title：Frontiers in immunology

authors： Thompson KK,Nissen JC,Pretory A,Tsirka SE

更新日期：2018-11-28 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapies are being explored for over 20 years and found to be very safe. Most often, granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4)-induced monocyte-derived DCs (moDCs) are being used, which have demonstrated some life-prolonging benefit to patients ...

journal_title：Frontiers in immunology

authors： Zeng Q,Zhou Y,Schwarz H

更新日期：2019-10-02 00:00:00

abstract：:Duck plague virus (DPV) is a representative pathogen transmitted among aquatic animals that causes gross lesions and immune inhibition in geese and ducks. The mechanism of organ tropism and innate immune evasion of DPV has not been completely deciphered due to a lack of cell models to study the innate immune manipulat...

journal_title：Frontiers in immunology

authors： Tian B,Cai D,He T,Deng L,Wu L,Wang M,Jia R,Zhu D,Liu M,Yang Q,Wu Y,Zhao X,Chen S,Zhang S,Huang J,Ou X,Mao S,Yu Y,Zhang L,Liu Y,Cheng A

更新日期：2020-01-28 00:00:00

abstract：:Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

journal_title：Frontiers in immunology

authors： Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

更新日期：2019-06-04 00:00:00

abstract：:The NT5E (CD73) molecule represents an ecto-5'-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in healthy organs and tissues. Importantly, NT5E can act as inhibitory ...

journal_title：Frontiers in immunology

authors： Kordaß T,Osen W,Eichmüller SB

更新日期：2018-04-18 00:00:00

abstract：:Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) ...

journal_title：Frontiers in immunology

authors： Vecellio M,Cohen CJ,Roberts AR,Wordsworth PB,Kenna TJ

更新日期：2019-01-10 00:00:00

abstract：:Autologous chimeric antigen receptor-modified (CAR) T cells with specificity for CD19 showed potent antitumor efficacy in clinical trials against relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL). Contrary to T cells, natural killer (NK) cells kill their targets in a non-antigen-specific manner and d...

journal_title：Frontiers in immunology

authors： Müller S,Bexte T,Gebel V,Kalensee F,Stolzenberg E,Hartmann J,Koehl U,Schambach A,Wels WS,Modlich U,Ullrich E

更新日期：2020-01-24 00:00:00

abstract：:Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocorticoids are potent immune modulators and cause apoptotic death of immatu...

journal_title：Frontiers in immunology

authors： Gieras A,Gehbauer C,Perna-Barrull D,Engler JB,Diepenbruck I,Glau L,Joosse SA,Kersten N,Klinge S,Mittrücker HW,Friese MA,Vives-Pi M,Tolosa E

更新日期：2017-11-13 00:00:00

abstract：Background:Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) is protein contained in the membrane of the endoplasmic reticulum. In lung adenocarcinoma (LUAD), the molecular function of ERLIN2 and the correlation between ERLIN2 and tumor-infiltrating immune cells have been unclear. The aim of our study was ...

journal_title：Frontiers in immunology

authors： Liu Y,Xie P,Jiang D,Liu J,Zhang J,Bian T,Shi J

更新日期：2020-12-07 00:00:00

abstract：:Immunoglobulin G (IgG), a glycoprotein secreted by plasma B-cells, plays a major role in the human adaptive immune response and are associated with a wide range of diseases. Glycosylation of the Fc binding region of IgGs, responsible for the antibody's effector function, is essential for prompting a proper immune resp...

journal_title：Frontiers in immunology

authors： Wahl A,van den Akker E,Klaric L,Štambuk J,Benedetti E,Plomp R,Razdorov G,Trbojević-Akmačić I,Deelen J,van Heemst D,Slagboom PE,Vučković F,Grallert H,Krumsiek J,Strauch K,Peters A,Meitinger T,Hayward C,Wuhrer M,Beekm

更新日期：2018-02-26 00:00:00

abstract：:Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 protease and canonical NF-κB signaling. Structural data and in vitro ass...

journal_title：Frontiers in immunology

authors： Seeholzer T,Kurz S,Schlauderer F,Woods S,Gehring T,Widmann S,Lammens K,Krappmann D

更新日期：2018-11-20 00:00:00

abstract：:Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing i...

journal_title：Frontiers in immunology

authors： Sancho D,Enamorado M,Garaude J

更新日期：2017-05-08 00:00:00

abstract：:Epidemiological investigations have shown that smoking ameliorates ulcerative colitis (UC) but exacerbates Crohn's disease (CD), diseases that feature a Th2-mediated and Th1-mediated response, respectively. Cigarette extracts, especially nicotine, affect the Th1/Th2 balance. We previously reported that nicotine protec...

journal_title：Frontiers in immunology

authors： Qin Z,Wang PY,Wan JJ,Zhang Y,Wei J,Sun Y,Liu X

更新日期：2020-02-21 00:00:00

abstract：:Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy. Objective: To demonstrate whether IgM memory B cells are necessary for generating IgA-secreting plasma ...

journal_title：Frontiers in immunology

authors： Carsetti R,Di Sabatino A,Rosado MM,Cascioli S,Piano Mortari E,Milito C,Grimsholm O,Aranburu A,Giorda E,Tinozzi FP,Pulvirenti F,Donato G,Morini F,Bagolan P,Corazza GR,Quinti I

更新日期：2020-01-08 00:00:00

abstract：:Patients with severe eosinophilic asthma (SEA; characterized by persistent eosinophilia in blood and airway tissues) experience frequent asthma exacerbations with poor clinical outcomes. Interleukin 5 (IL-5) and IL-5 receptor alpha subunit (IL-5α) play key roles in eosinophilia maintenance, and relevant therapeutic st...

journal_title：Frontiers in immunology

authors： Kim JE,Lee DH,Jung K,Kim EJ,Choi Y,Park HS,Kim YS

更新日期：2021-01-08 00:00:00

abstract：:Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,de Wolf ACM,Ludwig IS,Leufkens P,Broere F

更新日期：2017-11-30 00:00:00

abstract：:Short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, modulate immune responses in the gut. However, the effect of SCFAs on mucosal vaccine-induced immune cell migration is poorly understood. Here, we investigated whether SCFAs modulate chemokine expression induced by the killed whole-cell oral c...

journal_title：Frontiers in immunology

authors： Sim JR,Kang SS,Lee D,Yun CH,Han SH

更新日期：2018-01-29 00:00:00

abstract：:One of the main functions of the human placenta is to provide a barrier between the fetal and maternal blood circulations, where gas exchange and transfer of nutrients to the developing fetus take place. Despite being a barrier, there is a multitude of crosstalk between maternal immune cells and fetally derived semi-a...

journal_title：Frontiers in immunology

authors： Kaipe H,Raffetseder J,Ernerudh J,Solders M,Tiblad E

更新日期：2020-08-19 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.01137.]. ...

journal_title：Frontiers in immunology

authors： Luchini LSG,Pidde G,Squaiella-Baptistão CC,Tambourgi DV

更新日期：2019-07-03 00:00:00

abstract：:Despite the ever present need for an effective Mycobacterium tuberculosis (Mtb) vaccine, efforts for development have been largely unsuccessful. Correlates of immune protection against Mtb are not wholly defined, but Th1 and likely Th17 adaptive immune responses have been demonstrated to be necessary for vaccine-media...

journal_title：Frontiers in immunology

authors： Smith AJ,Miller SM,Buhl C,Child R,Whitacre M,Schoener R,Ettenger G,Burkhart D,Ryter K,Evans JT

更新日期：2019-02-28 00:00:00

abstract：:B cell activation via the B cell receptor (BCR) signalosome involves participation of signaling molecules such as BTK and BLNK. Genetic defects in these molecules are known to impair B cell differentiation and subsequently lead to agammaglobulinemia. Here we identified novel mutations in BTK and BLNK in two unrelated ...

journal_title：Frontiers in immunology

authors： Geier CB,Sauerwein KMT,Leiss-Piller A,Zmek I,Fischer MB,Eibl MM,Wolf HM

更新日期：2018-12-18 00:00:00

abstract：:CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In macrophages, CD5L promotes an anti-inflammatory cytokine profile in response to TLR activation. In the present study, we questione...

journal_title：Frontiers in immunology

authors： Sanjurjo L,Aran G,Téllez É,Amézaga N,Armengol C,López D,Prats C,Sarrias MR

更新日期：2018-03-12 00:00:00

abstract：:Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophylactic strategy to ...

journal_title：Frontiers in immunology

authors： Jamal F,Singh MK,Hansa J,Pushpanjali,Ahmad G,Dikhit MR,Umar MS,Bimal S,Das P,Mujeeb AA,Singh SK,Zubair S,Owais M

更新日期：2020-06-02 00:00:00

abstract：:The potential of natural killer (NK) cells to target numerous malignancies in vitro has been well documented; however, only limited success has been seen in the clinic. Although NK cells prove non-toxic and safe regardless of the cell numbers injected, there is often little persistence and expansion observed in a pati...

journal_title：Frontiers in immunology

authors： Domogala A,Madrigal JA,Saudemont A

更新日期：2015-06-03 00:00:00

abstract：:Distinctive molecular characteristics of functionally diverse lymphocyte populations may represent novel pharmacological targets for immunotherapy. The intrinsic apoptosis pathway is differently regulated among conventional and regulatory T cells (Tregs). Targeted pharmacological modulation of this pathway with a smal...

journal_title：Frontiers in immunology

authors： Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE

更新日期：2016-03-01 00:00:00

abstract：:Psoriasis is a common inflammatory skin disease characterized by the appearance of red scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration, disability, and associated comorbidity make it a challenge for clinicians of multiple specialties. Likewise, its complex pathogenesis, c...

journal_title：Frontiers in immunology

authors： Boehncke WH

更新日期：2018-04-05 00:00:00

abstract：:Background: This retrospective study assessed the use and long-term outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with severe autoimmune diseases (ADs), reported to the European Society for Blood and Marrow Transplantation (EBMT) registry. Methods: Between 1997 and 2014, 128 patients...

journal_title：Frontiers in immunology

authors： Greco R,Labopin M,Badoglio M,Veys P,Furtado Silva JM,Abinun M,Gualandi F,Bornhauser M,Ciceri F,Saccardi R,Lankester A,Alexander T,Gennery AR,Bader P,Farge D,Snowden JA

更新日期：2019-07-04 00:00:00

abstract：:Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL). The proper o...

journal_title：Frontiers in immunology

authors： Bannas P,Hambach J,Koch-Nolte F

更新日期：2017-11-22 00:00:00

abstract：:Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes, has multifunctional roles in cellular context. Here, we report a novel molecular mechanism and function of USP14 in regulating autophagy induction and nuclear factor-kappa B (NF-κB) activation induced by toll-like rece...

journal_title：Frontiers in immunology

authors： Min Y,Lee S,Kim MJ,Chun E,Lee KY

更新日期：2017-12-15 00:00:00

abstract：:Obesity-induced chronic low-grade inflammation, in particular in adipose tissue, contributes to the development of insulin resistance and type 2 diabetes. However, the mechanism by which obesity induces adipose tissue inflammation has not been completely elucidated. Recent studies suggest that alteration of the nuclea...

journal_title：Frontiers in immunology

authors： Kim Y,Bayona PW,Kim M,Chang J,Hong S,Park Y,Budiman A,Kim YJ,Choi CY,Kim WS,Lee J,Cho KW

更新日期：2018-04-20 00:00:00