Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis.

abstract：:Osteocytes are terminally differentiated cells of the osteoblast lineage. They are involved in the regulation of bone remodeling by increasing osteoclast formation or decreasing bone formation by the secretion of the osteoblast inhibitor sclerostin. Monoclonal antibody anti-sclerostin, Romosozumab, has been developed ...

journal_title：Frontiers in immunology

authors： Toscani D,Bolzoni M,Ferretti M,Palumbo C,Giuliani N

更新日期：2018-10-24 00:00:00

abstract：:Transfer of recipient regulatory T cells (Tregs) induces mixed chimerism and tolerance in an irradiation-free bone marrow (BM) transplantation (BMT) model involving short-course co-stimulation blockade and mTOR inhibition. Boosting endogenous Tregs pharmacologically in vivo would be an attractive alternative avoiding ...

journal_title：Frontiers in immunology

authors： Granofszky N,Farkas AM,Muckenhuber M,Mahr B,Unger L,Maschke S,Pilat N,Holly R,Wiletel M,Regele H,Wekerle T

更新日期：2017-07-19 00:00:00

abstract：:Plasma cells (PCs), the B lineage cells responsible for producing and secreting antibodies (Abs), are critical cellular components of the humoral immune system. While most of the antibody-secreting cells in the body have a rather short lifetime of a few days, some of them can become long-lived and persist in the body ...

journal_title：Frontiers in immunology

authors： Lindquist RL,Niesner RA,Hauser AE

更新日期：2019-04-24 00:00:00

abstract：:The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport, and antigen presentation of IgG-opsonized antigens. Previously, we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T-dependent humoral immune response with increased IgG pr...

journal_title：Frontiers in immunology

authors： Schneider Z,Jani PK,Szikora B,Végh A,Kövesdi D,Iliás A,Cervenak J,Balogh P,Kurucz I,Kacskovics I

更新日期：2015-07-20 00:00:00

abstract：:Background: Disease progression monitoring through CD4 counts alone can be inadequate in HIV infection as ongoing immune activation may result in Serious non-AIDS events (SNAEs). SNAEs involve monocyte activation driven chronic inflammation with significant sequelae observed even during HAART. Here, we attempted to de...

journal_title：Frontiers in immunology

authors： Prabhu VM,Singh AK,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-12-06 00:00:00

abstract：:Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount of lactic acid through aerobic glycolysis during the early pregnan...

journal_title：Frontiers in immunology

authors： Ma LN,Huang XB,Muyayalo KP,Mor G,Liao AH

更新日期：2020-02-27 00:00:00

abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies mainly target the hemidesmosomal component BP180 (also known as type XVII collagen) in basal keratinocytes. Various triggering factors are known to induce BP onset, including radiotherapy, burns, ultraviolet exposure, surgery, an...

journal_title：Frontiers in immunology

authors： Mai Y,Nishie W,Sato K,Hotta M,Izumi K,Ito K,Hosokawa K,Shimizu H

更新日期：2018-04-12 00:00:00

abstract：:MHC class I (MHC-I) polymorphisms are associated with the outcome of some viral infections and autoimmune diseases. MHC-I proteins present antigenic peptides and are recognized by receptors on natural killer cells and cytotoxic T lymphocytes, thus enabling the immune system to detect self-antigens and eliminate target...

journal_title：Frontiers in immunology

authors： Hudson LE,Allen RL

更新日期：2016-07-25 00:00:00

abstract：:Scavenger receptors are cell surface membrane-bound receptors that typically bind multiple ligands and promote the removal of endogenous proteins and pathogens. In this study, we characterized a novel scavenger receptor-like protein, namely, SpBark. SpBark was upregulated in hemocytes after challenges with bacteria, s...

journal_title：Frontiers in immunology

authors： Li XC,Zhou J,Zhou JF,Wang Y,Ma H,Wang Y,Zhao S,Fang WH

更新日期：2019-08-23 00:00:00

abstract：:Gestational age-dependent immune intolerance at the maternal-fetal interface might be a contributing factor to placental pathology and adverse pregnancy outcomes. Although the intrauterine setting is highly choreographed and considered to be a protective environment for the fetus, unscheduled inflammation might overwh...

journal_title：Frontiers in immunology

authors： Kamity R,Sharma S,Hanna N

更新日期：2019-04-05 00:00:00

abstract：:The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB, and ghC. A candidate receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding of gC1qR and gC1q interaction could provide an insight ...

journal_title：Frontiers in immunology

authors： Pednekar L,Pathan AA,Paudyal B,Tsolaki AG,Kaur A,Abozaid SM,Kouser L,Khan HA,Peerschke EI,Shamji MH,Stenbeck G,Ghebrehiwet B,Kishore U

更新日期：2016-12-13 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues ass...

journal_title：Frontiers in immunology

authors： Mancheño-Corvo P,Lopez-Santalla M,Menta R,DelaRosa O,Mulero F,Del Rio B,Ramirez C,Büscher D,Bueren JA,Lopez-Belmonte J,Dalemans W,Garin MI,Lombardo E

更新日期：2017-04-21 00:00:00

abstract：:Intrarenal robust inflammatory response following ischemia-reperfusion injury (IRI) is a major factor in the pathogenesis of renal injury in ischemic acute kidney injury (AKI). Although numerous studies have investigated various agents of immune modulation or suppression for ischemic AKI, few showed reproducible effec...

journal_title：Frontiers in immunology

authors： Jang HR,Lee K,Jeon J,Kim JR,Lee JE,Kwon GY,Kim YG,Kim DJ,Ko JW,Huh W

更新日期：2020-10-14 00:00:00

abstract：:Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID). Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the Royal-Free-Hospital (RFH) London CVID cohort, including symptoms,...

journal_title：Frontiers in immunology

authors： van Schewick CM,Nöltner C,Abel S,Burns SO,Workman S,Symes A,Guzman D,Proietti M,Bulashevska A,Moreira F,Soetedjo V,Lowe DM,Grimbacher B

更新日期：2020-07-31 00:00:00

abstract：:Cytotoxic chemotherapeutics (CCTs) are widely used in the treatment of cancer. Although their mechanisms of action have been best understood in terms of targeting the apparatus of mitosis, an ability to stimulate anti-tumor immune responses is increasing the recognition of these agents as immunotherapies. Immune check...

journal_title：Frontiers in immunology

authors： Opzoomer JW,Sosnowska D,Anstee JE,Spicer JF,Arnold JN

更新日期：2019-07-17 00:00:00

abstract：:The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid cancer 1, in intratumoral activated CD8+ T cells ...

journal_title：Frontiers in immunology

authors： Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA

更新日期：2017-03-22 00:00:00

abstract：:Interleukin 10 is a central regulator of the antigen-presenting function of myeloid cells. It exerts immunomodulatory effects in vivo and induces a regulatory phenotype in monocyte-derived cells in vitro. We analyzed phenotype and function of monocytic cells in vitro in relation to the cytokine milieu and the timing o...

journal_title：Frontiers in immunology

authors： Krakow S,Crescimone ML,Bartels C,Wiegering V,Eyrich M,Schlegel PG,Wölfl M

更新日期：2019-06-28 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

journal_title：Frontiers in immunology

authors： Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

更新日期：2018-08-06 00:00:00

abstract：:All animals develop in association with complex microbial communities. It is now well established that commensal microbiota is essential for the correct functionality of each organ in the host. Particularly, the commensal gastro-intestinal microbiota (CGIM) is a key factor for development, immunity and nutrient conver...

journal_title：Frontiers in immunology

authors： Montalban-Arques A,De Schryver P,Bossier P,Gorkiewicz G,Mulero V,Gatlin DM 3rd,Galindo-Villegas J

更新日期：2015-10-09 00:00:00

abstract：:Ectoenzyme and receptor BST-1/CD157 has been considered as a key molecule involved in the regulation of functional activity of cells in various tissues and organs. It is commonly accepted that CD157 catalyzes NAD+ hydrolysis and acts as a component of integrin adhesion receptor complex. Such properties are important f...

journal_title：Frontiers in immunology

authors： Lopatina OL,Komleva YK,Malinovskaya NA,Panina YA,Morgun AV,Salmina AB

更新日期：2020-11-10 00:00:00

abstract：OBJECTIVE:Roseburia hominis is a flagellated gut anaerobic bacterium belonging to the Lachnospiraceae family within the Firmicutes phylum. A significant decrease of R. hominis colonization in the gut of ulcerative colitis patients has recently been demonstrated. In this work, we have investigated the mechanisms of R. h...

journal_title：Frontiers in immunology

authors： Patterson AM,Mulder IE,Travis AJ,Lan A,Cerf-Bensussan N,Gaboriau-Routhiau V,Garden K,Logan E,Delday MI,Coutts AGP,Monnais E,Ferraria VC,Inoue R,Grant G,Aminov RI

更新日期：2017-09-26 00:00:00

abstract：:The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention. Recent studies have revealed that NK cells are heterogeneous populations consisti...

journal_title：Frontiers in immunology

authors： Cong J,Wei H

更新日期：2019-06-25 00:00:00

abstract：:Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

journal_title：Frontiers in immunology

authors： Reddehase MJ

更新日期：2016-08-04 00:00:00

abstract：:CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR). CoBRR has been attributed in part to pathogen-driven T cell repert...

journal_title：Frontiers in immunology

authors： Espinosa JR,Mou D,Adams BW,DiBernardo LR,MacDonald AL,McRae M,Miller AN,Song M,Stempora LL,Wang J,Iwakoshi NN,Kirk AD

更新日期：2018-06-15 00:00:00

abstract：:IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retinoic acid receptor-related orphan receptor gamma t (RORγt) but only a ...

journal_title：Frontiers in immunology

authors： Cole S,Murray J,Simpson C,Okoye R,Tyson K,Griffiths M,Baeten D,Shaw S,Maroof A

更新日期：2020-11-20 00:00:00

abstract：:Infections with respiratory syncytial virus (RSV) occurs repeatedly throughout life because sustained, protective memory responses fail to develop. Why this occurs is not known. During RSV infection the recognition of the virus via the cytosolic RIG-I like receptors and signaling via the adaptor protein MAVS is crucia...

journal_title：Frontiers in immunology

authors： Paulsen M,Varese A,Pinpathomrat N,Kirsebom FCM,Paulsen M,Johansson C

更新日期：2020-10-06 00:00:00

abstract：:KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. Unlike KIR2DL1-3, recognizing HLA-C allotypes through Ig-like domains of the D1-D2 type, KIR2DL5 shares a D0-D2 configuration with KIR2DL4, and its ligands have not...

journal_title：Frontiers in immunology

authors： Cisneros E,Estefanía E,Vilches C

更新日期：2017-01-17 00:00:00

abstract：:Short-chain fatty acids (SCFAs) are mainly produced by microbiota through the fermentation of carbohydrates in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and have been shown to be important in the maintenance of host health. In this study, head kidney macrophages (HKMs) wer...

journal_title：Frontiers in immunology

authors： Zhang J,Zhang H,Liu M,Lan Y,Sun H,Mai K,Wan M

更新日期：2020-12-23 00:00:00

abstract：:Liver fibrosis can result from various causes and could progress to cirrhosis and cancer; however, there are no effective treatments due to that its molecular mechanism is unclear. liver fibrosis model made by Schistosoma japonicum (S. japonicum) infection or Carbon tetrachloride (CCl4) intraperitoneal injection is a ...

journal_title：Frontiers in immunology

authors： Song LJ,Yin XR,Mu SS,Li JH,Gao H,Zhang Y,Dong PP,Mei CJ,Hua ZC

更新日期：2020-10-07 00:00:00

abstract：:Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL). The proper o...

journal_title：Frontiers in immunology

authors： Bannas P,Hambach J,Koch-Nolte F

更新日期：2017-11-22 00:00:00