Abstract:
:Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount of lactic acid through aerobic glycolysis during the early pregnancy. Moreover, the placenta expresses the transporters of the lactic acid. While several studies have described the role of lactic acid in the tumor microenvironment, especially lactic acid's modulation of immune cells, the role of lactic acid produced during pregnancy is still unclear. In this paper, we reviewed the scientific evidence detailing the effects of lactic acid in the tumor microenvironment. Based on the influence of the lactic acid on immune cells and tumors, we proposed that lactic acid released in the unique uterine environment could have similar effects on the trophoblast cells and immune cells during the early pregnancy.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Ma LN,Huang XB,Muyayalo KP,Mor G,Liao AHdoi
10.3389/fimmu.2020.00279subject
Has Abstractpub_date
2020-02-27 00:00:00pages
279issn
1664-3224journal_volume
11pub_type
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abstract::[This corrects the article DOI: 10.3389/fimmu.2020.00367.]. ...
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