Eosinophilic granulomatosis with polyangiitis: an overview.

abstract：:Attenuated vaccinia virus (VACV) vectors are considered prime vaccine candidates for use in immunotherapy of infectious disease. In spite of this, recent data show that the level of attenuation may hamper the efficient generation of protective CD8 T cells. This suggests that additional adjuvant-like activities may nee...

journal_title：Frontiers in immunology

authors： Zhao Y,Tahiliani V,Salek-Ardakani S,Croft M

更新日期：2012-11-08 00:00:00

abstract：:Platelet Derived Growth Factor Receptor Alpha (PDGFRA) mutations occur in only about 5-7% of gastrointestinal stromal tumors (GIST), notably with alterations on exons 12/14/18. The most frequent PDGFRA mutation is the exon 18 D842V, which is correlated to specific clinico-pathological features, such as primary imatini...

journal_title：Frontiers in immunology

authors： Indio V,Ravegnini G,Astolfi A,Urbini M,Saponara M,De Leo A,Gruppioni E,Tarantino G,Angelini S,Pession A,Pantaleo MA,Nannini M

更新日期：2020-06-02 00:00:00

abstract：:Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular events are involved in controlling malignant cell process. In this sense, the importance of studying multiple cell alterations in this pathology is overriding. A well-identified fact on immune response is that it can vary depend ...

journal_title：Frontiers in immunology

authors： Segovia-Mendoza M,Morales-Montor J

更新日期：2019-03-01 00:00:00

abstract：:Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed ...

journal_title：Frontiers in immunology

authors： Muire PJ,Mangum LH,Wenke JC

更新日期：2020-06-04 00:00:00

abstract：:The receptor for advanced glycation endproducts (RAGE) can engage a diverse class of ligands and contribute to the immune and inflammatory response to infection and injury. It is known to be a pathogenic receptor in many inflammatory diseases, including ischemia/reperfusion (IR) injuries in several tissues; however, i...

journal_title：Frontiers in immunology

authors： Wu MC,Gilmour TD,Mantovani S,Woodruff TM

更新日期：2015-12-07 00:00:00

abstract：:Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to orchestrate their expansion, functional polarization and effector activity in non-lymphoid tissues or in their draining lymph nodes. The concept of harnessing DC immunogenicity to induce protective responses in cancer patients was ...

journal_title：Frontiers in immunology

authors： Cancel JC,Crozat K,Dalod M,Mattiuz R

更新日期：2019-02-12 00:00:00

abstract：:Metabolic reprogramming is rapidly gaining appreciation in the etiology of immune cell dysfunction in a variety of diseases. Tuberculosis, schistosomiasis, and sarcoidosis represent an important class of diseases characterized by the formation of granulomas, where macrophages are causatively implicated in disease path...

journal_title：Frontiers in immunology

authors： Wilson JL,Mayr HK,Weichhart T

更新日期：2019-10-04 00:00:00

abstract：:Hematopoietic cell transplantation (HCT) is a therapy option for aggressive forms of hematopoietic malignancies that are resistant to standard antitumoral therapies. Hematoablative treatment preceding HCT, however, opens a "window of opportunity" for latent Cytomegalovirus (CMV) by releasing it from immune control wit...

journal_title：Frontiers in immunology

authors： Reddehase MJ

更新日期：2016-08-04 00:00:00

abstract：:The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrate neutrophil recruitment to inflammatory sites through chemotactic gu...

journal_title：Frontiers in immunology

authors： Isles HM,Herman KD,Robertson AL,Loynes CA,Prince LR,Elks PM,Renshaw SA

更新日期：2019-07-31 00:00:00

abstract：:Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early detection of PID remains a challenge, particularly in older children with milder and less specific ...

journal_title：Frontiers in immunology

authors： Korsunskiy I,Blyuss O,Gordukova M,Davydova N,Zaikin A,Zinovieva N,Zimin S,Molchanov R,Salpagarova A,Eremeeva A,Filipenko M,Prodeus A,Korsunskiy A,Hsu P,Munblit D

更新日期：2020-03-03 00:00:00

abstract：:The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae, the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alteratio...

journal_title：Frontiers in immunology

authors： Silva CAM,Belisle JT

更新日期：2018-02-02 00:00:00

abstract：:Infectious pancreatic necrosis virus (IPNV) infection has been a major problem in salmonid aquaculture. Marker-assisted selection of individuals with resistant genotype at the major IPN quantitative trait locus (IPN-QTL) has significantly reduced mortality in recent years. We have identified host miRNAs that respond t...

journal_title：Frontiers in immunology

authors： Woldemariam NT,Agafonov O,Sindre H,Høyheim B,Houston RD,Robledo D,Bron JE,Andreassen R

更新日期：2020-09-11 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is highly effective in the treatment of B-cell acute lymphoblastic leukemia (ALL) or B-cell lymphoma, providing alternative therapeutic options for patients who failed to respond to conventional treatment or relapse. Moreover, it can bridge other therapeutic strategies an...

journal_title：Frontiers in immunology

authors： Xu X,Sun Q,Liang X,Chen Z,Zhang X,Zhou X,Li M,Tu H,Liu Y,Tu S,Li Y

更新日期：2019-11-12 00:00:00

abstract：:Cervical cancer remains a global health burden despite the introduction of highly effective vaccines for the prophylaxis of causative human papillomavirus infection (HPV). Current efforts to eradicate cervical cancer focus on the development of broadly protective, cost-effective approaches. HPV minor capsid protein L2...

journal_title：Frontiers in immunology

authors： Yang F,Mariz FC,Zhao X,Spagnoli G,Ottonello S,Müller M

更新日期：2020-12-04 00:00:00

abstract：:Our aim was to analyze the relationship between plasma inflammatory biomarkers and CD4+ T-cells evolution in human immunodeficiency virus (HIV) elite controllers (HIV-ECs) with a suppressed viremia. We carried out a retrospective study in 30 HIV-ECs classified into two groups: those showing no significant loss of CD4+...

journal_title：Frontiers in immunology

authors： Gutiérrez-Rivas M,Jiménez-Sousa MÁ,Rallón N,Jiménez JL,Restrepo C,León A,Montero-Alonso M,González-García J,Muñoz-Fernández MÁ,Benito JM,Resino S,ECRIS Integrated in the Spanish AIDS Research Network.

更新日期：2018-06-18 00:00:00

abstract：:It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require adenosine triphosphate-generating processes, whereas proliferating Teff require high metabolic flux through growth-promoting pathways, such as glycolysis. Pathways...

journal_title：Frontiers in immunology

authors： Coe DJ,Kishore M,Marelli-Berg F

更新日期：2014-11-18 00:00:00

abstract：:Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal immunization include natural concern about safety as well as a d...

journal_title：Frontiers in immunology

authors： Whittaker E,Goldblatt D,McIntyre P,Levy O

更新日期：2018-04-04 00:00:00

abstract：:Maternal immune activation (MIA) caused by exposure to pathogens or inflammation during critical periods of neurodevelopment is a major risk factor for behavioral deficits and psychiatric illness in offspring. A spectrum of behavioral abnormalities can be recapitulated in rodents by inducing MIA using the viral mimeti...

journal_title：Frontiers in immunology

authors： Baines KJ,Hillier DM,Haddad FL,Rajakumar N,Schmid S,Renaud SJ

更新日期：2020-06-09 00:00:00

abstract：:Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations. Respiratory viruses can cause exacerbations in chronic pulmonary diseases including COPD or asthma and have been suggested to contribute to...

journal_title：Frontiers in immunology

authors： Sörensen M,Kantorek J,Byrnes L,Boutin S,Mall MA,Lasitschka F,Zabeck H,Nguyen D,Dalpke AH

更新日期：2020-02-04 00:00:00

abstract：:The ubiquitously expressed, monomorphic MHC class Ib molecule MHC class I-related protein 1 (MR1) presents microbial metabolites to mucosal-associated invariant T (MAIT) cells. However, recent work demonstrates that both the ligands bound by MR1 and the T cells restricted by it are more diverse than originally thought...

journal_title：Frontiers in immunology

authors： Kulicke C,Karamooz E,Lewinsohn D,Harriff M

更新日期：2020-09-02 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

journal_title：Frontiers in immunology

authors： Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

更新日期：2018-08-06 00:00:00

abstract：:The main role of the human immune system is to eliminate cells presenting foreign antigens and abnormal patterns, while maintaining self-tolerance. However, when facing highly variable pathogens or antigens very similar to self-antigens, this system can fail in completely eliminating the anomalies, leading to the esta...

journal_title：Frontiers in immunology

authors： Vigano S,Bobisse S,Coukos G,Perreau M,Harari A

更新日期：2020-06-30 00:00:00

abstract：:The Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development of organ inflammation in systemic lupus erythematosus (SLE). Metabolic pathways can regulate T cell differentiation and function, thus contributing to SLE inflammation. Increasingly, data have shown metabolism influences and repr...

journal_title：Frontiers in immunology

authors： Shan J,Jin H,Xu Y

更新日期：2020-05-22 00:00:00

abstract：:Natural killer cells (NK) represent a population of lymphocytes involved in innate immune response. In addition to their role in anti-viral and anti-tumor defense, they also regulate several aspects of the allo-immune response in kidney transplant recipients. Growing evidence suggests a key role of NK cells in the pat...

journal_title：Frontiers in immunology

authors： Pontrelli P,Rascio F,Castellano G,Grandaliano G,Gesualdo L,Stallone G

更新日期：2020-07-23 00:00:00

abstract：:Interleukin 10 is a central regulator of the antigen-presenting function of myeloid cells. It exerts immunomodulatory effects in vivo and induces a regulatory phenotype in monocyte-derived cells in vitro. We analyzed phenotype and function of monocytic cells in vitro in relation to the cytokine milieu and the timing o...

journal_title：Frontiers in immunology

authors： Krakow S,Crescimone ML,Bartels C,Wiegering V,Eyrich M,Schlegel PG,Wölfl M

更新日期：2019-06-28 00:00:00

abstract：:Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq). This technique produces large volume sequence snapshots of B-cell receptors that are indicative of the antibody repertoire. In this paper, we enrich these...

journal_title：Frontiers in immunology

authors： Krawczyk K,Kelm S,Kovaltsuk A,Galson JD,Kelly D,Trück J,Regep C,Leem J,Wong WK,Nowak J,Snowden J,Wright M,Starkie L,Scott-Tucker A,Shi J,Deane CM

更新日期：2018-07-23 00:00:00

abstract：:Many pathogens, including the malaria parasite Plasmodium falciparum, display high levels of polymorphism within T-cell epitope regions of proteins associated with protective immunity. The T-cell epitope variants are often non-cross-reactive. Herein, we show in a murine model, which modifies a protective CD8 T-cell ep...

journal_title：Frontiers in immunology

authors： Minigo G,Flanagan KL,Slattery RM,Plebanski M

更新日期：2017-02-14 00:00:00

abstract：:Background: Disease progression monitoring through CD4 counts alone can be inadequate in HIV infection as ongoing immune activation may result in Serious non-AIDS events (SNAEs). SNAEs involve monocyte activation driven chronic inflammation with significant sequelae observed even during HAART. Here, we attempted to de...

journal_title：Frontiers in immunology

authors： Prabhu VM,Singh AK,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-12-06 00:00:00

abstract：:A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and infections. Therefore, it is necessary to seek novel immunosuppressive ...

journal_title：Frontiers in immunology

authors： Zeng Q,Qiu F,Chen Y,Liu C,Liu H,Liang CL,Zhang Q,Dai Z

更新日期：2019-04-01 00:00:00

abstract：:Preclinical and early human clinical studies of broadly neutralizing antibodies (bNAbs) to prevent and treat HIV infection support the clinical utility and potential of bNAbs for prevention, postexposure prophylaxis, and treatment of acute and chronic infection. Observed and potential limitations of bNAbs from these r...

journal_title：Frontiers in immunology

authors： Hua CK,Ackerman ME

更新日期：2017-11-28 00:00:00