Metabolic regulation of regulatory T cell development and function.

abstract：:Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE-/-) mice exhibit systemic effects including skin inflammation and hypertrophic lymph nodes (LNs). However...

journal_title：Frontiers in immunology

authors： Tay MHD,Lim SYJ,Leong YFI,Thiam CH,Tan KW,Torta FT,Narayanaswamy P,Wenk M,Angeli V

更新日期：2019-03-27 00:00:00

abstract：:Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire microbial products and prime adaptive immune responses against pathogens. Furthermore, DCs also play a key role in induction and maintenance of tolerance. Although numerous studies have assessed the diverse functions of DCs, many unanswere...

journal_title：Frontiers in immunology

authors： Zelante T,Fric J,Wong AY,Ricciardi-Castagnoli P

更新日期：2012-06-18 00:00:00

abstract：BACKGROUND:Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from i...

journal_title：Frontiers in immunology

authors： Castro Eiro MD,Alvarez MG,Cooley G,Viotti RJ,Bertocchi GL,Lococo B,Albareda MC,De Rissio AM,Natale MA,Parodi C,Tarleton RL,Laucella SA

更新日期：2017-09-15 00:00:00

abstract：:Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. However, infected humans and ...

journal_title：Frontiers in immunology

authors： Tracy KE,Baumgarth N

更新日期：2017-02-20 00:00:00

abstract：:Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy. Objective: To demonstrate whether IgM memory B cells are necessary for generating IgA-secreting plasma ...

journal_title：Frontiers in immunology

authors： Carsetti R,Di Sabatino A,Rosado MM,Cascioli S,Piano Mortari E,Milito C,Grimsholm O,Aranburu A,Giorda E,Tinozzi FP,Pulvirenti F,Donato G,Morini F,Bagolan P,Corazza GR,Quinti I

更新日期：2020-01-08 00:00:00

abstract：:The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and adaptive immunity. The secret of this functional diversity, in turn, r...

journal_title：Frontiers in immunology

authors： Ghebrehiwet B,Kandov E,Kishore U,Peerschke EIB

更新日期：2018-02-05 00:00:00

abstract：:A recent pandemic caused by a single-stranded RNA virus, COVID-19, initially discovered in China, is now spreading globally. This poses a serious threat that needs to be addressed immediately. Genome analysis of SARS-CoV-2 has revealed its close relation to SARS-coronavirus along with few changes in its spike protein....

journal_title：Frontiers in immunology

authors： Naz A,Shahid F,Butt TT,Awan FM,Ali A,Malik A

更新日期：2020-07-10 00:00:00

abstract：:Atherosclerosis is an inflammatory disease caused by endothelial injury, lipid deposition, and oxidative stress. This progressive disease can be converted into an acute clinical event by plaque rupture and thrombosis. In the context of atherosclerosis, the underlying cause of myocardial infarction and stroke, macropha...

journal_title：Frontiers in immunology

authors： de Gaetano M,Crean D,Barry M,Belton O

更新日期：2016-07-19 00:00:00

abstract：:Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumstances (i.e., strong...

journal_title：Frontiers in immunology

authors： Agazio A,Cimons J,Shotts KM,Guo K,Santiago ML,Pelanda R,Torres RM

更新日期：2020-07-22 00:00:00

abstract：Background:New sequencing techniques have revolutionized the identification of the molecular basis of primary immunodeficiency disorders (PID) not only by establishing a gene-based diagnosis but also by facilitating defect-specific treatment strategies, improving quality of life and survival, and allowing factual genet...

journal_title：Frontiers in immunology

authors： Segundo GRS,Nguyen ATV,Thuc HT,Nguyen LNQ,Kobayashi RH,Le HT,Le HTM,Torgerson TR,Ochs HD

更新日期：2018-02-16 00:00:00

abstract：:Ectodermal dysplasias (ED) are uncommon genetic disorders resulting in abnormalities in ectodermally derived structures. Many ED-associated genes have been described, of which ectodysplasin-A (EDA) is one of the more common. The NF-κB essential modulator (NEMO encoded by the IKBKG gene) is unique in that mutations res...

journal_title：Frontiers in immunology

authors： Keller MD,Petersen M,Ong P,Church J,Risma K,Burham J,Jain A,Stiehm ER,Hanson EP,Uzel G,Deardorff MA,Orange JS

更新日期：2011-11-08 00:00:00

abstract：:The identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this context, public Ig sequences shared by different individuals exposed to the same antigen could be valuable markers ...

journal_title：Frontiers in immunology

authors： Bürckert JP,Dubois ARSX,Faison WJ,Farinelle S,Charpentier E,Sinner R,Wienecke-Baldacchino A,Muller CP

更新日期：2017-12-22 00:00:00

abstract：:Natural killer (NK) cells are innate immune lymphocytes with potent cytolytic and immune-regulatory activities. NK cells are well-known for their ability to kill infected and malignant cells in a fast and non-specific way without prior sensitization. For this purpose, NK cells are equipped with a set of cytotoxic mole...

journal_title：Frontiers in immunology

authors： Vandenhaute J,Wouters CH,Matthys P

更新日期：2020-01-15 00:00:00

abstract：:The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self receptors and effector mechanisms differ greatly among animal phyla, some aspects of recognition, regulation, and response are broadly conserved. A gene regulatory ne...

journal_title：Frontiers in immunology

authors： Buckley KM,Rast JP

更新日期：2017-10-23 00:00:00

abstract：:Transfer of recipient regulatory T cells (Tregs) induces mixed chimerism and tolerance in an irradiation-free bone marrow (BM) transplantation (BMT) model involving short-course co-stimulation blockade and mTOR inhibition. Boosting endogenous Tregs pharmacologically in vivo would be an attractive alternative avoiding ...

journal_title：Frontiers in immunology

authors： Granofszky N,Farkas AM,Muckenhuber M,Mahr B,Unger L,Maschke S,Pilat N,Holly R,Wiletel M,Regele H,Wekerle T

更新日期：2017-07-19 00:00:00

abstract：:Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1), Th17, and regulatory T-cell (Treg) responses, throughout life. Although known to be the major cause of peptic ulcer disease and gastric cancer, disease occurs in a minority of thos...

journal_title：Frontiers in immunology

authors： Hussain K,Letley DP,Greenaway AB,Kenefeck R,Winter JA,Tomlinson W,Rhead J,Staples E,Kaneko K,Atherton JC,Robinson K

更新日期：2016-03-07 00:00:00

abstract：:Sepsis is characterized by the host's dysregulated immune response to an infection followed by a potentially fatal organ dysfunction. Although there have been some advances in the treatment of sepsis, mainly focused on broad-spectrum antibiotics, mortality rates remain high, urging for the search of new therapies. Oxi...

journal_title：Frontiers in immunology

authors： Navegantes-Lima KC,Monteiro VVS,de França Gaspar SL,de Brito Oliveira AL,de Oliveira JP,Reis JF,de Souza Gomes R,Rodrigues CA,Stutz H,Sovrani V,Peres A,Romão PRT,Monteiro MC

更新日期：2020-07-01 00:00:00

abstract：:The newborn's immune system must transition from a sterile haploidentical uterus to the world full of antigens. Regulatory B-cells (Breg; broadly defined as CD19+CD24hiCD38hi) are tolerance promoters in the adult immune system. They can inhibit IFN-γ and IL-17 production by T-cells and are essential in different condi...

journal_title：Frontiers in immunology

authors： Esteve-Solé A,Teixidó I,Deyà-Martínez A,Yagüe J,Plaza-Martín AM,Juan M,Alsina L

更新日期：2017-03-07 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of ...

journal_title：Frontiers in immunology

authors： Rubin DC,Shaker A,Levin MS

更新日期：2012-05-08 00:00:00

abstract：:The dynamics of skin-draining cells following infection or vaccination provide important insight into the initiation of immune responses. In this study, the local recruitment and activation of immune cells in draining lymph nodes (LNs) was studied in calves in an adjuvant-induced inflammation. A transient but remarkab...

journal_title：Frontiers in immunology

authors： Lund H,Boysen P,Åkesson CP,Lewandowska-Sabat AM,Storset AK

更新日期：2016-08-29 00:00:00

abstract：:Current guidelines encourage administering pneumococcal vaccine Prevnar-13 to patients with lupus, but whether such vaccinations affect disease severity is unclear. To address this issue, we treated 3-month-old MRL-lpr mice, that spontaneously develop a lupus-like syndrome, with Prevnar-13 or vehicle control. After 3 ...

journal_title：Frontiers in immunology

authors： Cantarelli C,Guglielmo C,Hartzell S,Salem FE,Andrighetto S,Gazivoda VP,Fiaccadori E,La Manna G,Zaza G,Leventhal J,Tassiulas I,Cravedi P

更新日期：2019-11-20 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia (CLL) exhibit an indolent disease course and unresponsive B cell receptors (BCRs) exemplified by an anergic phenotype of their leukemic cells. In up to 5% of patients, CLL transforms from an indolent subtype to an aggressive form of B cell lymphoma (Richter's syndrome), ...

journal_title：Frontiers in immunology

authors： Märklin M,Fuchs AR,Tandler C,Heitmann JS,Salih HR,Kauer J,Quintanilla-Martinez L,Wirths S,Kopp HG,Müller MR

更新日期：2020-09-02 00:00:00

abstract：:TonEBP is a key transcriptional activator in macrophages with an M1 phenotype. High expression of TonEBP is associated with many inflammatory diseases. Heme oxygenase-1 (HO-1), a stress-inducible protein, is induced by various oxidative and inflammatory signals, and its expression is regarded as an adaptive cellular r...

journal_title：Frontiers in immunology

authors： Yoo EJ,Lee HH,Ye BJ,Lee JH,Lee CY,Kang HJ,Jeong GW,Park H,Lim SW,Lee-Kwon W,Kwon HM,Choi SY

更新日期：2019-04-18 00:00:00

abstract：:Malaria is a public health concern worldwide, and Togo has proven to be no exception. Effective approaches to provide information on biological insights for disease elimination are therefore a research priority. Local selection on malaria pathogens is due to multiple factors including host immunity. We undertook genom...

journal_title：Frontiers in immunology

authors： Kassegne K,Komi Koukoura K,Shen HM,Chen SB,Fu HT,Chen YQ,Zhou XN,Chen JH,Cheng Y

更新日期：2020-10-23 00:00:00

abstract：Purpose:To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods:Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) ca...

journal_title：Frontiers in immunology

authors： Fernandez-Robredo P,Recalde S,Hernandez M,Zarranz-Ventura J,Molins B,Casaroli-Marano RP,Adan A,Saenz-de-Viteri M,García-Layana A

更新日期：2018-08-14 00:00:00

abstract：:Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little is known about its action in the suppressi...

journal_title：Frontiers in immunology

authors： Li Y,Zheng JY,Liu JQ,Yang J,Liu Y,Wang C,Ma XN,Liu BL,Xin GZ,Liu LF

更新日期：2016-12-07 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.00702.]. ...

journal_title：Frontiers in immunology

authors： Ryffel B,Huang F,Robinet P,Panek C,Couillin I,Erard F,Piotet J,Le Bert M,Mackowiak C,Torres Arias M,Dimier-Poisson I,Zheng SG

更新日期：2020-10-28 00:00:00

abstract：:The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class switching, and germinal center (GC) formation. The Tfh cells are characterized by the expression of CXC chemokine receptor 5 (CXCR5), ICOS, programed death 1 (PD-1), B cell lymphoma 6 (BCL-6), and IL-21. They are involved in...

journal_title：Frontiers in immunology

authors： Jogdand GM,Mohanty S,Devadas S

更新日期：2016-11-23 00:00:00

abstract：:Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of ...

journal_title：Frontiers in immunology

authors： Kainthola A,Haritwal T,Tiwari M,Gupta N,Parvez S,Tiwari M,Prakash H,Agrawala PK

更新日期：2017-05-02 00:00:00