Metabolic regulation of regulatory T cell development and function.


:It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require adenosine triphosphate-generating processes, whereas proliferating Teff require high metabolic flux through growth-promoting pathways, such as glycolysis. Pathways that control metabolism and immune cell function are intimately linked, and changes in cell metabolism at both the cell and system levels have been shown to enhance or suppress specific T cell effector functions. Furthermore, functionally distinct T cell subsets require distinct energetic and biosynthetic pathways to support their specific functional needs. In particular, naturally occurring regulatory T cells (Treg) are characterized by a unique metabolic signature distinct to that of conventional Teff cells. We here briefly review the signaling pathways that control Treg metabolism and how this metabolic phenotype integrates their differentiation and function. Ultimately, these metabolic features may provide new opportunities for the therapeutic modulation of unwanted immune responses.


Front Immunol


Frontiers in immunology


Coe DJ,Kishore M,Marelli-Berg F




Has Abstract


2014-11-18 00:00:00








  • Stimulation of monocytes by placental microparticles involves toll-like receptors and nuclear factor kappa-light-chain-enhancer of activated B cells.

    abstract::Human pregnancy is accompanied by a mild systemic inflammatory response, which includes the activation of monocytes circulating in maternal blood. This response is exaggerated in preeclampsia, a placental-dependent disorder specific to human pregnancies. We and others showed that placental syncytiotrophoblast membrane...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Joerger-Messerli MS,Hoesli IM,Rusterholz C,Lapaire O

    更新日期:2014-04-15 00:00:00

  • CD70 Deficiency Associated With Chronic Epstein-Barr Virus Infection, Recurrent Airway Infections and Severe Gingivitis in a 24-Year-Old Woman.

    abstract::Most of the few patients with homozygous CD70 deficiency described to date suffered from EBV-related malignancies in early childhood. We present a woman with CD70 deficiency diagnosed in adulthood. She presented in childhood with recurrent airway infections due to encapsulated bacteria, herpes zoster and a fulminant E...

    journal_title:Frontiers in immunology



    authors: Krüger R,Martin E,Dmytrus J,Feiterna-Sperling C,Meisel C,Unterwalder N,Kölsch U,Wahn V,Hofmann J,Korn P,Latour S,Boztug K,von Bernuth H

    更新日期:2020-08-04 00:00:00

  • Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation.

    abstract::Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell activation and downstream effector functions of CD4+ and CD8+ T-cells are controlled by the strength of interaction between the T-cell receptor (TCR) and peptide...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Jones N,Cronin JG,Dolton G,Panetti S,Schauenburg AJ,Galloway SAE,Sewell AK,Cole DK,Thornton CA,Francis NJ

    更新日期:2017-11-09 00:00:00

  • miRNAs Predicted to Regulate Host Anti-viral Gene Pathways in IPNV-Challenged Atlantic Salmon Fry Are Affected by Viral Load, and Associated With the Major IPN Resistance QTL Genotypes in Late Infection.

    abstract::Infectious pancreatic necrosis virus (IPNV) infection has been a major problem in salmonid aquaculture. Marker-assisted selection of individuals with resistant genotype at the major IPN quantitative trait locus (IPN-QTL) has significantly reduced mortality in recent years. We have identified host miRNAs that respond t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Woldemariam NT,Agafonov O,Sindre H,Høyheim B,Houston RD,Robledo D,Bron JE,Andreassen R

    更新日期:2020-09-11 00:00:00

  • Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer.

    abstract::The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Rubin DC,Shaker A,Levin MS

    更新日期:2012-05-08 00:00:00

  • Role of Viral and Host microRNAs in Immune Regulation of Epstein-Barr Virus-Associated Diseases.

    abstract::Epstein-Barr virus (EBV) is an oncogenic human herpes virus that was discovered in 1964. Viral non-coding RNAs, such as BamHI-A rightward fragment-derived microRNAs (BART miRNAs) or BamHI-H rightward fragment 1-derived miRNAs (BHRF1 miRNA) in EBV-infected cells have been recently reported. Host miRNAs are also upregul...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

    更新日期:2020-03-03 00:00:00

  • Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination.

    abstract::Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA. Recently, there has been a growing interest in investigating physiological regulators of PAD acti...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Nagar M,Tilvawala R,Thompson PR

    更新日期:2019-02-19 00:00:00

  • Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity.

    abstract::Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocorticoids are potent immune modulators and cause apoptotic death of immatu...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gieras A,Gehbauer C,Perna-Barrull D,Engler JB,Diepenbruck I,Glau L,Joosse SA,Kersten N,Klinge S,Mittrücker HW,Friese MA,Vives-Pi M,Tolosa E

    更新日期:2017-11-13 00:00:00

  • Emerging Mechanisms of Insulin-Mediated Antiviral Immunity in Drosophila melanogaster.

    abstract::Arboviruses (arthropod-borne viruses), such as Zika (ZIKV), West Nile (WNV), and dengue (DENV) virus, include some of the most significant global health risks to human populations. The steady increase in the number of cases is of great concern due to the debilitating diseases associated with each viral infection. Beca...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Trammell CE,Goodman AG

    更新日期:2019-12-20 00:00:00

  • Evaluation of Leishmanization Using Iranian Lizard Leishmania Mixed With CpG-ODN as a Candidate Vaccine Against Experimental Murine Leishmaniasis.

    abstract::Background and Objectives: The live non-pathogenic Leishmania tarantolae has recently provided a promising approach as an effective vaccine candidate against experimental leishmaniasis (ILL). Here, we evaluated the immunoprotective potential of the live Iranian Lizard Leishmania mixed with CpG adjuvant against L. majo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Keshavarzian N,Noroozbeygi M,Haji Molla Hoseini M,Yeganeh F

    更新日期:2020-10-23 00:00:00

  • Rationale for a Multimodality Strategy to Enhance the Efficacy of Dendritic Cell-Based Cancer Immunotherapy.

    abstract::Dendritic cells (DC), master antigen-presenting cells that orchestrate interactions between the adaptive and innate immune arms, are increasingly utilized in cancer immunotherapy. Despite remarkable progress in our understanding of DC immunobiology, as well as several encouraging clinical applications - such as DC-bas...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Datta J,Berk E,Cintolo JA,Xu S,Roses RE,Czerniecki BJ

    更新日期:2015-06-02 00:00:00

  • The Heterogeneity, Origins, and Impact of Migratory iILC2 Cells in Anti-helminth Immunity.

    abstract::Soil-transmitted helminths represent a major global health burden with infections and infection-related comorbidities causing significant reductions in the quality of life for individuals living in endemic areas. Repeated infections and chronic colonization by these large extracellular worms in mammals led to the evol...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Miller MM,Reinhardt RL

    更新日期:2020-07-23 00:00:00

  • Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy.

    abstract::Acquired generalized lipodystrophy (AGL) is a rare condition characterized by an altered distribution of adipose tissue and predisposition to develop hepatic steatosis and fibrosis, diabetes, and hypertriglyceridemia. Diagnosis of AGL is based on the observation of generalized fat loss, autoimmunity and lack of family...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Corvillo F,Aparicio V,López-Lera A,Garrido S,Araújo-Vilar D,de Miguel MP,López-Trascasa M

    更新日期:2018-09-19 00:00:00

  • HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic Cells.

    abstract::Genital herpes is a common sexually transmitted infection caused by herpes simplex virus type 2 (HSV-2). Genital herpes significantly enhances the acquisition and transmission of HIV-1 by creating a microenvironment that supports HIV infection in the host. Dendritic cells (DCs) represent one of the first innate cell t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Crisci E,Svanberg C,Ellegård R,Khalid M,Hellblom J,Okuyama K,Bhattacharya P,Nyström S,Shankar EM,Eriksson K,Larsson M

    更新日期:2019-12-06 00:00:00

  • Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils.

    abstract::Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the joints of patients with RA. Calcium-dependent peptidyl-arginine deiminases (PAD) are the enzymes responsible for citrullination. PAD2 ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zhou Y,Chen B,Mittereder N,Chaerkady R,Strain M,An LL,Rahman S,Ma W,Low CP,Chan D,Neal F,Bingham CO 3rd,Sampson K,Darrah E,Siegel RM,Hasni S,Andrade F,Vousden KA,Mustelin T,Sims GP

    更新日期:2017-09-25 00:00:00

  • IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice.

    abstract::IRF-7 mediates robust production of type I IFN via MyD88 of the TLR9 pathway in plasmacytoid dendritic cells (pDCs). Previous in vitro studies using bone marrow-derived dendritic cells lacking either Irf7 or Irf3 have demonstrated that only IRF-3 is required for IFN-β production in the TLR4 pathway. Here, we show that...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Sin WX,Yeong JP,Lim TJF,Su IH,Connolly JE,Chin KC

    更新日期:2020-04-16 00:00:00

  • Anatomy of a discovery: m1 and m2 macrophages.

    abstract::M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom. In humans and other higher animals, M1 and M2-type macrophage responses also init...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Mills CD

    更新日期:2015-05-05 00:00:00

  • Neutrophil Inflammatory Response Is Downregulated by Uptake of Superparamagnetic Iron Oxide Nanoparticle Therapeutics.

    abstract::Superparamagnetic iron oxide nanoparticles (SPION) are employed as diagnostics and therapeutics following intravenous delivery for the treatment of iron deficiency anemia (IDA) in adult patients with chronic kidney failure. Neutrophils are the first defense against blood borne foreign insult and recruit to vascular si...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Garcia G,Kim MH,Morikis VA,Simon SI

    更新日期:2020-12-09 00:00:00

  • Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection.

    abstract::Chagas disease, which was once thought to be confined to endemic regions of Latin America, has now gone global becoming a new worldwide challenge. For more than a century since its discovery, it has remained neglected with no effective drugs or vaccines. The mechanisms by which Trypanosoma cruzi regulates and uses the...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Nde PN,Lima MF,Johnson CA,Pratap S,Villalta F

    更新日期:2012-11-06 00:00:00

  • Tumor-Associated Disialylated Glycosphingolipid Antigen-Revealing Antibodies Found in Melanoma Patients' Immunoglobulin Repertoire Suggest a Two-Direction Regulation Mechanism Between Immune B Cells and the Tumor.

    abstract::There is far less information available about the tumor infiltrating B (TIL-B) cells, than about the tumor infiltrating T cells. We focused on discovering the features and potential role of B lymphocytes in solid tumors. Our project aimed to develop innovative strategies to define cancer membrane structures. We chose ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kotlan B,Horvath S,Eles K,Plotar VK,Naszados G,Czirbesz K,Blank M,Farkas E,Toth L,Tovari J,Szekacs A,Shoenfeld Y,Godeny M,Kasler M,Liszkay G

    更新日期:2019-04-05 00:00:00

  • Rapid Evolution of HERC6 and Duplication of a Chimeric HERC5/6 Gene in Rodents and Bats Suggest an Overlooked Role of HERCs in Mammalian Immunity.

    abstract::Studying the evolutionary diversification of mammalian antiviral defenses is of main importance to better understand our innate immune repertoire. The small HERC proteins are part of a multigene family, including HERC5 and HERC6, which have probably diversified through complex evolutionary history in mammals. Here, we...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Jacquet S,Pontier D,Etienne L

    更新日期:2020-12-18 00:00:00

  • The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT).

    abstract::We conducted a prospective study of 312 patients (194 with multiple myeloma, 118 with lymphomas) receiving high-dose conditioning chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT). Polymorphisms of MBL2 and MASP2 genes were investigated and serial measurements of serum concentrations of m...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Świerzko AS,Michalski M,Sokołowska A,Nowicki M,Eppa Ł,Szala-Poździej A,Mitrus I,Szmigielska-Kapłon A,Sobczyk-Kruszelnicka M,Michalak K,Gołos A,Wierzbowska A,Giebel S,Jamroziak K,Kowalski ML,Brzezińska O,Thiel S,Jenseniu

    更新日期:2018-09-20 00:00:00

  • The Intestinal Microbiota and Colorectal Cancer.

    abstract::The intestinal microbiota, composed of a large population of microorganisms, is often considered a "forgotten organ" in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal cancer (CRC). The roles for intestinal microorganisms that initia...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Cheng Y,Ling Z,Li L

    更新日期:2020-11-30 00:00:00

  • New Chimeric Antigen Receptor Design for Solid Tumors.

    abstract::In recent years, chimeric antigen receptor (CAR) T-cell therapy has become popular in immunotherapy, particularly after its tremendous success in the treatment of lineage-restricted hematologic cancers. However, the application of CAR T-cell therapy for solid tumors has not reached its full potential because of the la...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Wang Y,Luo F,Yang J,Zhao C,Chu Y

    更新日期:2017-12-22 00:00:00

  • Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.

    abstract::The main role of the human immune system is to eliminate cells presenting foreign antigens and abnormal patterns, while maintaining self-tolerance. However, when facing highly variable pathogens or antigens very similar to self-antigens, this system can fail in completely eliminating the anomalies, leading to the esta...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Vigano S,Bobisse S,Coukos G,Perreau M,Harari A

    更新日期:2020-06-30 00:00:00

  • Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination.

    abstract::Central memory T cell (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB); however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses by CD4 T cell effect...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Maggioli MF,Palmer MV,Thacker TC,Vordermeier HM,McGill JL,Whelan AO,Larsen MH,Jacobs WR Jr,Waters WR

    更新日期:2016-10-17 00:00:00

  • IFN-I Mediates Dysfunction of Endothelial Progenitor Cells in Atherosclerosis of Systemic Lupus Erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease including the cardiovascular system. Atherosclerosis is the most common cardiovascular complication of SLE and a significant risk factor for morbidity and mortality. Vascular damage/protection mechanism in SLE patients is out of balance, caused by...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Ding X,Xiang W,He X

    更新日期:2020-11-11 00:00:00

  • Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse.

    abstract::Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6. Despite accumulating evidences that α-defensin functions in controlling the intesti...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Nakamura K,Yokoi Y,Fukaya R,Ohira S,Shinozaki R,Nishida T,Kikuchi M,Ayabe T

    更新日期:2020-10-13 00:00:00

  • CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine.

    abstract::Construction of an optimal vaccine against tumors relies on the availability of appropriate tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T cells (CTL). CTL are considered the major effectors of the anti-tumor adaptive immune response as they recognize antigens presented on M...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Accolla RS,Ramia E,Tedeschi A,Forlani G

    更新日期:2019-07-30 00:00:00

  • Immunological Relevance of the Coevolution of IDO1 and AHR.

    abstract::The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to play a crucial role in controlling innate and adaptive immune responses through several mechanism...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Jaronen M,Quintana FJ

    更新日期:2014-10-20 00:00:00