Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin d3-treated tolerogenic dendritic cells.


:Tolerogenic dendritic cells (DCs) work through silencing of differentiated antigen-specific T cells, activation and expansion of naturally occurring T regulatory cells (Tregs), transfer of regulatory properties to T cells, and the differentiation of naïve T cells into Tregs. Due to an operational definition based on T cell activation assays, the identity of tolerogenic DCs has been a matter of debate and it need not represent a specialized DC subset. Human tolerogenic DCs generated in vitro using inhibitory cytokines, growth factors, natural immunomodulators, or genetic manipulation have been effective and several of these tolerogenic DCs are currently being tested for clinical use. Ex vivo generated tolerogenic DCs reduce activation of naïve T cells using various means, promote a variety of regulatory T cells and most importantly, frequently show stable inhibitory phenotypes upon repetitive maturation with inflammatory factors. Yet, tolerogenic DCs differ with respect to the phenotype or the number of regulatory mechanisms they employ to modulate the immune system. In our experience, tolerogenic DCs generated using the biologically active form of vitamin D (VD3-DCs), alone, or combined with dexamethasone are proficient in their immunoregulatory functions. These tolerogenic DCs show a stable maturation-resistant semi-mature phenotype with low expression of activating co-stimulatory molecules, no production of the IL-12 family of cytokines and high expression of inhibitory molecules and IL-10. VD3-DCs induce increased apoptosis of effector T cells and induce antigen-specific regulatory T cells, which work through linked suppression ensuring infectious tolerance. Lessons learned on VD3-DCs help understanding the contribution of different pattern-recognition receptors (PRRs) and secondary signals to the tolerogenic function and how a cross-talk between DCs and T cells translates into immune regulation.


Front Immunol


Frontiers in immunology


Nikolic T,Roep BO




Has Abstract


2013-05-14 00:00:00








  • Complement Inhibitors in Clinical Trials for Glomerular Diseases.

    abstract::Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lup...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Zipfel PF,Wiech T,Rudnick R,Afonso S,Person F,Skerka C

    更新日期:2019-09-27 00:00:00

  • CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection.

    abstract::West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. F...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Koblischke M,Spitzer FS,Florian DM,Aberle SW,Malafa S,Fae I,Cassaniti I,Jungbauer C,Knapp B,Laferl H,Fischer G,Baldanti F,Stiasny K,Heinz FX,Aberle JH

    更新日期:2020-01-23 00:00:00

  • Natural Killer Cells in the Lungs.

    abstract::The lungs, a special site that is frequently challenged by tumors, pathogens and other environmental insults, are populated by large numbers of innate immune cells. Among these, natural killer (NK) cells are gaining increasing attention. Recent studies have revealed that NK cells are heterogeneous populations consisti...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Cong J,Wei H

    更新日期:2019-06-25 00:00:00

  • B-1 cell immunoglobulin directed against oxidation-specific epitopes.

    abstract::Natural antibodies (NAbs) are pre-existing antibodies with germline origin that arise in the absence of previous exposure to foreign antigens. NAbs are produced by B-1 lymphocytes and are primarily of the IgM isotype. There is accumulating evidence that - in addition to their role in antimicrobial host defense - NAbs ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Tsiantoulas D,Gruber S,Binder CJ

    更新日期:2013-01-09 00:00:00

  • The Joint-Brain Axis: Insights From Rheumatoid Arthritis on the Crosstalk Between Chronic Peripheral Inflammation and the Brain.

    abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive polyarthritis. Beyond joint pathology, RA is associated with neuropsychiatric comorbidity including depression, anxiety, and an increased risk to develop neurodegenerative diseases in later life. Studies investigating the central nerv...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Süß P,Rothe T,Hoffmann A,Schlachetzki JCM,Winkler J

    更新日期:2020-12-10 00:00:00

  • Cutaneous Leishmaniasis Vaccination: A Matter of Quality.

    abstract::There have been exhaustive efforts to develop an efficient vaccine against leishmaniasis. Factors like host and parasite genetic characteristics, virulence, epidemiological scenarios, and, mainly, diverse immune responses triggered by Leishmania species make the achievement of this aim a complex task. It is already cl...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: De Luca PM,Macedo AB

    更新日期:2016-04-21 00:00:00

  • Influenza and Antibody-Dependent Cellular Cytotoxicity.

    abstract::Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination results in antigenic shift that can rapidly move through populations ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Von Holle TA,Moody MA

    更新日期:2019-06-25 00:00:00

  • The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment.

    abstract::Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key con...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Mi Y,Guo N,Luan J,Cheng J,Hu Z,Jiang P,Jin W,Gao X

    更新日期:2020-04-24 00:00:00

  • Neddylation Facilitates the Antiviral Response in Zebrafish.

    abstract::Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of neddylation are the cullin-RING ligases (CRLs)...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Yu G,Liu X,Tang J,Xu C,Ouyang G,Xiao W

    更新日期:2019-06-25 00:00:00

  • SpBark Suppresses Bacterial Infection by Mediating Hemocyte Phagocytosis in an Invertebrate Model, Scylla paramamosain.

    abstract::Scavenger receptors are cell surface membrane-bound receptors that typically bind multiple ligands and promote the removal of endogenous proteins and pathogens. In this study, we characterized a novel scavenger receptor-like protein, namely, SpBark. SpBark was upregulated in hemocytes after challenges with bacteria, s...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Li XC,Zhou J,Zhou JF,Wang Y,Ma H,Wang Y,Zhao S,Fang WH

    更新日期:2019-08-23 00:00:00

  • Leukotriene A4 Hydrolase Is a Candidate Predictive Biomarker for Successful Allergen Immunotherapy.

    abstract:Background:Allergic rhinitis is a common disorder that affects 10% to 40% of the population worldwide. Allergen immunotherapy (AIT) represents the only therapy that has the potential to resolve clinical symptoms of allergic rhinitis. However, up to 30% of patients do not respond to AIT. Biomarkers predicting the clinic...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ma TT,Cao MD,Yu RL,Shi HY,Yan WJ,Liu JG,Pan C,Sun J,Wei QY,Wang DY,Wei JF,Wang XY,Yin JS

    更新日期:2020-11-24 00:00:00

  • RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.

    abstract::Efficient induction of effector and long-term protective antigen-specific CD8+ T memory response by vaccination is essential to eliminate malignant and pathogen-infected cells. Intracellular infectious bacteria, including Listeria monocytogenes, have been considered potent vectors to carry multiple therapeutic protein...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP

    更新日期:2020-04-09 00:00:00

  • Immune Checkpoint Molecules on Tumor-Infiltrating Lymphocytes and Their Association with Tertiary Lymphoid Structures in Human Breast Cancer.

    abstract::There is an exponentially growing interest in targeting immune checkpoint molecules in breast cancer (BC), particularly in the triple-negative subtype where unmet treatment needs remain. This study was designed to analyze the expression, localization, and prognostic role of PD-1, PD-L1, PD-L2, CTLA-4, LAG3, and TIM3 i...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Solinas C,Garaud S,De Silva P,Boisson A,Van den Eynden G,de Wind A,Risso P,Rodrigues Vitória J,Richard F,Migliori E,Noël G,Duvillier H,Craciun L,Veys I,Awada A,Detours V,Larsimont D,Piccart-Gebhart M,Willard-Gallo K

    更新日期:2017-10-30 00:00:00

  • Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.

    abstract::Cancer immunotherapy (CIT) with antibodies targeting the programmed cell death 1 protein (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis have changed the standard of care in multiple cancers. However, durable antitumor responses have been observed in only a minority of patients, indicating the presence of other i...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Hack SP,Zhu AX,Wang Y

    更新日期:2020-11-05 00:00:00

  • Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease.

    abstract::Alpha-1 antitrypsin (AAT) is an inhibitor of neutrophil elastase and a member of the serine proteinase inhibitor (serpin) superfamily, and little is known about its activity in sickle cell disease (SCD). We hypothesize that AAT may undergo changes in SCD because of the high oxidative stress and inflammation associated...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Carvalho MOS,Souza ALCS,Carvalho MB,Pacheco APAS,Rocha LC,do Nascimento VML,Figueiredo CVB,Guarda CC,Santiago RP,Adekile A,Goncalves MS

    更新日期:2017-11-06 00:00:00

  • Hodgkin Lymphoma-Derived Extracellular Vesicles Change the Secretome of Fibroblasts Toward a CAF Phenotype.

    abstract::Secretion of extracellular vesicles (EVs) is a ubiquitous mechanism of intercellular communication based on the exchange of effector molecules, such as growth factors, cytokines, and nucleic acids. Recent studies identified tumor-derived EVs as central players in tumor progression and the establishment of the tumor mi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Dörsam B,Bösl T,Reiners KS,Barnert S,Schubert R,Shatnyeva O,Zigrino P,Engert A,Hansen HP,von Strandmann EP

    更新日期:2018-06-18 00:00:00

  • Uncovering Low-Level Maternal Gonosomal Mosaicism in X-Linked Agammaglobulinemia: Implications for Genetic Counseling.

    abstract::X-linked agammaglobulinemia (XLA) is a clinically and genetically well-defined immunodeficiency and the most common form of agammaglobulinemia. It is characterized by susceptibility to recurrent bacterial infections, profound hypogammaglobulinemia, and few or no circulating B cells. XLA is caused by mutations in the B...

    journal_title:Frontiers in immunology



    authors: Rivière JG,Franco-Jarava C,Martínez-Gallo M,Aguiló-Cucurull A,Blasco-Pérez L,Paramonov I,Antolín M,Martín-Nalda A,Soler-Palacín P,Colobran R

    更新日期:2020-02-12 00:00:00

  • Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota.

    abstract::Alterations in the composition of the gut microbiota have profound effects on human health. Consequently, there is great interest in identifying, characterizing, and understanding factors that initiate these changes. Despite their high prevalence, studies have only recently begun to investigate how viral lung infectio...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Groves HT,Cuthbertson L,James P,Moffatt MF,Cox MJ,Tregoning JS

    更新日期:2018-02-12 00:00:00

  • Oxidized Hemoglobin Is Antigenic and Immunogenic in Lupus.

    abstract::Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in deleterious immunolo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Jain S,Bose A,Bastia B,Sharma H,Sachdeva R,Jain AK,Pal R

    更新日期:2017-06-26 00:00:00

  • Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses.

    abstract::In this review we discuss how the competition for cytokines between different cells of the immune system can shape the system wide immune response. We focus on interleukin-2 (IL-2) secretion by activated effector T cells (T(eff)) and on the competition for IL-2 consumption between T(eff) and regulatory T cells (T(reg)...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Höfer T,Krichevsky O,Altan-Bonnet G

    更新日期:2012-09-05 00:00:00

  • Children With Autism Spectrum Disorder and Their Mothers Share Abnormal Expression of Selected Endogenous Retroviruses Families and Cytokines.

    abstract::The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, only clinically diagnosed since the lack of reliable biomarkers. Autism etiology is probably attributable to the combination of genetic vulnerability and environmental factors, and recently, maternal immune activation has been...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Balestrieri E,Cipriani C,Matteucci C,Benvenuto A,Coniglio A,Argaw-Denboba A,Toschi N,Bucci I,Miele MT,Grelli S,Curatolo P,Sinibaldi-Vallebona P

    更新日期:2019-09-26 00:00:00

  • Examining Peripheral and Tumor Cellular Immunome in Patients With Cancer.

    abstract::Immunotherapies are rapidly being integrated into standard of care (SOC) therapy in conjunction with surgery, chemotherapy, and radiotherapy for many cancers and a large number of clinical studies continue to explore immunotherapy alone and as part of combination therapies in patients with cancer. It is evident that c...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Holl EK,Frazier VN,Landa K,Beasley GM,Hwang ES,Nair SK

    更新日期:2019-07-31 00:00:00

  • Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon.

    abstract::Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory dis...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Mylonas A,Conrad C

    更新日期:2018-11-28 00:00:00

  • Chymase-Cre; Mcl-1fl/fl Mice Exhibit Reduced Numbers of Mucosal Mast Cells.

    abstract::Mast cells (MCs) are considered as key effector cells in the elicitation of allergic symptoms, and they are essential players in innate and adaptive immune responses. In mice, two main types of MCs have been described: connective tissue MCs (CTMCs) and mucosal MCs (MMCs). However, little is known about the biological ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Luo Y,Meyer N,Jiao Q,Scheffel J,Zimmermann C,Metz M,Zenclussen A,Maurer M,Siebenhaar F

    更新日期:2019-10-15 00:00:00

  • Dried Blood Spots, an Affordable Tool to Collect, Ship, and Sequence gDNA from Patients with an X-Linked Agammaglobulinemia Phenotype Residing in a Developing Country.

    abstract:Background:New sequencing techniques have revolutionized the identification of the molecular basis of primary immunodeficiency disorders (PID) not only by establishing a gene-based diagnosis but also by facilitating defect-specific treatment strategies, improving quality of life and survival, and allowing factual genet...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Segundo GRS,Nguyen ATV,Thuc HT,Nguyen LNQ,Kobayashi RH,Le HT,Le HTM,Torgerson TR,Ochs HD

    更新日期:2018-02-16 00:00:00

  • Tumor-Associated Disialylated Glycosphingolipid Antigen-Revealing Antibodies Found in Melanoma Patients' Immunoglobulin Repertoire Suggest a Two-Direction Regulation Mechanism Between Immune B Cells and the Tumor.

    abstract::There is far less information available about the tumor infiltrating B (TIL-B) cells, than about the tumor infiltrating T cells. We focused on discovering the features and potential role of B lymphocytes in solid tumors. Our project aimed to develop innovative strategies to define cancer membrane structures. We chose ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kotlan B,Horvath S,Eles K,Plotar VK,Naszados G,Czirbesz K,Blank M,Farkas E,Toth L,Tovari J,Szekacs A,Shoenfeld Y,Godeny M,Kasler M,Liszkay G

    更新日期:2019-04-05 00:00:00

  • Evaluation of Leishmanization Using Iranian Lizard Leishmania Mixed With CpG-ODN as a Candidate Vaccine Against Experimental Murine Leishmaniasis.

    abstract::Background and Objectives: The live non-pathogenic Leishmania tarantolae has recently provided a promising approach as an effective vaccine candidate against experimental leishmaniasis (ILL). Here, we evaluated the immunoprotective potential of the live Iranian Lizard Leishmania mixed with CpG adjuvant against L. majo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Keshavarzian N,Noroozbeygi M,Haji Molla Hoseini M,Yeganeh F

    更新日期:2020-10-23 00:00:00

  • Ruggero Ceppellini: A Perspective on His Contributions to Genetics and Immunology.

    abstract::Ruggero Ceppellini, who died at the age of 71 in 1988, was one of the most stimulating and original human geneticists of his generation (1). Ceppellini's outstanding contributions to the genetics of the human blood groups, immunoglobulin allotypes and the HLA system epitomize the study of immunogenetics. By using his ...

    journal_title:Frontiers in immunology

    pub_type: 传,历史文章,杂志文章


    authors: Bodmer W

    更新日期:2019-06-05 00:00:00

  • Characterization of the Highly Prevalent Regulatory CD24hiCD38hi B-Cell Population in Human Cord Blood.

    abstract::The newborn's immune system must transition from a sterile haploidentical uterus to the world full of antigens. Regulatory B-cells (Breg; broadly defined as CD19+CD24hiCD38hi) are tolerance promoters in the adult immune system. They can inhibit IFN-γ and IL-17 production by T-cells and are essential in different condi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Esteve-Solé A,Teixidó I,Deyà-Martínez A,Yagüe J,Plaza-Martín AM,Juan M,Alsina L

    更新日期:2017-03-07 00:00:00

  • Interplay of Regulatory T Cell and Th17 Cells during Infectious Diseases in Humans and Animals.

    abstract::It is now clear that the outcome of an inflammatory process caused by infections depends on the balance of responses by several components of the immune system. Of particular relevance is the interplay between regulatory T cells (Tregs) and CD4+ T cells that produce IL-17 (Th17 cells) during immunoinflammatory events....

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Sehrawat S,Rouse BT

    更新日期:2017-04-03 00:00:00