NOD-Like Receptors in Lung Diseases.

abstract：:X-linked agammaglobulinemia (XLA) is a clinically and genetically well-defined immunodeficiency and the most common form of agammaglobulinemia. It is characterized by susceptibility to recurrent bacterial infections, profound hypogammaglobulinemia, and few or no circulating B cells. XLA is caused by mutations in the B...

journal_title：Frontiers in immunology

authors： Rivière JG,Franco-Jarava C,Martínez-Gallo M,Aguiló-Cucurull A,Blasco-Pérez L,Paramonov I,Antolín M,Martín-Nalda A,Soler-Palacín P,Colobran R

更新日期：2020-02-12 00:00:00

abstract：:Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-β1), are involved in tumor immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represent opportunities for the...

journal_title：Frontiers in immunology

authors： Klöss S,Chambron N,Gardlowski T,Weil S,Koch J,Esser R,Pogge von Strandmann E,Morgan MA,Arseniev L,Seitz O,Köhl U

更新日期：2015-11-02 00:00:00

abstract：:Avian influenza A of the subtype H7N9 has been responsible for almost 1,600 confirmed human infections and more than 600 deaths since its first outbreak in 2013. Although sustained human-to-human transmission has not been reported yet, further adaptations to humans in the viral genome could potentially lead to an infl...

journal_title：Frontiers in immunology

authors： de Bree LCJ,Marijnissen RJ,Kel JM,Rosendahl Huber SK,Aaby P,Benn CS,Wijnands MVW,Diavatopoulos DA,van Crevel R,Joosten LAB,Netea MG,Dulos J

更新日期：2018-04-30 00:00:00

abstract：:Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious respiratory impacts. Recently, we have discovered that burning coal generates large quantities of ot...

journal_title：Frontiers in immunology

authors： McDaniel DK,Ringel-Scaia VM,Morrison HA,Coutermarsh-Ott S,Council-Troche M,Angle JW,Perry JB,Davis G,Leng W,Minarchick V,Yang Y,Chen B,Reece SW,Brown DA,Cecere TE,Brown JM,Gowdy KM,Hochella MF Jr,Allen IC

更新日期：2019-11-28 00:00:00

abstract：:We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4+ T cells from DBA/2 mice into (C57BL/6 × DBA/2)F1 (BDF1) mice. Although the protective effects were ascribed to the induction of ad...

journal_title：Frontiers in immunology

authors： Horwitz DA,Liu A,Bickerton S,Castaldo G,Matarese G,Fahmy TM,La Cava A

更新日期：2020-12-16 00:00:00

abstract：:Allergic contact dermatitis (ACD) is a common inflammatory skin disease with a prevalence of approximately 20% in the European population. ACD is caused by contact allergens that are reactive chemicals able to modify non-immunogenic self-proteins to become immunogenic proteins. The most frequent contact allergens are ...

journal_title：Frontiers in immunology

authors： Mraz V,Geisler C,Bonefeld CM

更新日期：2020-05-19 00:00:00

abstract：:Patients with severe eosinophilic asthma (SEA; characterized by persistent eosinophilia in blood and airway tissues) experience frequent asthma exacerbations with poor clinical outcomes. Interleukin 5 (IL-5) and IL-5 receptor alpha subunit (IL-5α) play key roles in eosinophilia maintenance, and relevant therapeutic st...

journal_title：Frontiers in immunology

authors： Kim JE,Lee DH,Jung K,Kim EJ,Choi Y,Park HS,Kim YS

更新日期：2021-01-08 00:00:00

abstract：:A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit highest activity on di...

journal_title：Frontiers in immunology

authors： Schäfer D,Henze J,Pfeifer R,Schleicher A,Brauner J,Mockel-Tenbrinck N,Barth C,Gudert D,Al Rawashdeh W,Johnston ICD,Hardt O

更新日期：2020-08-07 00:00:00

abstract：:Phloretin (PT), isolated from the apple tree, was previously demonstrated to have antioxidative and anti-inflammatory effects in macrophages and anti-adiposity effects in adipocytes. Inflammatory immune cells generate high levels of reactive oxygen species (ROS) for stimulated severe airway hyperresponsiveness (AHR) a...

journal_title：Frontiers in immunology

authors： Huang WC,Fang LW,Liou CJ

更新日期：2017-02-13 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation is a potentially curative procedure for many malignant diseases. Donor T cells prevent disease recurrence via graft-versus-leukemia (GVL) effect. Donor T cells also contribute to graft-versus-host disease (GVHD), a debilitating and potentially fatal complication. Nove...

journal_title：Frontiers in immunology

authors： Mammadli M,Huang W,Harris R,Sultana A,Cheng Y,Tong W,Pu J,Gentile T,Dsouza S,Yang Q,Bah A,August A,Karimi M

更新日期：2020-11-26 00:00:00

abstract：:T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity. It is becoming increasingly evident that GC-Tfh cells are heterogeneous in nature with some cellular cha...

journal_title：Frontiers in immunology

authors： Velu V,Mylvaganam G,Ibegbu C,Amara RR

更新日期：2018-06-06 00:00:00

abstract：:Tuberculosis (TB) is currently one of the leading causes of global mortality. Medical non-compliance due to the length of the treatment and antibiotic side effects has led to the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis (M. tb) that are difficult to treat. A current therapeutic stra...

journal_title：Frontiers in immunology

authors： Hernandez J,Ashley D,Cao R,Abrahem R,Nguyen T,To K,Yegiazaryan A,Akinwale David A,Kumar Tiwari R,Venketaraman V

更新日期：2020-08-13 00:00:00

abstract：:Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. Proper function of DCs is crucial to elicit an effective immune response against pathogens and to induce antitumor immunity. Different members of the nuclear receptor (NR) family of transcription factors have been reported to aff...

journal_title：Frontiers in immunology

authors： Tel-Karthaus N,Kers-Rebel ED,Looman MW,Ichinose H,de Vries CJ,Ansems M

更新日期：2018-08-03 00:00:00

abstract：:Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast cells form a heterogeneous population of immune cells with differences in their ultra-structure, morphology, mediator content, and surface receptors. Mast cells are widely distributed throughout all tissues and are stromal compon...

journal_title：Frontiers in immunology

authors： Varricchi G,Galdiero MR,Loffredo S,Marone G,Iannone R,Marone G,Granata F

更新日期：2017-04-12 00:00:00

abstract：:This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with coronary artery disease. We assessed 84 patients with coronary ar...

journal_title：Frontiers in immunology

authors： Gruzdeva O,Uchasova E,Dyleva Y,Borodkina D,Akbasheva O,Antonova L,Matveeva V,Belik E,Ivanov S,Sotnikov A,Kozyrin K,Brel N,Sinitsky M,Karetnikova V,Kokov A,Bychkova E,Pecherina T,Barbarash O

更新日期：2019-09-19 00:00:00

abstract：:Malaria remains a significant health problem in many tropical and sub-tropical regions. The development of vaccines against the clinically active blood-stage of infection needs to consider variability and polymorphism in target antigens, and an adjuvant system able to induce broad spectrum immunity comprising both ant...

journal_title：Frontiers in immunology

authors： Wilson KL,Pouniotis D,Hanley J,Xiang SD,Ma C,Coppel RL,Plebanski M

更新日期：2019-03-15 00:00:00

abstract：:Normal term and spontaneous preterm births (PTB) are documented to be associated with oxidative stress (OS), and imbalances in the redox system (balance between pro- and antioxidant) have been reported in the maternal-fetal intrauterine compartments. The exact mechanism of labor initiation either at term or preterm by...

journal_title：Frontiers in immunology

authors： Menon R

更新日期：2014-11-12 00:00:00

abstract：:We have previously shown that the human obese adipose tissue (AT) contributes to increased secretion of adipocyte-specific IgG antibodies in individuals with obesity. This occurs without any exogenous stimulation, because the ongoing process of cell death in the obese AT leads to the release of "self" antigens able to...

journal_title：Frontiers in immunology

authors： Frasca D,Diaz A,Romero M,Garcia D,Jayram D,Thaller S,Del Carmen Piqueras M,Bhattacharya S,Blomberg BB

更新日期：2020-02-28 00:00:00

abstract：:There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are differentially expressed in human lung fibroblasts following the induction of inflammation us...

journal_title：Frontiers in immunology

authors： Hadjicharalambous MR,Roux BT,Feghali-Bostwick CA,Murray LA,Clarke DL,Lindsay MA

更新日期：2018-12-11 00:00:00

abstract：:Antibody-derived chimeric antigen receptor (CAR) T cell therapy has achieved gratifying breakthrough in hematologic malignancies but has shown limited success in solid tumor immunotherapy. Monoclonal antibody, TAB004, specifically recognizes the aberrantly glycosylated tumor form of MUC1 (tMUC1) in all subtypes of bre...

journal_title：Frontiers in immunology

authors： Zhou R,Yazdanifar M,Roy LD,Whilding LM,Gavrill A,Maher J,Mukherjee P

更新日期：2019-05-24 00:00:00

abstract：:The variables that influence the selection of a preparative regimen for a pediatric hematopoietic stem cell transplant procedure encompasses many issues. When one considers this procedure for non-malignant diseases, components in a preparative regimen that were historically developed to reduce malignant tumor burden m...

journal_title：Frontiers in immunology

authors： Hayashi RJ

更新日期：2020-10-19 00:00:00

abstract：:Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies with low endogenous immune responses, this approach has not show...

journal_title：Frontiers in immunology

authors： Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M

更新日期：2018-02-27 00:00:00

abstract：:Natural killer (NK) cells contribute to the first line of defense against viruses and to the control of tumor growth and metastasis spread. The discovery of HLA class I specific inhibitory receptors, primarily of killer Ig-like receptors (KIRs), and of activating receptors has been fundamental to unravel NK cell funct...

journal_title：Frontiers in immunology

authors： Pende D,Falco M,Vitale M,Cantoni C,Vitale C,Munari E,Bertaina A,Moretta F,Del Zotto G,Pietra G,Mingari MC,Locatelli F,Moretta L

更新日期：2019-05-28 00:00:00

abstract：:Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation an...

journal_title：Frontiers in immunology

authors： Zhao D,Abou-Daya KI,Dai H,Oberbarnscheidt MH,Li XC,Lakkis FG

更新日期：2020-05-28 00:00:00

abstract：:Thrombocytes, nucleated hemostatic blood cells of non-mammalian vertebrates, are regarded as the functional equivalent of anucleated mammalian platelets. Additional immune functions, including phagocytosis, have also been suggested for thrombocytes, but no conclusive molecular or cellular experimental evidence for the...

journal_title：Frontiers in immunology

authors： Nagasawa T,Nakayasu C,Rieger AM,Barreda DR,Somamoto T,Nakao M

更新日期：2014-09-16 00:00:00

abstract：:The complement anaphylatoxin, C5a, through binding to its receptors (C5aR or C5L2), has important biological properties for recruitment and activation of phagocytes. C5a has been identified as a powerful modulator of Toll-like receptor-induced cytokine and chemokine production by macrophages. Both the complement syste...

journal_title：Frontiers in immunology

authors： Grailer JJ,Bosmann M,Ward PA

更新日期：2013-01-09 00:00:00

abstract：:Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed...

journal_title：Frontiers in immunology

authors： Fu B,Wang D,Shen X,Guo C,Liu Y,Ye Y,Sun R,Li J,Tian Z,Wei H

更新日期：2020-12-23 00:00:00

abstract：:CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses. Thymic development and functio...

journal_title：Frontiers in immunology

authors： Yang G,Driver JP,Van Kaer L

更新日期：2018-11-14 00:00:00

abstract：:Natural killer (NK) cells play an important role in the containment of HIV replication during primary infection, though their functions are impaired during chronic HIV infection. Infants experience more rapid HIV disease progression than adults, but contributions of infant NK cells to containing HIV infection are unkn...

journal_title：Frontiers in immunology

authors： Slyker JA,Lohman-Payne B,John-Stewart GC,Dong T,Mbori-Ngacha D,Tapia K,Atzberger A,Taylor S,Rowland-Jones SL,Blish CA

更新日期：2012-12-31 00:00:00

abstract：:Objectives: Standardization of myositis specific antibody (MSA) detection is of high importance because these antibodies are relevant for diagnosis and stratification of patients with idiopathic inflammatory myositis (IIM) and have the potential to be used in classification criteria. Many laboratories rely on immunopr...

journal_title：Frontiers in immunology

authors： Mahler M,Betteridge Z,Bentow C,Richards M,Seaman A,Chinoy H,McHugh N

更新日期：2019-04-30 00:00:00