Paving the Way Towards Universal Chimeric Antigen Receptor Therapy in Cancer Treatment: Current Landscape and Progress.


:Chimeric antigen receptor (CAR) therapy has been proved effective in a stream of clinical trials, especially in hematologic malignancies. However, current CAR therapy is highly personalized as cells used are derived from patients themselves, which can be costly, time-consuming, and sometimes fails to achieve optimal therapeutic results due to poor quality/quantity of patient-derived cells. On the contrary, universal CAR therapy, which is based on healthy individuals' cells, circumvents several limitations of current autologous CAR therapy. To achieve the universality of CAR therapy, the allogeneic cell transplantation related issues, such as graft-versus-host disease (GVHD) and host-versus-graft activities (HVGA), must be addressed. In this review, we focus on current progress regarding GVHD and HVGA in the universal CAR therapy, followed by a universal CAR design that may be applied to allogeneic cells and a summary of key clinical trials in this field. This review may provide valuable insights into the future design of universal CAR products.


Front Immunol


Frontiers in immunology


Zhang Y,Li P,Fang H,Wang G,Zeng X




Has Abstract


2020-12-10 00:00:00








  • AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis.

    abstract::Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycosylation end-product...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Chen R,Zhu S,Zeng L,Wang Q,Sheng Y,Zhou B,Tang D,Kang R

    更新日期:2019-08-08 00:00:00

  • Dynamics of Natural Killer Cells Cytotoxicity in Microwell Arrays with Connecting Channels.

    abstract::Natural killer (NK) cells serve an important role in immune system by recognizing and killing the potentially malignant cells without antigen sensitization, and could be promising in cancer therapy. We have designed and fabricated microwell arrays with microchannel connections in polydimethylsiloxane (PDMS) substrates...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Xu Y,Zhou S,Lam YW,Pang SW

    更新日期:2017-08-17 00:00:00

  • Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy.

    abstract::Acquired generalized lipodystrophy (AGL) is a rare condition characterized by an altered distribution of adipose tissue and predisposition to develop hepatic steatosis and fibrosis, diabetes, and hypertriglyceridemia. Diagnosis of AGL is based on the observation of generalized fat loss, autoimmunity and lack of family...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Corvillo F,Aparicio V,López-Lera A,Garrido S,Araújo-Vilar D,de Miguel MP,López-Trascasa M

    更新日期:2018-09-19 00:00:00

  • Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection.

    abstract::Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chronic hepatitis B vi...

    journal_title:Frontiers in immunology

    pub_type: 临床试验,杂志文章


    authors: Yong YK,Saeidi A,Tan HY,Rosmawati M,Enström PF,Batran RA,Vasuki V,Chattopadhyay I,Murugesan A,Vignesh R,Kamarulzaman A,Rajarajeswaran J,Ansari AW,Vadivelu J,Ussher JE,Velu V,Larsson M,Shankar EM

    更新日期:2018-03-19 00:00:00

  • Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment.

    abstract::In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma. This tumor stroma, comprised of various cells, and extracellular mat...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Menon H,Ramapriyan R,Cushman TR,Verma V,Kim HH,Schoenhals JE,Atalar C,Selek U,Chun SG,Chang JY,Barsoumian HB,Nguyen QN,Altan M,Cortez MA,Hahn SM,Welsh JW

    更新日期:2019-02-15 00:00:00

  • The role of regulatory T cells in the biology of graft versus host disease.

    abstract::Graft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation. GVHD is characterized by an imbalance between the effector and regulatory arms of the immune system which results in the over production of inflammatory cytokines. Moreover, there is a persistent reduction...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Beres AJ,Drobyski WR

    更新日期:2013-06-24 00:00:00

  • Heterogeneity of HBV-Specific CD8+ T-Cell Failure: Implications for Immunotherapy.

    abstract::Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around 257 million people worldwide. The consequences of chronic HBV infection include progressive liver damage, liver cirrhosis, and hepatocellular carcinoma. Although current direct antiviral therapies successfully lead to suppressio...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Heim K,Neumann-Haefelin C,Thimme R,Hofmann M

    更新日期:2019-09-20 00:00:00

  • Bacterial Lipopolysaccharides Suppress Erythroblastic Islands and Erythropoiesis in the Bone Marrow in an Extrinsic and G- CSF-, IL-1-, and TNF-Independent Manner.

    abstract::Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic inflammation, chronic infections, or sepsis. Although several studies...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bisht K,Tay J,Wellburn RN,McGirr C,Fleming W,Nowlan B,Barbier V,Winkler IG,Levesque JP

    更新日期:2020-10-06 00:00:00

  • AIM2 Inflammasome's First Decade of Discovery: Focus on Oral Diseases.

    abstract::A common feature of many acute and chronic oral diseases is microbial-induced inflammation. Innate immune responses are the first line of defense against pathogenic microorganisms and are initiated by pattern recognition receptors (PRRs) that specifically recognize pathogen-associated molecular patterns and danger-ass...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Wang L,Sun L,Byrd KM,Ko CC,Zhao Z,Fang J

    更新日期:2020-08-13 00:00:00

  • Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.

    abstract::The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly increased numbers of B cells. However, it has remained unclear whether th...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J

    更新日期:2018-03-22 00:00:00

  • Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis.

    abstract::Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum or L. donovani infection. One of the main problems related to this disease is the emergence of severe clinical forms with a lethality of 5-20%, even while under specific treatment. In humans and other species susceptible to fatal VL, such as dogs...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: de Melo CVB,Hermida MD,Mesquita BR,Fontes JLM,Koning JJ,Solcà MDS,Benevides BB,Mota GBS,Freitas LAR,Mebius RE,Dos-Santos WLC

    更新日期:2020-04-15 00:00:00

  • Antiphospholipid Syndrome Nephropathy: From Pathogenesis to Treatment.

    abstract::Kidney damage is a well-recognized complication of the antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-associated APS. Kidney involvement in APS involves a variety of manifestations, such as renal artery thrombosis or stenosis, renal vein thrombosis, allograft loss due to thrombos...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Tektonidou MG

    更新日期:2018-05-31 00:00:00

  • Human Norovirus Proteins: Implications in the Replicative Cycle, Pathogenesis, and the Host Immune Response.

    abstract::Human noroviruses (HuNoVs) are the cause of more than 95% of epidemic non-bacterial gastroenteritis worldwide, with some lethal cases. These viral agents affect people of all ages. However, young children and older adults are the highest-risk groups, being affected with the greatest rate of hospitalizations and morbid...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Campillay-Véliz CP,Carvajal JJ,Avellaneda AM,Escobar D,Covián C,Kalergis AM,Lay MK

    更新日期:2020-06-16 00:00:00

  • Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors.

    abstract::The mechanisms underlying pathophysiological regulation of tissue macrophage (Mφ) subsets remain poorly understood. From the expression of 207 Mφ genes comprising 31 markers for 10 subsets, 45 transcription factors (TFs), 56 immunometabolism enzymes, 23 trained immunity (innate immune memory) enzymes, and 52 other gen...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Lai B,Wang J,Fagenson A,Sun Y,Saredy J,Lu Y,Nanayakkara G,Yang WY,Yu D,Shao Y,Drummer C 4th,Johnson C,Saaoud F,Zhang R,Yang Q,Xu K,Mastascusa K,Cueto R,Fu H,Wu S,Sun L,Zhu P,Qin X,Yu J,Fan D,Shen YH,Su

    更新日期:2019-11-14 00:00:00

  • IgG4 Autoantibodies Attenuate Systemic Lupus Erythematosus Progression by Suppressing Complement Consumption and Inflammatory Cytokine Production.

    abstract::Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains largely unknown. The titers of serum anti-nuclear-IgG antibodies (ANA-...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Pan Q,Xiao H,Shi L,He Y,Cai J,Wu J,Li A,Ye L,Yang C,Liu HF

    更新日期:2020-06-17 00:00:00

  • Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?

    abstract::Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies to define the molecular mechanisms of NET generation and the biol...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Rahman S,Gadjeva M

    更新日期:2014-08-11 00:00:00

  • Evolutionary Origin of the Interferon-Immune Metabolic Axis: The Sterol-Vitamin D Link.

    abstract::In vertebrate animals, the sterol metabolic network is emerging as a central player in immunity and inflammation. Upon infection, flux in the network is acutely moderated by the interferon (IFN) response through direct molecular and bi-directional communications. How sterol metabolism became linked to IFN control and ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Newmark H,Dantoft W,Ghazal P

    更新日期:2017-02-09 00:00:00

  • Role of innate lymphocytes in infection and inflammation.

    abstract::Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Koyasu S,Moro K

    更新日期:2012-05-07 00:00:00

  • Macrophage-Derived Extracellular Vesicles Induce Long-Lasting Immunity Against Hepatitis C Virus Which Is Blunted by Polyunsaturated Fatty Acids.

    abstract::Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. In this study, we aimed to further characterize the role of macrophage-derived EVs in immune responses against hepatitis C virus (HCV) and the potential of polyunsaturated fatty acids (PUFAs) to modulate thi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cai C,Koch B,Morikawa K,Suda G,Sakamoto N,Rueschenbaum S,Akhras S,Dietz J,Hildt E,Zeuzem S,Welsch C,Lange CM

    更新日期:2018-04-12 00:00:00

  • Human Milk Blocks DC-SIGN-Pathogen Interaction via MUC1.

    abstract::Beneficial effects of breastfeeding are well-recognized and include both immediate neonatal protection against pathogens and long-term protection against allergies and autoimmune diseases. Although several proteins have been identified to have anti-viral or anti-bacterial effects like secretory IgA or lactoferrin, the...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Koning N,Kessen SF,Van Der Voorn JP,Appelmelk BJ,Jeurink PV,Knippels LM,Garssen J,Van Kooyk Y

    更新日期:2015-03-13 00:00:00

  • Serum microRNA Profiles Serve as Novel Biomarkers for Autoimmune Diseases.

    abstract::Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are targeted by the damaging immune response. Many studies have focuse...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Jin F,Hu H,Xu M,Zhan S,Wang Y,Zhang H,Chen X

    更新日期:2018-10-16 00:00:00

  • Mycobacterium bovis Bacillus Calmette-Guérin Alters Melanoma Microenvironment Favoring Antitumor T Cell Responses and Improving M2 Macrophage Function.

    abstract::Intralesional Mycobacterium bovis bacillus Calmette-Guérin (BCG) has long been a relatively inexpensive therapy for inoperable cutaneous metastatic melanoma (CMM), although intralesional BCG skin mechanisms remain understudied. We analyzed intralesional BCG-treated CMM lesions combined with in vitro studies to further...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Lardone RD,Chan AA,Lee AF,Foshag LJ,Faries MB,Sieling PA,Lee DJ

    更新日期:2017-08-11 00:00:00

  • Donor Genotype in the Interleukin-7 Receptor α-Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation.

    abstract::The efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute and chronic graft-versus-host disease (aGVHD and cGVHD) and viral infections due to long-lasting immunodeficiency. Interleukin-7 (IL-7) is a cytokine essential for de novo T cell generation in thymus and peripheral T cell ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kielsen K,Enevold C,Heilmann C,Sengeløv H,Pedersen AE,Ryder LP,Müller K

    更新日期:2018-02-02 00:00:00

  • Perturbation of B Cell Gene Expression Persists in HIV-Infected Children Despite Effective Antiretroviral Therapy and Predicts H1N1 Response.

    abstract::Despite effective antiretroviral therapy (ART), HIV-infected individuals with apparently similar clinical and immunological characteristics can vary in responsiveness to vaccinations. However, molecular mechanisms responsible for such impairment, as well as biomarkers able to predict vaccine responsiveness in HIV-infe...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cotugno N,De Armas L,Pallikkuth S,Rinaldi S,Issac B,Cagigi A,Rossi P,Palma P,Pahwa S

    更新日期:2017-09-11 00:00:00

  • Nature vs. Nurture: Defining the Effects of Mesenchymal Stromal Cell Isolation and Culture Conditions on Resiliency to Palmitate Challenge.

    abstract::As MSC products move from early development to clinical translation, culture conditions shift from xeno- to xeno-free systems. However, the impact of isolation and culture-expansion methods on the long-term resiliency of MSCs within challenging transplant environments is not fully understood. Recent work in our lab ha...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Boland LK,Burand AJ,Boyt DT,Dobroski H,Di L,Liszewski JN,Schrodt MV,Frazer MK,Santillan DA,Ankrum JA

    更新日期:2019-05-10 00:00:00

  • TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells.

    abstract::B cells are capable of receptor-mediated responses to foreign antigens. Recognition of microbial-derived nucleic acid (NA) by toll-like receptors (TLRs) 7 and 9 in B cells has been substantiated. Endogenous NA released from damaged or dying cells can also be immunogenic in certain contexts and can incite aberrant acti...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Suthers AN,Sarantopoulos S

    更新日期:2017-07-13 00:00:00

  • Mononuclear Phagocyte Activation Is Associated With the Immunopathology of Psoriasis.

    abstract::Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Costa MC,Paixão CS,Viana DL,Rocha BO,Saldanha M,da Mota LMH,Machado PRL,Pagliari C,de Oliveira MF,Arruda S,Carvalho EM,Carvalho LP

    更新日期:2020-03-25 00:00:00

  • CD4+CD8+ T-Lymphocytes in Xenogeneic and Human Graft-versus-Host Disease.

    abstract::Mechanisms driving acute graft-versus-host disease (aGVHD) onset in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are still poorly understood. To provide a detailed characterization of tissue-infiltrating T lymphocytes (TL) and search for eventual site-specific specificities, we de...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Alhaj Hussen K,Michonneau D,Biajoux V,Keita S,Dubouchet L,Nelson E,Setterblad N,Le Buanec H,Bouaziz JD,Guimiot F,Socié G,Canque B

    更新日期:2020-11-24 00:00:00

  • Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile.

    abstract::Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal inflammation triggered by food intake. Taking advantage of the translucency of the larvae and the availability of transgenic zebrafish lin...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Coronado M,Solis CJ,Hernandez PP,Feijóo CG

    更新日期:2019-04-02 00:00:00

  • RNA Sequencing Keloid Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and JAK3-Skewing.

    abstract::Keloids are disfiguring, fibroproliferative growths and their pathogenesis remains unclear, inhibiting therapeutic development. Available treatment options have limited efficacy and harbor safety concerns. Thus, there is a great need to clarify keloid pathomechanisms that may lead to novel treatments. In this study, w...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wu J,Del Duca E,Espino M,Gontzes A,Cueto I,Zhang N,Estrada YD,Pavel AB,Krueger JG,Guttman-Yassky E

    更新日期:2020-11-23 00:00:00