Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation.


:A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irradiation (L-TBI) in a syngeneic mouse model of breast and colon carcinoma. The combination therapy of H-RT and L-TBI potentially enhanced SIME by infiltration of CD8+ T cell and altering the immunosuppressive microenvironment in non-irradiated subcutaneous tumor lesions. The frequency of IFN-γ, as a tumor-specific CD8+ T cells producing, significantly inhibited the secondary tumor growth of breast and colon. Our findings suggest that L-TBI could serve as a potential therapeutic agent for metastatic breast and colon cancer and, together with H-RT, their therapeutic potential is enhanced significantly.


Front Immunol


Frontiers in immunology


Liu J,Zhou J,Wu M,Hu C,Yang J,Li D,Wu P,Chen Y,Chen P,Lin S,Cui Y,Fu S,Wu J




Has Abstract


2019-02-27 00:00:00








  • Innate Lymphoid Cells in Mucosal Immunity.

    abstract::Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells. ILCs carry out some unique functions but share some tasks with T cells. ILCs are present in lymphoid and non-lympho...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Panda SK,Colonna M

    更新日期:2019-05-07 00:00:00

  • Toll-like Interleukin 1 Receptor Regulator Is an Important Modulator of Inflammation Responsive Genes.

    abstract::TILRR (Toll-like interleukin-1 receptor regulator), a transcript variant of FREM1, is a novel regulatory component, which stimulates innate immune responses through binding to IL-1R1 (Interleukin-1 receptor, type 1) and TLR (Toll-like receptor) complex. However, it is not known whether TILRR expression influences othe...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kashem MA,Li H,Toledo NP,Omange RW,Liang B,Liu LR,Li L,Yang X,Yuan XY,Kindrachuk J,Plummer FA,Luo M

    更新日期:2019-02-28 00:00:00

  • Selective Manipulation of the Gut Microbiota Improves Immune Status in Vertebrates.

    abstract::All animals develop in association with complex microbial communities. It is now well established that commensal microbiota is essential for the correct functionality of each organ in the host. Particularly, the commensal gastro-intestinal microbiota (CGIM) is a key factor for development, immunity and nutrient conver...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Montalban-Arques A,De Schryver P,Bossier P,Gorkiewicz G,Mulero V,Gatlin DM 3rd,Galindo-Villegas J

    更新日期:2015-10-09 00:00:00

  • The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?

    abstract::Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small lung cancer or renal cell carcinoma. These humanized monoclonal antibodies target inhibitory receptors (e.g. CTLA-4, PD-1, LAG-3, TIM-3) and lig...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Franzin R,Netti GS,Spadaccino F,Porta C,Gesualdo L,Stallone G,Castellano G,Ranieri E

    更新日期:2020-10-08 00:00:00

  • Extracellular Vesicles in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Functions and Applications.

    abstract::In the last two decades, extracellular vesicles (EVs) have aroused wide interest among researchers in basic and clinical research. EVs, small membrane vesicles are released by almost all kinds of cells into the extracellular environment. According to many recent studies, EVs participate in immunomodulation and play an...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Zhang B,Zhao M,Lu Q

    更新日期:2021-01-14 00:00:00

  • Hematopoietic Stem Cell Transplantation in an Infant with Immunodeficiency, Centromeric Instability, and Facial Anomaly Syndrome.

    abstract::Immunodeficiency, centromeric instability, and facial anomaly (ICF) syndrome is a rare autosomal recessive genetic condition with severe immunodeficiency, which leads to lethal infections if not recognized and treated in early childhood. Up-to-date treatment regimens consist of prophylactic and supportive treatment of...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gössling KL,Schipp C,Fischer U,Babor F,Koch G,Schuster FR,Dietzel-Dahmen J,Wieczorek D,Borkhardt A,Meisel R,Kuhlen M

    更新日期:2017-06-30 00:00:00

  • Differential MicroRNA Expression Levels in Cutaneous Acute Graft-Versus-Host Disease.

    abstract::Allogeneic hematopoietic stem cell transplantation is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGvHD) is a major complication affecting 40-70% of all transplant patients, whereby the earliest and most frequent presentation is in the skin. MicroRNAs play a ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Atarod S,Norden J,Bibby LA,Janin A,Ratajczak P,Lendrem C,Pearce KF,Wang XN,O'Reilly S,Van Laar JM,Collin M,Dickinson AM,Crossland RE

    更新日期:2018-07-10 00:00:00

  • IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole.

    abstract::Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

    更新日期:2019-06-04 00:00:00

  • Presence of Infected Gr-1intCD11bhiCD11cint Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice.

    abstract::Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with immunomodulatory function. To study the mechanism by which MDSC affect antimicrobial immunity, we infected mice with two M. avium strains of differential virulence, highly virulent Mycobacterium avium subsp. avium strain 25291 (MAA) and low virule...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Abdissa K,Nerlich A,Beineke A,Ruangkiattikul N,Pawar V,Heise U,Janze N,Falk C,Bruder D,Schleicher U,Bogdan C,Weiss S,Goethe R

    更新日期:2018-10-16 00:00:00

  • Mucosal SIV Vaccines Comprising Inactivated Virus Particles and Bacterial Adjuvants Induce CD8(+) T-Regulatory Cells that Suppress SIV-Positive CD4(+) T-Cell Activation and Prevent SIV Infection in the Macaque Model.

    abstract::A new paradigm of mucosal vaccination against human immunodeficiency virus (HIV) infection has been investigated in the macaque model. A vaccine consisting of inactivated simian immunodeficiency virus (SIV)mac239 particles together with a living bacterial adjuvant (either the Calmette and Guerin bacillus, Lactobacillu...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Andrieu JM,Chen S,Lai C,Guo W,Lu W

    更新日期:2014-06-30 00:00:00

  • Expression and Function of IL-33/ST2 Axis in the Central Nervous System Under Normal and Diseased Conditions.

    abstract::Interleukin-33 (IL-33) is a well-recognized immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pat...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Fairlie-Clarke K,Barbour M,Wilson C,Hridi SU,Allan D,Jiang HR

    更新日期:2018-11-20 00:00:00

  • iNOS Activity Is Required for the Therapeutic Effect of Mesenchymal Stem Cells in Experimental Systemic Sclerosis.

    abstract::Objectives: Fibrosis is a hallmark of systemic sclerosis (SSc), an intractable disease where innovative strategies are still being sought. Among novel anti-fibrotic approaches, mesenchymal stromal/stem cell (MSC)-based therapy appears promising. Previously, we reported anti-fibrotic effects of MSC in an experimental m...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Maria ATJ,Rozier P,Fonteneau G,Sutra T,Maumus M,Toupet K,Cristol JP,Jorgensen C,Guilpain P,Noël D

    更新日期:2018-12-21 00:00:00

  • NETosis in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-β (Aβ) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses. Neuroinflammation is a well-established fea...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Pietronigro EC,Della Bianca V,Zenaro E,Constantin G

    更新日期:2017-03-02 00:00:00

  • α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin.

    abstract::Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on α7 nicotinic acetylcho...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cao M,MacDonald JW,Liu HL,Weaver M,Cortes M,Durosier LD,Burns P,Fecteau G,Desrochers A,Schulkin J,Antonelli MC,Bernier RA,Dorschner M,Bammler TK,Frasch MG

    更新日期:2019-05-09 00:00:00

  • Immune Curbing of Cancer Stem Cells by CTLs Directed to NANOG.

    abstract::Cancer stem cells (CSCs) have been identified as the source of tumor growth and disease recurrence. Eradication of CSCs is thus essential to achieve durable responses, but CSCs are resistant to current anti-tumor therapies. Novel therapeutic approaches that specifically target CSCs will, therefore, be crucial to impro...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wefers C,Schreibelt G,Massuger LFAG,de Vries IJM,Torensma R

    更新日期:2018-06-19 00:00:00

  • Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis.

    abstract::Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ban Y,Dong W,Zhang L,Zhou T,Altiti AS,Ali K,Mootoo DR,Blaho VA,Hla T,Ren Y,Ma X

    更新日期:2019-03-19 00:00:00

  • Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells.

    abstract::Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. The effects of DCs on adaptive immune responses depend partly on functional specialization of distinct DC subsets, and partly on the activation state of DCs, which is largely dictated by environmental signals. Fully activated immunos...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Carenza C,Calcaterra F,Oriolo F,Di Vito C,Ubezio M,Della Porta MG,Mavilio D,Della Bella S

    更新日期:2019-06-11 00:00:00

  • Human NK Cell Subsets in Pregnancy and Disease: Toward a New Biological Complexity.

    abstract::In humans, NK cells are mainly identified by the surface expression levels of CD56 and CD16, which differentiate between five functionally different NK cell subsets. However, nowadays NK cells are considered as a more heterogeneous population formed by various subsets differing in function, surface phenotype, and anat...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Cristiani CM,Palella E,Sottile R,Tallerico R,Garofalo C,Carbone E

    更新日期:2016-12-27 00:00:00

  • Macrophage-Derived Extracellular Vesicles Induce Long-Lasting Immunity Against Hepatitis C Virus Which Is Blunted by Polyunsaturated Fatty Acids.

    abstract::Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. In this study, we aimed to further characterize the role of macrophage-derived EVs in immune responses against hepatitis C virus (HCV) and the potential of polyunsaturated fatty acids (PUFAs) to modulate thi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Cai C,Koch B,Morikawa K,Suda G,Sakamoto N,Rueschenbaum S,Akhras S,Dietz J,Hildt E,Zeuzem S,Welsch C,Lange CM

    更新日期:2018-04-12 00:00:00

  • The Exaptation of HERV-H: Evolutionary Analyses Reveal the Genomic Features of Highly Transcribed Elements.

    abstract::HERV-H endogenous retroviruses are thought to be essential to stem cell identity in humans. We embrace several decades of HERV-H research in order to relate the transcription of HERV-H loci to their genomic structure. We find that highly transcribed HERV-H loci are younger, more fragmented, and less likely to be prese...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gemmell P,Hein J,Katzourakis A

    更新日期:2019-07-09 00:00:00

  • Tailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes.

    abstract::T-dependent humoral immune responses to infection involve a collaboration between B and CD4 T cell activation, migration, and co-stimulation, thereby culminating in the formation of germinal centers (GCs) and eventual differentiation into memory cells and long-lived plasma cells (PCs). CD4 T cell-derived signals drive...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Good-Jacobson KL,Groom JR

    更新日期:2018-03-08 00:00:00

  • Oral Administration of Acrylamide Worsens the Inflammatory Responses in the Airways of Asthmatic Mice Through Agitation of Oxidative Stress in the Lungs.

    abstract::Acrylamide is a toxic chemical substance produced when starch-rich foods are fried at high temperatures. Asthma is a chronic and complicated respiratory disease, of which genetic and environmental factors are the main triggers. Orally-received components may have an effect on asthma pathophysiology. The aim of this st...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hajimohammadi B,Athari SM,Abdollahi M,Vahedi G,Athari SS

    更新日期:2020-10-09 00:00:00

  • HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic Cells.

    abstract::Genital herpes is a common sexually transmitted infection caused by herpes simplex virus type 2 (HSV-2). Genital herpes significantly enhances the acquisition and transmission of HIV-1 by creating a microenvironment that supports HIV infection in the host. Dendritic cells (DCs) represent one of the first innate cell t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Crisci E,Svanberg C,Ellegård R,Khalid M,Hellblom J,Okuyama K,Bhattacharya P,Nyström S,Shankar EM,Eriksson K,Larsson M

    更新日期:2019-12-06 00:00:00

  • Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption.

    abstract::Skeletal health is maintained by bone remodeling, a process in which microscopic sites of effete or damaged bone are degraded on bone surfaces by osteoclasts and subsequently replaced by new bone, which is laid down by osteoblasts. This normal process can be disturbed in a variety of pathologic processes, including lo...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Boyce BF,Li J,Xing L,Yao Z

    更新日期:2018-09-28 00:00:00

  • Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/- Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice.

    abstract::Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8+CD45RClow/- Tregs expressing Foxp3 and p...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bézie S,Meistermann D,Boucault L,Kilens S,Zoppi J,Autrusseau E,Donnart A,Nerrière-Daguin V,Bellier-Waast F,Charpentier E,Duteille F,David L,Anegon I,Guillonneau C

    更新日期:2018-01-31 00:00:00

  • Identification of a Newly Conserved SLA-II Epitope in a Structural Protein of Swine Influenza Virus.

    abstract::Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches ei...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Baratelli M,Morgan S,Hemmink JD,Reid E,Carr BV,Lefevre E,Montaner-Tarbes S,Charleston B,Fraile L,Tchilian E,Montoya M

    更新日期:2020-09-16 00:00:00

  • HLA Class II Genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 Are Associated With the Antibody Response to Inactivated Japanese Encephalitis Vaccine.

    abstract::Aim: The objective of this study was to evaluate the association of the human leukocyte antigen (HLA) class II genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 with the humoral immune response elicited by inactivated Japanese encephalitis (JE) vaccine (IJEV). Methods: A total of 373 individuals aged 3-12 years in the Inner Mong...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,随机对照试验


    authors: Yao Y,Yang H,Shi L,Liu S,Li C,Chen J,Zhou Z,Sun M,Shi L

    更新日期:2019-03-08 00:00:00

  • Characterization of γδ T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity.

    abstract::γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. However, the presence of this T cell subset in ancient vertebrates remains unclear. In this study, γδ T cells from a zebrafish (Danio rerio) model were subjected to...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wan F,Hu CB,Ma JX,Gao K,Xiang LX,Shao JZ

    更新日期:2017-01-09 00:00:00

  • Immunoglobulin replacement therapy in secondary hypogammaglobulinemia.

    abstract::Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events. Over the last two decades its use has been extended to secondary antibody deficiencies, particularly those related to hematological disorders as...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Compagno N,Malipiero G,Cinetto F,Agostini C

    更新日期:2014-12-08 00:00:00

  • MICAgen Mice Recapitulate the Highly Restricted but Activation-Inducible Expression of the Paradigmatic Human NKG2D Ligand MICA.

    abstract::NKG2D is a potent activating immunoreceptor expressed on nearly all cytotoxic lymphocytes promoting their cytotoxicity against self-cells expressing NKG2D ligands (NKG2DLs). NKG2DLs are MHC class I-like glycoproteins that usually are not expressed on "healthy" cells. Rather, their surface expression is induced by vari...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Kim Y,Born C,Bléry M,Steinle A

    更新日期:2020-06-04 00:00:00