Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation.

abstract：:Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity. However, insights into the role of CFH in B cell biology are limited. Here, we demonstrate that defic...

journal_title：Frontiers in immunology

authors： Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ

更新日期：2019-07-11 00:00:00

abstract：:Allergies and asthma are a major cause of chronic disease whose prevalence has been on the rise. Allergic disease including seasonal rhinitis, atopic dermatitis, urticaria, anaphylaxis, and asthma, are associated with activation of tissue-resident mast cells and circulating basophils. Although these cells can be activ...

journal_title：Frontiers in immunology

authors： Gomez G

更新日期：2019-02-07 00:00:00

abstract：:Currently, liver transplantation is the most effective treatment for end-stage liver disease. Immunosuppressive agents are required to be taken after the operations, which have significantly reduced rejection rates and improved the short-term (<1 year) survival rates. However, post-transplant complications related to ...

journal_title：Frontiers in immunology

authors： Huang H,Lu Y,Zhou T,Gu G,Xia Q

更新日期：2018-11-09 00:00:00

abstract：:Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has...

journal_title：Frontiers in immunology

authors： Dougan M

更新日期：2017-11-15 00:00:00

abstract：:In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor XCR1 is a lineage marker for cross-presenting DC in the spleen. Now, we provide evidence that i...

journal_title：Frontiers in immunology

authors： Becker M,Güttler S,Bachem A,Hartung E,Mora A,Jäkel A,Hutloff A,Henn V,Mages HW,Gurka S,Kroczek RA

更新日期：2014-07-28 00:00:00

abstract：:Natural antibodies (NAbs) are pre-existing antibodies with germline origin that arise in the absence of previous exposure to foreign antigens. NAbs are produced by B-1 lymphocytes and are primarily of the IgM isotype. There is accumulating evidence that - in addition to their role in antimicrobial host defense - NAbs ...

journal_title：Frontiers in immunology

authors： Tsiantoulas D,Gruber S,Binder CJ

更新日期：2013-01-09 00:00:00

abstract：Background and objectives:Mortality of patients on hemodialysis (HD) remains very high despite recent improvements in HD techniques. Cardiovascular (CV) complications and infections are the main causes of death. Some studies suggest that disturbances in the immune system could play a role in this disproportionate morta...

journal_title：Frontiers in immunology

authors： Molina M,Allende LM,Ramos LE,Gutiérrez E,Pleguezuelo DE,Hernández ER,Ríos F,Fernández C,Praga M,Morales E

更新日期：2018-06-15 00:00:00

abstract：:Immunoediting is an important concept in oncology, delineating the mechanisms through which tumors are selected for resistance to immune-mediated elimination. The recent emergence of immunotherapies, such as checkpoint inhibitors, as pillars of cancer therapy has intensified interest in immunoediting as a constraint l...

journal_title：Frontiers in immunology

authors： Huang SH,McCann CD,Mota TM,Wang C,Lipkin SM,Jones RB

更新日期：2019-08-06 00:00:00

abstract：:Genital herpes is a common sexually transmitted infection caused by herpes simplex virus type 2 (HSV-2). Genital herpes significantly enhances the acquisition and transmission of HIV-1 by creating a microenvironment that supports HIV infection in the host. Dendritic cells (DCs) represent one of the first innate cell t...

journal_title：Frontiers in immunology

authors： Crisci E,Svanberg C,Ellegård R,Khalid M,Hellblom J,Okuyama K,Bhattacharya P,Nyström S,Shankar EM,Eriksson K,Larsson M

更新日期：2019-12-06 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) elite controllers (ELCs) represent a unique population that control viral replication in the absence of antiretroviral therapy (cART). It is well established that expression of multiple inhibitory receptors on CD8+ T cells is associated with HIV-1 disease progression. Howeve...

journal_title：Frontiers in immunology

authors： Noyan K,Nguyen S,Betts MR,Sönnerborg A,Buggert M

更新日期：2018-01-22 00:00:00

abstract：:Neutrophils are known to extrude decondensed chromatin, thus forming NETs (neutrophil extracellular traps). These structures immobilize pathogens, thereby preventing their spreading, and are also adorned with antimicrobial molecules. NETs can also influence pathogenesis in chronic inflammation, autoimmunity, and cance...

journal_title：Frontiers in immunology

authors： Tatsiy O,McDonald PP

更新日期：2018-09-18 00:00:00

abstract：:Fc γ receptors (FcγR) expressed on the surface of human leukocytes bind clusters of immunoglobulin G (IgG) to induce a variety of responses. Many therapeutic antibodies and vaccine-elicited antibodies prevent or treat infectious diseases, cancers and autoimmune disorders by binding FcγRs, thus there is a need to fully...

journal_title：Frontiers in immunology

authors： Patel KR,Roberts JT,Barb AW

更新日期：2019-02-14 00:00:00

abstract：:A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit highest activity on di...

journal_title：Frontiers in immunology

authors： Schäfer D,Henze J,Pfeifer R,Schleicher A,Brauner J,Mockel-Tenbrinck N,Barth C,Gudert D,Al Rawashdeh W,Johnston ICD,Hardt O

更新日期：2020-08-07 00:00:00

abstract：:Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant source of morbidity worldwide. Here, we show that blood plasmablasts and CD27- memory B cells are elevated in untreated Lyme disease, with higher plasmablast levels associated with more rapid resolution of clinical symptoms. Stro...

journal_title：Frontiers in immunology

authors： Blum LK,Adamska JZ,Martin DS,Rebman AW,Elliott SE,Cao RRL,Embers ME,Aucott JN,Soloski MJ,Robinson WH

更新日期：2018-07-18 00:00:00

abstract：:Infectious diseases are still a significant cause of morbidity and mortality worldwide. Despite the progress in drug development, the occurrence of microbial resistance is still a significant concern. Alternative therapeutic strategies are required for non-responding or relapsing patients. Chimeric antigen receptor (C...

journal_title：Frontiers in immunology

authors： Seif M,Einsele H,Löffler J

更新日期：2019-11-21 00:00:00

abstract：:The dramatic female sex bias observed in human lupus is thought to be due, at least in part, to estrogens. Using mouse models, we have shown that estrogens, acting through estrogen receptor alpha (ERα) promote lupus development and contribute significantly to the female sex bias observed in this disease. C57Bl/6 (B6) ...

journal_title：Frontiers in immunology

authors： Graham JH,Yoachim SD,Gould KA

更新日期：2020-11-10 00:00:00

abstract：:The glycans on the plasma membrane of cells manifest as the glycocalyx, which serves as an information-rich frontier that is directly in contact with its immediate milieu. The glycoconjugates (GCs) that adorn most of the mammalian cells are also abundant in gametes, especially the spermatozoa where they perform unique...

journal_title：Frontiers in immunology

authors： Batra V,Dagar K,Nayak S,Kumaresan A,Kumar R,Datta TK

更新日期：2020-08-28 00:00:00

abstract：:Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with inflammatory diseases, cancer, after transplantation, and particularly in a...

journal_title：Frontiers in immunology

authors： Ran Z,Yue-Bei L,Qiu-Ming Z,Huan Y

更新日期：2020-08-20 00:00:00

abstract：:Indoles, as the ligands of aryl hydrocarbon receptor (AhR), have been shown to possess immune-modulating property in terms of the balancing between regulatory T cells (Treg) and T helper 17 cells (Th17) activities. In the present study, we examined the effects of dietary indoles, 3,3'-diindolylmethane (DIM) and indole...

journal_title：Frontiers in immunology

authors： Kim WH,Lillehoj HS,Min W

更新日期：2019-03-26 00:00:00

abstract：:In order to recognize and combat a diverse array of pathogens the immune system has a large repertoire of T cells having unique T cell receptors (TCRs) with only a few clones specific for any given antigen. We discuss how the number of different possible TCRs encoded in the genome (the potential repertoire) and the nu...

journal_title：Frontiers in immunology

authors： Zarnitsyna VI,Evavold BD,Schoettle LN,Blattman JN,Antia R

更新日期：2013-12-26 00:00:00

abstract：:Vaccination is one of the most cost-effective health interventions and, with the exception of water sanitization, no other action has had such a major effect in mortality reduction. Combined with other approaches, such as clean water, better hygiene, and health education, vaccination contributed to prevent millions of...

journal_title：Frontiers in immunology

authors： Vo HTM,Baudner BC,Sammicheli S,Iannacone M,D'Oro U,Piccioli D

更新日期：2018-04-09 00:00:00

abstract：:Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELISPOT response, PBMC transcriptomics, and PBMC cell compositions at 0, 3, and 28 days post-immu...

journal_title：Frontiers in immunology

authors： Voigt EA,Ovsyannikova IG,Kennedy RB,Grill DE,Goergen KM,Schaid DJ,Poland GA

更新日期：2019-02-27 00:00:00

abstract：:Plasmodium vivax is the most geographically widespread and the dominant human malaria parasite in most countries outside of sub-Saharan Africa and, although it was classically recognized to cause benign infection, severe cases and deaths caused by P. vivax have remarkably been reported. In contrast to Plasmodium falci...

journal_title：Frontiers in immunology

authors： Totino PR,Lopes SC

更新日期：2017-09-20 00:00:00

abstract：BACKGROUND:Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll-like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important ...

journal_title：Frontiers in immunology

authors： Katare PB,Bagul PK,Dinda AK,Banerjee SK

更新日期：2017-06-22 00:00:00

abstract：:Elimination of potential self-reactive T cells in the thymus is crucial for preventing the onset of autoimmune diseases. Epithelial cell subsets localized in thymic medulla [medullary thymic epithelial cells (mTECs)] contribute to this process by supplying a wide range of self-antigens that are otherwise expressed in ...

journal_title：Frontiers in immunology

authors： Akiyama T,Shinzawa M,Qin J,Akiyama N

更新日期：2013-08-26 00:00:00

abstract：:Background: Optimal timing of gestational tetanus-diphtheria-acellular pertussis (Tdap) vaccination is not well-defined. No well-established specific anti-pertussis antibody level correlates with protection, suggesting the importance of antibody quality such as avidity. We aimed to determine the effect of timing of va...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Giles ML,Kollmann TR,Sadarangani M

更新日期：2019-10-11 00:00:00

abstract：:Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 protease and canonical NF-κB signaling. Structural data and in vitro ass...

journal_title：Frontiers in immunology

authors： Seeholzer T,Kurz S,Schlauderer F,Woods S,Gehring T,Widmann S,Lammens K,Krappmann D

更新日期：2018-11-20 00:00:00

abstract：:The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic complications, and transformation to acute myeloid leukemia (AML). JAK2 inhibitors improve the quality of life for MPN patients, but these approved therapeutics do not ...

journal_title：Frontiers in immunology

authors： Sharma V,Wright KL,Epling-Burnette PK,Reuther GW

更新日期：2020-11-30 00:00:00

abstract：:Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expr...

journal_title：Frontiers in immunology

authors： Faber H,Kurtoic D,Krishnamoorthy G,Weber P,Pütz B,Müller-Myhsok B,Weber F,Andlauer TFM

更新日期：2020-09-18 00:00:00

abstract：:One of the most significant challenges of cell biology is to understand how each type of cell copes with its specific workload without suffering damage. Among the most intriguing questions concerns intestinal epithelial cells in mammals; these cells act as a barrier between the internally protected region and the exte...

journal_title：Frontiers in immunology

authors： Randall-Demllo S,Chieppa M,Eri R

更新日期：2013-09-30 00:00:00