Neddylation Facilitates the Antiviral Response in Zebrafish.

abstract：:Keloids are disfiguring, fibroproliferative growths and their pathogenesis remains unclear, inhibiting therapeutic development. Available treatment options have limited efficacy and harbor safety concerns. Thus, there is a great need to clarify keloid pathomechanisms that may lead to novel treatments. In this study, w...

journal_title：Frontiers in immunology

authors： Wu J,Del Duca E,Espino M,Gontzes A,Cueto I,Zhang N,Estrada YD,Pavel AB,Krueger JG,Guttman-Yassky E

更新日期：2020-11-23 00:00:00

abstract：:Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to understanding B-cell immun...

journal_title：Frontiers in immunology

authors： Jeliazkov JR,Sljoka A,Kuroda D,Tsuchimura N,Katoh N,Tsumoto K,Gray JJ

更新日期：2018-03-02 00:00:00

abstract：:Targeting the programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) pathway has been shown to enhance T cell-mediated antitumor immunity. Clinical responses are limited to subgroups of patients. The search for biomarkers of response is a strategy to predict response and outcome of PD-1/PD-L1 checkpoint interventi...

journal_title：Frontiers in immunology

authors： Merhi M,Raza A,Inchakalody VP,Nashwan AJJ,Allahverdi N,Krishnankutty R,Uddin S,Zar Gul AR,Al Homsi MU,Dermime S

更新日期：2018-07-30 00:00:00

abstract：:Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, CD4+ T cells mount an immune response against invading pathogens. Therefore, mechanistic identificatio...

journal_title：Frontiers in immunology

authors： Degoot AM,Chirove F,Ndifon W

更新日期：2018-06-20 00:00:00

abstract：:Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transp...

journal_title：Frontiers in immunology

authors： Sarvaria A,Jawdat D,Madrigal JA,Saudemont A

更新日期：2017-03-23 00:00:00

abstract：:The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is regulated by members of the interleukin IL-20 subfamily. This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in reg...

journal_title：Frontiers in immunology

authors： Lai X,Li X,Chang L,Chen X,Huang Z,Bao H,Huang J,Yang L,Wu X,Wang Z,Bellanti JA,Zheng SG,Zhang G

更新日期：2019-07-17 00:00:00

abstract：:Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cytokines, especially interleukin (IL)-1β. The convertion of 31KDa inacti...

journal_title：Frontiers in immunology

authors： Medeiros NI,Pinto BF,Elói-Santos SM,Teixeira-Carvalho A,Magalhães LMD,Dutra WO,Correa-Oliveira R,Gomes JAS

更新日期：2019-04-18 00:00:00

abstract：:Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains largely unknown. The titers of serum anti-nuclear-IgG antibodies (ANA-...

journal_title：Frontiers in immunology

authors： Pan Q,Xiao H,Shi L,He Y,Cai J,Wu J,Li A,Ye L,Yang C,Liu HF

更新日期：2020-06-17 00:00:00

abstract：:Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards. Initial phase I trials demonstrated that the administration of a number of...

journal_title：Frontiers in immunology

authors： Phillips BE,Garciafigueroa Y,Engman C,Trucco M,Giannoukakis N

更新日期：2019-02-06 00:00:00

abstract：:Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory dis...

journal_title：Frontiers in immunology

authors： Mylonas A,Conrad C

更新日期：2018-11-28 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can modulate MSC functions is limited. Here, we report that osteopon...

journal_title：Frontiers in immunology

authors： Scutera S,Salvi V,Lorenzi L,Piersigilli G,Lonardi S,Alotto D,Casarin S,Castagnoli C,Dander E,D'Amico G,Sozzani S,Musso T

更新日期：2018-06-01 00:00:00

abstract：:The classical model of cytokine signaling dominates our view of specific gene activation by cytokines such as the interferons (IFNs). The importance of the model extends beyond cytokines and applies to hormones such as growth hormone (GH) and insulin, and growth factors such as epidermal growth factor (EGF) and fibrob...

journal_title：Frontiers in immunology

authors： Johnson HM,Noon-Song EN,Dabelic R,Ahmed CM

更新日期：2013-07-25 00:00:00

abstract：:Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to different fate-determining mediators. These macrophage subsets display distinct molecular markers and ...

journal_title：Frontiers in immunology

authors： Ariel A,Serhan CN

更新日期：2012-01-31 00:00:00

abstract：:By uncovering complex dynamics in the expression or localization of transcriptional regulators in single cells that were otherwise hidden at the population level, live cell imaging has transformed our understanding of how cells sense and orchestrate appropriate responses to changes in their internal state or extracell...

journal_title：Frontiers in immunology

authors： Nelson RH,Nelson DE

更新日期：2018-12-14 00:00:00

abstract：:The lung is a particularly vulnerable organ at the interface of the body and the exterior environment. It is constantly exposed to microbes and particles by inhalation. The innate immune system needs to react promptly and adequately to potential dangers posed by these microbes and particles, while at the same time avo...

journal_title：Frontiers in immunology

authors： Chaput C,Sander LE,Suttorp N,Opitz B

更新日期：2013-11-21 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle equipped with mechanisms for proper protein folding, trafficking, and degradation to maintain protein homeostasis in the secretory pathway. As a defense mechanism, perturbation of ER proteostasis by ER stress agents activates a cascade of signaling pathways from the ER to...

journal_title：Frontiers in immunology

authors： Li A,Song NJ,Riesenberg BP,Li Z

更新日期：2020-02-11 00:00:00

abstract：:The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in PRF1, UNC13D, STX11, or STXBP2 leads to a potentially fatal immune dysregulation,...

journal_title：Frontiers in immunology

authors： Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

更新日期：2018-03-15 00:00:00

abstract：:Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions. Stressed and damaged cells need to be cleared to control local inflammation and trigger tissue healing. Engagement of the activa...

journal_title：Frontiers in immunology

authors： Antonangeli F,Soriani A,Cerboni C,Sciumè G,Santoni A

更新日期：2017-11-20 00:00:00

abstract：:In human brucellosis, the liver is frequently affected. Brucella abortus triggers a profibrotic response on hepatic stellate cells (HSCs) characterized by inhibition of MMP-9 with concomitant collagen deposition and TGF-β1 secretion through type 4 secretion system (T4SS). Taking into account that it has been reported ...

journal_title：Frontiers in immunology

authors： Arriola Benitez PC,Pesce Viglietti AI,Gomes MTR,Oliveira SC,Quarleri JF,Giambartolomei GH,Delpino MV

更新日期：2020-01-21 00:00:00

abstract：:Despite significant breakthroughs in understanding of immunological and physiological features of autoimmune diseases, there is currently no specific therapeutic option with prolonged remission. Cell-based therapy using engineered-T cells has attracted tremendous attention as a practical treatment for autoimmune disea...

journal_title：Frontiers in immunology

authors： Sadeqi Nezhad M,Seifalian A,Bagheri N,Yaghoubi S,Karimi MH,Adbollahpour-Alitappeh M

更新日期：2020-11-26 00:00:00

abstract：:An important goal for personalized treatment is predicting response to a particular therapeutic. A drawback of biological treatment is immunogenicity and the development of antibodies directed against the drug [anti-drug antibodies (ADA)], which are associated with a poorer clinical outcome. Here we set out to identif...

journal_title：Frontiers in immunology

authors： Magill L,Adriani M,Berthou V,Chen K,Gleizes A,Hacein-Bey-Abina S,Hincelin-Mery A,Mariette X,Pallardy M,Spindeldreher S,Szely N,Isenberg DA,Manson JJ,Jury EC,Mauri C

更新日期：2018-12-05 00:00:00

abstract：:This study develops an original co-infection model in mice using Brucella melitensis, the most frequent cause of human brucellosis, and Trypanosoma brucei, the agent of African trypanosomiasis. Although the immunosuppressive effects of T. brucei in natural hosts and mice models are well established, we observed that t...

journal_title：Frontiers in immunology

authors： Machelart A,Van Vyve M,Potemberg G,Demars A,De Trez C,Tima HG,Vanwalleghem G,Romano M,Truyens C,Letesson JJ,Muraille E

更新日期：2017-07-31 00:00:00

abstract：:Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

journal_title：Frontiers in immunology

authors： Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

更新日期：2018-05-22 00:00:00

abstract：:Induced expression of serum amyloid A (SAA) is a hallmark of many inflammatory diseases, but whether SAA exacerbates inflammation or protects tissues against injury remains unclear. In dextran sulfate sodium (DSS)-induced colitis, SAA3 is the predominant isoform of inducible SAA proteins that also include SAA1 and SAA...

journal_title：Frontiers in immunology

authors： Zhang G,Liu J,Wu L,Fan Y,Sun L,Qian F,Chen D,Ye RD

更新日期：2018-06-29 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.01135.]. ...

journal_title：Frontiers in immunology

authors： Ramirez GA,Rovere-Querini P,Blasi M,Sartorelli S,Di Chio MC,Baldini M,De Lorenzo R,Bozzolo EP,Leone R,Mantovani A,Manfredi AA,Tombetti E

更新日期：2019-07-24 00:00:00

abstract：:Recent events have made it clear that potentially pandemic strains of influenza regularly pose a threat to human populations. Therefore, it is essential that we develop better strategies to enhance vaccine design and evaluation to predict those that will be poor responders to vaccination and to identify those that are...

journal_title：Frontiers in immunology

authors： DiPiazza A,Richards KA,Knowlden ZA,Nayak JL,Sant AJ

更新日期：2016-01-25 00:00:00

abstract：:Monoclonal antibodies against the cell surface antigen CD38, e.g., isatuximab, daratumumab, or Mor202, have entered the therapeutic armamentarium in multiple myeloma due to single agent overall response rates of 29 vs. 36 vs. 31%, effectivity in combination regimen, e.g., with lenalidomide or bortezomib plus dexametha...

journal_title：Frontiers in immunology

authors： Seckinger A,Hillengass J,Emde M,Beck S,Kimmich C,Dittrich T,Hundemer M,Jauch A,Hegenbart U,Raab MS,Ho AD,Schönland S,Hose D

更新日期：2018-07-20 00:00:00

abstract：:Allergies and asthma are a major cause of chronic disease whose prevalence has been on the rise. Allergic disease including seasonal rhinitis, atopic dermatitis, urticaria, anaphylaxis, and asthma, are associated with activation of tissue-resident mast cells and circulating basophils. Although these cells can be activ...

journal_title：Frontiers in immunology

authors： Gomez G

更新日期：2019-02-07 00:00:00

abstract：:Tuberculosis (TB) is currently one of the leading causes of global mortality. Medical non-compliance due to the length of the treatment and antibiotic side effects has led to the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis (M. tb) that are difficult to treat. A current therapeutic stra...

journal_title：Frontiers in immunology

authors： Hernandez J,Ashley D,Cao R,Abrahem R,Nguyen T,To K,Yegiazaryan A,Akinwale David A,Kumar Tiwari R,Venketaraman V

更新日期：2020-08-13 00:00:00

abstract：:NH36 is a vital enzyme of the DNA metabolism and a specific target for anti-Leishmania chemotherapy. We developed second-generation vaccines composed of the FML complex or its main native antigen, the NH36 nucleoside hydrolase of Leishmania (L.) donovani and saponin, and a DNA vaccine containing the NH36 gene. All the...

journal_title：Frontiers in immunology

authors： Palatnik-de-Sousa CB

更新日期：2019-04-16 00:00:00