Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling.

abstract：:Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However, the clinical course following SCT appears to demonstrate many characteristics of dynamical systems, especially when outcomes are considered in the context of immune reconstitution. Dynamical systems tend to evolve over time acco...

journal_title：Frontiers in immunology

authors： Toor AA,Kobulnicky JD,Salman S,Roberts CH,Jameson-Lee M,Meier J,Scalora A,Sheth N,Koparde V,Serrano M,Buck GA,Clark WB,McCarty JM,Chung HM,Manjili MH,Sabo RT,Neale MC

更新日期：2014-12-03 00:00:00

abstract：:Vaccination is the most reliable measure to prevent infectious diseases in domestic animals. Development of novel vaccines demands extensive studies with new technologies, such as using novel adjuvants and immunomodulatory molecules. The co-stimulatory molecule 4-1BB provides a key signal that directs the fate of T ce...

journal_title：Frontiers in immunology

authors： Huang G,Liu X,Duszynski DW,Tang X,El-Ashram S,Liu Z,Suo X,Li Q

更新日期：2017-12-18 00:00:00

abstract：:Soluble factors are an essential means of communication between cells and their environment. However, many molecules readily interact with extracellular matrix components, giving rise to multiple modes of diffusion. The molecular quantification of diffusion in situ is thus a challenging imaging frontier, requiring ver...

journal_title：Frontiers in immunology

authors： Miller H,Cosgrove J,Wollman AJM,Taylor E,Zhou Z,O'Toole PJ,Coles MC,Leake MC

更新日期：2018-05-22 00:00:00

abstract：:Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tis...

journal_title：Frontiers in immunology

authors： Wu Y,Tian Z,Wei H

更新日期：2017-08-04 00:00:00

abstract：:Leishmania parasites infect macrophages, causing a wide spectrum of human diseases, from cutaneous to visceral forms. In search of novel therapeutic targets, we performed comprehensive in vitro and ex vivo mapping of the signaling pathways upstream and downstream of antioxidant transcription factor [nuclear factor ery...

journal_title：Frontiers in immunology

authors： Vivarini ÁC,Calegari-Silva TC,Saliba AM,Boaventura VS,França-Costa J,Khouri R,Dierckx T,Dias-Teixeira KL,Fasel N,Barral AMP,Borges VM,Van Weyenbergh J,Lopes UG

更新日期：2017-09-15 00:00:00

abstract：:Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8+ T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. However, the metabolic determinants of a...

journal_title：Frontiers in immunology

authors： Nicoli F,Papagno L,Frere JJ,Cabral-Piccin MP,Clave E,Gostick E,Toubert A,Price DA,Caputo A,Appay V

更新日期：2018-12-21 00:00:00

abstract：:TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously showed that in human primary monocytes and monocyte derived macrophages, TLR8 senses entire Staphylococcus aureus and Streptococcus agalactiae (group B strepto...

journal_title：Frontiers in immunology

authors： Moen SH,Ehrnström B,Kojen JF,Yurchenko M,Beckwith KS,Afset JE,Damås JK,Hu Z,Yin H,Espevik T,Stenvik J

更新日期：2019-05-31 00:00:00

abstract：:Early detection of Primary Immunodeficiencies Disorders (PIDDs) is of paramount importance for effective treatment and disease management. Many PIDDs would be strong candidates for newborn screening (NBS) if robust screening methods could identify patients from dried blood spots (DBS) during the neonatal period. As ma...

journal_title：Frontiers in immunology

authors： Collins CJ,Yi F,Dayuha R,Whiteaker JR,Ochs HD,Freeman A,Su HC,Paulovich AG,Segundo GRS,Torgerson T,Hahn SH

更新日期：2020-04-01 00:00:00

abstract：:The dendritic cell (DC) compartment comprises subsets of cells with distinct phenotypes. Previously this lab reported methodology for hematopoiesis of dendritic-like cells in vitro dependent on a murine splenic stromal cell line (5G3). Co-cultures of lineage-depleted bone marrow (Lin(-) BM) over 5G3 continuously produ...

journal_title：Frontiers in immunology

authors： Petvises S,O'Neill HC

更新日期：2014-01-02 00:00:00

abstract：:Immunoediting is an important concept in oncology, delineating the mechanisms through which tumors are selected for resistance to immune-mediated elimination. The recent emergence of immunotherapies, such as checkpoint inhibitors, as pillars of cancer therapy has intensified interest in immunoediting as a constraint l...

journal_title：Frontiers in immunology

authors： Huang SH,McCann CD,Mota TM,Wang C,Lipkin SM,Jones RB

更新日期：2019-08-06 00:00:00

abstract：:Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chronic hepatitis B vi...

journal_title：Frontiers in immunology

authors： Yong YK,Saeidi A,Tan HY,Rosmawati M,Enström PF,Batran RA,Vasuki V,Chattopadhyay I,Murugesan A,Vignesh R,Kamarulzaman A,Rajarajeswaran J,Ansari AW,Vadivelu J,Ussher JE,Velu V,Larsson M,Shankar EM

更新日期：2018-03-19 00:00:00

abstract：:For decades, cancer was considered a disease driven by genetic mutations in tumor cells, therefore afflicting a single cell type. This simplified view was slowly replaced by the understanding that interactions between malignant cells and neighboring stromal and immune cells-the tumor microenvironment (TME)-profoundly ...

journal_title：Frontiers in immunology

authors： Haas L,Obenauf AC

更新日期：2019-11-28 00:00:00

abstract：:Natural killer (NK) cells are a promising tool for the use in adoptive immunotherapy, since they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an attractive option to increase NK cells in numbers and to improve their antitumor potential prior to clinical applications. Consequently...

journal_title：Frontiers in immunology

authors： Granzin M,Wagner J,Köhl U,Cerwenka A,Huppert V,Ullrich E

更新日期：2017-04-26 00:00:00

abstract：:Amino acids (AAs) are necessary nutrients which act not only as building blocks in protein synthesis but also in crucial anabolic cellular signaling pathways. It has been demonstrated that SLC7A5 is a critical transporter that mediates uptake of several essential amino acids in highly proliferative tumors and activate...

journal_title：Frontiers in immunology

authors： Yoon BR,Oh YJ,Kang SW,Lee EB,Lee WW

更新日期：2018-01-25 00:00:00

abstract：:Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed ...

journal_title：Frontiers in immunology

authors： Muire PJ,Mangum LH,Wenke JC

更新日期：2020-06-04 00:00:00

abstract：:Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,de Wolf ACM,Ludwig IS,Leufkens P,Broere F

更新日期：2017-11-30 00:00:00

abstract：:Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

journal_title：Frontiers in immunology

authors： Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

更新日期：2018-05-22 00:00:00

abstract：:Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation. The molecular machinery of macroautophagy, a catabolic pathway that delivers cytoplasmic constituents to...

journal_title：Frontiers in immunology

authors： Münz C

更新日期：2018-11-27 00:00:00

abstract：:Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to different fate-determining mediators. These macrophage subsets display distinct molecular markers and ...

journal_title：Frontiers in immunology

authors： Ariel A,Serhan CN

更新日期：2012-01-31 00:00:00

abstract：:The rabbit monoclonal antibodies (mAbs) have advantages in pharmaceuticals and diagnostics with high affinity and specificity. During the past decade, many techniques have been developed for isolating rabbit mAbs, including single B cell antibody technologies. This review describes the basic characterization of rabbit...

journal_title：Frontiers in immunology

authors： Zhang Z,Liu H,Guan Q,Wang L,Yuan H

更新日期：2017-05-05 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are quiescent cells with self-renewal capacity and the ability to generate all mature blood cells. HSCs normally reside in specialized niches in the bone marrow that help maintain their quiescence and long-term repopulating activity. There is emerging evidence that certain cytokines ind...

journal_title：Frontiers in immunology

authors： Schuettpelz LG,Link DC

更新日期：2013-07-19 00:00:00

abstract：:The fundamental problem of autoimmune diseases is the failure of the immune system to downregulate its own potentially dangerous cells, which leads to destruction of tissue expressing the relevant autoantigens. Current immunosuppressive therapies offer relief but fail to restore the basic condition of self-tolerance. ...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,Ludwig I,van Kooten P,van der Zee R,Broere F

更新日期：2017-11-21 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small...

journal_title：Frontiers in immunology

authors： Park AM,Khadka S,Sato F,Omura S,Fujita M,Hsu DK,Liu FT,Tsunoda I

更新日期：2020-09-23 00:00:00

abstract：:Background: We report here two new familial cases of associated del15q11 and del7p22, with the latter underlining the clinical variability of this deletion. Two siblings patients presented a similar familial imbalanced translocation, originating from a balanced maternal translocation, with deletions of 7p22 and of 15q...

journal_title：Frontiers in immunology

authors： Sloboda N,Sorlin A,Valduga M,Beri-Dexheimer M,Bilbault C,Fouyssac F,Becker A,Lambert L,Bonnet C,Leheup B

更新日期：2019-08-16 00:00:00

abstract：:Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells ...

journal_title：Frontiers in immunology

authors： Krystel-Whittemore M,Dileepan KN,Wood JG

更新日期：2016-01-06 00:00:00

abstract：:The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self receptors and effector mechanisms differ greatly among animal phyla, some aspects of recognition, regulation, and response are broadly conserved. A gene regulatory ne...

journal_title：Frontiers in immunology

authors： Buckley KM,Rast JP

更新日期：2017-10-23 00:00:00

abstract：:Cytokines are major players regulating immune responses toward inflammatory and tolerogenic results. In organ and bone marrow transplantation, new reagents are needed to inhibit tissue destructive mechanisms and eventually induce immune tolerance without overall immunosuppression. IL-34 is a cytokine with no significa...

journal_title：Frontiers in immunology

authors： Bézie S,Freuchet A,Sérazin C,Salama A,Vimond N,Anegon I,Guillonneau C

更新日期：2020-08-11 00:00:00

abstract：:The progressive infiltration of immune cells is associated with the progression of melanoma. Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor effects. It is now necessary to understand the contradictory data associated with how Th17 cells play a role in melanoma. This review will ...

journal_title：Frontiers in immunology

authors： Chen C,Gao FH

更新日期：2019-02-08 00:00:00

abstract：:Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events. Over the last two decades its use has been extended to secondary antibody deficiencies, particularly those related to hematological disorders as...

journal_title：Frontiers in immunology

authors： Compagno N,Malipiero G,Cinetto F,Agostini C

更新日期：2014-12-08 00:00:00

abstract：:Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on their surface, preve...

journal_title：Frontiers in immunology

authors： Kárpáti É,Papp A,Schneider AE,Hajnal D,Cserhalmi M,Csincsi ÁI,Uzonyi B,Józsi M

更新日期：2020-07-16 00:00:00