Short-Chain Fatty Acids Promote Intracellular Bactericidal Activity in Head Kidney Macrophages From Turbot (Scophthalmus maximus L.) via Hypoxia Inducible Factor-1α.

abstract：:Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, both in adults and children. It is characterized by an aberrant lipid storage in hepatocytes, named hepatic steatosis. Simple steatosis remains a benign process in most affected patients, while some of them develop superimp...

journal_title：Frontiers in immunology

authors： Meli R,Mattace Raso G,Calignano A

更新日期：2014-04-23 00:00:00

abstract：:Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL). The proper o...

journal_title：Frontiers in immunology

authors： Bannas P,Hambach J,Koch-Nolte F

更新日期：2017-11-22 00:00:00

abstract：:Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its re...

journal_title：Frontiers in immunology

authors： Haskó G,Cronstein B

更新日期：2013-04-08 00:00:00

abstract：:Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Intestinal mononuclear phagocytes (MNPs) have a crucial role in maintaining epithelial barrier i...

journal_title：Frontiers in immunology

authors： Caër C,Wick MJ

更新日期：2020-03-18 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are important for immune function. Limited evidence indicates that immune cell activation involves endogenous PUFA synthesis, but this has not been characterised. To address this, we measured metabolism of 18:3n-3 in quiescent and activated peripheral blood mononuclear cells (PBMCs)...

journal_title：Frontiers in immunology

authors： Sibbons CM,Irvine NA,Pérez-Mojica JE,Calder PC,Lillycrop KA,Fielding BA,Burdge GC

更新日期：2018-03-05 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells essential for the induction of adaptive immune responses. Their unprecedented ability to present antigens to T cells has made them excellent targets for vaccine development. In the last years, a new technology based on antigen delivery directly to different DC subsets...

journal_title：Frontiers in immunology

authors： Antonialli R,Sulczewski FB,Amorim KNDS,Almeida BDS,Ferreira NS,Yamamoto MM,Soares IS,Ferreira LCS,Rosa DS,Boscardin SB

更新日期：2017-12-04 00:00:00

abstract：:It has been previously shown that the amyloid precursor protein (APP) support the innate immune defense as an immune receptor. Amyloid β (Aβ) peptides seem to have properties of an antimicrobial peptide and can act as opsonines. In APP-deficient mouse models, a reduced secretion of cytokines has been observed. Still, ...

journal_title：Frontiers in immunology

authors： Spitzer P,Walter M,Göth C,Oberstein TJ,Linning P,Knölker HJ,Kornhuber J,Maler JM

更新日期：2020-09-03 00:00:00

abstract：:An essential role of the intestine is to build and maintain a barrier preventing the luminal gut microbiota from invading the host. This involves two coordinated physical and immunological barriers formed by single layers of intestinal epithelial and endothelial cells, which avoid the activation of local immune respon...

journal_title：Frontiers in immunology

authors： López-Posadas R,Stürzl M,Atreya I,Neurath MF,Britzen-Laurent N

更新日期：2017-10-05 00:00:00

abstract：:Leishmania parasites infect macrophages, causing a wide spectrum of human diseases, from cutaneous to visceral forms. In search of novel therapeutic targets, we performed comprehensive in vitro and ex vivo mapping of the signaling pathways upstream and downstream of antioxidant transcription factor [nuclear factor ery...

journal_title：Frontiers in immunology

authors： Vivarini ÁC,Calegari-Silva TC,Saliba AM,Boaventura VS,França-Costa J,Khouri R,Dierckx T,Dias-Teixeira KL,Fasel N,Barral AMP,Borges VM,Van Weyenbergh J,Lopes UG

更新日期：2017-09-15 00:00:00

abstract：:Antibodies have proven their high value in antitumor therapy over the last two decades. They are currently being used as the first-choice to treat some of the most frequent metastatic cancers, like HER2+ breast cancers or colorectal cancers, currently treated with trastuzumab (Herceptin) and bevacizumab (Avastin), res...

journal_title：Frontiers in immunology

authors： Corraliza-Gorjón I,Somovilla-Crespo B,Santamaria S,Garcia-Sanz JA,Kremer L

更新日期：2017-12-21 00:00:00

abstract：:Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of...

journal_title：Frontiers in immunology

authors： Loewendorf AI,Matynia A,Saribekyan H,Gross N,Csete M,Harrington M

更新日期：2016-04-19 00:00:00

abstract：:Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about the direct impact of PI3Kδ blockade on effector T cells from CAL-101 t...

journal_title：Frontiers in immunology

authors： Bowers JS,Majchrzak K,Nelson MH,Aksoy BA,Wyatt MM,Smith AS,Bailey SR,Neal LR,Hammerbacher JE,Paulos CM

更新日期：2017-09-29 00:00:00

abstract：:Microvilli are finger-like membrane protrusions, supported by the actin cytoskeleton, and found on almost all cell types. A growing body of evidence suggests that the dynamic lymphocyte microvilli, with their highly curved membranes, play an important role in signal transduction leading to immune responses. Neverthele...

journal_title：Frontiers in immunology

authors： Orbach R,Su X

更新日期：2020-09-11 00:00:00

abstract：:The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, only clinically diagnosed since the lack of reliable biomarkers. Autism etiology is probably attributable to the combination of genetic vulnerability and environmental factors, and recently, maternal immune activation has been...

journal_title：Frontiers in immunology

authors： Balestrieri E,Cipriani C,Matteucci C,Benvenuto A,Coniglio A,Argaw-Denboba A,Toschi N,Bucci I,Miele MT,Grelli S,Curatolo P,Sinibaldi-Vallebona P

更新日期：2019-09-26 00:00:00

abstract：:TILRR (Toll-like interleukin-1 receptor regulator), a transcript variant of FREM1, is a novel regulatory component, which stimulates innate immune responses through binding to IL-1R1 (Interleukin-1 receptor, type 1) and TLR (Toll-like receptor) complex. However, it is not known whether TILRR expression influences othe...

journal_title：Frontiers in immunology

authors： Kashem MA,Li H,Toledo NP,Omange RW,Liang B,Liu LR,Li L,Yang X,Yuan XY,Kindrachuk J,Plummer FA,Luo M

更新日期：2019-02-28 00:00:00

abstract：:Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery, few approved treatments are available for this complication. Wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic...

journal_title：Frontiers in immunology

authors： Li B,Hu Y,Zhao Y,Cheng M,Qin H,Cheng T,Wang Q,Peng X,Zhang X

更新日期：2017-01-31 00:00:00

abstract：:Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 protease and canonical NF-κB signaling. Structural data and in vitro ass...

journal_title：Frontiers in immunology

authors： Seeholzer T,Kurz S,Schlauderer F,Woods S,Gehring T,Widmann S,Lammens K,Krappmann D

更新日期：2018-11-20 00:00:00

abstract：:Pigs are important livestock and comprehensive understanding of their immune responses in infections is critical to improve vaccines and therapies. Moreover, similarities between human and swine physiology suggest that pigs are a superior animal model for immunological studies. However, paucity of experimental tools f...

journal_title：Frontiers in immunology

authors： Schäfer A,Hühr J,Schwaiger T,Dorhoi A,Mettenleiter TC,Blome S,Schröder C,Blohm U

更新日期：2019-06-18 00:00:00

abstract：:Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent studies suggest that dynamic programing of macrophages and monocytes may give rise to distinct "memory" states. Lipopolysaccharide (LPS), a classical pattern recognition molecule, dynamically programs innate immune responses. Emerging...

journal_title：Frontiers in immunology

authors： Morris MC,Gilliam EA,Li L

更新日期：2015-01-06 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen presenting cells that are exquisitely adapted to sense pathogens and induce the development of adaptive immune responses. They form a complex network of phenotypically and functionally distinct subsets. Within this network, individual DC subsets display highly specific rol...

journal_title：Frontiers in immunology

authors： Chopin M,Allan RS,Belz GT

更新日期：2012-02-27 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key con...

journal_title：Frontiers in immunology

authors： Mi Y,Guo N,Luan J,Cheng J,Hu Z,Jiang P,Jin W,Gao X

更新日期：2020-04-24 00:00:00

abstract：:Human cytomegalovirus (HCMV) is under constant selective pressure from the immune system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically altered by, such selection can focus research toward findings of in vivo significance. We have been particularly interested in the most pronounced ...

journal_title：Frontiers in immunology

authors： Patel M,Vlahava VM,Forbes SK,Fielding CA,Stanton RJ,Wang ECY

更新日期：2018-10-01 00:00:00

abstract：Purpose:Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM). Objective:To evaluate changes in lipoproteins, insulin resistance, mediators of systemi...

journal_title：Frontiers in immunology

authors： Yadav R,Hama S,Liu Y,Siahmansur T,Schofield J,Syed AA,France M,Pemberton P,Adam S,Ho JH,Aghamohammadzadeh R,Dhage S,Donn R,Malik RA,New JP,Jeziorska M,Durrington P,Ammori BA,Soran H

更新日期：2017-11-15 00:00:00

abstract：:Ticks, blood-feeding arthropods, and secrete immunosuppressive molecules that inhibit host immune responses and provide survival advantages to pathogens. In this study, we characterized the immunosuppressive function of a novel tick salivary protein, DsCystatin, from Dermacentor silvarum of China. DsCystatin directly ...

journal_title：Frontiers in immunology

authors： Sun T,Wang F,Pan W,Wu Q,Wang J,Dai J

更新日期：2018-06-01 00:00:00

abstract：:Background: We report here two new familial cases of associated del15q11 and del7p22, with the latter underlining the clinical variability of this deletion. Two siblings patients presented a similar familial imbalanced translocation, originating from a balanced maternal translocation, with deletions of 7p22 and of 15q...

journal_title：Frontiers in immunology

authors： Sloboda N,Sorlin A,Valduga M,Beri-Dexheimer M,Bilbault C,Fouyssac F,Becker A,Lambert L,Bonnet C,Leheup B

更新日期：2019-08-16 00:00:00

abstract：:Conventional influenza vaccines aim at the induction of virus-neutralizing antibodies that provide with sterilizing immunity. However, influenza vaccination often confers protection from disease but not from infection. The impact of infection-permissive vaccination on the immune response elicited by subsequent influen...

journal_title：Frontiers in immunology

authors： Choi A,Ibañez LI,Strohmeier S,Krammer F,García-Sastre A,Schotsaert M

更新日期：2020-06-09 00:00:00

abstract：:Glioblastoma is one of the most common neoplasms in the central nervous system characterized by limited immune response and unlimited expansion capability. Cancer stem cells (GSCs), a small fraction of the tumor cells, possess a pivotal regulation capability in the tumor microenvironment with a superior proliferation ...

journal_title：Frontiers in immunology

authors： Zhai Y,Li G,Li R,Chang Y,Feng Y,Wang D,Wu F,Zhang W

更新日期：2020-10-08 00:00:00

abstract：:Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast cells form a heterogeneous population of immune cells with differences in their ultra-structure, morphology, mediator content, and surface receptors. Mast cells are widely distributed throughout all tissues and are stromal compon...

journal_title：Frontiers in immunology

authors： Varricchi G,Galdiero MR,Loffredo S,Marone G,Iannone R,Marone G,Granata F

更新日期：2017-04-12 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle equipped with mechanisms for proper protein folding, trafficking, and degradation to maintain protein homeostasis in the secretory pathway. As a defense mechanism, perturbation of ER proteostasis by ER stress agents activates a cascade of signaling pathways from the ER to...

journal_title：Frontiers in immunology

authors： Li A,Song NJ,Riesenberg BP,Li Z

更新日期：2020-02-11 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airway. Its major symptoms are reversible breathing problems causing airway narrowing and obstruction. IL-19 is a member of the IL-10 family cytokines. We previously showed that IL-19 induces T-helper 2 (Th2) cytokines and that asthma patients had higher serum IL-19 leve...

journal_title：Frontiers in immunology

authors： Weng YH,Chen WY,Lin YL,Wang JY,Chang MS

更新日期：2019-04-30 00:00:00