RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis-Novel Targets for Therapy?

Abstract:

:Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by TBX21), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Vecellio M,Cohen CJ,Roberts AR,Wordsworth PB,Kenna TJ

doi

10.3389/fimmu.2018.03132

subject

Has Abstract

pub_date

2019-01-10 00:00:00

pages

3132

issn

1664-3224

journal_volume

9

pub_type

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