RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis-Novel Targets for Therapy?


:Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by TBX21), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.


Front Immunol


Frontiers in immunology


Vecellio M,Cohen CJ,Roberts AR,Wordsworth PB,Kenna TJ




Has Abstract


2019-01-10 00:00:00








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    pub_type: 临床试验,杂志文章


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    pub_type: 杂志文章,评审


    authors: Xia Y,Chen S,Zhu G,Huang R,Yin Y,Ren W

    更新日期:2018-11-20 00:00:00

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Becerril-García MA,Yam-Puc JC,Maqueda-Alfaro R,Beristain-Covarrubias N,Heras-Chavarría M,Gallegos-Hernández IA,Calderón-Amador J,Munguía-Fuentes R,Donis-Maturano L,Flores-Langarica A,Flores-Romo L

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    pub_type: 杂志文章,评审


    authors: Petousis-Harris H,Radcliff FJ

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    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Toscani D,Bolzoni M,Ferretti M,Palumbo C,Giuliani N

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