Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance.

abstract：:Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by Plasmodium falciparum blood-stage parasites will help to understand how immunity is acquired and...

journal_title：Frontiers in immunology

authors： Yap XZ,Lundie RJ,Feng G,Pooley J,Beeson JG,O'Keeffe M

更新日期：2019-01-31 00:00:00

abstract：:Amino acids (AAs) are necessary nutrients which act not only as building blocks in protein synthesis but also in crucial anabolic cellular signaling pathways. It has been demonstrated that SLC7A5 is a critical transporter that mediates uptake of several essential amino acids in highly proliferative tumors and activate...

journal_title：Frontiers in immunology

authors： Yoon BR,Oh YJ,Kang SW,Lee EB,Lee WW

更新日期：2018-01-25 00:00:00

abstract：:The main environmental risk factor associated with the development of Crohn's disease (CD) is cigarette smoking. Although the mechanism is still unknown, some studies have shown that cigarette exposure affects the intestinal barrier of the small bowel. Among the factors that may be involved in this process are Paneth ...

journal_title：Frontiers in immunology

authors： Berkowitz L,Pardo-Roa C,Salazar GA,Salazar-Echegarai F,Miranda JP,Ramírez G,Chávez JL,Kalergis AM,Bueno SM,Álvarez-Lobos M

更新日期：2019-09-25 00:00:00

abstract：:New biomarkers are needed for discriminating active tuberculosis (TB) from latent TB infection (LTBI), especially in vulnerable groups representing the major diagnostic challenge. This pilot study was carried out to explore the diagnostic potential of selected genes, IFN-γ, IL-17, IL-4, and FoxP3, associated with TB i...

journal_title：Frontiers in immunology

authors： Savolainen LE,Kantele A,Knuuttila A,Pusa L,Karttunen R,Valleala H,Tuuminen T

更新日期：2016-06-14 00:00:00

abstract：:In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the IL-22-pSTAT3 pathway have been identified as risk factors for inflammatory bowel disease (IBD) and some of them are considered as promising therapeutic targets. However, new pers...

journal_title：Frontiers in immunology

authors： Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW

更新日期：2018-11-05 00:00:00

abstract：:Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both types of rejections can be seen in a variable number of sampled gra...

journal_title：Frontiers in immunology

authors： Matsuda Y,Sarwal MM

更新日期：2016-10-21 00:00:00

abstract：:The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in PRF1, UNC13D, STX11, or STXBP2 leads to a potentially fatal immune dysregulation,...

journal_title：Frontiers in immunology

authors： Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

更新日期：2018-03-15 00:00:00

abstract：:Normal term and spontaneous preterm births (PTB) are documented to be associated with oxidative stress (OS), and imbalances in the redox system (balance between pro- and antioxidant) have been reported in the maternal-fetal intrauterine compartments. The exact mechanism of labor initiation either at term or preterm by...

journal_title：Frontiers in immunology

authors： Menon R

更新日期：2014-11-12 00:00:00

abstract：:HERV-H endogenous retroviruses are thought to be essential to stem cell identity in humans. We embrace several decades of HERV-H research in order to relate the transcription of HERV-H loci to their genomic structure. We find that highly transcribed HERV-H loci are younger, more fragmented, and less likely to be prese...

journal_title：Frontiers in immunology

authors： Gemmell P,Hein J,Katzourakis A

更新日期：2019-07-09 00:00:00

abstract：:Cow's milk protein allergy (CMPA) is the most common allergy in the first year of life. Non-IgE mediated CMPA is characterized by digestive symptoms and tolerance development before the age of three. Gut microbiota composition in early life has been associated with food allergy. The ingestion of different foods/nutrie...

journal_title：Frontiers in immunology

authors： Guadamuro L,Diaz M,Jiménez S,Molinos-Norniella C,Pérez-Solis D,Rodríguez JM,Bousoño C,Gueimonde M,Margolles A,Delgado S,Díaz JJ

更新日期：2019-08-02 00:00:00

abstract：:Tolerogenic dendritic cells (DCs) work through silencing of differentiated antigen-specific T cells, activation and expansion of naturally occurring T regulatory cells (Tregs), transfer of regulatory properties to T cells, and the differentiation of naïve T cells into Tregs. Due to an operational definition based on T...

journal_title：Frontiers in immunology

authors： Nikolic T,Roep BO

更新日期：2013-05-14 00:00:00

abstract：:Skeletal health is maintained by bone remodeling, a process in which microscopic sites of effete or damaged bone are degraded on bone surfaces by osteoclasts and subsequently replaced by new bone, which is laid down by osteoblasts. This normal process can be disturbed in a variety of pathologic processes, including lo...

journal_title：Frontiers in immunology

authors： Boyce BF,Li J,Xing L,Yao Z

更新日期：2018-09-28 00:00:00

abstract：:Intralesional Mycobacterium bovis bacillus Calmette-Guérin (BCG) has long been a relatively inexpensive therapy for inoperable cutaneous metastatic melanoma (CMM), although intralesional BCG skin mechanisms remain understudied. We analyzed intralesional BCG-treated CMM lesions combined with in vitro studies to further...

journal_title：Frontiers in immunology

authors： Lardone RD,Chan AA,Lee AF,Foshag LJ,Faries MB,Sieling PA,Lee DJ

更新日期：2017-08-11 00:00:00

abstract：Background:Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. Objectives:To determine whether normal pregnancy and delivery are associated with local activation of...

journal_title：Frontiers in immunology

authors： Livson S,Jarva H,Kalliala I,Lokki AI,Heikkinen-Eloranta J,Nieminen P,Meri S

更新日期：2021-01-11 00:00:00

abstract：:Antibody production and function represent an essential part of the immune response, particularly in fighting bacterial and viral infections. Multiple immunological phenotypes can result in dysregulation of the immune system humoral compartment, including class-switch recombination (CSR) defects associated with hyper-...

journal_title：Frontiers in immunology

authors： Jhamnani RD,Nunes-Santos CJ,Bergerson J,Rosenzweig SD

更新日期：2018-09-26 00:00:00

abstract：:Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS) is abundant in neural tissue, NOS2 is upregulated in a...

journal_title：Frontiers in immunology

authors： Mattila JT,Thomas AC

更新日期：2014-10-09 00:00:00

abstract：:Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules. Diseases associated with deregulated mast cell functions are hard to treat ...

journal_title：Frontiers in immunology

authors： Rubíková Z,Sulimenko V,Paulenda T,Dráber P

更新日期：2018-07-09 00:00:00

abstract：:Viral hemorrhagic fever (VHF) as a disease entity was first codified in the 1930s by soviet scientists investigating patients suffering from hantavirus infection. The group of hemorrhagic fever viruses (HFVs) has since expanded to include members from at least four different virus families: Arenaviridae, Bunyaviridae,...

journal_title：Frontiers in immunology

authors： Schönrich G,Raftery MJ

更新日期：2017-09-26 00:00:00

abstract：:Sepsis is characterized by the host's dysregulated immune response to an infection followed by a potentially fatal organ dysfunction. Although there have been some advances in the treatment of sepsis, mainly focused on broad-spectrum antibiotics, mortality rates remain high, urging for the search of new therapies. Oxi...

journal_title：Frontiers in immunology

authors： Navegantes-Lima KC,Monteiro VVS,de França Gaspar SL,de Brito Oliveira AL,de Oliveira JP,Reis JF,de Souza Gomes R,Rodrigues CA,Stutz H,Sovrani V,Peres A,Romão PRT,Monteiro MC

更新日期：2020-07-01 00:00:00

abstract：:A successful outcome to pregnancy is dependent on the ability of the maternal uterine microenvironment to regulate inflammation processes and establish maternal tolerance. Recently, B cells have been shown to influence pregnancy outcomes as aberrations in their numbers and functions are associated with obstetric compl...

journal_title：Frontiers in immunology

authors： Guzman-Genuino RM,Eldi P,Garcia-Valtanen P,Hayball JD,Diener KR

更新日期：2019-12-11 00:00:00

abstract：:Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells ...

journal_title：Frontiers in immunology

authors： Krystel-Whittemore M,Dileepan KN,Wood JG

更新日期：2016-01-06 00:00:00

abstract：:Natural killer (NK) cells serve an important role in immune system by recognizing and killing the potentially malignant cells without antigen sensitization, and could be promising in cancer therapy. We have designed and fabricated microwell arrays with microchannel connections in polydimethylsiloxane (PDMS) substrates...

journal_title：Frontiers in immunology

authors： Xu Y,Zhou S,Lam YW,Pang SW

更新日期：2017-08-17 00:00:00

abstract：:Autoimmune blistering diseases (AIBDs) of the skin are characterized by autoantibodies against different intra-/extracellular structures within the epidermis and at the basement membrane zone (BMZ). Binding of the antibodies to their target antigen leads to inflammation at the respective binding site and degradation o...

journal_title：Frontiers in immunology

authors： Olbrich M,Künstner A,Witte M,Busch H,Fähnrich A

更新日期：2019-10-15 00:00:00

abstract：:Differentiation of Natural Killer (NK) cells is a stepwise process having its origin in the bone marrow and proceeding in the periphery, where these cells follow organ specific trajectories. Several soluble factors and cytokines regulate the distinct stages of NK cell differentiation, and ultimately, their functional ...

journal_title：Frontiers in immunology

authors： Scarno G,Pietropaolo G,Di Censo C,Gadina M,Santoni A,Sciumè G

更新日期：2019-10-17 00:00:00

abstract：:The development of autoimmunity involves complex interactions between genetics and environmental triggers. The gut microbiota is an important environmental constituent that can heavily influence both local and systemic immune reactivity through distinct mechanisms. It is therefore a relevant environmental trigger or a...

journal_title：Frontiers in immunology

authors： Brown J,Robusto B,Morel L

更新日期：2020-08-04 00:00:00

abstract：:The immune response of a host to a pathogen is typically described as either innate or adaptive. The innate form of the immune response is conserved across all organisms, including insects. Previous and recent research has focused on the nature of the insect immune system and the results imply that the innate immune r...

journal_title：Frontiers in immunology

authors： Cooper D,Eleftherianos I

更新日期：2017-05-09 00:00:00

abstract：:Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell (HSC) transplantation, but when histocompatibility leukocyte antigen-matched donors are lacking, this can be a high-risk procedure. Correcting the patient's o...

journal_title：Frontiers in immunology

authors： Ott de Bruin LM,Volpi S,Musunuru K

更新日期：2015-05-21 00:00:00

abstract：:The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self receptors and effector mechanisms differ greatly among animal phyla, some aspects of recognition, regulation, and response are broadly conserved. A gene regulatory ne...

journal_title：Frontiers in immunology

authors： Buckley KM,Rast JP

更新日期：2017-10-23 00:00:00

abstract：:M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom. In humans and other higher animals, M1 and M2-type macrophage responses also init...

journal_title：Frontiers in immunology

authors： Mills CD

更新日期：2015-05-05 00:00:00

abstract：:Neosporosis is considered as one of the main causes of abortion and severe economic losses in dairy industry. The Canis genus serving as one of the confirmed definitive hosts of the apicomplexan parasite Neospora caninum (N. caninum) plays a critical role in its life cycle. However, the effects of N. caninum on its de...

journal_title：Frontiers in immunology

authors： Wei Z,Hermosilla C,Taubert A,He X,Wang X,Gong P,Li J,Yang Z,Zhang X

更新日期：2016-10-31 00:00:00