The role of Peyer's patches in synchronizing gut IgA responses.

abstract：Background:The PD-1/PD-L1 axis has recently emerged as an immune checkpoint that controls antitumor immune responses also in hematological malignancies. However, the use of anti-PD-L1/PD-1 antibodies in multiple myeloma (MM) patients still remains debated, at least in part because of discordant literature data on PD-L1...

journal_title：Frontiers in immunology

authors： Costa F,Vescovini R,Marchica V,Storti P,Notarfranchi L,Dalla Palma B,Toscani D,Burroughs-Garcia J,Catarozzo MT,Sammarelli G,Giuliani N

更新日期：2021-01-08 00:00:00

abstract：:microRNAs (miRNAs) are conserved non-coding small nucleotide molecules found in nearly all species and breastmilk. miRNAs present in breastmilk are very stable to freeze-thaw, RNase treatment, and low pH as they are protected inside exosomes. They are involved in regulating several physiologic and pathologic processes...

journal_title：Frontiers in immunology

authors： Carr LE,Bowlin AK,Elolimy AA,Byrum SD,Washam CL,Randolph CE,MacLeod SL,Yeruva L

更新日期：2020-06-23 00:00:00

abstract：:As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated immunization of stages IIB-III CM patients with the irradiated, allogeneic cellular CSF-470 vaccine plu...

journal_title：Frontiers in immunology

authors： Pampena MB,Cartar HC,Cueto GR,Levy EM,Blanco PA,Barrio MM,Mordoh J

更新日期：2018-11-02 00:00:00

abstract：:Short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, modulate immune responses in the gut. However, the effect of SCFAs on mucosal vaccine-induced immune cell migration is poorly understood. Here, we investigated whether SCFAs modulate chemokine expression induced by the killed whole-cell oral c...

journal_title：Frontiers in immunology

authors： Sim JR,Kang SS,Lee D,Yun CH,Han SH

更新日期：2018-01-29 00:00:00

abstract：Background:The toll-like receptor 2 (TLR2)-mediated immune response is critical for host defense against Mycobacterium tuberculosis. There is evidence that TLR10, a TLR2 signaling modulator, may be involved in progression of tuberculosis (TB). Methods:Using a self-validating case-control design, we tested for an assoc...

journal_title：Frontiers in immunology

authors： Wang Y,Zhang MM,Huang WW,Wu SQ,Wang MG,Tang XY,Sandford AJ,He JQ

更新日期：2018-02-23 00:00:00

abstract：:Mast cells are implicated as detrimental players in inflammatory lung diseases, particularly asthma. Mast cells respond to activating stimuli by releasing a wide panel of pro-inflammatory compounds that can contribute profoundly to the pathology, and there is currently an unmet need for strategies that efficiently ame...

journal_title：Frontiers in immunology

authors： Paivandy A,Sandelin M,Igelström H,Landelius P,Janson C,Melo FR,Pejler G

更新日期：2017-11-27 00:00:00

abstract：Background:The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury. Methods:This was a single ...

journal_title：Frontiers in immunology

authors： Spinella PC,Thomas KA,Turnbull IR,Fuchs A,Bochicchio K,Schuerer D,Reese S,Coleoglou Centeno AA,Horn CB,Baty J,Shea SM,Meledeo MA,Pusateri AE,Levy JH,Cap AP,Bochicchio GV,TAMPITI Investigators.

更新日期：2020-09-08 00:00:00

abstract：:Cigarette smoke (CS) is the major cause of chronic lung injuries, such as chronic obstructive pulmonary disease (COPD). In patients with severe COPD, tertiary lymphoid follicles containing B lymphocytes and B cell-activating factor (BAFF) overexpression are associated with disease severity. In addition, BAFF promotes ...

journal_title：Frontiers in immunology

authors： Nascimento M,Huot-Marchand S,Gombault A,Panek C,Bourinet M,Fanny M,Savigny F,Schneider P,Le Bert M,Ryffel B,Riteau N,Quesniaux VFJ,Couillin I

更新日期：2020-07-29 00:00:00

abstract：:Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface, which play an essential role in innate immunity and tissue homeosta...

journal_title：Frontiers in immunology

authors： Rubio JM,Astudillo AM,Casas J,Balboa MA,Balsinde J

更新日期：2018-07-24 00:00:00

abstract：:Background: Each year, over 5 million red blood cell (RBC) transfusions are administered to patients in the USA. Despite the therapeutic benefits of RBC transfusions, there are associated risks. RBC-specific alloantibodies may form in response to antigenic differences between RBC donors and recipients; these alloantib...

journal_title：Frontiers in immunology

authors： Richards AL,Sheldon K,Wu X,Gruber DR,Hudson KE

更新日期：2018-10-05 00:00:00

abstract：:Natural Killer (NK) cells are characterized by their potential to kill tumor cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the...

journal_title：Frontiers in immunology

authors： Terrén I,Orrantia A,Vitallé J,Zenarruzabeitia O,Borrego F

更新日期：2019-09-24 00:00:00

abstract：:Asthma is a chronic airway disease often due to sensitization to aeroallergens, especially house dust mite allergens (HDMs). The Dermatophagoides pteronyssinus group 2 (Der p 2), is one of the most representative HDM allergens and is recognized by more than 90% of HDM-allergic patients. In mouse models, all asthma-rel...

journal_title：Frontiers in immunology

authors： Klein M,Colas L,Cheminant MA,Brosseau C,Sauzeau V,Magnan A,Bouchaud G

更新日期：2020-11-18 00:00:00

abstract：:Immunity to influenza is unique among pathogens, in that immune memory is established both via intermittent lung localized infections with highly variable influenza virus strains and by intramuscular vaccinations with inactivated protein-based vaccines. Studies in the past decades have suggested that the B cell respon...

journal_title：Frontiers in immunology

authors： Nelson SA,Sant AJ

更新日期：2019-05-07 00:00:00

abstract：:The genome has the ability to respond in a precise and co-ordinated manner to cellular signals. It achieves this through the concerted actions of transcription factors and the chromatin platform, which are targets of the signaling pathways. Our understanding of the molecular mechanisms through which transcription fact...

journal_title：Frontiers in immunology

authors： Brettingham-Moore KH,Taberlay PC,Holloway AF

更新日期：2015-09-29 00:00:00

abstract：:Specific antibody deficiency (SAD) is a primary immunodeficiency disease characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination. There is a lack of consensus regarding t...

journal_title：Frontiers in immunology

authors： Perez E,Bonilla FA,Orange JS,Ballow M

更新日期：2017-05-22 00:00:00

abstract：:Highly sensitive reporter-gene assays have been developed that allow both the direct vascular endothelial growth factor (VEGF) neutralizing activity of bevacizumab and the ability of bevacizumab to activate antibody dependent cellular cytotoxicity (ADCC) to be quantified rapidly and in a highly specific manner. The us...

journal_title：Frontiers in immunology

authors： Lallemand C,Ferrando-Miguel R,Auer M,Iglseder S,Czech T,Gaber-Wagener A,Di Pauli F,Deisenhammer F,Tovey MG

更新日期：2020-10-15 00:00:00

abstract：:The Kallikrein-Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report, we show that KKS regulate...

journal_title：Frontiers in immunology

authors： Seliga A,Lee MH,Fernandes NC,Zuluaga-Ramirez V,Didukh M,Persidsky Y,Potula R,Gallucci S,Sriram U

更新日期：2018-02-02 00:00:00

abstract：:Functional cross-talk between osteoblasts and osteoclasts is a key process for bone homeostasis. Although osteoblast hypoxia-inducible factor-1α (HIF-1α) pathway activation results in impaired osteoclastogenesis via the direct regulation of osteoprotegerin (OPG), it is unclear whether there are other efficient mediato...

journal_title：Frontiers in immunology

authors： Kang H,Yang K,Xiao L,Guo L,Guo C,Yan Y,Qi J,Wang F,Ryffel B,Li C,Deng L

更新日期：2017-10-16 00:00:00

abstract：Background:Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. Objectives:To determine whether normal pregnancy and delivery are associated with local activation of...

journal_title：Frontiers in immunology

authors： Livson S,Jarva H,Kalliala I,Lokki AI,Heikkinen-Eloranta J,Nieminen P,Meri S

更新日期：2021-01-11 00:00:00

abstract：:Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as ...

journal_title：Frontiers in immunology

authors： Krupkova O,Sadowska A,Kameda T,Hitzl W,Hausmann ON,Klasen J,Wuertz-Kozak K

更新日期：2018-08-17 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key con...

journal_title：Frontiers in immunology

authors： Mi Y,Guo N,Luan J,Cheng J,Hu Z,Jiang P,Jin W,Gao X

更新日期：2020-04-24 00:00:00

abstract：:Adenosine is a potent immunosuppressive purine metabolite contributing to the pathogenesis of solid tumors. Extracellular adenosine signals on tumor-infiltrating NK cells to inhibit their proliferation, maturation, and cytotoxic function. Cytokine priming imparts upon NK cells distinct activation statuses, which modul...

journal_title：Frontiers in immunology

authors： Chambers AM,Wang J,Lupo KB,Yu H,Atallah Lanman NM,Matosevic S

更新日期：2018-10-30 00:00:00

abstract：:Normal term and spontaneous preterm births (PTB) are documented to be associated with oxidative stress (OS), and imbalances in the redox system (balance between pro- and antioxidant) have been reported in the maternal-fetal intrauterine compartments. The exact mechanism of labor initiation either at term or preterm by...

journal_title：Frontiers in immunology

authors： Menon R

更新日期：2014-11-12 00:00:00

abstract：:Natural killer (NK) cells contribute to immunosurveillance and first-line defense in the control of tumor growth and metastasis diffusion. NK-cell-derived extracellular vesicles (NKEVs) are constitutively secreted and biologically active. They reflect the protein and genetic repertoire of originating cells, and exert ...

journal_title：Frontiers in immunology

authors： Federici C,Shahaj E,Cecchetti S,Camerini S,Casella M,Iessi E,Camisaschi C,Paolino G,Calvieri S,Ferro S,Cova A,Squarcina P,Bertuccini L,Iosi F,Huber V,Lugini L

更新日期：2020-03-13 00:00:00

abstract：:Salmonella infections remain a big problem worldwide, causing enteric fever by Salmonella Typhi (or Paratyphi) or self-limiting gastroenteritis by non-typhoidal Salmonella (NTS) in healthy individuals. NTS may become invasive and cause septicemia in elderly or immuno-compromised individuals, leading to high mortality ...

journal_title：Frontiers in immunology

authors： Li P,Liu Q,Luo H,Liang K,Yi J,Luo Y,Hu Y,Han Y,Kong Q

更新日期：2017-12-04 00:00:00

abstract：:Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed ...

journal_title：Frontiers in immunology

authors： Muire PJ,Mangum LH,Wenke JC

更新日期：2020-06-04 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are quiescent cells with self-renewal capacity and the ability to generate all mature blood cells. HSCs normally reside in specialized niches in the bone marrow that help maintain their quiescence and long-term repopulating activity. There is emerging evidence that certain cytokines ind...

journal_title：Frontiers in immunology

authors： Schuettpelz LG,Link DC

更新日期：2013-07-19 00:00:00

abstract：:Human monocyte-derived dendritic cells (DCs) exposed to pathogen-associated molecular patterns (PAMPs) undergo bioenergetic changes that influence the immune response. We found that stimulation with PAMPs enhanced glycolysis in DCs, whereas oxidative phosphorylation remained unaltered. Glucose starvation and the hexok...

journal_title：Frontiers in immunology

authors： Márquez S,Fernández JJ,Terán-Cabanillas E,Herrero C,Alonso S,Azogil A,Montero O,Iwawaki T,Cubillos-Ruiz JR,Fernández N,Crespo MS

更新日期：2017-06-19 00:00:00

abstract：:Malaria remains a significant health problem in many tropical and sub-tropical regions. The development of vaccines against the clinically active blood-stage of infection needs to consider variability and polymorphism in target antigens, and an adjuvant system able to induce broad spectrum immunity comprising both ant...

journal_title：Frontiers in immunology

authors： Wilson KL,Pouniotis D,Hanley J,Xiang SD,Ma C,Coppel RL,Plebanski M

更新日期：2019-03-15 00:00:00

abstract：:Indoles, as the ligands of aryl hydrocarbon receptor (AhR), have been shown to possess immune-modulating property in terms of the balancing between regulatory T cells (Treg) and T helper 17 cells (Th17) activities. In the present study, we examined the effects of dietary indoles, 3,3'-diindolylmethane (DIM) and indole...

journal_title：Frontiers in immunology

authors： Kim WH,Lillehoj HS,Min W

更新日期：2019-03-26 00:00:00