Specific Antibody Deficiency: Controversies in Diagnosis and Management.

abstract：:The human bone marrow (BM) gives rise to all distinct blood cell lineages, including CD1c+ (cDC2) and CD141+ (cDC1) myeloid dendritic cells (DC) and monocytes. These cell subsets are also present in peripheral blood (PB) and lymphoid tissues. However, the difference between the BM and PB compartment in terms of differ...

journal_title：Frontiers in immunology

authors： van Leeuwen-Kerkhoff N,Lundberg K,Westers TM,Kordasti S,Bontkes HJ,Lindstedt M,de Gruijl TD,van de Loosdrecht AA

更新日期：2018-07-16 00:00:00

abstract：:T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity. It is becoming increasingly evident that GC-Tfh cells are heterogeneous in nature with some cellular cha...

journal_title：Frontiers in immunology

authors： Velu V,Mylvaganam G,Ibegbu C,Amara RR

更新日期：2018-06-06 00:00:00

abstract：:Neisseria gonorrhoeae is a significant health problem worldwide due to multi-drug resistance issues and absence of an effective vaccine. Patients infected with N. gonorrhoeae have not shown a better immune response in successive infections. This might be explained by the fact that N. gonorrhoeae possesses several mech...

journal_title：Frontiers in immunology

authors： Escobar A,Rodas PI,Acuña-Castillo C

更新日期：2018-12-21 00:00:00

abstract：:Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with repetitive antigenic stimulation from chronic infections or tumors. Using intracerebral (i.c.) inoculation with mouse polyomavirus (MuPyV), we have shown that CD8 T cells establish a PD-1hi, tissue-resident memory populat...

journal_title：Frontiers in immunology

authors： Shwetank,Frost EL,Mockus TE,Ren HM,Toprak M,Lauver MD,Netherby-Winslow CS,Jin G,Cosby JM,Evavold BD,Lukacher AE

更新日期：2019-04-17 00:00:00

abstract：:In recent years, chimeric antigen receptor (CAR) T-cell therapy has become popular in immunotherapy, particularly after its tremendous success in the treatment of lineage-restricted hematologic cancers. However, the application of CAR T-cell therapy for solid tumors has not reached its full potential because of the la...

journal_title：Frontiers in immunology

authors： Wang Y,Luo F,Yang J,Zhao C,Chu Y

更新日期：2017-12-22 00:00:00

abstract：:Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (MØs) and dendritic cells (DCs), but also in controlling the function ...

journal_title：Frontiers in immunology

authors： Zhan Y,Lew AM,Chopin M

更新日期：2019-11-15 00:00:00

abstract：:T cells play a critical role in cancer control, but a range of potent immunosuppressive mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their activity. While various immunotherapies (IMTs) aiming at re-invigorating the T-cell-mediated anti-tumor response, such as immune checkpoint blockad...

journal_title：Frontiers in immunology

authors： Vigano S,Alatzoglou D,Irving M,Ménétrier-Caux C,Caux C,Romero P,Coukos G

更新日期：2019-06-06 00:00:00

abstract：:The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid cancer 1, in intratumoral activated CD8+ T cells ...

journal_title：Frontiers in immunology

authors： Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA

更新日期：2017-03-22 00:00:00

abstract：:The complement anaphylatoxin, C5a, through binding to its receptors (C5aR or C5L2), has important biological properties for recruitment and activation of phagocytes. C5a has been identified as a powerful modulator of Toll-like receptor-induced cytokine and chemokine production by macrophages. Both the complement syste...

journal_title：Frontiers in immunology

authors： Grailer JJ,Bosmann M,Ward PA

更新日期：2013-01-09 00:00:00

abstract：:In early human immunodeficiency virus (HIV) infection, the virus population escapes from multiple CD8(+) cell responses. The later an escape mutation emerges, the slower it outgrows its competition, i.e., the escape rate is lower. This pattern could indicate that the strength of the CD8(+) cell responses is waning, or...

journal_title：Frontiers in immunology

authors： Garcia V,Regoes RR

更新日期：2015-01-13 00:00:00

abstract：:Among kidney transplant recipients, the treatment of choice for acute T cell-mediated rejection (TCMR) with pulse steroids or antibody protocols has variable outcomes. Some rejection episodes are resistant to an initial steroid pulse, but respond to subsequent antibody protocols. The biological mechanisms causing the ...

journal_title：Frontiers in immunology

authors： Kadota PO,Hajjiri Z,Finn PW,Perkins DL

更新日期：2015-11-06 00:00:00

abstract：:Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating lymphocytes (TILs). To understand how tumors escape anti-tumor immunity, we investigated tumor-associated T-cell repertoires of pat...

journal_title：Frontiers in immunology

authors： Arakawa A,Vollmer S,Tietze J,Galinski A,Heppt MV,Bürdek M,Berking C,Prinz JC

更新日期：2019-06-18 00:00:00

abstract：:Human pregnancy is accompanied by a mild systemic inflammatory response, which includes the activation of monocytes circulating in maternal blood. This response is exaggerated in preeclampsia, a placental-dependent disorder specific to human pregnancies. We and others showed that placental syncytiotrophoblast membrane...

journal_title：Frontiers in immunology

authors： Joerger-Messerli MS,Hoesli IM,Rusterholz C,Lapaire O

更新日期：2014-04-15 00:00:00

abstract：:Monocytes are critical defense components that play an important role in the primary innate immune response. The heterogeneous nature of monocytes and their ability to differentiate into either monocyte-derived macrophages or monocyte-derived dendritic cells allows them to serve as a bridge between the innate and adap...

journal_title：Frontiers in immunology

authors： Sampath P,Moideen K,Ranganathan UD,Bethunaickan R

更新日期：2018-07-30 00:00:00

abstract：Background:Immunotherapies targeting CTLA-4 and PD-1 have elicited promising responses in a variety of cancers. However, the relatively low response rates warrant the identification of additional immunosuppressive pathways. V domain immunoglobulin suppressor of T cell activation (VISTA) plays a critical role in antitum...

journal_title：Frontiers in immunology

authors： Xie X,Zhang J,Shi Z,Liu W,Hu X,Qie C,Chen W,Wang Y,Wang L,Jiang J,Liu J

更新日期：2020-10-29 00:00:00

abstract：:Advances in microsurgical techniques and immunomodulatory protocols have contributed to the expansion of vascularized composite allotransplantation (VCA) with very encouraging immunological, functional, and cosmetic results. Rejection remains however a major hurdle that portends serious threats to recipients. Rejectio...

journal_title：Frontiers in immunology

authors： Sarhane KA,Tuffaha SH,Broyles JM,Ibrahim AE,Khalifian S,Baltodano P,Santiago GF,Alrakan M,Ibrahim Z

更新日期：2013-11-25 00:00:00

abstract：:Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. The high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization ...

journal_title：Frontiers in immunology

authors： Cassado Ados A,D'Império Lima MR,Bortoluci KR

更新日期：2015-05-19 00:00:00

abstract：:The newborn's immune system must transition from a sterile haploidentical uterus to the world full of antigens. Regulatory B-cells (Breg; broadly defined as CD19+CD24hiCD38hi) are tolerance promoters in the adult immune system. They can inhibit IFN-γ and IL-17 production by T-cells and are essential in different condi...

journal_title：Frontiers in immunology

authors： Esteve-Solé A,Teixidó I,Deyà-Martínez A,Yagüe J,Plaza-Martín AM,Juan M,Alsina L

更新日期：2017-03-07 00:00:00

abstract：:It is now clear that the outcome of an inflammatory process caused by infections depends on the balance of responses by several components of the immune system. Of particular relevance is the interplay between regulatory T cells (Tregs) and CD4+ T cells that produce IL-17 (Th17 cells) during immunoinflammatory events....

journal_title：Frontiers in immunology

authors： Sehrawat S,Rouse BT

更新日期：2017-04-03 00:00:00

abstract：:Background: This retrospective study assessed the use and long-term outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with severe autoimmune diseases (ADs), reported to the European Society for Blood and Marrow Transplantation (EBMT) registry. Methods: Between 1997 and 2014, 128 patients...

journal_title：Frontiers in immunology

authors： Greco R,Labopin M,Badoglio M,Veys P,Furtado Silva JM,Abinun M,Gualandi F,Bornhauser M,Ciceri F,Saccardi R,Lankester A,Alexander T,Gennery AR,Bader P,Farge D,Snowden JA

更新日期：2019-07-04 00:00:00

abstract：:The diseases caused by African trypanosomes (AT) are of both medical and veterinary importance and have adversely influenced the economic development of sub-Saharan Africa. Moreover, so far not a single field applicable vaccine exists, and chemotherapy is the only strategy available to treat the disease. These strictl...

journal_title：Frontiers in immunology

authors： Stijlemans B,Caljon G,Van Den Abbeele J,Van Ginderachter JA,Magez S,De Trez C

更新日期：2016-06-24 00:00:00

abstract：:The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functio...

journal_title：Frontiers in immunology

authors： Wosen JE,Ilstad-Minnihan A,Co JY,Jiang W,Mukhopadhyay D,Fernandez-Becker NQ,Kuo CJ,Amieva MR,Mellins ED

更新日期：2019-08-20 00:00:00

abstract：:Platelets are non-nucleated cells that play central roles in the processes of hemostasis, innate immunity, and inflammation; however, several reports show that these distinct functions are more closely linked than initially thought. Platelets express numerous receptors and contain hundreds of secretory products. These...

journal_title：Frontiers in immunology

authors： Cognasse F,Nguyen KA,Damien P,McNicol A,Pozzetto B,Hamzeh-Cognasse H,Garraud O

更新日期：2015-03-02 00:00:00

abstract：:Graft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation. GVHD is characterized by an imbalance between the effector and regulatory arms of the immune system which results in the over production of inflammatory cytokines. Moreover, there is a persistent reduction...

journal_title：Frontiers in immunology

authors： Beres AJ,Drobyski WR

更新日期：2013-06-24 00:00:00

abstract：:NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of inflammation (NLRC3, NLR...

journal_title：Frontiers in immunology

authors： Lupfer C,Kanneganti TD

更新日期：2013-09-17 00:00:00

abstract：:TNFAIP3 encodes the NF-κB regulatory protein A20. High-penetrance heterozygous mutations in TNFAIP3 cause a haploinsufficiency of A20 (HA20), inadequate inhibition of NF-κB pathway, and an early onset autoinflammatory disorder. However, the clinical phenotype of patients with HA20 varies greatly and clinical diagnoses...

journal_title：Frontiers in immunology

authors： Lawless D,Pathak S,Scambler TE,Ouboussad L,Anwar R,Savic S

更新日期：2018-07-04 00:00:00

abstract：:Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the target tissue, immune ...

journal_title：Frontiers in immunology

authors： Zondler L,Herich S,Kotte P,Körner K,Schneider-Hohendorf T,Wiendl H,Schwab N,Zarbock A

更新日期：2020-12-14 00:00:00

abstract：:For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it is well recognized that a single wave of host-derived thymocytes reconstitutes the irradiated thymu...

journal_title：Frontiers in immunology

authors： Calvo-Asensio I,Sugrue T,Bosco N,Rolink A,Ceredig R

更新日期：2018-06-11 00:00:00

abstract：:IRF-7 mediates robust production of type I IFN via MyD88 of the TLR9 pathway in plasmacytoid dendritic cells (pDCs). Previous in vitro studies using bone marrow-derived dendritic cells lacking either Irf7 or Irf3 have demonstrated that only IRF-3 is required for IFN-β production in the TLR4 pathway. Here, we show that...

journal_title：Frontiers in immunology

authors： Sin WX,Yeong JP,Lim TJF,Su IH,Connolly JE,Chin KC

更新日期：2020-04-16 00:00:00

abstract：:Mast cells are implicated as detrimental players in inflammatory lung diseases, particularly asthma. Mast cells respond to activating stimuli by releasing a wide panel of pro-inflammatory compounds that can contribute profoundly to the pathology, and there is currently an unmet need for strategies that efficiently ame...

journal_title：Frontiers in immunology

authors： Paivandy A,Sandelin M,Igelström H,Landelius P,Janson C,Melo FR,Pejler G

更新日期：2017-11-27 00:00:00