IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice.

abstract：:High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of li...

journal_title：Frontiers in immunology

authors： Mamedov IZ,Britanova OV,Zvyagin IV,Turchaninova MA,Bolotin DA,Putintseva EV,Lebedev YB,Chudakov DM

更新日期：2013-12-23 00:00:00

abstract：:TNF-Receptor Associated Factor (TRAF)-3 is a master regulator of B cell homeostasis and function. TRAF3 has been shown to bind and regulate various proteins involved in the control of innate and adaptive immune responses. Previous studies showed that TRAF3 overexpression renders B cells hyper-reactive to antigens and ...

journal_title：Frontiers in immunology

authors： Perez-Chacon G,Adrados M,Vallejo-Cremades MT,Lefebvre S,Reed JC,Zapata JM

更新日期：2019-01-11 00:00:00

abstract：:Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL). The proper o...

journal_title：Frontiers in immunology

authors： Bannas P,Hambach J,Koch-Nolte F

更新日期：2017-11-22 00:00:00

abstract：:Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast cells form a heterogeneous population of immune cells with differences in their ultra-structure, morphology, mediator content, and surface receptors. Mast cells are widely distributed throughout all tissues and are stromal compon...

journal_title：Frontiers in immunology

authors： Varricchi G,Galdiero MR,Loffredo S,Marone G,Iannone R,Marone G,Granata F

更新日期：2017-04-12 00:00:00

abstract：:Atopic dermatitis (AD) is a complex multifactorial inflammatory skin disease that affects ~280 million people worldwide. About 85% of AD cases begin in childhood, a significant portion of which can persist into adulthood. Moreover, a typical progression of children with AD to food allergy, asthma or allergic rhinitis ...

journal_title：Frontiers in immunology

authors： Ghosh D,Bernstein JA,Khurana Hershey GK,Rothenberg ME,Mersha TB

更新日期：2018-12-12 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and a high predisposition to lymphoid malignancies. The majority of NBS patients are identified with a homozygous five base pair deletion in the Nibrin (NBN) gene (c.657_661del5, p.K219fsX19) with a founder effect obse...

journal_title：Frontiers in immunology

authors： Sharapova SO,Pashchenko OE,Bondarenko AV,Vakhlyarskaya SS,Prokofjeva T,Fedorova AS,Savchak I,Mareika Y,Valiev TT,Popa A,Tuzankina IA,Vlasova EV,Sakovich IS,Polyakova EA,Rumiantseva NV,Naumchik IV,Kulyova SA,Aleshkevich

更新日期：2021-01-08 00:00:00

abstract：:Whether and how γδT cells play a protective role in immunity against Plasmodium infection remain open questions. γδT cells expand in patients and mice infected with Plasmodium spp, and cytokine production and cytotoxic responses against blood-stage parasites are observed in vitro. Their expansion is associated with pr...

journal_title：Frontiers in immunology

authors： Deroost K,Langhorne J

更新日期：2018-12-20 00:00:00

abstract：:Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of ...

journal_title：Frontiers in immunology

authors： Kainthola A,Haritwal T,Tiwari M,Gupta N,Parvez S,Tiwari M,Prakash H,Agrawala PK

更新日期：2017-05-02 00:00:00

abstract：:Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tis...

journal_title：Frontiers in immunology

authors： Wu Y,Tian Z,Wei H

更新日期：2017-08-04 00:00:00

abstract：:Hyaluronan (HA), the major extracellular matrix component, is often anchored to CD44, a family of structurally/functionally important cell surface receptors. Recent results indicate that UV irradiation (UVR)-induced cutaneous squamous cell carcinomas (SCC) overexpress a variety of CD44 variant isoforms (CD44v), with d...

journal_title：Frontiers in immunology

authors： Bourguignon LY,Bikle D

更新日期：2015-05-13 00:00:00

abstract：:Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressiv...

journal_title：Frontiers in immunology

authors： Stegner D,Klaus V,Nieswandt B

更新日期：2019-11-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

journal_title：Frontiers in immunology

authors： Martin-Gayo E,Yu XG

更新日期：2019-06-06 00:00:00

abstract：:Superparamagnetic iron oxide nanoparticles (SPION) are employed as diagnostics and therapeutics following intravenous delivery for the treatment of iron deficiency anemia (IDA) in adult patients with chronic kidney failure. Neutrophils are the first defense against blood borne foreign insult and recruit to vascular si...

journal_title：Frontiers in immunology

authors： Garcia G,Kim MH,Morikis VA,Simon SI

更新日期：2020-12-09 00:00:00

abstract：:Epidermal infiltration of neutrophils is a hallmark of psoriasis, where their activation leads to release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis pathogenesis has been unclear, but here we demonstrate that NETs drive inflammatory responses in skin through activation of epidermal...

journal_title：Frontiers in immunology

authors： Shao S,Fang H,Dang E,Xue K,Zhang J,Li B,Qiao H,Cao T,Zhuang Y,Shen S,Zhang T,Qiao P,Li C,Gudjonsson JE,Wang G

更新日期：2019-04-05 00:00:00

abstract：:Early detection of Primary Immunodeficiencies Disorders (PIDDs) is of paramount importance for effective treatment and disease management. Many PIDDs would be strong candidates for newborn screening (NBS) if robust screening methods could identify patients from dried blood spots (DBS) during the neonatal period. As ma...

journal_title：Frontiers in immunology

authors： Collins CJ,Yi F,Dayuha R,Whiteaker JR,Ochs HD,Freeman A,Su HC,Paulovich AG,Segundo GRS,Torgerson T,Hahn SH

更新日期：2020-04-01 00:00:00

abstract：:The ability of dendritic cells (DCs) to stimulate and regulate T cells is critical to effective anti-tumor immunity. Therefore, it is important to fully recognize any inherent factors which may influence DC function under experimental conditions, especially in laboratory mice since they are used so heavily to model im...

journal_title：Frontiers in immunology

authors： Kokolus KM,Spangler HM,Povinelli BJ,Farren MR,Lee KP,Repasky EA

更新日期：2014-02-10 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00

abstract：:Antibody-derived chimeric antigen receptor (CAR) T cell therapy has achieved gratifying breakthrough in hematologic malignancies but has shown limited success in solid tumor immunotherapy. Monoclonal antibody, TAB004, specifically recognizes the aberrantly glycosylated tumor form of MUC1 (tMUC1) in all subtypes of bre...

journal_title：Frontiers in immunology

authors： Zhou R,Yazdanifar M,Roy LD,Whilding LM,Gavrill A,Maher J,Mukherjee P

更新日期：2019-05-24 00:00:00

abstract：:Continued discoveries of negative regulators of inflammatory signaling provide detailed molecular insights into peripheral tolerance and anti-tumor immunity. Accumulating evidence indicates that peripheral tolerance is maintained at multiple levels of immune responses by negative regulators of proinflammatory signalin...

journal_title：Frontiers in immunology

authors： Guram K,Kim SS,Wu V,Sanders PD,Patel S,Schoenberger SP,Cohen EEW,Chen SY,Sharabi AB

更新日期：2019-03-18 00:00:00

abstract：:Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early detection of PID remains a challenge, particularly in older children with milder and less specific ...

journal_title：Frontiers in immunology

authors： Korsunskiy I,Blyuss O,Gordukova M,Davydova N,Zaikin A,Zinovieva N,Zimin S,Molchanov R,Salpagarova A,Eremeeva A,Filipenko M,Prodeus A,Korsunskiy A,Hsu P,Munblit D

更新日期：2020-03-03 00:00:00

abstract：:The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly increased numbers of B cells. However, it has remained unclear whether th...

journal_title：Frontiers in immunology

authors： Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J

更新日期：2018-03-22 00:00:00

abstract：:Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition, there has been an increasing number of patients with wild-type FOXP3 gene and, in some cases, mutations in other immune regulatory genes. Objectiv...

journal_title：Frontiers in immunology

authors： Gambineri E,Ciullini Mannurita S,Hagin D,Vignoli M,Anover-Sombke S,DeBoer S,Segundo GRS,Allenspach EJ,Favre C,Ochs HD,Torgerson TR

更新日期：2018-11-01 00:00:00

abstract：:Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone...

journal_title：Frontiers in immunology

authors： Clark HL,Abbondante S,Minns MS,Greenberg EN,Sun Y,Pearlman E

更新日期：2018-05-29 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues ass...

journal_title：Frontiers in immunology

authors： Mancheño-Corvo P,Lopez-Santalla M,Menta R,DelaRosa O,Mulero F,Del Rio B,Ramirez C,Büscher D,Bueren JA,Lopez-Belmonte J,Dalemans W,Garin MI,Lombardo E

更新日期：2017-04-21 00:00:00

abstract：:Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis. While platelet activation and elevated platelet counts (thrombocytosis) are associated with increased risk of thrombotic complications, low platelet counts (thrombocytopenia) and several platelet function disorders increase ...

journal_title：Frontiers in immunology

authors： Assinger A

更新日期：2014-12-18 00:00:00

abstract：:Patients with severe eosinophilic asthma (SEA; characterized by persistent eosinophilia in blood and airway tissues) experience frequent asthma exacerbations with poor clinical outcomes. Interleukin 5 (IL-5) and IL-5 receptor alpha subunit (IL-5α) play key roles in eosinophilia maintenance, and relevant therapeutic st...

journal_title：Frontiers in immunology

authors： Kim JE,Lee DH,Jung K,Kim EJ,Choi Y,Park HS,Kim YS

更新日期：2021-01-08 00:00:00

abstract：:The ability of the host to clear hepatitis B virus (HBV) is closely correlated to the establishment of commensal microbiota. However, how microbiota affects anti-HBV immunity is still unclear. Using a well-known hydrodynamical HBV transfection mouse model and treatment with antibiotics (Atb), we explored the change in...

journal_title：Frontiers in immunology

authors： Wu T,Li F,Chen Y,Wei H,Tian Z,Sun C,Sun R

更新日期：2019-04-30 00:00:00

abstract：:The onset of hepatic disorders in patients with systemic lupus erythematosus (SLE) is frequent; however, the etiology and liver pathogenesis of SLE remain unknown. In the present study, the role of hepatic deposited immunoglobulin G (IgG) in SLE-derived liver damage was investigated. From a retrospective analysis of t...

journal_title：Frontiers in immunology

authors： Fang X,Zaman MH,Guo X,Ding H,Xie C,Zhang X,Deng GM

更新日期：2018-06-25 00:00:00

abstract：:Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors as minor histocompatibility antigens (mHAs). While the impact of individual mHAs on allo-HSCT o...

journal_title：Frontiers in immunology

authors： Ritari J,Hyvärinen K,Koskela S,Niittyvuopio R,Nihtinen A,Salmenniemi U,Putkonen M,Volin L,Kwan T,Pastinen T,Itälä-Remes M,Partanen J

更新日期：2019-07-16 00:00:00

abstract：:Common variable immunodeficiency (CVID) is increasingly recognized for its association with autoimmune and inflammatory complications. Despite recent advances in immunophenotypic and genetic discovery, clinical care of CVID remains limited by our inability to accurately model risk for non-infectious disease developmen...

journal_title：Frontiers in immunology

authors： Farmer JR,Ong MS,Barmettler S,Yonker LM,Fuleihan R,Sullivan KE,Cunningham-Rundles C,USIDNET Consortium.,Walter JE

更新日期：2018-01-09 00:00:00